Heart Valve Patents (Class 623/1.26)
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Patent number: 12186184Abstract: An expandable docking station includes an annular valve seat having an end, an annular outer wall comprising struts disposed around the valve seat, and links that connect the end of the annular valve seat to the annular outer wall. Each of the links extends from the struts of the annular outer wall directly toward a longitudinal axis that runs longitudinally through a center of the docking station, and to a corresponding one of a plurality of circumferentially spaced axially extending legs at least partially defining the annular valve seat. The outer wall is configured to conform to an interior shape of a blood vessel, when expanded inside the blood vessel, such that the outer wall can expand in multiple locations to conform to multiple bulges of the blood vessel and can contract in multiple locations to conform to multiple narrowed regions of the blood vessel.Type: GrantFiled: April 1, 2022Date of Patent: January 7, 2025Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Liron Tayeb, Eran Goldberg, David Maimon, Adi Carmi, Arie Tylis, Ralph Schneider, Mohammad Jafari, Hengchu Cao, Eitan Atias
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Patent number: 12156810Abstract: Methods are described herein for delivering a replacement valve to a native valve location. In one method, ventricular anchors of the replacement valve are released and allowed to reverse orientation while positioned in the atrium of a human heart. After reversing orientation, the ventricular anchors extend in a generally proximal direction. The ventricular anchors can then be advanced through the annulus into the ventricle and then moved back toward the atrium to capture native valve leaflets between the main body and the ventricular anchors of the replacement valve. In one modification, the ventricular anchors are allowed to reverse orientation at a level adjacent the annulus. The implantation methods described herein are preferably performed via a transseptal delivery approach or a transapical delivery approach.Type: GrantFiled: November 23, 2022Date of Patent: December 3, 2024Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: J. Brent Ratz, Glen T. Rabito
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Patent number: 12150855Abstract: A valved conduit including a bioprosthetic aortic heart valve connected to a tubular conduit graft forming an ascending aorta. The conduit graft may attach to the heart valve in a manner that facilitates a redo operation in which the valve is replaced with another valve. A sewing ring may be pre-attached to the inflow end of the graft, and then the valve connected to a delivery holder advanced into the graft and secured to the sewing ring. Dry bioprosthetic valves coupled with conduit grafts sealed with a bioresorbable medium can be stored with the delivery holder.Type: GrantFiled: May 15, 2023Date of Patent: November 26, 2024Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Michael C. Murad, Hilda Z. Fann, Mark Van Nest, John X. Wang, Derrick Johnson
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Patent number: 12138155Abstract: Embodiments are provided of an assembly having a prosthetic valve, the prosthetic valve having a radially expandable and compressible annular frame, and a crimping accessory device, and methods for using the assembly in compressing the prosthetic valve. The frame includes an outer surface and an inner surface. A leaflet assembly is supported inside the annular frame. The leaflet assembly includes a plurality of leaflets, each having an inner surface and an outer surface. The crimping accessory device has a plurality of axially-extending fingers. At least a first finger of the plurality of fingers is disposed between the outer surface of a first leaflet of the plurality of leaflets, and at least a second finger of the plurality of fingers is disposed radially-inwardly of the inner surface of the first leaflet.Type: GrantFiled: April 12, 2021Date of Patent: November 12, 2024Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Taylor Jacob Scheinblum, Mindy Lee Ann Black, Tamir S. Levi, Evan T. Schwartz, Waina Michelle Chu, Linda Thai, Hanoch Cohen-Tzemach, Michael Bukin
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Patent number: 12121434Abstract: This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.Type: GrantFiled: September 8, 2022Date of Patent: October 22, 2024Assignee: Tendyne Holdings, Inc.Inventors: Robert Vidlund, Kemal Schankereli, Lucian Lozonschi, Georg Lutter
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Patent number: 12083010Abstract: A method of implanting a prosthetic apparatus preferably includes delivering the prosthetic apparatus to a native mitral valve and exposing ventricular anchors and a spacer body of the prosthetic apparatus from a distal end portion of a delivery apparatus. The ventricular anchors are controllably and forcibly expanded outwardly from the spacer body to an expanded configuration. The prosthetic apparatus is positioned relative to the native mitral valve such that native mitral valve leaflets are located between the ventricular anchors and the spacer body. The ventricular anchors are then contracted radially inwardly toward the spacer body to a compressed configuration. In the compressed configuration, the native mitral valve leaflets are secured between the ventricular anchors and the spacer body. After implantation, the spacer body is held between the native mitral valve leaflets, thereby blocking regurgitation and improving the function of the native mitral valve.Type: GrantFiled: October 31, 2019Date of Patent: September 10, 2024Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Stephen C. Geist, Robert C. Taft, Travis Zenyo Oba, Sam Sok, Matthew A. Peterson, Kevin M. Golemo, Mark Chau, Seung-Beom Yi
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Patent number: 12059343Abstract: This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.Type: GrantFiled: June 4, 2022Date of Patent: August 13, 2024Assignee: Tendyne Holdings, Inc.Inventors: Robert Vidlund, Kemal Schankereli, Lucian Lozonschi, Georg Lutter
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Patent number: 12059349Abstract: A valve prosthesis can be manufactured by aligning a membrane along a support frame and attaching the membrane to the support frame. The membrane can have a plurality of first fibers arranged in a warp direction and a plurality of second fibers arranged in a weft direction that is transverse relative to the warp direction. The plurality of first fibers and the plurality of second fibers can be woven together. The warp and weft directions can be oriented oblique relative to a longitudinal axis of the support frame.Type: GrantFiled: December 8, 2021Date of Patent: August 13, 2024Assignee: JC Medical, Inc.Inventors: Ji Zhang, Brandon G. Walsh, Cheng Yong Yang, Jinhua Zhu
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Patent number: 12053370Abstract: An implantable prosthetic valve can include a radially expandable and collapsible annular frame having an inflow end and an outflow end. A leaflet structure can be positioned within the frame. An annular inner skirt can be positioned around an inner surface of the frame, wherein the inner skirt includes an outflow edge portion secured to the frame and an inflow edge portion secured to the frame. An outer skirt can be positioned around the outer surface of the frame, wherein the outer skirt comprises an outflow edge portion secured to the frame and an inflow edge portion that is secured to the inflow edge portion of the inner skirt, wherein the inner and outer skirts are configured such that when the prosthetic valve is implanted, antegrade blood can flow through a space between the inflow edge portion of the inner skirt and the inflow edge portion of the outer skirt.Type: GrantFiled: January 22, 2021Date of Patent: August 6, 2024Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Tamir S. Levi, Son V. Nguyen
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Patent number: 12053379Abstract: A delivery tool includes a nosepiece that is fixed to a shaft, and distal to an implant, and an expandable element proximal to the nosepiece. Maximally-expanded, the expandable element (i) has an expanded external diameter at its widest part that is smaller than the expanded internal diameter of a lumen of the frame of the implant, (ii) tapers proximally away from the widest part and from the nosepiece, and (iii) is dimensioned to slide proximally through the lumen of the implant in its expanded state, between leaflets of the implant, and out of the lumen. When non-expanded, the widest part of the expandable element has a non-expanded external diameter that is smaller than the expanded external diameter of the expandable element. In a compressed state of the implant a portion of the expandable element is disposed within the lumen of the frame. Other applications are also described.Type: GrantFiled: February 22, 2021Date of Patent: August 6, 2024Assignee: CARDIOVALVE LTD.Inventors: Ilia Hariton, Boaz Harari, Maxim Karalnik, Michael Albitov, Meni Iamberger
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Patent number: 12023241Abstract: An implantable prosthetic valve assembly, according to one embodiment, comprises a frame assembly including a plurality of struts and a prosthetic valve secured inside the frame assembly by sutures. At least one of the plurality of spaced struts contains at least one hole that passes from one side of the at least one strut to another side of the at least one strut and a recess disposed around the hole.Type: GrantFiled: August 6, 2021Date of Patent: July 2, 2024Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Yong Gao, Pu Zhou, Tianwen Zhao, Jeffrey Wu
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Patent number: 11986389Abstract: Systems, devices, and methods for treating a diseased native valve in a patient, the system comprising a compressible and expandable frame structure and an anchor. The anchor comprises a wire having a free end and is configured to be fully advanced from an atrial side of a native valve in a patient into a ventricle of the heart and anchor the frame structure to the native valve when the frame structure is in the expanded configuration adjacent the native valve.Type: GrantFiled: March 16, 2023Date of Patent: May 21, 2024Assignee: Shifamed Holdings, LLCInventors: Claudio Argento, Andrew Backus, Alice Yang
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Patent number: 11911264Abstract: A prosthetic spacer assembly includes a spacer body, a first anchor, and a second anchor. The first anchor and the second anchor are each connected to the spacer body. The first anchor is configured to capture a first native valve leaflet between the first anchor and the spacer body. The second anchor is configured to capture a second native valve leaflet between the second anchor and the spacer body. When inside a delivery sheath, the first anchor and the second anchor can extend distally from the spacer body.Type: GrantFiled: September 10, 2020Date of Patent: February 27, 2024Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Mark Chau, Marlowe E. Patterson, Seung-Beom Yi, Stephen C. Geist, Travis Zenyo Oba
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Patent number: 11903823Abstract: Prosthetic heart valves, which are collapsible to a relatively small circumferential size for less invasive delivery into a patient and which then re-expand to operating size at an implant site in the patient, include a collapsible/expandable stent-like supporting structure and various components of flexible, sheet-like material that are attached to the supporting structure. For example, these sheet-like other components may include prosthetic valve leaflets, layers of buffering material, cuff material, etc. Improved structures and techniques are provided for securing such other components to the stent-like supporting structure of the valve.Type: GrantFiled: March 26, 2021Date of Patent: February 20, 2024Assignee: St. Jude Medical, LLCInventors: Peter Nicholas Braido, Andrea L. McCarthy, Rubem L. Figueiredo, Julia A. Schraut
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Patent number: 11826252Abstract: A method of replacing the function of a native heart valve is achieved by inserting a distal end portion of a delivery apparatus into a patient's body, wherein a prosthetic valve is disposed along the distal end portion of the delivery apparatus. The prosthetic valve includes a collapsible and expandable annular body having a network of struts interconnected at a plurality of nodes to form a plurality of open cells. Atrial and ventricular flanges are coupled to the annular body and extend radially away from the annular body. The annular body includes three commissure support posts of fixed length that extend substantially the entire length of the annular body. A valve member is secured to the commissure support posts. The annular body is radially expanded within the native heart valve and the atrial and ventricular flanges are deployed on opposite sides of the native heart valve.Type: GrantFiled: December 18, 2020Date of Patent: November 28, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Alexander H. Cooper, Matthew A. Peterson
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Patent number: 11759320Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.Type: GrantFiled: March 31, 2022Date of Patent: September 19, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Tamir S. Levi, Son V. Nguyen, Netanel Benichou, David Maimon, Ziv Yohanan, Nikolay Gurovich, Bella Felsen, Larisa Dadonkina, Ron Sharoni, Elena Sherman
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Patent number: 11737872Abstract: A method of delivering a prosthetic valve to a native mitral valve of patient's heart may include providing a radially expandable prosthetic mitral valve which has an upstream atrial portion, a downstream ventricular portion and an annular region therebetween. A constraint is removed from the ventricular portion thereby allowing radial expansion of a ventricular portion. A first anchoring tab on the ventricular portion is radially expanded and an annular region is radially expanded. An atrial skirt on the atrial flange is radially expanded after radial expansion of the ventricular portion.Type: GrantFiled: November 8, 2019Date of Patent: August 29, 2023Assignee: Neovasc Tiara Inc.Inventors: Eric Soun-Sang Fung, Kathleen Hung, Karen Tsoek-Ji Wong, David Andrew Moffatt
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Patent number: 11730596Abstract: A method of replacing the function of a native heart valve is achieved by inserting a distal end portion of a delivery apparatus into a patient's body, wherein a prosthetic valve is disposed along the distal end portion of the delivery apparatus. The prosthetic valve includes a collapsible and expandable annular body having a network of struts interconnected at a plurality of nodes to form a plurality of open cells. Atrial and ventricular flanges are coupled to the annular body and extend radially away from the annular body. The annular body includes three commissure support posts of fixed length that extend substantially the entire length of the annular body. A valve member is secured to the commissure support posts. The annular body is radially expanded within the native heart valve and the atrial and ventricular flanges are deployed on opposite sides of the native heart valve.Type: GrantFiled: December 18, 2020Date of Patent: August 22, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Alexander H. Cooper, Matthew A. Peterson
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Patent number: 11717425Abstract: The present invention relates to an implantable apparatus and methods of use thereof for treating congestive heart failure. An apparatus of this invention may be anchored by implantation of a section of the apparatus within in a branch pulmonary artery, for example the left pulmonary artery, which then positions and anchors another section, for example a device frame section of the apparatus within the main pulmonary artery. A medical device may be attached to the anchored device frame.Type: GrantFiled: June 1, 2020Date of Patent: August 8, 2023Assignee: Restore Medical Ltd.Inventors: Elchanan Bruckheimer, Tanhum Feld, Gil Naor, Stephen F. Bellomo
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Patent number: 11666434Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.Type: GrantFiled: April 8, 2022Date of Patent: June 6, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Ziv Yohanan, Tamir S. Levi, Netanel Benichou, Michael Bukin, Nikolai Gurovich, Elena Sherman
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Patent number: 11648116Abstract: A valved conduit including a bioprosthetic aortic heart valve connected to a tubular conduit graft forming an ascending aorta. The conduit graft may attach to the heart valve in a manner that facilitates a redo operation in which the valve is replaced with another valve. A sewing ring may be pre-attached to the inflow end of the graft, and then the valve connected to a delivery holder advanced into the graft and secured to the sewing ring. Dry bioprosthetic valves coupled with conduit grafts sealed with a bioresorbable medium can be stored with the delivery holder.Type: GrantFiled: May 14, 2021Date of Patent: May 16, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Michael C. Murad, Hilda Z. Fann, Mark Van Nest, John X. Wang, Derrick Johnson
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Patent number: 11648109Abstract: A transcatheter valve prosthesis includes a balloon expandable stent and a prosthetic valve. An inflow portion of the stent includes a plurality of crowns and a plurality of struts with each crown being formed between a pair of opposing struts. Endmost inflow side openings and endmost inflow crowns are formed at the inflow end of the stent and the inflow end of the stent has a total of twelve endmost inflow crowns. An outflow portion of the stent includes a plurality of crowns and a plurality of struts with each crown being formed between a pair of opposing struts. Endmost outflow crowns are formed at the outflow end of the stent and the outflow end of the stent has a total of six endmost outflow crowns. The prosthetic valve is disposed within and secured to the stent.Type: GrantFiled: January 31, 2020Date of Patent: May 16, 2023Assignee: MEDTRONIC, INC.Inventors: Justin Peterson, Justin Goshgarian, Stuart Kari, Tracey Tien, Michael Krivoruchko, Yas Neuberger
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Patent number: 11648108Abstract: A heart valve prosthesis, including a valved stent and valve leaflets, where the valve leaflets are accommodated in the valved stent, at least two valve leaflets are provided and centrosymmetrically distributed along the circumferential direction of an inner surface of the valve leaflet stent, one ends of each of two adjacent valve leaflets are combined together on the valve leaflet stent to form a valve corner, the valved stent is provided with a positioning member, and the projections of a perpendicular line of one of the valve corners to the axis of the valved stent and a perpendicular line of the positioning member to the axis of the valved stent are coincident on a plane perpendicular to the axis of the valved stent. The heart valve prosthesis can considerably reduce regurgitation at the center.Type: GrantFiled: September 25, 2018Date of Patent: May 16, 2023Assignee: LIFETECH SCIENTIFIC (SHENZHEN) CO., LTDInventor: Xiangdong Liu
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Patent number: 11633278Abstract: A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.Type: GrantFiled: January 28, 2020Date of Patent: April 25, 2023Assignee: Cephea Valve Technologies, Inc.Inventors: Spencer Noe, Dan Wallace, Jonathan Oakden
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Patent number: 11628062Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.Type: GrantFiled: March 29, 2022Date of Patent: April 18, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Tamir S. Levi, Son V. Nguyen, Netanel Benichou, David Maimon, Ziv Yohanan, Nikolai Gurovich, Bella Felsen, Larisa Dadonkina, Ron Sharoni, Elena Sherman
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Patent number: 11622856Abstract: A percutaneous heart valve prosthesis including a collapsible valve body frame has a first end and a second end. The valve body frame is formed by a plurality of sub-frame members, each sub-frame member having a general form of a diamond with acute-angled vertices and oblique-angled vertices, wherein adjacent sub-frame members are joined at the oblique-angled vertices. A flexible skirt made from pericardial material extends around a periphery of the valve body frame. A one-way valve including a plurality of flexible valve leaflets is positioned within the valve body frame. The first end of the valve body frame is sized to pass through a valve orifice associated with a heart valve to be replaced and the second end of the valve body frame is sized so as not to pass through a valve orifice.Type: GrantFiled: October 14, 2022Date of Patent: April 11, 2023Assignee: Percutaneous Cardiovascular Solutions Pty LtdInventors: Suku Thambar, Stayajit Rohan Jayasinghe
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Patent number: 11583395Abstract: Prosthetic heart valve leaflet with a fixed end and a free end characterized by the fact that it has a variable thickness.Type: GrantFiled: January 19, 2018Date of Patent: February 21, 2023Assignee: EPYGONInventors: Enrico Pasquino, Marcio Scorsin
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Patent number: 11510778Abstract: Methods are described herein for delivering a replacement valve to a native valve location. In one method, ventricular anchors of the replacement valve are released and allowed to reverse orientation while positioned in the atrium of a human heart. After reversing orientation, the ventricular anchors extend in a generally proximal direction. The ventricular anchors can then be advanced through the annulus into the ventricle and then moved back toward the atrium to capture native valve leaflets between the main body and the ventricular anchors of the replacement valve. In one modification, the ventricular anchors are allowed to reverse orientation at a level adjacent the annulus. The implantation methods described herein are preferably performed via a transseptal delivery approach or a transapical delivery approach.Type: GrantFiled: August 14, 2020Date of Patent: November 29, 2022Assignee: Edwards Lifesciences CorporationInventors: J. Brent Ratz, Glen T. Rabito
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Patent number: 11504239Abstract: Apparatus, systems, and methods for percutaneous valve replacement and/or augmentation are provided. The apparatus includes a valve having a valve frame, a valve leaflet coupled to the valve frame, and a leaflet transition member coupled to the valve leaflet. The valve leaflet and leaflet transition member can transition from a first position where the valve leaflet and leaflet frame are at least partially outside a lumen of the valve frame to a second position where the valve leaflet and the leaflet transition member are within the lumen of the valve frame.Type: GrantFiled: December 5, 2018Date of Patent: November 22, 2022Assignee: Boston Scientific Scimed, Inc.Inventors: Tracee Eidenschink, Joseph M. Thielen, William J. Drasler, Graig L. Kveen
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Patent number: 11413172Abstract: An anchor stent assembly to be used with a valve component includes a generally tubular frame having a first end and a second end, the frame defining a central passage and a central axis. A secondary passage is defined between n inner surface of the frame and an outer surface of an inner rib disposed closer to the central axis than the frame. An extension tube is disposed through the secondary passage. The extension tube includes an extension tube lumen having a first opening at a first end of the extension tube and a second opening at a second end of the extension tube.Type: GrantFiled: March 19, 2019Date of Patent: August 16, 2022Assignee: Medtronic, Inc.Inventors: Shishira Nagesh, Paul Rothstein
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Patent number: 11395675Abstract: A clot retrieval cleaning instrument can have bristles, fluid sprays, or other techniques to liberate captured clot material from a clot retrieval device so that it can be reinserted into a patient's vasculature for successive capture attempts. The cleaning instrument can be conveniently integrated or connected to a hemostasis valve assembly so that the cleaning function can be performed without completely removing the clot retrieval device from the delivery system. Aspiration can be applied to remove the freed thrombus material. The cleaning instrument can be removable from the delivery system to facilitate the instrument's washing or disposal.Type: GrantFiled: July 11, 2019Date of Patent: July 26, 2022Assignee: DePuy Synthes Products, Inc.Inventors: Roberto Echarri, Kirk Johnson
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Patent number: 11364116Abstract: This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.Type: GrantFiled: August 16, 2021Date of Patent: June 21, 2022Assignee: Tendyne Holdings, Inc.Inventors: Robert Vidlund, Kemal Schankereli, Lucian Lozonschi, Georg Lutter
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Patent number: 11344410Abstract: Implantable first atrial and ventricular arms are articulatable at a first articulation site to clamp a first heart valve leaflet. A first implantable elongate transitioning member is (a) connected at a fixed connection point at a portion of the first ventricular arm farthest from the first articulation site, (b) has a portion that faces an opposite surface of the first ventricular arm, and (c) is controllable to move the first ventricular arm. Implantable second atrial and ventricular arms are articulatable at a second articulation site to clamp a second leaflet. A second implantable elongate transitioning member is (a) connected at a fixed connection point at a portion of the second ventricular arm farthest from the second articulation site, (b) has a portion that faces an opposite surface of the second ventricular arm, and (c) is controllable to move the second ventricular arm. Other embodiments are also described.Type: GrantFiled: July 2, 2021Date of Patent: May 31, 2022Assignee: CARDIOVALVE LTD.Inventors: Gil Hacohen, Yossi Gross
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Patent number: 11253356Abstract: A delivery system and method for percutaneous aortic valve (PAV) replacement and apparatus used therein. A temporary aortic valve including a reversibly expandable occluder surrounds a central catheter mechanism. The temporary valve is positioned within the ascending aorta, just above and downstream from the coronary ostia. The occluder is configured such that, when fully expanded against the aortic wall, gaps are left that promote continuous coronary perfusion during the cardiac cycle. The temporary valve substitutes for the function of the native aortic valve during its replacement. The native aortic valve is next dilated, and then ablated through deployment of low profile, elongated, sequentially delivered stents. The stent(s) displace the native tissues and remain within the aortic annulus to receive and provide a structure for retaining the PAV. The PAV is delivered, positioned and deployed within the stent(s) at the aortic annulus with precision and relative ease.Type: GrantFiled: August 17, 2018Date of Patent: February 22, 2022Assignee: HOCOR CARDIOVASCULAR TECHNOLOGIES, LLCInventor: Paul C. Ho
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Patent number: 11224512Abstract: A coronary artery check valve includes a stent configured to attach to an inner wall of a coronary artery of a living subject, and a tapered helical coil coupled to the stent and configured to regulate blood flow in the coronary artery. The coronary artery check valve is configured to prevent retrograde flow of the coronary blood supply during diastole by closing during systole of the heart when the tapered helical coil compresses longitudinally, and opening when the tapered helical coil expands longitudinally to permit blood flow into the coronary artery when a coronary pressure of the living subject drops below diastolic blood pressure.Type: GrantFiled: March 5, 2019Date of Patent: January 18, 2022Assignee: Edwards Lifesciences CorporationInventors: Grant Matthew Stearns, Gregory Bak-Boychuk, Sergio Delgado
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Patent number: 11123180Abstract: This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.Type: GrantFiled: October 7, 2019Date of Patent: September 21, 2021Assignee: Tendyne Holdings, Inc.Inventors: Robert Vidlund, Kemal Schankereli, Lucian Lozonschi, Georg Lutter
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Patent number: 11123179Abstract: A prosthetic device for a heart valve, comprising a valve portion with prosthetic leaflets capable of reproducing the function of the valve leaflets of a native heart valve, selectively expandable from a collapsed configuration for implantation to a working expanded configuration. The prosthetic device also comprises a containment portion which surrounds the valve portion to contain its expansion in the working expanded configuration. The prosthetic device also comprises a connecting portion which stably connects the valve portion to the containment portion by means of connecting elements. The invention allows for both the use of minimally invasive surgical implantation procedures and implantation procedures based completely on transcatheteral techniques.Type: GrantFiled: February 4, 2015Date of Patent: September 21, 2021Assignee: INNOVHEART S.r.l.Inventors: Giovanni Righini, Sarah Zanon
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Patent number: 11090157Abstract: Apparatus and methods are described herein for various embodiments of a prosthetic heart valve, delivery apparatus and delivery methods for delivering a prosthetic heart valve to a heart of a patient via a transapical or transvascular delivery approach. In some embodiments, a prosthetic heart valve includes an outer frame coupled to an inner frame and the outer frame is movable between a first configuration relative to the inner frame and a second inverted configuration relative to the inner frame. The valve can be delivered to a heart using an apparatus that includes a delivery sheath that defines a lumen that can receive the prosthetic heart valve therein when the outer frame is in the inverted configuration. Actuation wires are releasably coupled to the outer frame and can be used to help revert the outer frame after the valve is deployed outside of the delivery sheath and within the heart.Type: GrantFiled: June 29, 2017Date of Patent: August 17, 2021Assignee: Tendyne Holdings, Inc.Inventors: Zachary J. Tegels, Zachary Vidlund, Robert M. Vidlund
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Patent number: 11083583Abstract: Implantable valve for treating venous insufficiency having a self-expanding frame encased in polymer having a distal section for blood in-flow, a bulbous center section and a proximal section for blood out-flow. Polymeric leaflets have proximal ends forming an S-shaped valve outlet, or a valve outlet which spirals toward the proximal section. The valve opens and closes in response to venous blood flow and has distal portions which are integral with the inner polymer surface of the distal end of said bulbous section. The leaflets define a predominantly biomimetic sinus region with the bulbous section. Opening of the valve induces flushing of blood from the sinus region for smooth non-traumatic blood flow through said valve.Type: GrantFiled: December 3, 2018Date of Patent: August 10, 2021Assignee: VENARUM MEDICAL, LLCInventors: Taylor Kirk, Andrew Filachek, Janet Burpee
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Patent number: 11058535Abstract: A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.Type: GrantFiled: March 2, 2018Date of Patent: July 13, 2021Assignee: Cephea Valve Technologies, Inc.Inventors: Spencer Noe, Dan Wallace, Jonathan Oakden
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Patent number: 11045183Abstract: Apparatus and methods are described herein for repositioning a tether attached to a prosthetic heart valve. In some embodiments, a method includes inserting a distal end portion of a snare device through an incision at a first location in a ventricular wall of a heart and within the left ventricle of the heart. A tether extending from a prosthetic mitral valve, through the left ventricle and out an incision at a second location on the ventricular wall of the heart is snared with the snare device. The tether is pulled with the snare device such that a proximal end of the tether is moved back through the incision at the second location on the ventricular wall and into the left ventricle. The snare device is pulled proximally such that the tether is pulled proximally through the incision at the first location in the ventricular wall of the heart.Type: GrantFiled: May 22, 2018Date of Patent: June 29, 2021Assignee: Tendyne Holdings, Inc.Inventors: Robert M. Vidlund, Craig A. Ekvall
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Patent number: 11039919Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a valved conduit. The valved conduit may include at least one leaflet and an interior surface that mitigates against thrombus formation within the conduit.Type: GrantFiled: September 12, 2018Date of Patent: June 22, 2021Assignee: W. L. Gore & Associates, Inc.Inventors: Kyle W. Colavito, Edwin W. Field, Colin T. Burns-Heffner
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Patent number: 11026783Abstract: A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.Type: GrantFiled: March 2, 2018Date of Patent: June 8, 2021Assignee: Cephea Valve Technologies, Inc.Inventors: Spencer Noe, Dan Wallace, Jonathan Oakden
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Patent number: 11007047Abstract: An endoleak preventing stent graft system, used for preventing the endoleaks except for type II endoleak, comprising: a metal mesh support layer fit for the shape of the artery blood vessel; a cover film layer covering on said metal mesh support layer; and a flexible mesh layer covering outside said cover film layer, said flexible mesh layer fills up the gap formed between said cover film layer and the inwall of said artery blood vessel under the effect of the flexibility of itself.Type: GrantFiled: December 18, 2015Date of Patent: May 18, 2021Assignee: THE SECOND MILITARY MEDICAL UNIVERSITYInventors: Junmin Bao, Jian Dong, Liangxi Yuan, Yanchun Meng, Jian Zhou, Zaiping Jing
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Patent number: 10945835Abstract: Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having a first portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a valve support coupled to a second portion of the anchoring member, configured to support a prosthetic valve and having a cross-sectional shape. In some embodiments, the first portion of the anchoring member is mechanically isolated from the valve support such that the cross-sectional shape of the valve support remains sufficiently stable that the prosthetic valve remains competent when the anchoring member is deformed in the non-circular shape.Type: GrantFiled: May 7, 2018Date of Patent: March 16, 2021Assignee: TWELVE, INC.Inventors: John Morriss, Hanson Gifford, III, James I. Fann, Jean-Pierre Dueri, Matt McLean, Darin Gittings, Michael Luna, Mark Deem, Douglas Sutton, Jeffry J. Grainger
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Patent number: 10898319Abstract: An implantable prosthetic valve can include a radially expandable and collapsible annular frame having an inflow end and an outflow end. A leaflet structure can be positioned within the frame. An annular inner skirt can be positioned around an inner surface of the frame, wherein the inner skirt includes an outflow edge portion secured to the frame and an inflow edge portion that wraps around the inflow end of the frame and extends at least partially along an outer surface of the frame, with the inflow edge portion being secured to the frame. An outer skirt can be positioned around the outer surface of the frame, wherein the outer skirt comprises an outflow edge portion secured to the frame and an inwardly folded inflow edge portion that is secured to the inflow edge portion of the inner skirt.Type: GrantFiled: August 13, 2018Date of Patent: January 26, 2021Assignee: Edwards Lifesciences CorporationInventors: Tamir S. Levi, Son V. Nguyen
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Patent number: 10874510Abstract: A prosthetic heart valve may include a collapsible and expandable stent having a proximal end, a distal end, an annulus section adjacent the proximal end, and a plurality of cells connected to one another in annular rows around the stent, a cuff attached to the stent, and a sealing member attached to the cuff and extending from a proximal end of the cuff to a free edge. The sealing member may be movable between an extended condition in which the free edge is located proximally of the proximal end of the stent, and an inverted condition in which the free edge is located distally of the proximal end of the stent and a first surface of the sealing member confronts an outward-facing surface of the cuff. Various mechanisms for moving the sealing member are also described.Type: GrantFiled: October 30, 2018Date of Patent: December 29, 2020Assignee: St. Jude Medical, Cardiology Division, Inc.Inventors: Peter N. Braido, Yousef F. Alkhatib, Steven Frederick Anderl, Jacob John Daly, Mina S. Fahim, Kent J. Smith, Ralph Joseph Thomas
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Patent number: 10856984Abstract: A sequentially deployed prosthetic cardiac valve includes a self-expanding frame having an atrial skirt, a ventricular skirt, and an annular region disposed therebetween. A first anterior tab is disposed on an anterior portion of the frame. A posterior tab is on a posterior portion of the self-expanding frame. The frame may be designed so that any portion may expand sequentially in any desired order. For example, a portion of the first anterior tab and a portion of the posterior tab may partially self-expand first. Next, the first anterior tab may fully self-expand before the posterior tab fully self-expands. The posterior tab may fully self-expand next followed by the ventricular skirt, or the ventricular skirt may self-expand next followed by full expansion of the posterior tab.Type: GrantFiled: August 24, 2018Date of Patent: December 8, 2020Assignee: Neovasc Tiara Inc.Inventors: Randy Matthew Lane, Colin A. Nyuli, Alexei J. Marko, Krista L. Neale
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Patent number: 10849743Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.Type: GrantFiled: November 26, 2019Date of Patent: December 1, 2020Assignee: Edwards Lifesciences CorporationInventors: Tamir S. Levi, Son V. Nguyen, Netanel Benichou, David Maimon, Ziv Yohanan, Nikolay Gurovich, Bella Felsen, Larisa Dadonkina, Ron Sharoni, Elena Sherman
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Patent number: 10842622Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.Type: GrantFiled: November 27, 2019Date of Patent: November 24, 2020Assignee: Edwards Lifesciences CorporationInventors: Tamir S. Levi, Son V. Nguyen, Netanel Benichou, David Maimon, Ziv Yohanan, Nikolay Gurovich, Bella Felsen, Larisa Dadonkina, Ron Sharoni, Elena Sherman