Abstract: In some implementations, a PDT system may include a probe assembly having an elongated cylinder having a probe inner diameter and a probe outer diameter optical surface and a probe tip positioned on a distal end, a therapy window positioned proximal the probe tip, a door positioned inside of the elongated cylinder and configured to move between an open position to expose the therapy window and a closed position to seal the therapy window, a balloon positioned within the inner probe diameter, a cylindrical light diffuser position inside of the balloon, and a detector fiber positioned proximate the cylindrical light diffuser.

Abstract: To provide a method of producing an endoscope flexible tube and the like which can realize an endoscope with high insertability. A method of producing the endoscope flexible tube including: continuously discharging a liquid resin into a film shape from an annular discharge port surrounding an axis and a side surface of a cylindrical substrate; bringing the discharged film-shape resin into contact with the entire periphery of the substrate on the downstream side of the discharge port; covering a side surface of the substrate with the resin while moving the substrate in an axial direction to separate a portion where the resin and the substrate are in contact from the discharge port; and curing the resin covering the side surface of the substrate.

Abstract: Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through such optical arrangement (or through another optical arrangement), and receive at least one fourth radiation from the portion which is based on the third radiation. Based on an interaction between the optical arrangement (or the other optical arrangement) and the third radiation and/or the fourth radiation, the optical arrangement (or the other optical arrangement) can have a second transfer function.

Abstract: A high-power light system includes a lamp for producing light within a designated wavelength range, a chiller for maintaining the lamp below a defined temperature threshold, and a control module for regulating operation of both the lamp and the chiller. The lamp includes a plurality of light emitting diodes (LEDs) arranged into independently-operable modules. In use, the control module selectively overdrives the LEDs to yield high-power light within the designated wavelength range. To prevent overheating within the lamp, the control module restricts the lamp to a pulse-based operational cycle, whereby each period of LED activation is of limited duration and is immediately followed by a period of deactivation at least three times as long in duration as the period of activation. Additionally, one or more temperature sensors are disposed within the lamp and enable the control module to temporarily suspend LED activation when measured temperature levels exceed the defined threshold.

Abstract: Provided herein is an occlusion device for implantation into a body lumen or aneurysm comprising, a continuous compressible mesh structure comprising axial mesh carriages configured end to end, wherein each end of each carriage is a pinch point in the continuous mesh structure. Also provided herein is a kit comprising the occlusion device disclosed herein and a means for delivery thereof. Methods of manufacture and use of the occlusion device are also disclosed.

Abstract: An attachment apparatus for use in combination with a known low-level laser therapy device. The apparatus is attachable to the front portion of, and operable with, a low-level laser therapy device for passing coherent light past the fur of an animal patient. The apparatus has a body with a plurality of pins that can be pushed through the fur, and which transmit a low-level laser therapy light to skin of the animal. The pins are composed of material that transmits the required light wavelength to the animal's skin.

Abstract: An apparatus and method for directing light radiation onto an intended treatment area to create an optimum power density in order to promote photobiostimulation to aid in the healing of damaged tissue in the intended treatment area. The apparatus includes a light emitting element capable of simultaneously emitting multiple beams of light radiation have multiple wavelengths onto a target surface area. A hand guide protects the hand of a user from being irradiated and a distance control element ensures a optimum distance between the light emitting element and the target surface area. The apparatus includes multiple layers of safety features to prevent thermal damage of the target surface area and to prevent leakage of the non-focussed light radiation into the atmosphere. The method includes steps for using the apparatus of the present invention.

Abstract: The present disclosure provides a device for monitoring and visualising electrical activity of biological tissue. The device uses a sensor arrangement comprising a matrix of conductive sensors and a transducing element for transducing electric fields in a variation of an optical property. In use, electric fields generated by the biological tissue are sensed by the sensor arrangement and transduced by the transducing element for optical imaging.

Abstract: A hand-held device for combined light therapy and electrotherapy of a skin surface with acne, includes: a hand-held housing having an output port; at least one light source configured to emit light of different colors through the output port of the housing for light therapy of an acne lesion; and electrodes configured to apply a current across a center part of the output port for electrotherapy of the acne lesion, wherein the center part of the output port is located between the electrodes.

Abstract: Methods and systems are provided for delivering visible or infrared biostimulatory energy to bone marrow to subjects having or developing Alzheimer's disease. The radiation is delivered to sites remote from the brain at a dose sufficient to cause stimulated mesenchymal stem cells to appear in the brain and degrade ?-amyloid. The energy may be coherent light and can be administered transcutaneously, subcutaneously, or via an intramedullary probe.

Abstract: Embodiments disclosed herein include fiber optic connectors employing a movable optical interface connected by optical fibers to a fiber optic cable, components and methods. In one embodiment, the movable optical interface moves between an extended position for cleaning by the user of the movable optical interface and a retracted position to optically connect the fiber optic connector to an optical device in a mechanically-secure manner. Because the fiber optic cable employs the movable optical interfaces, embodiments described herein involve one or more fiber protection features to prevent optical fiber attenuation and/or damage to the end portions of the optical fibers.

Abstract: An electrical system including one or more bodies having an underlying structure resembling a double helix may be used, together with one or more flexible and transparent fibers that transmit electromagnetic radiation, to produce useful electromagnetic effects for various applications, including therapy. A flexible and transparent fiber may be a fiberoptic cable.

Abstract: A therapeutic laser with a source of pulsed electromagnetic radiation, a control device for controlling the intensity and/or the duration of the therapeutic laser applied to the tissue, and a detection device for detecting optoacoustic signals triggered by irradiating the living tissue with the pulsed electromagnetic radiation. The therapeutic laser is characterized by an evaluation device that acts on the control device and is used for calculating a degree of quality B(t) from the optoacoustic signals detected by the detection device for individual laser pulses applied to a predetermined laser spot and determining a fit function f(t) at a predetermined point in time ?t1, the fit function f(t) approximating the mean curve of B(t) for 0?t??t1. The intensity and/or the irradiation time of the therapeutic laser is defined by the parameters for the predetermined laser spot, the parameters being determined for the fit function f(t).

Abstract: There are provided an apparatus and a method for blocking abnormal conduction in the cardiac muscle using a photodynamic therapy or for treating arrhythmia. There is provided a catheter ablation apparatus for the treatment of arrhythmia using a photodynamic therapy, comprising a catheter leading a photoradiation unit to an abnormal electrical conduction site or a hyperexcitability occurring site in the cardiac muscle of a test subject in which a photosensitizer is present by administering the photosensitizer beforehand and which causes arrhythmia, means for generating a light ray with which the abnormal electrical conduction site or the hyperexcitability occurring site is irradiated, and means for transmitting the light ray to the abnormal electrical conduction site or the hyperexcitability occurring site, wherein the photosensitizer used is a water-soluble chlorine-based photosensitizer and the light ray used is a light ray having an excitation wavelength equal to that of the photosensitizer.

Abstract: An improvement in a light therapy device including multiple light-emitting diodes (LEDs) positioned in a handheld portable device is disclosed. Where the housing and the LEDs are configured to have direct contact with the skin or tissue of the user without any intermediary materials, and light the surface and underlying layers of tissue for photodynamic stimulation of the cells. Two iterations of the device utilize light known to have a bactericidal effect in the case or acne or Rosacea. The devices are fabricated from an injection molded plastic housing. The housing contains an arrangement of 36-72 LEDs on a circuit board in an arrangement to provide even lighting over the skin or tissue surface.

Abstract: A light emitting device, comprises: a light source that emits excitation light; a light guide that propagates the excitation light, and in which the refractive index of the center part (core) of a cross section is higher than the refractive index of the peripheral part (cladding); a wavelength conversion member that absorbs the excitation light propagated by the light guide and converts the wavelength thereof, and releases light of a predetermined wavelength band; and a shielding member that blocks the wavelength of at least part of the excitation light and the light emitted from the wavelength conversion member.

Abstract: Apparatus and methods for treating psychiatric disorders, mood disorders and circadian rhythm disorders with a multi-stage light protocol are disclosed. The presently disclosed multi-stage light protocol provides a synergistic treatment including up to 4 types of therapies: bright light therapy, extended sleep deprivation therapy, dawn simulation therapy and short to medium wavelength light therapy. According to some embodiments, the first stage of the protocol includes a first time window of 20 minutes during which, for a majority of the time, the light intensity is between 50 lux and 2000 lux. According to some embodiments, the second stage of the protocol includes a second time window of at least 90 minutes during which, for every 10 minute period within the second time window, for a majority of the time, the light intensity is exceeds 100 lux.

Abstract: Embodiments include an apparatus including an optical fiber having a proximal end and a distal end. The distal end of the optical fiber has a surface configured to emit energy transverse to a longitudinal axis of the optical fiber. The apparatus also includes a tube including a channel, and the distal end of the optical fiber is disposed in the channel of the tube. The apparatus further includes an element disposed at a distal end of the tube such that a pocket is formed in the channel of the tube between the element and the distal end of the optical fiber.

Abstract: Methods and systems for modifying tissue use a pressurized fluid stream carrying coherent light energy. The methods and systems may be used for resecting and debulking soft and hard biological tissues. The coherent light is focused within a stream of fluid to deliver energy to the tissue to be treated.

Abstract: A method of light therapy includes non-invasive, intra-cranial administration of bright light via the ear canal of a subject by using a light intensity of 0.7-12 lumens, and a treatment time of 1-15 minutes. A medical device including radiation elements for directing the light via the ear canal for use in the light therapy is described.

Abstract: Embodiments include an apparatus including an optical fiber having a proximal end and a distal end. The distal end of the optical fiber has a surface configured to emit energy transverse to a longitudinal axis of the optical fiber. The apparatus also includes a tube including a channel, and the distal end of the optical fiber is disposed in the channel of the tube. The apparatus further includes an element disposed at a distal end of the tube such that a pocket is formed in the channel of the tube between the element and the distal end of the optical fiber.

Abstract: A technique for detecting and providing alerts or indications that can be used for controlling or altering the displacement speed of an applicator coupling skin heating energy across a treated skin. A temperature sensor monitors the rate of skin temperature change and provides feedback related to altering the applicator displacement speed according to the rate of skin temperature change. Disclosed is also an applicator for implementing this method.

Abstract: Techniques disclosed herein include systems and methods for treating spinal cord injury. Techniques include using a diode laser assembly, a power source, a fiber optic cable, and a fenestrated tip. The power source can be connected to the diode laser assembly, with a fiber optic cable connected to the diode laser assembly. The fenestrated tip is connected to the fiber optic cable to emit a plurality of laser light beams produced by the diode laser assembly at a location remote from the diode laser assembly. The apparatus can be used in a method for treating a spinal cord injury. The method is carried out by providing a source of laser light having a wavelength in the range of 500-1000 nm and a power in the range of 5 to 500 milliwatts. The laser light is transmitted through an optical wire to a position adjacent a spinal cord injury site, with at least a portion of the apparatus positioned within a human body. The spinal cord injury site is then irradiated with laser light from the optical wire.

Abstract: Various embodiments of an eccentric balloon catheter are disclosed. In some embodiments, an eccentric balloon catheter includes an eccentrically positioned guidewire tube, with an interior lumen, that extends at least a portion of the length of the catheter body. Optical fibers may extend the length of the catheter body and may also be eccentrically positioned within the catheter body. An inflatable balloon may be positioned within a window within the catheter body near the distal end of the catheter. When inflated, the balloon and catheter may slide relative to one another. When used within a vessel, an inflated balloon may press against a vessel wall and bias the catheter toward an opposite vessel wall.

Abstract: A light therapy device for applying an image produced from a therapeutically effective aqueous liquid, is provided. The device includes a slide, prepared by Kirlian and/or corona discharge photography, of a sample of an aqueous liquid removed from a liquid-retaining body and mixed with ethanol, and a projection device with a light device which emits visible light and is designed to project the slide onto an object, in particular a living being, in such a way that a sample of the liquid contained in a container which is permeable to and can be irradiated by the visible light is arranged in a light path between a unit, which holds the slide, of the projection device and the object.

Abstract: An apparatus and a method are provided for the treatment of soft tissue. The apparatus includes a light source and at least two optical assemblies. Each of the optical assemblies includes at least one optical element and a light-transmitting contact surface configured to transmit a substantially uniform distribution of light therethrough. The apparatus further includes at least two optical transmission devices each disposed between the light source and a corresponding one of the at least two optical assemblies. The apparatus also includes a handpiece to which the at least two optical assemblies are attached, and which is adapted to bring the light-transmitting contact surfaces of the at least two optical assemblies in contact with soft tissue disposed therebetween.

Abstract: A light-beam therapeutic apparatus ensured patient safety is disclosed, which includes an apparatus body portion having a light source; a light guide rod that guides light from the light source, a connecting socket, a cooling fan, an electronic component that performs control required for a therapy, and a control display panel that displays the contents of therapy; a therapeutic portion including a light guide portion including a plurality of bundled optical fibers, and a pad portion formed of the optical fibers spread out adjacently to one another into a flat-panel shape, wherein the therapeutic portion is formed into a light-receiving plug insertable into a connecting socket of the apparatus body portion, and the light-receiving plug is configured to be kept in a coupled state by an attracting action of a permanent magnet provided on the side of the connecting socket.

Abstract: A light-beam therapeutic apparatus used for a therapy for neonatal hyperbilirubinemia is disclosed, which includes an apparatus body portion having a light source; a light guide rod that guides light from the light source, a connecting socket, a cooling fan, an electronic component that performs control required for a therapy, and a control display panel that displays the contents of therapy; a therapeutic portion including a light guide portion including a plurality of bundled optical fibers, and a pad portion formed of the optical fibers spread out adjacently to one another into a flat-panel shape, and the therapeutic portion is formed into a light-receiving plug insertable into a connecting socket of the apparatus body portion, and the optical fibers positioned on the pad portion are subjected to exposing processing and have a protecting surface layer portion formed of a bag member filled with transparent and highly flexible high-molecular gel.

Abstract: A modulating light having a wavelength of 600 nm to 1000 nm excluding a range of 870 nm to 910 nm is irradiated to a portion around hair roots such that a light absorptive component existing in a human body around the hair roots absorbs the light for modulating hair growth. The light having the wavelength in the above range enhances hair growth free from causing inflammation, yet safely and gentle to skin.

Abstract: Disclosed herein is a light irradiating apparatus including: a light source block configured to radiate a light to eyes of a user; a view line detection block configured to detect a view line direction of the user; and a light source control block configured to control the light radiated from the light source so as to restrict a light quantity in an area corresponding to a view line direction detected by the view line detection block.

Abstract: This invention may be implemented as a microstructure probe for delivering light of variable color and/or power, via a set of integrated lightguides, from an optical source (or set of sources) to regions spatially arranged 3-dimensionally, with a length scale of microns to millimeters. In exemplary embodiments of this invention, a microstructure probe comprises many lightguides and is adapted to be inserted into neural or other tissue. The lightguides run in parallel along at least a portion of the axis of the probe. The probe may deliver light to many points along the axis of insertion of the probe. This invention may be implemented as an array of two or more such probes (each of which comprises multiple lightguides). This array may be used to deliver light to neural tissue in a complex 3D pattern.

Abstract: A phototherapy device includes a light source; a light emanation block; and a heat exchanger for the dissipation of heat from one or more heat loads associated with the device. Heat may be transferred via the heat exchanger from the light source independently of the dissipation of heat from one or more of the other device heat loads. Substantially thermally isolated heat transfer regions may be provided, and such regions may be maintained at different operating temperatures, to control the transfer of heat in conjunction with a phototherapy method and to promote efficient and enhanced device operation and performance.

Abstract: A method and device for light color therapy, which is a method for simultaneously exposing specific surface regions of the human body to light of specific but possibly different frequencies, temporal characteristics and polarization. The device is constructed to match anatomical details of the human body such as to apply the simultaneous local light exposures to the desired body regions and to compensate for possible movement of the head, thereby minimizing the time required for a single treatment.

Abstract: A device delivers light within a patient using an inner cannula, fiber optics, LED along an endotracheal tube, ETT or tracheostomy tube or a strip with embedded LED adhered to an ETT. The inner cannula includes a tubular thin walled device that transmits light by fiber optics or delivers electrical power to an LED. The light passes along one or more fibers placed within the walls of the inner cannula for outward delivery of the light. The light affects the inside of the cannula, the area between the cannula and the ETT, the area outside the ETT, and into the tracheobronchial tree. The light delivers an antimicrobial effect into the upper airway of a patient. Alternatively, the light delivery device involves tubes and cannulas attaching to existing medical tubes and devices. Alternatively, a transparent strip of embedded LED secures to an existing medical tube.

Abstract: An apparatus comprises a flexible substrate including a modular electrode array disposed on the flexible substrate. The modular electrode array includes a plurality of electrode modules, where an electrode module includes a plurality of electrodes. The flexible substrate also includes a spatial separation between the electrode modules of the modular electrode array, and conductive interconnect coupled to the electrodes of the plurality of electrodes.

Abstract: Stationary UV light therapy apparatus for treatment of vitamin D deficiency, comprising: a daylight and/or sunlight collector for collecting daylight and/or sunlight over a collector square area, a light transmission component for transmitting the light collected by the collector to the interior of a room of a building, an optical filter for transmission of UV-light included in the daylight and/or sunlight, and a light distributor for distributing the UV-light over a square area of the room, wherein the square area is a part or all of the room square area and larger than the collector square area, and building comprising the same.

Abstract: A system/method for destruction/ablation of stones, calculi or other hard substances using laser is disclosed. Lithotripsy is particularly benefitted. The system comprises a diode laser source, one or more optical fibers and a liquid delivery system creating a liquid environment around stones (calculi). At least one emitted wavelength is highly absorbed in surrounding/covering medium, causing evaporation and cavitation effects that lead to stone/calculi destruction. Different radiation configurations may be used. in one embodiment continuous radiation is used to create sparkler-less plasma bubbles to destroy hard substances. In another embodiment high peak power pulsed radiation is used. Wavelengths of 1470 nm, 1940 nm, or 1550 nm are preferred. Additionally device/method is used with another wavelength having absorption in water e.g. 980 nm. Safer/improved methods/system provide enhanced lithotripsy treatments with shorter treatment times to destroy a wider range of stones with less tissue damage risk.

Abstract: A non-contact laser handpiece contains optical components modified to provide a high-density uniform laser beam at a distance from the handpiece that minimizes effects of back reflection.

Abstract: The invention is a rotating tip catheter-imaging probe where electromagnetic energy is delivered to the distal end of a catheter and converted to mechanical energy using a light drive apparatus. The mechanical energy is then used to rotate a mirror that redirects light in fixed pattern on a sample. The rotating element of the light drive apparatus contains vanes, which rotate about an axis and positioned with bearings to minimize friction. A chamber encompasses the rotating element and is set to a vacuum pressure. The rotational speed of the catheter tip can be controlled by varying the optical power delivered to the vanes, the vacuum pressure in the chamber, or by a braking mechanism applied to the rotating element. The vanes may be shaped in a particular geometry to increase forces on the vanes from thermally driven gas flow.

Abstract: Skin disorders such as, for example, atopic dermatitis, dyshidrosis, eczema, lichen planus, psoriasis, and vitiligo, are treated by applying high doses of ultraviolet light to diseased regions of a patients skin. The dosage employed exceeds 1 MED, an MED being determined for the particular patient being treated, and may range from about 1 MED to about 20 MED or higher. The ultraviolet light has a wavelength within the range of between about 295 nanometers to about 320 nanometers and preferably is between about 300 nanometers and about 310 nanometers. High doses of ultraviolet light are restricted to diseased tissue areas so as to avoid risk of detrimental side affects in healthy skin, which is more susceptible to damage from UV light. Cooling the skin prior to and/or while exposing the skin to the UV light can be used to minimize tissue damage resulting from exposure to the UV light. Higher doses of UV light can therefore be employed without injurious affects.

Abstract: An apparatus for carrying out antibacterial photodynamic therapy that includes an illumination means and a means for dispensing the photosensitizer, wherein the means for dispensing the photosensitizer is adapted in such a manner that the photosensitizer is dispensed in spatial proximity to the body region to be treated.

Abstract: A method of mitigating the effect of bodily pathogens including providing a light applicator including a housing, a power supply, and at least one light source wherein the light source is configured to emit light in the ultraviolet range when energized by the power supply, and directing the applicator toward a bodily orifice so as to directly irradiate the orifice for a period of time.

Abstract: A handpiece can treat biological tissue using electromagnetic radiation, which can be substantially fluorescent light. The handpiece includes a source of electromagnetic radiation and a waveguide. The waveguide is adjacent the source, receives electromagnetic radiation from the source, and delivers the electromagnetic radiation to the biological tissue. The handpiece also includes a system for moving a fluorescent substance through the waveguide. The fluorescent substance includes a fluid base and a fluorescing agent and is capable of modulating at least one property of the electromagnetic radiation. A device is provided to remove a fluorescing agent from the fluorescing substance so that more of the same fluorescing agent can be added to clean fluid base.

Abstract: A handpiece can treat biological tissue using electromagnetic radiation, which can be substantially fluorescent light. The handpiece includes a source of electromagnetic radiation and a waveguide. The waveguide is adjacent the source, receives electromagnetic radiation from the source, and delivers the electromagnetic radiation to the biological tissue. The handpiece also includes a system for moving a fluorescent substance through the waveguide. The fluorescent substance includes a fluid base and a fluorescing agent and is capable of modulating at least one property of the electromagnetic radiation. A method is described for removing the fluorescing agent from the fluorescing substance and replacing it with a second, different fluorescing agent.

Abstract: The present invention provides for eyeglasses used together with contact lenses to deliver light therapy to the wearer. The eyeglass lenses or frames feature an embedded light source in logical and electrical communication with power, sensors, processors, and other components contained within the eyeglasses. The eyeglass lenses or frames project light into complimentary contact lenses which refract, diffract or reflect light into the wearer's eyes.

Abstract: The present invention provides for eyeglasses to deliver light therapy to the wearer. The eyeglass lenses or frames feature an embedded light source in logical and electrical communication with power, sensors, processors, and other components contained within the eyeglasses.

Abstract: An interstitial laser energy treatment apparatus having co-acting movable probe holders which facilitate positioning of a laser probe and thermal probe in different positions relative to a tissue mass such as the tumor to be treated and relative to each other to facilitate treating tissue masses based on the exact position, size and shape of the tissue mass.

Abstract: A light therapy device for rhinitis treatment. The light therapy device includes a hollow tube body with a longitudinal axis, being dimensioned and configured to permit insertion into a nostril of a treatment subject. A light emitting diode package disposed within the hollow tube body includes a first LED chip as a red light source and a second LED chip as an infrared light source. The first LED chip and the second LED chip are at different plane substantially orthogonal to the longitudinal axis.

Abstract: A flexible infrared delivery apparatus useful for endoscopic infrared coagulating of human or animal blood and tissue or for other uses employs a source of infrared radiation which is not a laser and an elongated flexible fiber optic member which transmits radiation from the source to a contact portion at a distal end of the member and to a material such as human or animal tissue proximate the contact portion. The elongated member has an outer diameter which enables it to be inserted into and through an accessory channel of an endoscope to view the human or animal tissue or material to be treated with infrared radiation. A connector on the proximal end of the member allows the elongated member to be quickly connected to and disconnected from the apparatus where the member is aligned for receiving infrared radiation from the source. The contact portion defines a size, direction and shape of a radiation delivery area from the member to the human or animal tissue or material proximate the contact portion.

Abstract: Present invention discloses methods and devices for treating skin and nail infections such as onychomycosis and dermatophytosis, caused by pathogenic microbes such as fungi. in a preferred embodiment, a method for treating skin and nail infections comprises irradiating the treatment site with a light radiation source operating at one or more near infrared wavelengths which are absorbed by the pathogenic microbes, specifically operating at 980±30 nm, 1470±40 nm and/or 1900±60 nm. In another preferred embodiment, a method for treating skin and nail fungus comprises irradiating the treatment site with a device emitting laser radiation of 980±30 nm wavelength. In another embodiment, a device for treating toenail fungus comprises a laser radiation source which emits a combination of radiation wavelengths at about 980±30 nm and 1470±40 nm; or 980±30 nm and 1900±60 nm; or 1470±40 nm and 1900±60 nm; or 980±30 nm, 1470±40 nm and 1900±60 nm.