Heart Valve Patents (Class 623/1.26)
  • Patent number: 11911264
    Abstract: A prosthetic spacer assembly includes a spacer body, a first anchor, and a second anchor. The first anchor and the second anchor are each connected to the spacer body. The first anchor is configured to capture a first native valve leaflet between the first anchor and the spacer body. The second anchor is configured to capture a second native valve leaflet between the second anchor and the spacer body. When inside a delivery sheath, the first anchor and the second anchor can extend distally from the spacer body.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: February 27, 2024
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Mark Chau, Marlowe E. Patterson, Seung-Beom Yi, Stephen C. Geist, Travis Zenyo Oba
  • Patent number: 11903823
    Abstract: Prosthetic heart valves, which are collapsible to a relatively small circumferential size for less invasive delivery into a patient and which then re-expand to operating size at an implant site in the patient, include a collapsible/expandable stent-like supporting structure and various components of flexible, sheet-like material that are attached to the supporting structure. For example, these sheet-like other components may include prosthetic valve leaflets, layers of buffering material, cuff material, etc. Improved structures and techniques are provided for securing such other components to the stent-like supporting structure of the valve.
    Type: Grant
    Filed: March 26, 2021
    Date of Patent: February 20, 2024
    Assignee: St. Jude Medical, LLC
    Inventors: Peter Nicholas Braido, Andrea L. McCarthy, Rubem L. Figueiredo, Julia A. Schraut
  • Patent number: 11826252
    Abstract: A method of replacing the function of a native heart valve is achieved by inserting a distal end portion of a delivery apparatus into a patient's body, wherein a prosthetic valve is disposed along the distal end portion of the delivery apparatus. The prosthetic valve includes a collapsible and expandable annular body having a network of struts interconnected at a plurality of nodes to form a plurality of open cells. Atrial and ventricular flanges are coupled to the annular body and extend radially away from the annular body. The annular body includes three commissure support posts of fixed length that extend substantially the entire length of the annular body. A valve member is secured to the commissure support posts. The annular body is radially expanded within the native heart valve and the atrial and ventricular flanges are deployed on opposite sides of the native heart valve.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: November 28, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Alexander H. Cooper, Matthew A. Peterson
  • Patent number: 11759320
    Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
    Type: Grant
    Filed: March 31, 2022
    Date of Patent: September 19, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Tamir S. Levi, Son V. Nguyen, Netanel Benichou, David Maimon, Ziv Yohanan, Nikolay Gurovich, Bella Felsen, Larisa Dadonkina, Ron Sharoni, Elena Sherman
  • Patent number: 11737872
    Abstract: A method of delivering a prosthetic valve to a native mitral valve of patient's heart may include providing a radially expandable prosthetic mitral valve which has an upstream atrial portion, a downstream ventricular portion and an annular region therebetween. A constraint is removed from the ventricular portion thereby allowing radial expansion of a ventricular portion. A first anchoring tab on the ventricular portion is radially expanded and an annular region is radially expanded. An atrial skirt on the atrial flange is radially expanded after radial expansion of the ventricular portion.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: August 29, 2023
    Assignee: Neovasc Tiara Inc.
    Inventors: Eric Soun-Sang Fung, Kathleen Hung, Karen Tsoek-Ji Wong, David Andrew Moffatt
  • Patent number: 11730596
    Abstract: A method of replacing the function of a native heart valve is achieved by inserting a distal end portion of a delivery apparatus into a patient's body, wherein a prosthetic valve is disposed along the distal end portion of the delivery apparatus. The prosthetic valve includes a collapsible and expandable annular body having a network of struts interconnected at a plurality of nodes to form a plurality of open cells. Atrial and ventricular flanges are coupled to the annular body and extend radially away from the annular body. The annular body includes three commissure support posts of fixed length that extend substantially the entire length of the annular body. A valve member is secured to the commissure support posts. The annular body is radially expanded within the native heart valve and the atrial and ventricular flanges are deployed on opposite sides of the native heart valve.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: August 22, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Alexander H. Cooper, Matthew A. Peterson
  • Patent number: 11717425
    Abstract: The present invention relates to an implantable apparatus and methods of use thereof for treating congestive heart failure. An apparatus of this invention may be anchored by implantation of a section of the apparatus within in a branch pulmonary artery, for example the left pulmonary artery, which then positions and anchors another section, for example a device frame section of the apparatus within the main pulmonary artery. A medical device may be attached to the anchored device frame.
    Type: Grant
    Filed: June 1, 2020
    Date of Patent: August 8, 2023
    Assignee: Restore Medical Ltd.
    Inventors: Elchanan Bruckheimer, Tanhum Feld, Gil Naor, Stephen F. Bellomo
  • Patent number: 11666434
    Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: June 6, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Ziv Yohanan, Tamir S. Levi, Netanel Benichou, Michael Bukin, Nikolai Gurovich, Elena Sherman
  • Patent number: 11648109
    Abstract: A transcatheter valve prosthesis includes a balloon expandable stent and a prosthetic valve. An inflow portion of the stent includes a plurality of crowns and a plurality of struts with each crown being formed between a pair of opposing struts. Endmost inflow side openings and endmost inflow crowns are formed at the inflow end of the stent and the inflow end of the stent has a total of twelve endmost inflow crowns. An outflow portion of the stent includes a plurality of crowns and a plurality of struts with each crown being formed between a pair of opposing struts. Endmost outflow crowns are formed at the outflow end of the stent and the outflow end of the stent has a total of six endmost outflow crowns. The prosthetic valve is disposed within and secured to the stent.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: May 16, 2023
    Assignee: MEDTRONIC, INC.
    Inventors: Justin Peterson, Justin Goshgarian, Stuart Kari, Tracey Tien, Michael Krivoruchko, Yas Neuberger
  • Patent number: 11648116
    Abstract: A valved conduit including a bioprosthetic aortic heart valve connected to a tubular conduit graft forming an ascending aorta. The conduit graft may attach to the heart valve in a manner that facilitates a redo operation in which the valve is replaced with another valve. A sewing ring may be pre-attached to the inflow end of the graft, and then the valve connected to a delivery holder advanced into the graft and secured to the sewing ring. Dry bioprosthetic valves coupled with conduit grafts sealed with a bioresorbable medium can be stored with the delivery holder.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: May 16, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Michael C. Murad, Hilda Z. Fann, Mark Van Nest, John X. Wang, Derrick Johnson
  • Patent number: 11648108
    Abstract: A heart valve prosthesis, including a valved stent and valve leaflets, where the valve leaflets are accommodated in the valved stent, at least two valve leaflets are provided and centrosymmetrically distributed along the circumferential direction of an inner surface of the valve leaflet stent, one ends of each of two adjacent valve leaflets are combined together on the valve leaflet stent to form a valve corner, the valved stent is provided with a positioning member, and the projections of a perpendicular line of one of the valve corners to the axis of the valved stent and a perpendicular line of the positioning member to the axis of the valved stent are coincident on a plane perpendicular to the axis of the valved stent. The heart valve prosthesis can considerably reduce regurgitation at the center.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: May 16, 2023
    Assignee: LIFETECH SCIENTIFIC (SHENZHEN) CO., LTD
    Inventor: Xiangdong Liu
  • Patent number: 11633278
    Abstract: A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: April 25, 2023
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Spencer Noe, Dan Wallace, Jonathan Oakden
  • Patent number: 11628062
    Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
    Type: Grant
    Filed: March 29, 2022
    Date of Patent: April 18, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Tamir S. Levi, Son V. Nguyen, Netanel Benichou, David Maimon, Ziv Yohanan, Nikolai Gurovich, Bella Felsen, Larisa Dadonkina, Ron Sharoni, Elena Sherman
  • Patent number: 11622856
    Abstract: A percutaneous heart valve prosthesis including a collapsible valve body frame has a first end and a second end. The valve body frame is formed by a plurality of sub-frame members, each sub-frame member having a general form of a diamond with acute-angled vertices and oblique-angled vertices, wherein adjacent sub-frame members are joined at the oblique-angled vertices. A flexible skirt made from pericardial material extends around a periphery of the valve body frame. A one-way valve including a plurality of flexible valve leaflets is positioned within the valve body frame. The first end of the valve body frame is sized to pass through a valve orifice associated with a heart valve to be replaced and the second end of the valve body frame is sized so as not to pass through a valve orifice.
    Type: Grant
    Filed: October 14, 2022
    Date of Patent: April 11, 2023
    Assignee: Percutaneous Cardiovascular Solutions Pty Ltd
    Inventors: Suku Thambar, Stayajit Rohan Jayasinghe
  • Patent number: 11583395
    Abstract: Prosthetic heart valve leaflet with a fixed end and a free end characterized by the fact that it has a variable thickness.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: February 21, 2023
    Assignee: EPYGON
    Inventors: Enrico Pasquino, Marcio Scorsin
  • Patent number: 11510778
    Abstract: Methods are described herein for delivering a replacement valve to a native valve location. In one method, ventricular anchors of the replacement valve are released and allowed to reverse orientation while positioned in the atrium of a human heart. After reversing orientation, the ventricular anchors extend in a generally proximal direction. The ventricular anchors can then be advanced through the annulus into the ventricle and then moved back toward the atrium to capture native valve leaflets between the main body and the ventricular anchors of the replacement valve. In one modification, the ventricular anchors are allowed to reverse orientation at a level adjacent the annulus. The implantation methods described herein are preferably performed via a transseptal delivery approach or a transapical delivery approach.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: November 29, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: J. Brent Ratz, Glen T. Rabito
  • Patent number: 11504239
    Abstract: Apparatus, systems, and methods for percutaneous valve replacement and/or augmentation are provided. The apparatus includes a valve having a valve frame, a valve leaflet coupled to the valve frame, and a leaflet transition member coupled to the valve leaflet. The valve leaflet and leaflet transition member can transition from a first position where the valve leaflet and leaflet frame are at least partially outside a lumen of the valve frame to a second position where the valve leaflet and the leaflet transition member are within the lumen of the valve frame.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: November 22, 2022
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Tracee Eidenschink, Joseph M. Thielen, William J. Drasler, Graig L. Kveen
  • Patent number: 11413172
    Abstract: An anchor stent assembly to be used with a valve component includes a generally tubular frame having a first end and a second end, the frame defining a central passage and a central axis. A secondary passage is defined between n inner surface of the frame and an outer surface of an inner rib disposed closer to the central axis than the frame. An extension tube is disposed through the secondary passage. The extension tube includes an extension tube lumen having a first opening at a first end of the extension tube and a second opening at a second end of the extension tube.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: August 16, 2022
    Assignee: Medtronic, Inc.
    Inventors: Shishira Nagesh, Paul Rothstein
  • Patent number: 11395675
    Abstract: A clot retrieval cleaning instrument can have bristles, fluid sprays, or other techniques to liberate captured clot material from a clot retrieval device so that it can be reinserted into a patient's vasculature for successive capture attempts. The cleaning instrument can be conveniently integrated or connected to a hemostasis valve assembly so that the cleaning function can be performed without completely removing the clot retrieval device from the delivery system. Aspiration can be applied to remove the freed thrombus material. The cleaning instrument can be removable from the delivery system to facilitate the instrument's washing or disposal.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: July 26, 2022
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Roberto Echarri, Kirk Johnson
  • Patent number: 11364116
    Abstract: This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: June 21, 2022
    Assignee: Tendyne Holdings, Inc.
    Inventors: Robert Vidlund, Kemal Schankereli, Lucian Lozonschi, Georg Lutter
  • Patent number: 11344410
    Abstract: Implantable first atrial and ventricular arms are articulatable at a first articulation site to clamp a first heart valve leaflet. A first implantable elongate transitioning member is (a) connected at a fixed connection point at a portion of the first ventricular arm farthest from the first articulation site, (b) has a portion that faces an opposite surface of the first ventricular arm, and (c) is controllable to move the first ventricular arm. Implantable second atrial and ventricular arms are articulatable at a second articulation site to clamp a second leaflet. A second implantable elongate transitioning member is (a) connected at a fixed connection point at a portion of the second ventricular arm farthest from the second articulation site, (b) has a portion that faces an opposite surface of the second ventricular arm, and (c) is controllable to move the second ventricular arm. Other embodiments are also described.
    Type: Grant
    Filed: July 2, 2021
    Date of Patent: May 31, 2022
    Assignee: CARDIOVALVE LTD.
    Inventors: Gil Hacohen, Yossi Gross
  • Patent number: 11253356
    Abstract: A delivery system and method for percutaneous aortic valve (PAV) replacement and apparatus used therein. A temporary aortic valve including a reversibly expandable occluder surrounds a central catheter mechanism. The temporary valve is positioned within the ascending aorta, just above and downstream from the coronary ostia. The occluder is configured such that, when fully expanded against the aortic wall, gaps are left that promote continuous coronary perfusion during the cardiac cycle. The temporary valve substitutes for the function of the native aortic valve during its replacement. The native aortic valve is next dilated, and then ablated through deployment of low profile, elongated, sequentially delivered stents. The stent(s) displace the native tissues and remain within the aortic annulus to receive and provide a structure for retaining the PAV. The PAV is delivered, positioned and deployed within the stent(s) at the aortic annulus with precision and relative ease.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: February 22, 2022
    Assignee: HOCOR CARDIOVASCULAR TECHNOLOGIES, LLC
    Inventor: Paul C. Ho
  • Patent number: 11224512
    Abstract: A coronary artery check valve includes a stent configured to attach to an inner wall of a coronary artery of a living subject, and a tapered helical coil coupled to the stent and configured to regulate blood flow in the coronary artery. The coronary artery check valve is configured to prevent retrograde flow of the coronary blood supply during diastole by closing during systole of the heart when the tapered helical coil compresses longitudinally, and opening when the tapered helical coil expands longitudinally to permit blood flow into the coronary artery when a coronary pressure of the living subject drops below diastolic blood pressure.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: January 18, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Grant Matthew Stearns, Gregory Bak-Boychuk, Sergio Delgado
  • Patent number: 11123180
    Abstract: This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: September 21, 2021
    Assignee: Tendyne Holdings, Inc.
    Inventors: Robert Vidlund, Kemal Schankereli, Lucian Lozonschi, Georg Lutter
  • Patent number: 11123179
    Abstract: A prosthetic device for a heart valve, comprising a valve portion with prosthetic leaflets capable of reproducing the function of the valve leaflets of a native heart valve, selectively expandable from a collapsed configuration for implantation to a working expanded configuration. The prosthetic device also comprises a containment portion which surrounds the valve portion to contain its expansion in the working expanded configuration. The prosthetic device also comprises a connecting portion which stably connects the valve portion to the containment portion by means of connecting elements. The invention allows for both the use of minimally invasive surgical implantation procedures and implantation procedures based completely on transcatheteral techniques.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: September 21, 2021
    Assignee: INNOVHEART S.r.l.
    Inventors: Giovanni Righini, Sarah Zanon
  • Patent number: 11090157
    Abstract: Apparatus and methods are described herein for various embodiments of a prosthetic heart valve, delivery apparatus and delivery methods for delivering a prosthetic heart valve to a heart of a patient via a transapical or transvascular delivery approach. In some embodiments, a prosthetic heart valve includes an outer frame coupled to an inner frame and the outer frame is movable between a first configuration relative to the inner frame and a second inverted configuration relative to the inner frame. The valve can be delivered to a heart using an apparatus that includes a delivery sheath that defines a lumen that can receive the prosthetic heart valve therein when the outer frame is in the inverted configuration. Actuation wires are releasably coupled to the outer frame and can be used to help revert the outer frame after the valve is deployed outside of the delivery sheath and within the heart.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: August 17, 2021
    Assignee: Tendyne Holdings, Inc.
    Inventors: Zachary J. Tegels, Zachary Vidlund, Robert M. Vidlund
  • Patent number: 11083583
    Abstract: Implantable valve for treating venous insufficiency having a self-expanding frame encased in polymer having a distal section for blood in-flow, a bulbous center section and a proximal section for blood out-flow. Polymeric leaflets have proximal ends forming an S-shaped valve outlet, or a valve outlet which spirals toward the proximal section. The valve opens and closes in response to venous blood flow and has distal portions which are integral with the inner polymer surface of the distal end of said bulbous section. The leaflets define a predominantly biomimetic sinus region with the bulbous section. Opening of the valve induces flushing of blood from the sinus region for smooth non-traumatic blood flow through said valve.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: August 10, 2021
    Assignee: VENARUM MEDICAL, LLC
    Inventors: Taylor Kirk, Andrew Filachek, Janet Burpee
  • Patent number: 11058535
    Abstract: A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: July 13, 2021
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Spencer Noe, Dan Wallace, Jonathan Oakden
  • Patent number: 11045183
    Abstract: Apparatus and methods are described herein for repositioning a tether attached to a prosthetic heart valve. In some embodiments, a method includes inserting a distal end portion of a snare device through an incision at a first location in a ventricular wall of a heart and within the left ventricle of the heart. A tether extending from a prosthetic mitral valve, through the left ventricle and out an incision at a second location on the ventricular wall of the heart is snared with the snare device. The tether is pulled with the snare device such that a proximal end of the tether is moved back through the incision at the second location on the ventricular wall and into the left ventricle. The snare device is pulled proximally such that the tether is pulled proximally through the incision at the first location in the ventricular wall of the heart.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: June 29, 2021
    Assignee: Tendyne Holdings, Inc.
    Inventors: Robert M. Vidlund, Craig A. Ekvall
  • Patent number: 11039919
    Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a valved conduit. The valved conduit may include at least one leaflet and an interior surface that mitigates against thrombus formation within the conduit.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: June 22, 2021
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Kyle W. Colavito, Edwin W. Field, Colin T. Burns-Heffner
  • Patent number: 11026783
    Abstract: A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: June 8, 2021
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Spencer Noe, Dan Wallace, Jonathan Oakden
  • Patent number: 11007047
    Abstract: An endoleak preventing stent graft system, used for preventing the endoleaks except for type II endoleak, comprising: a metal mesh support layer fit for the shape of the artery blood vessel; a cover film layer covering on said metal mesh support layer; and a flexible mesh layer covering outside said cover film layer, said flexible mesh layer fills up the gap formed between said cover film layer and the inwall of said artery blood vessel under the effect of the flexibility of itself.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: May 18, 2021
    Assignee: THE SECOND MILITARY MEDICAL UNIVERSITY
    Inventors: Junmin Bao, Jian Dong, Liangxi Yuan, Yanchun Meng, Jian Zhou, Zaiping Jing
  • Patent number: 10945835
    Abstract: Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having a first portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a valve support coupled to a second portion of the anchoring member, configured to support a prosthetic valve and having a cross-sectional shape. In some embodiments, the first portion of the anchoring member is mechanically isolated from the valve support such that the cross-sectional shape of the valve support remains sufficiently stable that the prosthetic valve remains competent when the anchoring member is deformed in the non-circular shape.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: March 16, 2021
    Assignee: TWELVE, INC.
    Inventors: John Morriss, Hanson Gifford, III, James I. Fann, Jean-Pierre Dueri, Matt McLean, Darin Gittings, Michael Luna, Mark Deem, Douglas Sutton, Jeffry J. Grainger
  • Patent number: 10898319
    Abstract: An implantable prosthetic valve can include a radially expandable and collapsible annular frame having an inflow end and an outflow end. A leaflet structure can be positioned within the frame. An annular inner skirt can be positioned around an inner surface of the frame, wherein the inner skirt includes an outflow edge portion secured to the frame and an inflow edge portion that wraps around the inflow end of the frame and extends at least partially along an outer surface of the frame, with the inflow edge portion being secured to the frame. An outer skirt can be positioned around the outer surface of the frame, wherein the outer skirt comprises an outflow edge portion secured to the frame and an inwardly folded inflow edge portion that is secured to the inflow edge portion of the inner skirt.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: January 26, 2021
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tamir S. Levi, Son V. Nguyen
  • Patent number: 10874510
    Abstract: A prosthetic heart valve may include a collapsible and expandable stent having a proximal end, a distal end, an annulus section adjacent the proximal end, and a plurality of cells connected to one another in annular rows around the stent, a cuff attached to the stent, and a sealing member attached to the cuff and extending from a proximal end of the cuff to a free edge. The sealing member may be movable between an extended condition in which the free edge is located proximally of the proximal end of the stent, and an inverted condition in which the free edge is located distally of the proximal end of the stent and a first surface of the sealing member confronts an outward-facing surface of the cuff. Various mechanisms for moving the sealing member are also described.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: December 29, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Peter N. Braido, Yousef F. Alkhatib, Steven Frederick Anderl, Jacob John Daly, Mina S. Fahim, Kent J. Smith, Ralph Joseph Thomas
  • Patent number: 10856984
    Abstract: A sequentially deployed prosthetic cardiac valve includes a self-expanding frame having an atrial skirt, a ventricular skirt, and an annular region disposed therebetween. A first anterior tab is disposed on an anterior portion of the frame. A posterior tab is on a posterior portion of the self-expanding frame. The frame may be designed so that any portion may expand sequentially in any desired order. For example, a portion of the first anterior tab and a portion of the posterior tab may partially self-expand first. Next, the first anterior tab may fully self-expand before the posterior tab fully self-expands. The posterior tab may fully self-expand next followed by the ventricular skirt, or the ventricular skirt may self-expand next followed by full expansion of the posterior tab.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: December 8, 2020
    Assignee: Neovasc Tiara Inc.
    Inventors: Randy Matthew Lane, Colin A. Nyuli, Alexei J. Marko, Krista L. Neale
  • Patent number: 10849743
    Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: December 1, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tamir S. Levi, Son V. Nguyen, Netanel Benichou, David Maimon, Ziv Yohanan, Nikolay Gurovich, Bella Felsen, Larisa Dadonkina, Ron Sharoni, Elena Sherman
  • Patent number: 10842622
    Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: November 24, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: Tamir S. Levi, Son V. Nguyen, Netanel Benichou, David Maimon, Ziv Yohanan, Nikolay Gurovich, Bella Felsen, Larisa Dadonkina, Ron Sharoni, Elena Sherman
  • Patent number: 10813748
    Abstract: A prosthetic heart valve having an inflow end and an outflow end includes a collapsible and expandable stent, a collapsible and expandable valve assembly disposed within the stent and having a plurality of leaflets, and a deformable frame having a first end and a second end. The frame includes braided wires forming a body having a lumen extending therethrough for receiving the stent and the valve assembly, the body having a plurality of diameters from the first end to the second end.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: October 27, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Stephanie Marie Board, Aaron J. Chalekian, Patrick P. Russo, John Oslund
  • Patent number: 10806578
    Abstract: A sutureless implant for replacing damaged natural chordae tedingeae of a human or possibly animal heart, the implant including a distal implant part, a proximal implant part, and an artificial chord. The distal implant part is configured to fit in a lumen of an implant delivery device and includes a self-spreading portion spreading radially outside when the distal implant part is released from the lumen, the self-spreading portion being capable of anchoring the distal implant part in human muscle tissue. The proximal implant part is configured to fit in the lumen of the implant delivery device and comprises a self-spreading portion spreading radially outside when the proximal implant part is released from the lumen, the self-spreading portion being capable of bearing on a tissue portion of leaflet tissue. The distal implant part and the proximal implant part are connected by the chord.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: October 20, 2020
    Assignee: COREMEDIC AG
    Inventors: Silvio Schaffner, Tobias Aeschlimann, Oliver W├╝thrich, Thomas Bauer
  • Patent number: 10806574
    Abstract: A delivery system for percutaneously delivering a heart valve prosthesis to a site of a native heart valve includes a delivery catheter and a heart valve prosthesis. The delivery catheter includes an outer sheath, an inner shaft, and an orifice restriction mechanism. The heart valve prosthesis has a valve member and a docking member. When the orifice restriction mechanism is positioned within the docking member within an annulus of the native heart valve, the orifice restriction mechanism temporarily replicates the operation of the native heart valve until the valve member is positioned within the docking member.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: October 20, 2020
    Assignee: Medtronic Vascular, Inc.
    Inventors: Marian Lally, James R. Keogh, Jason Quill
  • Patent number: 10786240
    Abstract: A method of delivering and recovering a curved needle includes a step of inserting a first needle holder into abdominal cavity, a step of inserting a second needle holder holding a curved needle into gastrointestinal tract, a step of penetrating gastrointestinal wall with the curved needle to protrude the curved needle to the abdominal cavity, a step of removing the curved needle from the gastrointestinal wall and delivering the curved needle and the suture thread to the abdominal cavity, a suture step of suturing tissues in the abdominal cavity, a step of protruding the curved needle to the gastrointestinal tract, a step of removing the curved needle from the gastrointestinal wall and returning the curved needle from the abdominal cavity to the gastrointestinal tract, and a step of taking out the curved needle from the gastrointestinal tract to outside of body to recover the curved needle.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: September 29, 2020
    Assignee: OLYMPUS CORPORATION
    Inventors: Kosuke Motai, Shotaro Takemoto
  • Patent number: 10758348
    Abstract: Methods are described herein for delivering a replacement mitral valve to a native mitral valve location. In one method, ventricular anchors of the replacement mitral valve are released and allowed to reverse orientation while positioned in the left atrium of a human heart. After reversing orientation, the ventricular anchors extend in a generally proximal direction. The ventricular anchors can then be advanced through the mitral annulus into the left ventricle and then moved back toward the left atrium to capture native mitral valve leaflets between the main body and the ventricular anchors of the replacement mitral valve. In one modification, the ventricular anchors are allowed to reverse orientation at a level adjacent the mitral annulus. The implantation methods described herein are preferably performed via a transseptal delivery approach or a transapical delivery approach.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: September 1, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: J. Brent Ratz, Glen T. Rabito
  • Patent number: 10751169
    Abstract: Various embodiments of the present invention comprise a single-chamber collapsible and expandable prosthetic valve implant device comprising the following capabilities: (1) preservation of native valve functionality; (2) initial preservation of native valve functionality with subsequent full replacement of native valve functionality; (3) full replacement of native valve functionality; and/or (4) mitigation of the prolapsing distance of the dysfunctional leaflets by preventing the anterior excursion of the prolapsing leaflets above the upper annular surface and into the left atrial chamber in order to preserve native leaflet functionality for as long as possible. The expanded and implanted device does not extend beyond the boundaries of the subject heart chamber, e.g., the left atrium, thereby enabling the preservation of any remaining native valve functionality with subsequent full replacement of native valve functionality if and when needed.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: August 25, 2020
    Assignee: 4C Medical Technologies, Inc.
    Inventor: Jeffrey W. Chambers
  • Patent number: 10736741
    Abstract: A prosthetic heart valve can include a valve frame having a wireform portion and a stent portion. The wireform and stent portions can be undetachably coupled together via a plurality of upright struts so as to form a one-piece prosthetic heart valve frame. Alternatively, a self-expanding wireform portion and a balloon-expandable stent portion can be coupled together via one or more leaflets and a subassembly having a flexible leaflet support stent and a sealing ring. The wireform portion can include cusps and commissures configured to support a plurality of leaflets. The prosthetic valve can be radially collapsible for minimally invasive and/or transcatheter delivery techniques. Disclosed embodiments can also provide flexion of the wireform portion (e.g., of the commissures) in response to physiologic pulsatile loading when the valve is implanted in a patient's native valve annulus. Methods of making and using prosthetic heart valves are also disclosed.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: August 11, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventor: Brian S. Conklin
  • Patent number: 10702382
    Abstract: A method of placing an implant including a stent at a native heart valve site includes orienting an expandable body of the stent such that a first open end of the stent is upstream a second open end of the stent relative to a direction of blood flow through a native heart valve. The native heart valve includes native leaflets and an annulus. The method also includes radially expanding a plurality of positioning arches positioned around an outer perimeter of the expandable body. The method additionally includes inserting the plurality of positioning arches respectively within a plurality of pockets defined by leaflets of the native heart valve and a heart structure from which the native leaflets extend. The method further includes radially expanding the first open end of the stent into a position upstream of the annulus and out of contact with nerve bundles.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: July 7, 2020
    Assignee: JenaValve Technology, Inc.
    Inventors: Helmut Straubinger, Johannes Jung, Michael J. Girard, Arnulf Mayer
  • Patent number: 10695179
    Abstract: A constricting cord can be delivered to the vicinity of an annulus using an apparatus that includes a set of support arms, with a respective anchor launcher supported by each of the support arms. An inflatable first balloon is configured to push the support arms away from each other when the first balloon is inflated. An inflatable second balloon is mounted to a shaft and is configured for inflation when the second balloon is disposed distally beyond the first balloon. In some embodiments, the distal balloon is inflated while it is in a ventricle. In some embodiments, the distal balloon is inflated while it is in a pulmonary artery.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: June 30, 2020
    Assignee: Cardiac Implants LLC
    Inventor: David Alon
  • Patent number: 10682226
    Abstract: A heart valve prosthesis (1), including: a stent framework (2), which can be transferred from a collapsed state into an expanded state, in which the stent framework (2) extends along an axis (A?), wherein the stent framework (2) has a plurality of struts (20, 24), which form a plurality of cells (21a, 21b, 25) connected to one another; and a heart valve (3), which is fixed to the stent framework (2). In accordance with the invention, the thickness (d?) of the struts varies in the peripheral direction (U) of the expanded stent framework (2).
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: June 16, 2020
    Assignee: BIOTRONIK AG
    Inventors: Jens Ulmer, Nicolas Degen
  • Patent number: 10660750
    Abstract: Heart valve assembly systems and methods configured for medical interventional procedures. In one aspect, the methods and systems involve a modular approach to treatment.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: May 26, 2020
    Assignee: Caisson Interventional, LLC
    Inventors: Cyril J. Schweich, Jr., Todd J. Mortier
  • Patent number: 10646339
    Abstract: Methods are described herein for delivering a replacement mitral valve to a native mitral valve location. In one method, ventricular anchors of the replacement mitral valve are released and allowed to reverse orientation while positioned in the left atrium of a human heart. After reversing orientation, the ventricular anchors extend in a generally proximal direction. The ventricular anchors can then be advanced through the mitral annulus into the left ventricle and then moved back toward the left atrium to capture native mitral valve leaflets between the main body and the ventricular anchors of the replacement mitral valve. In one modification, the ventricular anchors are allowed to reverse orientation at a level adjacent the mitral annulus. The implantation methods described herein are preferably performed via a transseptal delivery approach or a transapical delivery approach.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: May 12, 2020
    Assignee: Edwards Lifesciences Corporation
    Inventors: J. Brent Ratz, Glen T. Rabito