Abstract: In one aspect, a system for in vivo stimulation of targeted tissues of a subject integrated in Exosome and/or stem cell therapies may include at least one light source, a controller to control operation of the light source, a signal detecting unit and a processor configured to receive signals from the signal detecting unit, analyze the signals and generate a feedback signal to the controller to control the light source until optimal results are obtained. In one embodiment, the light source is a laser instrument and the wavelength can range from 400 to 1100 nm. In another embodiment, the irradiance of the laser instrument can range from 10 to 3000 mW/cm2.

Abstract: A lighting fixture appears as a skylight and is referred to as a skylight fixture. First and second light engines of the fixture provide different color points, peak light intensity angles, far-field light distribution characteristics, and/or circadian stimulus values. A skylight fixture may include a sky-resembling assembly and a plurality of sun-resembling assemblies, with dedicated optical assemblies and/or light sources. A lighting fixture may include multiple waveguides that different extraction feature patterns and/or may be sequentially arranged.

Abstract: Systems and methods are disclosed for a surgical laser system with illumination. In some embodiments, a laser system comprises a surgical laser and an illumination source having their outputs combined into a fiber-optic cable and directed by the fiber-optic cable to a target surface. The illuminating visible light may be continuous and/or in pulses. Surgical laser pulses and illumination pulses may be synchronized for a stroboscopic effect. The laser system may also monitor laser electromagnetic radiation that is returned back through the fiber-optic cable.

Abstract: A converging thermal lens is transiently formed by directing a shaped pulsed light beam having at least a first wavelength to a thermo-optic material, whereby the thermo-optic material absorbs the light beam and experiences local heating in response thereto. The heating induces a refractive index profile in the thermo-optic material that temporarily forms the converging thermal lens. In some embodiments, the refractive index of the thermo-optic material has a negative temperature dependence, and the pulsed light beam is shaped to have an inverted light pattern with a maximum intensity in an outer region of the beam cross-section. Alternatively, in some embodiments, the refractive index of the thermo-optic material has a positive temperature dependence, and the pulsed light beam is shaped to have a radially-varying light pattern with a maximum intensity in a central region of the beam cross-section.

Abstract: A method includes emitting a first light having a first color that is on a first Tritan confusion line defined by a Tritan copunctual point and emitting a second light having a second color that is on a second Tritan confusion line defined by the Tritan copunctual point. The second light is emitted out of phase with the first light, and the first Tritan confusion line, the Tritan copunctual point, and the second Tritan confusion line form an angle that is less than 10 degrees.

Abstract: A lighting arrangement for providing visible light and radiation in another spectrum that is medically beneficial is provided. The lighting arrangement comprises a light source adapted to emit visible light; a radiation source adapted to emit radiation in a predetermined spectrum, and a driver circuit adapted to provide a first driving current that is pulsed and has a duty cycle of not greater than 20%. The predetermined spectrum is preferably in the range 760-1400 nm. The lighting arrangement is adapted to provide the first driving current to the radiation source but not the light source. Corresponding method and products employing such lighting arrangement are also provided.

Abstract: A material and apparel that positively affect the health and well-being of a mammal include fibers that are formed with a semiconductor. Upon contact of the material or apparel with a region of the mammal's body, a positive effect occurs that relates to the health and wellbeing of that mammal. The material includes a region that includes an expanse. The expanse is formed with a semiconductor and constructed for contact with the skin of the mammal. The apparel has a body that includes a region that has a wearable form made of a semiconductor, and is constructed for making contact with a human body when the human wears the apparel.

Abstract: According to some embodiments, a system for fractionally treating tissue includes: an electromagnetic radiation (EMR) source configured to generate an EMR beam having a transverse ring energy profile; an optic configured to converge the EMR beam to a focal region located within a tissue; and, a window assembly located down-beam from the optic configured to cool the tissue when placed in contact with an outer surface of the tissue.

Abstract: A surgical imaging system for presenting one or more operational parameters to a user in an augmented reality display disposed in a user's field of vision. The one or more operational parameters may be derived from or include signals from one or more sensors of a smart surgical instrument. The augmented reality display may comprise a transparent or semitransparent display positioned between the user and the surgical field such that the user may look through the augmented reality display to view the surgical field. In this regard, a user may observe the one or more operational parameters without diverting attention from the surgical field.

Abstract: In one aspect, a method for measuring cell metabolism through photobiomodulation comprising steps of receiving a broadband near-infrared spectroscopy (bbNIRS) image including one or more responding signals to light stimulation regarding a specific cell; extracting two or more turning points on one of the responding signals; extracting two or more threshold points on one of the responding signals; generating a first line by curve fitting to approximate the turning points on the responding signal and determining a slop of the first line; generating a second line by curve fitting to approximate the threshold points on the responding signal and determining a slop of the second line; and comparing the input images, the first line and the second line to determine a rate of cell metabolism of the specific cell.

Abstract: A skin care device according to an embodiment of the present disclosure includes an outer case having a first opening, an inner case configured to be fastened to the outer case and having a second opening corresponding to the first opening, and a light output module configured to be accommodated between the outer case and the inner case, in which the light output module includes a module body configured to form a predetermined area based on a shape of the outer case or the inner case, a module cover formed along a part of an outer part of the module body, and, between the module body and the module cover, a plurality of light sources disposed in an array form along the outer part of the module body, and in which each of the plurality of light sources is disposed to face the module body.

Abstract: A material and apparel that positively affect the health and well-being of a mammal include fibers that are formed with a semiconductor. Upon contact of the material or apparel with a region of the mammal's body, a positive effect occurs that relates to the health and wellbeing of that mammal. The material includes a region that includes an expanse. The expanse is formed with a semiconductor and constructed for contact with the skin of the mammal. The apparel has a body that includes a region that has a wearable form made of a semiconductor, and is constructed for making contact with a human body when the human wears the apparel.

Abstract: Methods and systems for method for acoustic treatment of tissue to disperse vacuoles within the tissue. Some of the present methods and systems comprise: directing pulsed acoustic waves from the acoustic wave generator into the tissue containing the vacuoles. Some of the present methods include identifying the location of tissue containing vacuoles, and/or coupling (e.g., acoustically) an acoustic wave generator to the tissue containing the vacuoles.

Abstract: A phototherapy device for modulating an optical dosage delivered to targeted tissues extraorally based on measured tissue properties, such that the targeted tissues receive a particular dose of optical power.

Abstract: An illumination device includes a light source and a deformable light guide optically coupled to the light source. The deformable light guide is configured to conform to a surface of tissue when in contact with the tissue such that light from the light source is coupled directly from the deformable light guide to the tissue. By using a deformable light guide, more light can be delivered to a target tissue. This may increase treatment efficacy, reduce treatment time, or both.

Abstract: The present invention relates the field of ultrasound and neurostimulation. The inventors have shown that using ultrasound neurostimulation with specific parameters provides similar or better effects that fluoxetine administration in depression. Such assessment was made in unpredictable chronic mild stress model in mouse. The proposed use also provides with positive effects in other cases, such as modulating emotion or attenuating anxiety-related behaviours (stress notably).

Abstract: A method of treating a non-human animal subject includes irradiating, one or more times, light having a peak wavelength in a range of 315-335 nm to an affected area of the animal subject.

Abstract: A phototherapy system having sensor(s) for detecting parameters associated with light generation by a light source and circuitry for modulating the light source based on the detected parameters. Also, a phototherapy system having a light guide interfacing with a light source at a connection point, an ambient light sensor, a connector light sensor for detecting (at the connection point) ambient light received by a light emitting pad that is directed into the light guide, and circuitry for determining whether the light guide is correctly connected to the light source based on a difference between the output of the ambient light source and the connector light sensor. Further, a phototherapy system including a light emitting pad having an identification tag and circuitry that modulates a light source based on the identification tag. Additionally, a phototherapy system including a casing encapsulating multiple light emitters and a light emitting pad.

Abstract: The present invention pertains to a method for projecting a pattern of interest on a modified retinal area of a human eye, comprising the steps of providing a pulsed input light beam, modulation and dividing the pulsed input light beam into a pulsed modulated light pattern of modulated pulsed sub-beams based on a pattern of interest, wherein the modulated light pattern forms a pulsed output beam reflecting the pattern of interest, wherein performing an individual pulse width modulation of a modulation duty cycle of the modulated individual sub-beams forming the output beam, and to correspondingly adapted device.

Abstract: Methods and apparatus for treating melasma and/or related hyperpigmentation disorders of a patient are disclosed. The treatment includes delivering laser pulses onto a body of the patient, wherein the delivering laser pulses includes two or more of the following steps: 1) delivering laser pulses p1 onto the body, wherein each pulse of the laser pulses p1 is configured to have a diameter of at least 100 ?m and a duration of at most 1 ?s; 2) delivering laser pulses p2 onto the body, wherein each pulse of the laser pulses p2 is configured to have a diameter of at least 100 ?m and a duration of more than 1 ?s; 3) delivering laser pulses p3 onto the body, wherein each pulse of the laser pulses p3 is configured to comprise a plurality of microbeams, each microbeam having a diameter below 1 mm.

Abstract: In one aspect, a system for in vivo and transcranial stimulation of brain tissue of a subject may include at least one light source, a controller to control operation of the light source, a signal detecting unit and a processor configured to receive signals from the signal detecting unit, analyze the signals and generate a feedback signal to the controller to control the light source until optimal results are obtained. In one embodiment, the light source is a laser instrument and the wavelength can range from 800 to 1100 nm. In another embodiment, the irradiance of the laser instrument can range from 50 to 1000 mW/cm2.

Abstract: A disposable and flexible electronic device for photobiomodulation of biological tissues, particularly applied as a bandage in several formats, in either domestic or clinical applications, biostimulating or biomodulating biological tissues, for healing wounds and treating inflammation, edema and pain.

Abstract: A system for in vivo and transcranial stimulation of brain tissue of a subject may include at least one light source; a controller to control operation of the light source; a signal detecting unit and a processor configured to receive a signal from the signal detecting unit; analyze the signal and generate a feedback signal to the controller to control the light source until optimal results are obtained, wherein the detected signal is an electroencephalogram (EEG) signal, on which local peak frequencies are extracted and recorded periodically and repeatedly within a predetermined time frame before, during and after light stimulation, and the feedback signal is generated by comparing the local peak frequencies of before, during and after the brain stimulation to determine if brain synchronization occurs and sustains, and the feedback signal is generated.

Abstract: A light source for myopia prevention article includes a light emitter to emit light having an emission spectrum continuing from a first wavelength of not less than 360 nm nor more than 400 nm to a second wavelength of more than 400 nm.

Abstract: An apparatus and method for a sleep disorder treatment including an input device a light-emitting device for use in precise tissue heating and tightening, including one or more light settings, a processor; and a memory communicatively connected to the processor, the memory containing instructions configuring the processor to receive user data from the input device, receive diagnostic test data from a plurality of diagnostic tests, wherein a diagnostic test comprises a nocturnal polysomnography test, generate a plurality of light emission parameters for the one or more light settings as a function of the user data and treat user with the light-emitting device in oral tissue area.

Abstract: An illumination apparatus is disclosed, comprising: a first light source having a first spectral light distribution with a first light intensity peak about a first peak wavelength, and a second light source having a second spectral light distribution with a second light intensity peak about a second peak wavelength being different from the first peak wavelength, a third light source having a third spectral light distribution with a main light intensity peak about a third peak wavelength being different from the first peak wavelength and from the second peak wavelength, wherein the illumination apparatus is configured to provide adjustment of light intensity of the first light source and of light of the second light source, wherein the illumination apparatus provides an adjustment of light intensity of the third light source to compensate for the adjusting of the relative light intensity between the first light source and the second light source.

Abstract: Lumiphoric materials and corresponding light-emitting devices, and more particularly localized surface plasmon resonance for enhanced photoluminescence of lumiphoric materials are disclosed. Plasmonic materials are disclosed that are configured to induce localized surface plasmon resonance and excite a corresponding localized surface plasmon enhanced electric field in response to incident light. An increase in photoluminescence of lumiphoric materials may be realized when the lumiphoric materials are arranged within the localized surface plasmon enhanced electric field. Plasmonic materials are disclosed that include various arrangements of nanoparticles and/or patterned structures with corresponding dielectric materials that are collectively arranged in close proximity to lumiphoric materials.

Abstract: Embodiments of the present invention generally relate to methods, devices, and systems for reducing a pigmentation of a skin of a patient. In some embodiments, freezing of the skin may be desirable to effect the hypopigmentation of the skin of the patient. Generally, embodiments may limit supercooling (or promote freezing) of the skin of the patient during a cooling treatment. In some embodiments, coupling fluids are provided to reduce a thermal contact resistance between a cooling treatment probe and the skin of the patient to improve cooling treatment. Optionally, a fluid carrier may be provided to help retain the coupling fluid at the treatment site. In some embodiments, the coupling fluid may include ice nucleating agents to promote ice crystal formation in the coupling fluid during cooling treatment. The ice crystal formation in the coupling fluid may progress into the skin to limit supercooling of the skin during treatment.

Abstract: A surgical system comprising a surgical hub, a surgical instrument, a generator configured to energize an end effector; and a smoke evacuation system configured to remove smoke from a surgical site is disclosed. The surgical instrument comprises the end effector. A control command is passed directly from the surgical hub to the surgical instrument. The surgical instrument is configured to pass the control command received from the surgical hub to the generator and the smoke evacuation system in a daisy-chain manner.

Abstract: A computer implemented method for controlling a device adapted for projecting an image on at least a part of an eye of a wearer of said device, the method comprising the steps of providing the direction gaze of an eye of the wearer, providing an initial image to be projected, determining at least a filter depending from the provided gaze direction, filtering the initial image using the determined filter, and sending a command to the device for projecting the filtered image in the eye.

Abstract: A method for quantifying an exposure dose for a surface is disclosed. The method may include emitting one or more beams of 222 nm light onto a portion of the surface using one or more far ultraviolet (UV) light sources capable of emitting 222 nm light, the portion of the surface being coated with one or more fluorescent coatings. The method may include capturing images of the portion of the surface. The method may include adjusting one or more image characteristics for the captured images using one or more filtering methods. The method may include generating a histogram of the adjusted images based on the one or more filtering methods. The method may include determining a pixel surface area for the generated histogram. The method may include calculating the exposure dose for the surface based on the generated pixel surface area and a predetermined calibration curve.

Abstract: A system and method for aiding in the proper placement of ECG electrodes and other resuscitation parameters. The system includes motion sensors disposed on the ECG electrodes, and a defibrillator control system operable to interpret motion signals from the motions sensors to determine that an electrode is in motion, and thus being handled by rescuer setting up the system for use, and, based on this determination, prompt the rescuer to place the electrode in its intended location on the body of the patient. The control system may also be operable to determine relative motion and/orientation of the motion sensors and control resuscitation based on the relative motion and/orientation of the motion sensors.

Abstract: A security system. The security system has a camera operated by a microcontroller. The microcontroller has a logic to scan the images collected by the camera and determine if a dangerous event is happening. After a dangerous event is identified, the microcontroller activates a security system. The security system will activate several functional features including a speaker, a light and a door lock.

Abstract: An intraocular micro-display (IOMD) system includes an auxiliary head unit. The auxiliary head unit includes a frame for mounting to a head of a user, a scene camera module mounted in or on the frame in a forward-facing orientation, a gaze tracking module disposed in or on the frame and configured to monitor an eye of the user, and an auxiliary controller. The auxiliary controller includes for: acquiring a scene image with the scene camera module, determining a gazing direction of the eye based upon gaze direction data from the gaze tracking module, identifying a sub-portion of the scene image based upon the gazing direction, and wirelessly relaying the sub-portion of the scene image to an IOMD implant within the eye for displaying to a retina of the eye.

Abstract: Technology for a light therapy device is disclosed. The light therapy device can comprise: a housing; and a combination of light sources coupled to the housing in an orientation operable to radiate a subject, and provide light therapy from the combination of light sources. The combination of light sources can include: a first discrete light source configured to emit light at a wavelength limited to between about 500 nanometers (nm) to about 700 nm; a second discrete light source configured to emit light at a wavelength limited to between about 700 nm to about 850 nm; a third discrete light source configured to emit light at a wavelength limited to between about 800 nm to about 900 nm; and a fourth discrete light source configured to emit light at a wavelength limited to between about 850 nm to about 1050 nm.

Abstract: A method and apparatus for stimulating neural activity in the brain of a user of an apparatus with a display screen by causing at least one portion of the display screen to flicker in a controlled manner and utilizing the apparatus to measure an effect on a user exposed to the flicker for a time.

Abstract: Various embodiments relate to the field of communications technologies, and provide a light adjustment method and a terminal to resolve a problem that an existing light therapy device cannot flexibly adjust light based on a light requirement of a user and cannot more intelligently adjust a circadian rhythm of the user. In those embodiments, an awake time period and a sleep time period of a user is determined by the terminal, and parameter thresholds in the awake time period and the sleep time period is determined by the terminal. In those embodiments, a light parameter in a current time period is obtain by the terminal, and based on the light parameter in the current time period, a light parameter of light emitted by a light source device is then adjusted by the terminal.

Abstract: A rejuvenation and massage device is provided for treating mucosa tissue, such as vaginal tissue, affected by Vaginal Relaxation Syndrome (VRS) or other conditions, through vibration, thermal loading, and light emittance for a duration of time. In one embodiment, the device is an insertable device that includes Low-Level Laser Light (LLLT) therapy to treat the vaginal tissue. The light emittance by one or more light emitters is in a range sufficient to provide therapeutic effects through light radiation. To enhance the therapeutic effects of light radiation provided by the device, the device is configured to provide increased energy density into target tissue of vaginal muscles though a light configuration component (e.g., a focusing component, such as a concave lens assembly, a convex assembly, a pre-lensed light emitter or other focusing optical mechanism) associated with the light emitter that concentrates the light emitted from the light emitter.

Abstract: In certain embodiments a light therapy system (e.g., phototherapy device), such as for treatment of Alzheimer's disease, depression, dementia, short-term memory, or for improved learning, improved athletic performance or improved cognitive performance, is provided where the light system comprises a blue light source that operates at a frequency in the range from 20 to 50 Hz (preferably around 40 Hz), whereby the system enables retinal ganglion cells of a human to be exposed in order to stimulate brain waves (gamma oscillations in the human's brain).

Abstract: Ablation catheters and systems include flexible catheter tips with a distal needle or ports for delivery of an ablative agent to a target tissue. Pressure monitoring during ablation ensure operation is performed within safe limits and with desired efficacy. Positioning elements help maintain the devices in the proper position with respect to the target tissue and also prevent the passage of ablative agent to normal tissues.

Abstract: A treatment that regenerates cells, remodels collagen, and reverses atrophy to restore full sexual function of human genitalia.

Abstract: Methods for a generally safe and effective therapy to lower excessive and chronic inflammation via the promotion of the body's powerful anti-inflammatory Interleukin-10 cytokine and re-activation of dormant T regulatory cells are provided. The methods balance the safety and efficacy of both Interleukin-10 (IL-10) and Treg optimization with excessive risk of UV overexposure to treat and improve several chronic autoimmune inflammatory conditions.

Abstract: In one aspect, a system for in vivo and transcranial stimulation of brain tissue of a subject may include at least one light source, a controller to control operation of the light source, a signal detecting unit and a processor configured to receive signals from the signal detecting unit, analyze the signals and generate a feedback signal to the controller to control the light source until optimal results are obtained. In one embodiment, the light source is a laser instrument and the wavelength can range from 800 to 1100 nm. In another embodiment, the irradiance of the laser instrument can range from 50 to 1000 mW/cm2.

Abstract: Methods and systems as described herein may be used for independently controlling the color temperature, intensity, and/or circadian response (CR) of one or more light sources (e.g., discrete-spectrum light sources) to adjust one or more color temperature, intensity, and circadian metrics in a space. For example, a light fixture may have four controllable light sources, a warm CR boost, cool CR boost, warm non-boost CR and a cool non-boost CR to independently control intensity, color temperature, and CR outputs.

Abstract: Provided is a laser patch, and the laser patch includes: a patch body having a through hole for laser transmission; a circuit substrate disposed in the patch body; a built-in battery disposed, facing the circuit substrate, in the patch body; a laser diode element electrically connected to the circuit substrate and emitting a low-output laser beam to the outside of the patch body by using its own power coming from the built-in battery; and a charging terminal provided in the patch body for selectively supplying electricity to the built-in battery from an external charger.

Abstract: Bio-photonic devices or target cells and cell cultures including bio-photonic devices and target cells are provided. Methods of preparing cell cultures including bio-photonic devices and target cells are also provided. Methods of analyzing the electrophysiology of target cells using the cell cultures are provided. Systems for analyzing the electrophysiology of target cells are also provided.

Abstract: The present disclosure provides a circadian rhythm correcting apparatus including a bio-illuminance measuring part configured to measure bio-illuminance of external light, a light source configured to irradiate light of a circadian wavelength band toward a retinal ganglion cell, a light source driver configured to drive the light source by supplying power to the light source, and a controller configured to control the light source driver on the basis of the bio-illuminance measured by the bio-illuminance measuring part, to correct the circadian rhythm.

Abstract: A handheld light treatment device that aims to provide a wide variety of uses in personal care and household cleaning. The device contains a panel with light sources positioned behind a translucent or transparent head plate, to which is attachable an applicator disc and, optionally, applicator disc attachments with selected functionalities. The light panel shines light of different frequencies that may be useful for cleaning and sanitizing various surfaces. The applicator disc and applicator disc attachments have a substantially translucent or transparent base, allowing light from the light sources to shine through the head plate as well as applicator disc and applicator disc attachment, and the applicator disc to rotate while the light panel remains fixed. The applicator disc and applicator disc attachments may have bristles or other surface elements to facilitate cleaning or other uses, and the device may dispense an ingredient.

Abstract: A system (20) includes a plurality of electrodes (28), one or more radiofrequency (RF) generators (30), and a controller (36). The controller is configured to treat skin of a user (22), using one or more decision rules, responsively to multiple ascertained values of at least one parameter, by iteratively ascertaining at least one respective value of the ascertained values, by applying at least one of the decision rules to the ascertained value, identifying a treatment setting from among multiple treatment settings, and causing the RF generators to cause one or more RF currents to pass, through the skin, between at least some of the electrodes in accordance with the identified treatment setting. The controller is further configured to modify at least one of the decision rules in response to the ascertained values. Other embodiments are also described.

Abstract: A method and device for photodynamic therapy for treating cancer. The method includes: providing a photodynamic therapeutic device for treating cancer. The provided device includes a plurality of light emitting diodes that are positionable in proximity of a patient's body and are adapted to provide a light fluence to a lesion area. The method also includes administering an effective dose of a photosensitizer in the lesion area; positioning the device in proximity to the patient's body; and irradiating the patient's body.