Including Valve Patents (Class 623/1.24)
  • Patent number: 11872130
    Abstract: A prosthetic heart valve implant is provided including a frame shaped so as to define upstream and downstream openings at upstream and downstream ends of the frame, respectively, when the implant is in an expanded state for implantation at a heart native valve. A sheet is coupled to the frame. When the implant is in the expanded state, the frame is shaped so as to define the following longitudinal portions arranged along a central longitudinal axis of the prosthetic heart valve implant: a substantially cylindrical mid portion having a diameter greater than respective diameters of the upstream and the downstream ends of the frame; an upstream portion, extending upstream and radially inward from the mid portion; and a downstream portion, extending downstream and radially inward from the mid portion. Other embodiments are also described.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: January 16, 2024
    Assignee: CARDIOVALVE LTD.
    Inventors: Tal Hammer, Meni Iamberger, Yaron Herman, Yuval Zipory, Eran Hoffer, Michael Albitov, Natalia Kruglova, Tal Reich, Ilia Hariton, Aviram Baum
  • Patent number: 11857414
    Abstract: A prosthetic heart valve includes a frame, a valve component, and an actuation mechanism. The frame has a plurality of struts interconnected by a plurality of joints and is movable between expanded and compressed configurations. The valve component is inside the frame and has a plurality of leaflets. The actuation mechanism has a first expansion element coupled to the frame at a first location and a second expansion element coupled to the frame at a second location. The actuation mechanism is configured such that moving the first expansion element and the second expansion element toward each other in a first direction results in the frame moving from the compressed configuration to the expanded configuration, and such that moving the first expansion element and the second expansion element away from each other in a second direction results in the frame moving from the expanded configuration to the compressed configuration.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: January 2, 2024
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventor: Jennifer K. White
  • Patent number: 11833041
    Abstract: Described is a prosthetic valve, comprising: an expandable stent including an inner lumen and having a first and a second end; and a spring attached to the first end of the expandable stent; wherein the expandable stent and the spring can expand radially to a desired diametric configuration in order to anchor the prosthetic valve at an implantation position in a body lumen. Related systems and methods.
    Type: Grant
    Filed: December 16, 2022
    Date of Patent: December 5, 2023
    Assignee: MEDTRONIC, INC.
    Inventors: Jason Quill, Cynthia T. Clague, Paul T. Rothstein
  • Patent number: 11833037
    Abstract: An implantable prosthetic valve has an upper frame section and a lower frame section. The upper frame section has a plurality of struts and a first leaflet receiving surface at a lower portion of the upper frame section. The lower frame section has a second leaflet receiving surface at an upper portion of the lower frame section. An edge of a flexible leaflet is disposed between the first and second leaflet receiving surfaces to attach the leaflet to the upper and lower frame sections.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: December 5, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventor: Netanel Benichou
  • Patent number: 11786367
    Abstract: A stented valve including a generally tubular stent structure that has a longitudinal axis, first and second opposite ends, a plurality of commissure support structures spaced from the first and second ends and extending generally parallel to the longitudinal axis, at least one structural wire positioned between each two adjacent commissure support structures, and at least one wing portion extending from two adjacent commissure support structures and toward one of the first and second ends of the stent structure. The stented valve further includes a valve structure attached within the generally tubular stent structure to the commissure support structures.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: October 17, 2023
    Assignee: MEDTRONIC, INC.
    Inventors: Charles Tabor, Carol E. Eberhardt, Timothy G. Laske, Timothy R. Ryan, Joseph C. Morrow, Tammy Y. Tam, Brian A. Glynn, Anne L. Brody Rubin, Michael J. Tuchek
  • Patent number: 11744701
    Abstract: A prosthetic heart valve comprises a radially collapsible and expandable annular frame and a leaflet structure comprising three leaflets. Each leaflet has an upper edge portion, a curved lower edge portion and two side flaps, wherein each side flap is connected to an adjacent side flap of another leaflet to form commissures of the leaflet structure, with each commissure being attached to the frame. An annular inner sleeve comprises three U-shaped portions positioned along the curved lower edge portions of the leaflets. An annular outer sleeve extends around are outer surface of the frame, wherein the outer sleeve is made of pericardium. The frame is made of Nitinol and the prosthetic valve can be radially crimped to a radially collapsed configuration inside a sheath for delivery into a patient's body and self-expand to a radially expanded configuration when released from the sheath inside the patient's body.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: September 5, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
  • Patent number: 11690713
    Abstract: A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: July 4, 2023
    Assignee: Medtronic CV Luxembourg S.A.R.L.
    Inventors: Kshitija Garde, Joel Racchini, Paul Rothstein, Jeffrey Sandstrom
  • Patent number: 11666314
    Abstract: Aspects of the present invention provide apparatuses and methods for closing an apical hole in a heart of a subject, including a hole-closure device that includes a tissue-attachment portion configured to attach to cardiac tissue around the apical hole, and a collapsible portion coupled to the tissue-attachment portion and configured to close the hole by collapsing inwardly inside the apical hole.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: June 6, 2023
    Assignee: Medtronic Vascular Galway
    Inventor: Yossi Tuval
  • Patent number: 11660187
    Abstract: A prosthetic heart valve is designed to be circumferentially collapsible for less invasive delivery into the patient. At the implant site the valve re-expands to a larger circumferential size, i.e., the size that it has for operation as a replacement for one of the patient's native heart valves. The valve includes structures that, at the implant site, extend radially outwardly to engage tissue structures above and below the native heart valve annulus. These radially outwardly extending structures clamp the native tissue between them and thereby help to anchor the prosthetic valve at the desired location in the patient.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: May 30, 2023
    Assignee: St. Jude Medical, LLC
    Inventor: Peter N. Braido
  • Patent number: 11559690
    Abstract: Various embodiments of a ventricular assist system and a method of using such system are disclosed. The system includes a pump adapted to be connected to a heart of a patient, an outflow cannula including a first end adapted to be connected to an outlet of the pump and a second end adapted to be connected to an artery of the patient, and an electrode disposed on an outer surface of the outflow cannula and adapted to be disposed adjacent to an exterior wall of the heart. The system further includes a controller electrically connected to the pump and the electrode, where the controller is adapted to provide a pacing signal to the electrode.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: January 24, 2023
    Assignee: MEDTRONIC, INC.
    Inventors: Alan Cheng, Jian Cao, Hai Huang
  • Patent number: 11491006
    Abstract: A prosthetic valve may be formed to direct flow out of the outflow orifice toward a posterior portion of a heart wall. The prosthetic valve includes an expandable frame which may be covered with a cover that is suturelessly attached to the frame. The prosthetic valve may also include an outflow orifice size which is controlled. Methods of using these devices are also disclosed.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: November 8, 2022
    Assignee: Neovasc Tiara Inc.
    Inventors: Shmuel Banai, Kathleen Hung, Aaron J. Chalekian, Karen Tsoek-Ji Wong, Eric Soun-Sang Fung, Connor Lucas Haberl, David Andrew Moffatt
  • Patent number: 11439504
    Abstract: A medical implant may include an expandable anchor member having a lumen extending through the expandable anchor member from an inflow end to an outflow end; a plurality of valve leaflets disposed within the lumen extending through the expandable anchor member; a seal member disposed adjacent an exterior of the expandable anchor member; and a porous material extending from the seal member to the plurality of valve leaflets.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: September 13, 2022
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Michael G. Hayes, Tara Hogan
  • Patent number: 11439503
    Abstract: An implantable valve prosthesis for preventing blood reflux from a cardiac atrium into a vein opening into the atrium, with a generally tubular stent (2), also a flexible tube (3) that can be closed by collapsing the tube (3) and which is arranged at least in a partial area of a second end section (9) of the stent (2) on the outer peripheral surface. The second end opening (11) of the flexible tube (3) is open in the pressureless state. As a result of this valve design, during a physiological flow out of the pulmonary vein in the direction of the left atrium or out of the caval vein in the direction of the right atrium, there is no rise or an only insubstantial rise in the resistance to flow.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: September 13, 2022
    Assignee: Universitaetsklinikum Hamburg-Eppendorf
    Inventors: Yalin Yildirim, Simon Pecha, Hermann Reichenspurner
  • Patent number: 11406495
    Abstract: Support frames and medical devices are described. An example medical device comprises an expandable support frame with first and second leaflets attached to the support frame. Each of the first and second leaflets defines a domed radius that is equal to or less than the radius of the expandable support frame when the expandable support frame is in an expanded configuration and the leaflets are subjected to fluid pressure sufficient to affect closure of the valve orifice.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: August 9, 2022
    Assignee: Cook Medical Technologies LLC
    Inventors: Joshua Krieger, Sean Chambers, Zachary Berwick, Ghassan Kassab
  • Patent number: 11395749
    Abstract: A medical device including a valve member with an elongate tubular portion with at least one aperture disposed in a sidewall at a location between the proximal and distal ends, and a plurality of leaflets; a first endovascular graft coupled to the valve member; and a second endovascular graft coupled to the first endovascular graft; and an expandable anchor member coupled to the second endovascular graft.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: July 26, 2022
    Inventor: Gilbert H. L. Tang
  • Patent number: 11376123
    Abstract: Prosthetic valves are provided with a leaflet assembly having at least one leaflet attached to a supporting element, which leaflet has a free margin that can move between a first position wherein the free margin is flexed away from a closure surface to allow body fluid to flow through the valve, and a second position wherein the free margin abuts the closure surface to close the valve, and wherein the leaflet, without pulsatile load on the valve, can form a coaptation height H of more than 0.1 mm along the length of the free margin. Such prosthetic valve provides good performance during prolonged time, and can be made using various materials for the leaflets.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: July 5, 2022
    Assignee: DSM IP ASSETS B.V.
    Inventors: Paul Frederik Gründeman, Jolanda Kluin, Karlien Kristal Boon-Ceelen, Thomas König
  • Patent number: 11364119
    Abstract: This invention relates to the design and function of a retrieval device for a prosthetic heart valve for re-positioning or removal of a previously implanted valve prosthesis from a beating heart without extracorporeal circulation using a transcatheter retrieval system.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: June 21, 2022
    Assignee: Tendyne Holdings, Inc.
    Inventors: Zachary Tegels, Robert Vidlund, Mark Christianson
  • Patent number: 11357622
    Abstract: A prosthetic mitral valve may be anchored in a native mitral valve. The prosthetic mitral valve preferably has a large anterior prosthetic leaflet that spans the entire width of the native anterior leaflet and the anterior prosthetic leaflet moves away from left ventricular outflow tract during systole to create a clear unobstructed outflow path.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: June 14, 2022
    Assignee: Neovase Tiara Inc.
    Inventors: Randy Matthew Lane, Karen Tsoek-Ji Wong, Ian Fraser Kerr, Mark Segal
  • Patent number: 11344311
    Abstract: The present technology relates to aneurysm devices with additional anchoring mechanisms, and associated systems and methods. The aneurysm device is endovascularly deliverable to a site proximate an aneurysm near a parent artery with bifurcating branches. The device can include a closure structure comprising a distal-facing aspect configured to at least partially occlude the aneurysm. The closure structure can be formed from a generally flat pattern and is transformable between a compressed configuration and a deployed configuration. The device can also have one or more lodging elements which fold to form loop elements configured for anchoring within at least one of the bifurcating branches. The struts of the lodging elements can include hinge points which bias the folding of the lodging elements. The devices further include a supplemental stabilizer connected to the closure structure and configured to reside in the parent artery.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: May 31, 2022
    Assignee: PULSAR VASCULAR, INC.
    Inventor: Brent Gerberding
  • Patent number: 11318015
    Abstract: A prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body, a plurality of atrial anchoring arms configured to extend radially outward from the annular valve body, and a plurality of ventricular anchoring legs configured to extend radially outward from the annular valve body. The arms may be configured to engage an atrial portion of the native mitral valve and the ventricular anchoring legs may be configured to engage a ventricular portion of the native mitral valve. The atrial anchoring arms and the ventricular anchoring legs may be positioned relative to each other such that when the atrial anchoring arms and ventricular anchoring legs engage the native mitral valve, a volume between the atrial anchoring arms and ventricular anchoring legs is configured to be substantially filled with tissue.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: May 3, 2022
    Assignee: CARDIOVALVE LTD.
    Inventors: Ilia Hariton, Meni Iamberger, Aviram Baum, Boaz Harari
  • Patent number: 11318029
    Abstract: Devices and methods for treating heart disease by increasing the pulmonary vascular compliance and thereby decreasing the right ventricular afterload are disclosed. Devices may include a means for reducing the cross-sectional area of the pulmonary artery during diastole and allowing the cross-sectional area to increase during systole.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: May 3, 2022
    Inventor: Michael Warren Sutherland
  • Patent number: 11291544
    Abstract: Devices and methods for treating tricuspid regurgitation (TR) are provided. A clasp or clamp is used to anchor a TR-treatment device to an existing lead of a pacemaker or an implantable cardioverter defibrillator (ICD) that passes through the tricuspid valve. The TR-treatment device can be a balloon occluder that is adjustable by filling or withdrawing filler material from the occluder through a proximal port implanted in the skin of the patient.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: April 5, 2022
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Robert James Siegel, Richard Cheng
  • Patent number: 11284998
    Abstract: A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: March 29, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Stanton J. Rowe, Larry L. Wood, Henry Bourang, George Bakis, Benjamin Spenser, Netanel Benichou, Assaf Bash, Yaron Keidar
  • Patent number: 11278398
    Abstract: The present invention provides an apparatus for endovascularly replacing a patient's heart valve. In some embodiments, the apparatus includes an expandable anchor supporting a replacement valve, the anchor and replacement valve being adapted for percutaneous delivery and deployment to replace the patient's heart valve, the anchor having a braid having atraumatic grasping elements adapted to grasp tissue in a vicinity of the patient's heart valve.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: March 22, 2022
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Amr Salahieh, Daniel K. Hildebrand, Tom Saul
  • Patent number: 11278400
    Abstract: A prosthetic heart valve includes a frame, a valvular structure coupled to the frame, and a sealing member coupled to the frame. The frame has inflow and outflow ends and a lumen extending therebetween. The frame includes struts that form cells, and the cells are arranged in three rows. The frame is radially expandable from a collapsed state to an expanded state. The valvular structure includes a plurality of leaflets configured to allow blood flow through the lumen of the frame from the inflow end to the outflow end and to block blood flow through the lumen of the frame from the outflow end to the inflow end. The sealing skirt extends from an intermediate location of the frame disposed between the inflow and outflow ends to the inflow end of the frame. The sealing skirt covers two rows of cells to block blood flow through the cells.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: March 22, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Ziv Yohanan, Nikolay Gurovich, Bella Felsen, Itai Pelled, Oded Meiri
  • Patent number: 11259918
    Abstract: A frame for an implantable medical device, comprising: a first member, comprising a plurality of struts defining a plurality of cells, wherein the first member is annular and defines a longitudinal direction which is parallel to the axis of the first member, a radial direction, and a circumferential direction; a second member, comprising a plurality of struts and coupled to the first member at circumferentially distributed locations; wherein the second member overlaps a first end portion of the first member and extends beyond the first end portion of the first member.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: March 1, 2022
    Assignee: Carena Healthcare Ltd
    Inventors: Neil W. Bressloff, Jonathan Bailey
  • Patent number: 11259925
    Abstract: The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treat mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: March 1, 2022
    Assignees: University of Maryland, Baltimore, University of Maryland Medical System LLC
    Inventors: James Gammie, Rachael Quinn, Chetan Pasrija
  • Patent number: 11246704
    Abstract: A frame assembly (222) includes a tubular portion (32) that defines a lumen along an axis; a plurality of arms (46) coupled to the tubular portion at a first axial level, each of the arms extending radially outward from the tubular portion to a respective arm-tip; and a plurality of ventricular legs (50) that are coupled to the tubular portion at a second axial level, and that extend radially outward from the tubular portion. A first sheet (440) has a greater perimeter (446), and a smaller perimeter (448) that defines an opening. The first sheet is stitched onto the plurality of arms, with the opening aligned with the lumen. Subsequently, an outer perimeter (454) of a second sheet (450) is stitched to the greater perimeter of the first sheet. Subsequently, the second sheet is everted by passing an inner perimeter (452) of the second sheet around the arm-tips.
    Type: Grant
    Filed: July 4, 2018
    Date of Patent: February 15, 2022
    Assignee: CARDIOVALVE LTD.
    Inventors: Ilia Hariton, Meni Iamberger, Aviram Baum, Yelena Kasimov
  • Patent number: 11241307
    Abstract: A replacement heart valve system may include a delivery sheath and a replacement heart valve. The replacement heart valve may include a mesh anchor member disposed within the delivery sheath in an elongated delivery configuration, the mesh anchor member being expandable to a deployed configuration when unconstrained by the delivery sheath. The mesh anchor member may include an upstream chamber, a downstream chamber, and a tubular middle portion extending between the upstream chamber and the downstream chamber. The replacement heart valve may include a diaphragm disposed within the downstream chamber of the mesh anchor member, wherein the diaphragm is configured to selectively prevent fluid flow through the replacement heart valve.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: February 8, 2022
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Fionn Stapleton, Sean O'Sullivan, John Kilcooley, Niamh McNamara, Desmond McGreevy
  • Patent number: 11191640
    Abstract: An embolic material blocking catheter includes a handle assembly, an elongated element having a lumen, and a deployable embolic material blocking element. The embolic material blocking catheter is configured to accommodate insertion of a treatment catheter into the lumen to position a treatment device distal to the embolic material blocking element for administering a treatment at a treatment site and/or convey embolic material blocked by the embolic material blocking element for extraction from the patient.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: December 7, 2021
    Assignee: EmStop Inc.
    Inventor: Mark Groh
  • Patent number: 11179236
    Abstract: This invention relates to the design and function of a compressible valve replacement prosthesis which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: November 23, 2021
    Assignees: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION, AVALON MEDICAL, LTD.
    Inventors: Kemal Schankereli, E. Christopher Orton
  • Patent number: 11160903
    Abstract: A prosthetic valve comprising a conical shaped ribbon structure comprising an extracellular matrix (ECM) composition. The ribbon structure comprises a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, wherein the ribbon members are positioned adjacent each other and form a plurality of fluid flow modulating regions that open when fluid flow through the valve exhibits a negative flow pressure and open when fluid flow through the valve exhibits a positive flow pressure.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: November 2, 2021
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 11154395
    Abstract: A prosthetic valve comprising a conical shaped ribbon structure comprising a polymeric composition. The ribbon structure comprises a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, wherein the ribbon members are positioned adjacent each other and form a plurality of fluid flow modulating regions that open when fluid flow through the valve exhibits a negative flow pressure and open when fluid flow through the valve exhibits a positive flow pressure.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: October 26, 2021
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 11141274
    Abstract: A method of treating a defective heart valve includes inserting a delivery catheter through a small incision in a patient's groin, wherein the delivery catheter has a prosthetic device positioned along a distal end. The prosthetic device includes an insert member and an anchoring member. The insert member is positioned between the native heart valve and is allowed to self-expand. The anchoring member is preferably a stent connected to the insert member by at least one elongate member. The stent is deployed within an adjacent blood vessel for anchoring the insert member between the native leaflets. After deployment of the prosthetic device, the native leaflets of the heart valve form a tight seal against the insert member for preventing regurgitation through the native heart valve during ventricular systole.
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: October 12, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: David L. Hauser, Jan Otto Solem, David Alon
  • Patent number: 11051934
    Abstract: A mitral valve prosthesis includes an hourglass shaped inner frame and a bulbous outer frame. A valve body having a plurality of leaflets is positioned within an interior region of the inner frame. The leaflets are shaped to substantially conform to an interior surface of the inner frame when the leaflets are in an open position. As a result, the gap between the leaflets and the inner frame is decreased, thereby reducing the likelihood of thrombus formation. Ventricular anchors are preferably provided along a distal end of the inner frame. The anchors extend proximally for placement behind native mitral valve leaflets. A fabric skirt may extend along an inner or outer surface of the outer frame. In preferred embodiments, the fabric skirt extends distally beyond a distal end of the outer frame and is adapted for forming a seal along the mitral valve annulus.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: July 6, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Alexander H. Cooper, Juliet Laura Schwartz, Wendy Vo Pham, Hieu Minh Luong, Julio Cesar Sanchez, Matthew A. Peterson, J. Brent Ratz, Lisong Ai
  • Patent number: 11033384
    Abstract: An implantable endoluminal prosthesis for replacing a damaged aortic valve is provided. In one embodiment, the prosthesis includes a balloon-expandable stent, a tubular conduit that extends into the ascending aorta, and a self-expanding stent. The tubular conduit extends across the balloon-expandable stent. The tubular conduit includes an artificial valve. The self-expanding stent extends across the tubular conduit into the ascending aorta. The balloon-expandable stent, the tubular conduit, and the self-expanding stent are coupled to provide unidirectional flow of fluid into the aorta and further into the coronary arteries. Also provided is a method for implanting the endoluminal prosthesis.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: June 15, 2021
    Assignee: COOK MEDICAL TECHNOLOGIES LLC
    Inventor: Timothy A M Chuter
  • Patent number: 11020222
    Abstract: A prosthetic heart valve includes a frame, a valvular structure coupled to the frame, and a sealing member coupled to the frame. The frame has inflow and outflow ends and a lumen extending therebetween. The frame includes struts that form cells, and the cells are arranged in three rows. The frame is radially expandable from a collapsed state to an expanded state. The valvular structure includes a plurality of leaflets configured to allow blood flow through the lumen of the frame from the inflow end to the outflow end and to block blood flow through the lumen of the frame from the outflow end to the inflow end. The sealing skirt extends from an intermediate location of the frame disposed between the inflow and outflow ends to the inflow end of the frame. The sealing skirt covers two rows of cells to block blood flow through the cells.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: June 1, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Ziv Yohanan, Nikolay Gurovich, Bella Felsen, Itai Pelled, Oded Meiri
  • Patent number: 11013625
    Abstract: A prosthetic vascular valve includes one or more continuous loops of frame material or one or more strands of material that do not form a continuous loop. The frame includes a plurality of longitudinal portions, wherein a membrane is attached to at least one of the longitudinal portions, and wherein the membrane is configured to open and close. During implantation, the frame engages the inner surface of the vein wall and is biased against the vein wall to remain stationary. In use, blood flows from an upstream end to a downstream end, wherein the membrane mitigates regurgitation of the blood as the blood is conveyed through the subject vein.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: May 25, 2021
    Assignee: Incubar LLC
    Inventor: R. David Fish
  • Patent number: 10973640
    Abstract: A venous valve prosthesis includes a frame and a prosthetic valve coupled to the frame. With the venous valve prosthesis implanted in a vein, the prosthetic valve includes a closed configuration wherein an outer surface of the prosthetic valve is in contact with a wall of the vein around a circumference of the prosthetic valve to prevent blood from flowing past the prosthetic valve between the wall of the vein and the outer surface of the prosthetic valve. The prosthetic valve is configured to move to an open configuration such that at least a portion of an outer wall of the prosthetic valve partially collapses away from the wall of the vein in response to antegrade blood flow through the vein to enable blood flow between the outer surface of the prosthetic valve and the wall of the vein.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: April 13, 2021
    Assignee: Medtronic Vascular, Inc.
    Inventors: Jeffery Argentine, Todd Malsbary, Keith Perkins, Travis Rowe
  • Patent number: 10966826
    Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: April 6, 2021
    Assignees: Children's Medical Center Corporation, President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Elazer R. Edelman, Peter E. Hammer, Christopher Payne
  • Patent number: 10966825
    Abstract: A prosthetic heart valve includes a collapsible and expandable annular frame. The frame includes a plurality of rows of hexagonal cells. Each of the hexagonal cells is defined by six struts, including: two opposing side struts extending parallel to each other, a first pair of angled struts extending from respective first ends of the side struts and converging to intersect with each other, and a second pair of angled struts extending from respective second ends of the side struts and converging to intersect with each other. The prosthetic heart valve can also include a valvular structure with a plurality of leaflets. The prosthetic heart valve can further include a sealing member.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: April 6, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Ziv Yohanan, Nikolay Gurovich, Bella Felsen, Itai Pelled, Oded Meiri
  • Patent number: 10952839
    Abstract: Venous endoluminal devices, in particular for the treatment of defects of the veins, are provided with a substantially tubular body which defines an inner lumen and support modules oriented longitudinally and joined, in a distal direction, by distal bridges and in a proximal direction, by proximal bridges. Each support module includes a distal section, extending in a distal direction beyond the distal bridges, wherein the distal section is at least partially projecting in a radial direction, internally in relation to the inner lumen of the body. Methods of treatment using such devices are also provided.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: March 23, 2021
    Inventor: Pierfrancesco Veroux
  • Patent number: 10952843
    Abstract: A prosthetic valve comprising a conical shaped ribbon structure comprising an extracellular matrix (ECM) composition. The ribbon structure comprises a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, wherein the ribbon members are positioned adjacent each other and form a plurality of fluid flow modulating regions that open when fluid flow through the valve exhibits a negative flow pressure and open when fluid flow through the valve exhibits a positive flow pressure.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: March 23, 2021
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Patent number: 10905573
    Abstract: The invention relates to a radially expandable stent (1) comprising a plurality of flexibly interconnected meandering ring elements (2, 3) defining a stent (1) having a proximal and a distal end and a longitudinal axis, wherein said ring elements (2, 3) being arranged side by side along the longitudinal axis of the stent and adjoining ring elements (2, 3) being attached to each other through connection elements (4), wherein connection elements (4) are arranged between at least two adjoining ring elements (2, 3), said connection elements each having at least one expandable expansion element with predetermined breaking point (10), wherein the expansion being possible in the longitudinal and/or transverse direction and the predetermined breaking points (10) only disrupting after the expansion element has been overstretched beyond its maximum expansion point.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: February 2, 2021
    Assignee: AndraTech GmbH
    Inventors: Malte Neuss, Gunter Kohl, Jay Pillai
  • Patent number: 10888444
    Abstract: An example medical device is disclosed. An example medical device includes an expandable stent. The stent includes a tubular scaffold formed of one or more interwoven filament. The tubular scaffold includes an inner surface and a flexible valve extending radially inward from the inner surface of the scaffold. Further, the valve is configured to shift between a closed configuration and an open configuration and the one or more filaments of the scaffold bias the valve to the closed configuration while in a nominally deployed state.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: January 12, 2021
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Martin Coyne, Niall Feeney, James Byrne, Harshad Holehonnur, Jonathan Dolan
  • Patent number: 10881430
    Abstract: In an aspect, a device includes a body structure including a core and a sleeve disposed around at least a portion of the core, the core defining a channel through the core extending from a first end of the core to a second end of the core, the sleeve including a flange adjacent the second end of the core; and a deployable portion coupled to the body structure adjacent the first end of the core, the deployable portion having a wired structure transitionable between a retained configuration and a deployed configuration, wherein a top portion of the wired structure extends beyond the first end of the core in a longitudinal direction when the wired structure is in the retained configuration, and wherein first end of the core extends beyond the top portion of the wired structure when the wired structure is in the deployed configuration.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: January 5, 2021
    Assignee: VADovations, Inc.
    Inventors: J. Ryan Stanfield, James W. Long, Michael A. Vladovich
  • Patent number: 10869755
    Abstract: Prosthetic mitral valves and their methods of manufacture and use.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: December 22, 2020
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Juan F. Granada, Gary Erzberger, Michael P. Corcoran, Dan Wallace, Matteo Montorfano, Alaide Chieffo, Thierry Thaure, Aaron Grogan, Peter Gregg
  • Patent number: 10856974
    Abstract: A prosthetic heart valve having an inflow end and an outflow end includes a collapsible and expandable stent having a plurality of commissure features, a plurality of first struts and a plurality of second struts. The plurality of first struts define a substantially cylindrical portion and the plurality of second struts have first ends attached to the cylindrical portion and free ends projecting radially outward from the cylindrical portion and configured to couple to adjacent heart tissue to anchor the stent. A collapsible and expandable valve assembly disposed within the stent has a plurality of leaflets coupled to the commissure features.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: December 8, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter N. Braido, Mina S. Fahim, Thomas M. Benson, Theodore Paul Dale, Andrea N. Para, Mark Krans, Mathias Charles Glimsdale
  • Patent number: 10849740
    Abstract: A collapsible and expandable stent body includes a generally tubular annulus section, one or more prosthetic valve elements mounted to the stent body, and a cuff attached to the stent body. The prosthetic valve is operative to allow flow in an antegrade direction but to substantially block flow in a retrograde direction. The prosthetic heart valve may include paravalvular leak mitigation features in the form of first and second sealing members. The sealing members are attached to the cuff and extend circumferentially around an abluminal surface of the stent body. The sealing members each have an open side facing in a first axial direction and a closed side facing in an opposite second axial direction. Flow of blood in the second axial direction will tend to force blood into the sealing members and cause the sealing members to billow outwardly relative to the stent body, helping to mitigate paravalvular leak.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: December 1, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter N. Braido, Mina S. Fahim
  • Patent number: RE49792
    Abstract: An implant device (V), such as a heart valve, for implantation in an animal body includes an annular structure and one or more elongated anchoring members deployable to a deployed condition for insertion into an animal body. The anchoring members are retractable from the deployed condition to a rolled up condition wherein the anchoring members protrude radially out from the annular structure of the device (V) to provide anchoring to a body structure (AS) of an animal. In the rolled up condition the anchoring members at least partly protrude axially of the annular structure of the device (V).
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: January 9, 2024
    Assignee: Corcym S.r.l.
    Inventors: Laura Ghione, Paolo Gaschino, Monica Francesca Achiluzzi