Including Valve Patents (Class 623/1.24)
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Patent number: 7867274Abstract: A venous valve with a frame and a cover on the frame for unidirectional flow of a liquid through the valve.Type: GrantFiled: February 23, 2005Date of Patent: January 11, 2011Assignee: Boston Scientific Scimed, Inc.Inventors: Jason P. Hill, Susan M. Shoemaker, William J. Drasler
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Publication number: 20110004295Abstract: An implant valve for implantation in a blood vessel is comprised of a flexible tube and a hollow, substantially cylindrical support with a casing, expandable in diameter from an initial position to an implantation position. The support extends substantially coaxially over a part of the length of the tube along the inner wall of the tube. The casing of the support cooperates with the inner wall of the tube such that, in the implantation position, a first part of the tube can be formed into a rigid shell, which can be clamped substantially coaxially along the inner wall of a blood vessel. A second, axially contiguous part of the tube can then form a flexible, tubular valve body, which can extend substantially clear in the blood vessel. In an advantageous embodiment, the flexible tube comprises a vein turned inside out and the ends of the tube are connected to form a ring embracing the support.Type: ApplicationFiled: September 3, 2010Publication date: January 6, 2011Inventor: Cornelis Hendrikus Anna Wittens
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Patent number: 7854759Abstract: An implantable flow modifying device and a method of modifying flow through a lumen are provided. The flow modifying device includes a flexible member configured for permitting fluid flow through the body lumen in a first direction at a first rate and for restricting fluid flow through the body lumen in a second direction at a second rate. The flexible member includes a passageway defined by a sheath of biocompatible material, the passageway having a first end portion and a second end portion. The first end portion is sized and shaped to at least partially restrict fluid flow in the first direction and capable of at least partially collapsing in response to fluid flow in the second direction. The second end portion is adapted to seal with a wall of the body lumen. A diameter of a first opening defined in the first end portion is smaller than a diameter of a second opening defined in the second end portion.Type: GrantFiled: December 17, 2008Date of Patent: December 21, 2010Assignee: Cook IncorporatedInventor: Gary B. Shirley
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Patent number: 7854761Abstract: A venous valve apparatus, system and method for valve replacement. The valve includes a valve frame, a valve leaflet joined to the valve frame, and a support frame. The valve leaflet includes surfaces defining a reversibly sealable opening for unidirectional flow of a liquid. The support frame meets the valve frame on an axis, where the valve frame and the support frame extend from the axis in an opposing direction. The system further includes a catheter, where the valve can be reversibly joined to the catheter at a location between a proximal end and a distal end of the catheter. The system can be used to deploy the valve from the catheter at a predetermined location.Type: GrantFiled: December 19, 2003Date of Patent: December 21, 2010Assignee: Boston Scientific Scimed, Inc.Inventors: Leonard B. Richardson, Jason P. Hill
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Patent number: 7846199Abstract: Prosthetic medical devices with delayed valve function and in situ remodeling of a portion thereof are provided, as well as methods of manufacturing the medical devices and methods of treatment using the medical devices. The medical devices may be adapted to initially maintain a remodelable material within a body vessel in a first configuration suitable to contact the remodelable material with a body fluid contacting the remodelable material for a first time period or a second configuration adapted to regulate the flow of body fluid contacting the remodelable material. The medical devices may include a releasable holding member configured to retain the remodelable material in the first configuration.Type: GrantFiled: November 18, 2008Date of Patent: December 7, 2010Assignees: Cook Incorporated, Cook Biotech IncorporatedInventors: Ram H. Paul, Jr., Sean D. Chambers, Chad E. Johnson
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Publication number: 20100298927Abstract: An apparatus for repairing the function of a diseased valve includes an annular first support member expandable to a first diameter. An annular second support member is spaced axially apart from the first support member and is expandable to a second diameter that is independent of the first diameter. A tubular graft section interconnects the first and second support members. The graft section defines an annulus having a third diameter that is independent of each of the first and second diameters. A prosthetic valve is secured within the annulus of the graft section. The bioprosthetic valve has at least two valve leaflets that are coaptable to permit the unidirectional flow of blood. Methods for repairing the function of a diseased valve and for making the apparatus are also provided.Type: ApplicationFiled: July 30, 2010Publication date: November 25, 2010Inventor: Roy K. Greenberg
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Patent number: 7837727Abstract: A replacement valve for implantation centrally within the orifice of a malfunctioning native heart valve. The valve is designed for minimally invasive entry through an intercostal opening in the chest of a patient and an opening in the apex of the human heart. The replacement valve includes either a separate anchor (11, 87, 111) or a combined anchor (67) that folds around the malfunctioning native valve leaflets, sandwiching them in a manner so as to securely anchor the replacement valve in a precise, desired location.Type: GrantFiled: August 15, 2008Date of Patent: November 23, 2010Assignee: Transcatheter Technologies GmbHInventors: Wolfgang Goetz, Hou-Sen Lim
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Publication number: 20100292772Abstract: A router device is a intraluminal prosthesis which is used in the repair of aneurysms and other diseases of the aorta. The device also has applications in other vascular beds. The device incorporates an inflatable cuff or sequence of cuffs at one end for fixation and sealing. This cuff may be placed proximal to branch vessels of the aorta. Attached to the cuff is a tubular graft consisting of a generally cylindrical graft material. The graft material may contain one or more fenestrations, intended to align with branch vessels as they emerge from the parent vessel, the aorta in the preferred embodiment. The device features a deliberate taper of its diameter as the device crosses the area of branch vessels. This taper brings the diameter of the graft material to a lesser diameter than that of the parent vessel, leaving a deliberate and distinct space between the device and the wall of the vessel.Type: ApplicationFiled: April 22, 2010Publication date: November 18, 2010Inventor: Shaun L.W. Samuels
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Publication number: 20100280595Abstract: A system for treating atherosclerotic cardiovascular disease and cardiac valve dysfunction comprises delivering one or more calcium chelating agents locally to a treatment site. One aspect of the invention provides a method including delivering a nano-particulate calcium chelating agent into a vascular wall. Another aspect of the invention provides a method and device for forming a sealed chamber around a cardiac valve, releasing one or more calcium chelating agents into the sealed chamber and decalcifying a cardiac valve in need thereof.Type: ApplicationFiled: April 29, 2010Publication date: November 4, 2010Applicant: Medtronic Vascular, Inc.Inventors: Iskender Bilge, Joseph Berglund, Ayala Hezi-Yamit
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Patent number: 7815673Abstract: A double walled stent system particularly suited for treating abnormalities of the right ventricular outflow tract is disclosed having an exterior stent component and an interior stent component. The exterior stent component includes a plurality of longitudinally-extending connectors such as straight or sinusoidal bands. The interior stent component has a generally tubular cylindrical body and is centered within the exterior stent component. The stent system has a contracted delivery configuration and a radially expanded configuration for contacting the vessel wall. When deployed, the longitudinally-extending connectors of the exterior stent component come in contact with the vessel wall and fix the stent system to the treatment site. The interior stent component also radially expands but remains centered inside the exterior component and makes little to no contact with the vessel wall.Type: GrantFiled: April 1, 2008Date of Patent: October 19, 2010Assignee: Medtronic Vascular, Inc.Inventors: Eliot Bloom, Gian Pellegrini, Juan-Pablo Mas, Nasser Rafiee, Morgan House
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Patent number: 7811316Abstract: An elongated support dimensioned and configured for implantation in a blood vessel. The support has two axially spaced apart portions, which may be in the form of an expandable crown or a similar structure. At least one linking member connects the two portions to one another. A valve membrane is supported between the axially spaced apart portions. The valve membrane is adapted and configured for movement between a first position in which blood flow through the support is permitted and a second position in which blood flow through the support is inhibited.Type: GrantFiled: May 10, 2007Date of Patent: October 12, 2010Assignee: Deep Vein Medical, Inc.Inventors: Menno Kalmann, Peter W. J. Hinchliffe, Adam I. Lehman
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Patent number: 7811315Abstract: An implant valve for implantation in a blood vessel is comprised of a flexible tube and a hollow, substantially cylindrical support with a casing, expandable in diameter from an initial position to an implantation position. The support extends substantially coaxially over a part of the length of the tube along the inner wall of the tube. The casing of the support cooperates with the inner wall of the tube such that, in the implantation position, a first part of the tube can be formed into a rigid shell, which can be clamped substantially coaxially along the inner wall of a blood vessel. A second, axially contiguous part of the tube can then form a flexible, tubular valve body, which can extend substantially clear in the blood vessel. In an advantageous embodiment, the flexible tube comprises a vein turned inside out and the ends of the tube are connected to form a ring embracing the support.Type: GrantFiled: January 16, 2001Date of Patent: October 12, 2010Inventor: Cornelis Hendrikus Anna Wittens
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Publication number: 20100256743Abstract: An implantable device for regulating blood flow through a blood vessel includes an elongated support. The support includes axially spaced apart first and second substantially annular support portions, and an x-shaped linking member linking the axially spaced apart portions to one another. The device also includes a valve membrane extending between the axially spaced apart support portions and having an upper portion, a lower portion and an intermediate portion. The valve membrane includes a first region and a second lower region. The first region is folded over the linking member for attachment and the second region is adjacent the first region and unattached to the linking member. The second region is movable between a first position to enable blood flow and a second position to inhibit blood flow.Type: ApplicationFiled: February 26, 2010Publication date: October 7, 2010Applicant: Deep Vein Medical, Inc.Inventors: Peter W.J. Hinchliffe, Menno Kalmann, Adam I. Lehman
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Publication number: 20100256723Abstract: A prosthetic valve having a stent structure with a prosthetic valve component secured therein is disclosed that includes a device for restricting expansion, i.e., an expansion restrictor device, disposed at a blood inflow end of the stent structure. The expansion restrictor device defines a deployed diameter of the stent structure to prevent the prosthetic valve from being over-sized upon initial deployment and/or from continued expansion in vivo. The expansion restrictor device may be a loop of suture, flexible line, thread or cord for defining or constraining a circumference of the prosthetic valve with a loop diameter that is less than or substantially equal to a diameter of the treatment site in which the prosthetic valve is to be deployed in vivo.Type: ApplicationFiled: April 3, 2009Publication date: October 7, 2010Applicant: Medtronic Vascular, Inc.Inventor: Robert Murray
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Patent number: 7806921Abstract: The disclosure relates to implantable prosthetic valves comprising support frames. The support frames may include a plurality of symmetrically arrayed interconnected U-shaped member structures. Preferred support frames are tubular structures enclosing a longitudinal axis and including a plurality of U-shaped member structures facing a distal or a proximal end of the support frame. Each U-shaped member structure may be connected to a single longitudinally adjacent U-shaped member facing in an opposite longitudinal direction, as well as two laterally adjacent U-shaped members.Type: GrantFiled: November 5, 2008Date of Patent: October 5, 2010Assignee: Cook IncorporatedInventor: Grant T. Hoffman
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Patent number: 7806920Abstract: A multi-leaflet valve adapted to serve as a prosthesis for diseased native valve of a mammal is incorporated in self-expandable or inflatable endovascular stents or stents to form a combination which is introduced on a catheter with a guide wire into the circulatory system of the mammal to replace the diseased native valve. Once the combination is at the desired location the stent is caused to expand and affix itself to the patient's vessel wall. The prosthetic valve has the shape of a truncated cone that has an inflow and an outflow orifice with leaflets forming the outflow orifice and forming a plurality of commissures. A first flexible circular support is affixed in a substantially circular fashion around the truncated cone in proximity of the inflow orifice, and a second flexible circular support is affixed at the location of the commissures to form a circle around the truncated cone in proximity of the outflow orifice.Type: GrantFiled: September 21, 2006Date of Patent: October 5, 2010Assignee: The International Heart Institute Of Montana FoundationInventor: Carlos Duran
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Patent number: 7806919Abstract: A double walled stent system particularly suited for treating abnormalities of the right ventricular outflow tract is disclosed having an exterior stent component and an interior stent component. The exterior stent component is secured to the interior stent component in a non-fixed, sliding relationship. The exterior stent component includes a plurality of longitudinally-extending connectors such as straight or sinusoidal bands. The interior stent component has a generally tubular cylindrical body and is centered within the exterior stent component. The stent system has a contracted delivery configuration and a radially expanded configuration for contacting the vessel wall. When deployed, the longitudinally-extending connectors of the exterior stent component come in contact with the vessel wall and fix the stent system to the treatment site. The interior stent component also radially expands but remains centered inside the exterior component and makes little to no contact with the vessel wall.Type: GrantFiled: April 1, 2008Date of Patent: October 5, 2010Assignee: Medtronic Vascular, Inc.Inventors: Eliot Bloom, Nasser Rafiee, Morgan House
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Patent number: 7799069Abstract: This invention relates to prosthetic cardiac and venous valves and a single catheter device and minimally invasive techniques for percutaneous and transluminal valvuloplasty and prosthetic valve implantation.Type: GrantFiled: March 27, 2006Date of Patent: September 21, 2010Assignee: ABPS Venture One, Ltd.Inventors: Steven R. Bailey, Christopher T. Boyle
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Publication number: 20100234939Abstract: A bioprosthetic valve for repairing a deep venous insufficiency in a subject includes a single leaflet from a xenogeneic heart valve attached at natural margins of attachment to a patch of valve wall tissue. The patch may extend axially above and below the leaflet and circumferentially on either side of the leaflet to provide a region for attaching the patch to a fenestration in a host vein. A bioprosthetic valve may be manufactured by excising a portion of a xenogeneic heart valve including a single leaflet and contiguous wall tissue, and may further comprise shaving off excess leaflet tissue from adjacent leaflets. A method of replacing a malfunctioning venous valve in a subject includes providing a bioprosthetic valve as described above and inserting it to the host vein.Type: ApplicationFiled: May 27, 2010Publication date: September 16, 2010Applicant: Hancock Jaffe LaboratoriesInventor: Norman Jaffe
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Publication number: 20100234940Abstract: A prosthetic valve delivery system for percutaneously delivering and deploying a prosthetic valve within an existing valve is disclosed. The delivery system includes a stented prosthetic valve having a balloon-expandable stent portion with a prosthetic valve disposed therein and at least one self-expanding stent portion. The delivery system further includes a dual balloon catheter having a first balloon on which the stented prosthetic valve is disposed during delivery and a second balloon. Upon delivery within the existing valve, the self-expanding stent portion contacts the existing valve and the first balloon expands the balloon-expandable stent portion to a first diameter such that the stented prosthetic valve is in a first stage deployment configuration.Type: ApplicationFiled: March 12, 2009Publication date: September 16, 2010Applicant: Medtronic Vascular , Inc.Inventor: Mark Dolan
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Publication number: 20100234937Abstract: A recoverable, safe and reliable valve stent for unidirectional flow of human lumen which can be implanted temporarily or for a long term and is used in the interventional therapy so as to obstruct from anisotropic flow, in the case of lung diseases. It comprises a cylindrical stent made up of memory alloy material. In particular, an elastic diaphragm is arranged inside the cylindrical stent and at least one gap is arranged on the diaphragm so that the spring piece is divided into a bendable section. One end of the cylindrical stent is provided with a fixed rear clip which is used to fix the alloy material making up the cylindrical stent. The rear clip is provided with screwthreads which can be connected with the conveyor. The stent in the present invention is in a structure without hook body, so the stent can be accurately positioned, adjusted and placed or recovered in double directions with strong anti-backflow ability.Type: ApplicationFiled: May 28, 2010Publication date: September 16, 2010Inventors: Tao Wang, Kunling Tian
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Publication number: 20100222869Abstract: A vascular graft that has a valve incorporated into a wall thereof is described. The graft may be used in gaining access to interior portions of the heart. The valve is normally closed and may be opened by a surgical device threaded into the vascular graft and to the valve. Surgical procedures may be performed within the heart with the access provided. Alternately, the valve may be placed in an open state to permit blood communication between the interior of the graft and the interior of the heart or in a closed state to prevent such communication. The vascular graft described has application in Fontan procedures and is useful in pediatric cardiac surgery and in further treating patients who have undergone Fontan procedures.Type: ApplicationFiled: September 20, 2006Publication date: September 2, 2010Inventor: Jeffrey W. Delaney
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Patent number: 7785364Abstract: A kit includes a tubular endoprosthesis having an inner surface which delimits a channel with a longitudinal axis. The kit includes a prosthetic valve to be implanted in the channel. The valve includes a supporting framework having an outer surface to be applied against the inner surface, and a flexible obturator which is connected to the framework. The endoprosthesis includes a stop for locking the supporting framework in order to block the axial displacement of the outer surface along the inner surface in at least a first direction. The stop includes at least one flexible connection extending transversely in the channel between two connection points, which are located on the inner surface and are angularly spaced about the axis.Type: GrantFiled: June 6, 2008Date of Patent: August 31, 2010Assignee: Laboratoires PerouseInventor: Mykolaj Styrc
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Patent number: 7780722Abstract: A venous valve with a frame and a cover on the frame for unidirectional flow of a liquid through the valve.Type: GrantFiled: February 7, 2005Date of Patent: August 24, 2010Assignee: Boston Scientific Scimed, Inc.Inventors: Joseph M. Thielen, Jason P. Hill, Susan M. Shoemaker
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Patent number: 7776083Abstract: A cardiovascular valve system including a permanent base unit that is affixed to the patient using conventional sutures or staples, and a collapsible valve having a collapsible frame that mates with the permanent base unit, and supports valve leaflets. An installed collapsible frame may be re-collapsed and disengaged from the permanent housing. A new collapsible valve is then installed, to resume the function of the prosthesis.Type: GrantFiled: December 28, 2005Date of Patent: August 17, 2010Assignee: The Cleveland Clinic FoundationInventor: Ivan Vesely
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Patent number: 7776082Abstract: A method and device for repairing incompetent venous valves and more specifically relates to repair method and an implantable support device—extravenous corrector (3), which is positionable about a dilated veins of the Sapheno-Femoral Junction (SFJ) (1) with the aim to apply an external compression force on the insufficient veins of SFJ and especially in the area of the venous valves. There are proposed several embodiments of a extravenous corrector for external correction of insufficient valves in venous junctions. The corrector is adapted to be placed immediately around the junction with venous valves, in abutting contact with its external area.Type: GrantFiled: February 28, 2003Date of Patent: August 17, 2010Assignee: Valcor Ltd.Inventors: Edward Shifrin, Gennady S. Nichelshpur, Andrew Nicolaides, Wesley S. Moore
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Patent number: 7771467Abstract: An apparatus for repairing the function of a native aortic valve, defining a native valve annulus, of a patient includes a tubular valve support member having oppositely disposed first and second valve member ends and a valve member body located between the first and second valve member ends. The valve support member defines a longitudinal axis. A prosthetic valve has at least two prosthetic valve leaflets that are coaptable to permit the unidirectional flow of blood. The prosthetic valve is attached to the valve support member adjacent the second valve member end. At least two coronary openings in the valve member body are located longitudinally adjacent free edges of the at least two prosthetic valve leaflets. At least one of the coronary openings is located so as to be selectively radially aligned with a coronary ostium when the prosthetic valve is located substantially within the native valve annulus.Type: GrantFiled: October 24, 2007Date of Patent: August 10, 2010Assignee: The Cleveland Clinic FoundationInventor: Lars G. Svensson
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Publication number: 20100185274Abstract: A prosthetic implant for treating a diseased aortic valve is described. The prosthetic implant includes a substantially tubular body configured to be positioned in an aorta of a patient, at or near the patient's aortic valve. The body includes a lumen extending through the body from a proximal end to a distal end of the body; and an adjustable frame surrounding the lumen. The prosthetic implant further includes at least one adjustable element located in or on the body and extending at least partially around a circumference of the lumen. The at least one adjustable element includes a shape memory material and is transformable, in response to application of an activation energy, from a first configuration to a second configuration, wherein the first configuration and second configuration differ in a size of at least one dimension of the at least one adjustable element.Type: ApplicationFiled: August 19, 2009Publication date: July 22, 2010Applicant: Micardia CorporationInventors: Shawn Moaddeb, Samuel Shaolian, Emanuel Shaoulian, Jay A. Lenker
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Patent number: 7758632Abstract: The present invention relates to a medical device, and in particular, to a stent-based valve. The valve includes a radially expandable structural frame comprising a proximal and distal anchors formed from a lattice of interconnected elements, and having a substantially cylindrical configuration with first and second open ends and a longitudinal axis extending there between. One or more cantilevered valve struts are attached directly or indirectly to the proximal anchor. The stent based valve also comprises one or more connecting members attached between the proximal and distal anchors. A biocompatible valve assembly is coaxially disposed and attached to the proximal anchor and extends in the longitudinal direction along the one or more connecting members.Type: GrantFiled: May 9, 2003Date of Patent: July 20, 2010Assignee: Cordis CorporationInventors: Hikmat Hojeibane, David Christopher Majercak
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Patent number: 7753925Abstract: An occlusive device includes a hollow cylindrical element which can be twisted axially in order to create a constricted region. The device also includes a body which can be deformed by transverse compression and which is applied against the inner wall of the aforementioned cylindrical element, the body having a through hole along the axis of the cylindrical element.Type: GrantFiled: October 15, 2003Date of Patent: July 13, 2010Inventor: Claude Mialhe
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Patent number: 7744642Abstract: A prosthetic venous valve includes a frame and leaflets. The frame includes: (i) a generally hollow base disposed at a blood inflow end; (ii) a plurality of struts connected with the base and extending generally parallel to a direction of forward flow of blood from the generally hollow base to a blood outflow end; and (iii) inwardly oriented flanges disposed at the blood outflow ends of the struts. The leaflets are disposed in gaps between the struts and are supported by the frame. The leaflets are arranged to close into the vein lumen to substantially seal against backflow of blood from the blood outflow end to the blood inflow end. The inwardly oriented flanges of the struts enhance the sealing.Type: GrantFiled: November 18, 2005Date of Patent: June 29, 2010Assignees: Biomedical Research Associates, Inc., The University of AkronInventors: Stanley E. Rittgers, M. Michelle Evancho-Chapman, Matthew T. Oberdier, Steven P. Schmidt, Stephanie T. Lopina
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Patent number: 7740655Abstract: A pulmonary valve replacement system having a vascular conduit and a prosthetic valve device including a valve operably connected to a support structure. The prosthetic valve device is positioned within the vascular conduit. A conduit support includes a substantially circular cross-section. The conduit support is positioned adjacent to and reinforces the vascular conduit. In one embodiment, the pulmonary valve replacement system includes a catheter and an inflatable member operably attached to the catheter. The prosthetic valve device is disposed on the inflatable member. The invention provides a method for replacing a pulmonary valve including providing a vascular conduit positioned at a treatment site. The vascular conduit includes a conduit support positioned adjacent the vascular conduit. A prosthetic valve device is deployed within the vascular conduit via catheter. The prosthetic valve device includes a valve operably connected to a support structure.Type: GrantFiled: April 6, 2006Date of Patent: June 22, 2010Assignee: Medtronic Vascular, Inc.Inventor: Matthew J. Birdsall
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Publication number: 20100152839Abstract: A prosthetic medical device is formed by the combination of a biological tissue a shape memory polymer structure. The biological tissue provides an in-situ physiological function of the device. The shape memory polymer provides a capability for minimizing the device profile during insertion and then deploying after placement into a memory shape that achieves suitable mechanical structure and stability within an anatomical lumen or cavity. This configuration may be applied to form various prosthetic devices including aortic, mitral, and tricuspid valves in the heart; venous valves; anti-reflux valves for the lower esophageal sphincter; and other biological valve structures. Alternatively, an entirely non-biologic implementation using only shape memory polymer-based structures may be used as a prosthetic valve device.Type: ApplicationFiled: October 29, 2009Publication date: June 17, 2010Applicant: The Regents of the University of Colorado, a body corporateInventors: Robin Shandas, Avery Nelson, Bryan Rech, Devatha P. Nair, Michael B. Lyons, Jeffrey Paul Castleberry, Timothy Francis Scott
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Publication number: 20100152838Abstract: An implantable valvular prosthesis is adapted for replacement of an anatomic valve that controls passage of blood flowing from an atrium to a ventricle in a patient's heart. The implantable valvular prosthesis includes a tubular stent body, at least one valve flap member, and a graft member. The tubular stent body includes a tubular trailing region and a tubular leading region. The valve flap member is disposed to associate with the tubular stent body. The graft member covers an abluminal surface of the tubular stent body.Type: ApplicationFiled: December 15, 2008Publication date: June 17, 2010Inventors: Wei-Chang Kang, Yu-Li Kang
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Patent number: 7736327Abstract: Disclosed is a conduit that provides a bypass around an occlusion or stenosis in a coronary artery. The conduit is a tube adapted to be positioned in the heart wall to provide a passage for blood to flow between a heart chamber and a coronary artery, at a site distal to the occlusion or stenosis. The conduit has a section of blood vessel attached to its interior lumen which preferably includes at least one naturally occurring one-way valve positioned therein. The valve prevents the backflow of blood from the coronary artery into the heart chamber.Type: GrantFiled: May 9, 2008Date of Patent: June 15, 2010Assignee: JenaValve Technology, Inc.Inventors: Peter J. Wilk, David Y. Phelps, Scott J. Wolf
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Publication number: 20100145435Abstract: An implantable PROSTHESIS with formed power couch+, including a primary tube as an half finished product in a form of an additional support stent, the additional support stem forms a circular structure upon its expansion that allows to reduce the total mass of the implantable valve device upon keeping of its high dynamics stability and to establish axis-symmetrical shape similar to hyperboloid. The leaflets of a valve device functional part are provided a system of a low-profile guiding spiral relief, under which blood flow imposes additionally a component of a spiral movement.Type: ApplicationFiled: February 21, 2008Publication date: June 10, 2010Inventors: Valerian Voinov, Romul Boldyrev, Valentin Voinov
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Publication number: 20100131049Abstract: A one-way valve prosthesis for percutaneous placement within a vein, the valve including a valve body having an inlet and an outlet with a lumen that extends there between. The valve body is operable to alternate between a closed configuration wherein the valve body has a double cone shape and an open configuration wherein the valve body has a double frustoconical shape. A valve seat if formed within the lumen of the valve body at a midsection thereof. The valve seat is constricted to prevent flow there through when the valve body is in the closed configuration and the valve seat is open to allow flow there through when the valve body is in the open configuration. The valve seat opens in response to an actuation pressure and closes in the absence of the actuation pressure.Type: ApplicationFiled: November 24, 2008Publication date: May 27, 2010Applicant: Medtronic Vascular, Inc.Inventors: D.H. Perkins, Dustin Thompson
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Patent number: 7717952Abstract: Implantable medical devices, such as intraluminally implantable stents and valves, are provided having certain preferred shapes. Preferably, a portion of the implantable medical device can define a sinus region having a preferred geometry. The sinus region can have one or more preferred geometric configurations described herein, for example to mitigate or prevent thrombosis within a body vessel. The medical device can include a valve means, such as one or more valve leaflets positioned within the sinus region. The implantable medical devices can be delivered from a catheter within a body vessel, and are preferably expandable from a compressed configuration to a radially expanded configuration. The implantable frames can be self-expanding or balloon expandable. Portions of the medical device, such as the implantable frame or a valve leaflet, are optionally coated with one or more bioactive materials.Type: GrantFiled: October 25, 2006Date of Patent: May 18, 2010Assignee: Cook IncorporatedInventors: Brian C. Case, Ram H. Paul, Jr., Grant T. Hoffman
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Publication number: 20100121431Abstract: An elongate hollow body (1) comprising crystalline cellulose has on an inside wall a plurality of protuberances (3, 4) which extend into a lumen of the hollow body (1). A process for the production of an elongate hollow body (1) comprising crystalline cellulose comprises the steps: preparation of a hollow mould (12); cultivation of cellulose-forming organisms in an interior space formed by the hollow mould (12), in order to allow the hollow body (1) to grow in the interior space; demoulding of the hollow mould (12). In the step of demoulding the hollow mould (12), at least part of the hollow mould (12) is irreversibly deformed.Type: ApplicationFiled: February 12, 2008Publication date: May 13, 2010Applicant: Bioregeneration GmbHInventor: Günter Bertholdt
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Publication number: 20100121423Abstract: The invention relates to a stent that comprises a single sinus section and is preferably provided at the proximal end thereof with a native vessel valve (26). The stent comprises a first and a second hollow-cylindrical section (10, 11) having a first and a second diameter each, and a third section (12) disposed therebetween having a third maximum diameter. The third maximum diameter is greater than the first and second diameters and forms the sinus section. The stent according to the invention with the single sinus has an increased functionality. Particularly when used with a graft with a sinus and vessel valve, the functionality of the stent is secured and the wear is diminished. The stent is particularly suitable for native valves and particularly as a pulmonary valve replacement.Type: ApplicationFiled: March 6, 2008Publication date: May 13, 2010Applicants: CARAG AG, Universität ZürichInventors: Jérôme Bernhard, Rolf Jenni
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Publication number: 20100114300Abstract: Medical devices that provide valves for regulating fluid flow through a body vessel are provided. The valves include a support frame having one or more adaptations for forming a leak path between the support frame and an interior wall of a body vessel in which the valve is implanted. A controlled amount of retrograde flow is able to flow through the leak path when the valve is implanted in a body vessel.Type: ApplicationFiled: January 15, 2010Publication date: May 6, 2010Applicant: COOK INCORPORATEDInventors: Brian C. Case, Charles W. Agnew
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Publication number: 20100114299Abstract: A flow reducing implant for reducing blood flow in a blood vessel having a cross sectional dimension, the flow reducing implant comprising a hollow element adapted for placement in the blood vessel defining a flow passage therethrough, said flow passage comprising at least two sections, one with a larger diameter and one with a smaller diameter, wherein said smaller diameter is smaller than a cross section of the blood vessel. A plurality of tabs anchor, generally parallel to the blood vessel wall, are provided in some embodiments of the invention.Type: ApplicationFiled: October 21, 2009Publication date: May 6, 2010Applicant: NEOVASC MEDICAL LTD.Inventors: Shmuel Ben Muvhar, Ilan Shalev, Jonathan Tsehori, Nissim Darvish
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Patent number: 7704222Abstract: Disclosed is a conduit that provides a bypass around an occlusion or stenosis in a coronary artery. The conduit is a tube adapted to be positioned in the heart wall to provide a passage for blood to flow between a heart chamber and a coronary artery, at a site distal to the occlusion or stenosis. The conduit has a section of blood vessel attached to its interior lumen which preferably includes at least one naturally occurring one-way valve positioned therein. The valve prevents the backflow of blood from the coronary artery into the heart chamber.Type: GrantFiled: August 30, 2004Date of Patent: April 27, 2010Assignee: JenaValve Technology, Inc.Inventors: Peter J. Wilk, David Y. Phelps, Scott J. Wolf
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Publication number: 20100087907Abstract: An endovascular stent and an aortic valve replacement can be used to treat the aorta. An endovascular stent suitable for treating the ascending aorta includes a circumferential wall with one or more portions configured to allow blood to flow therethrough, and one or more portions configured to be substantially impermeable. In one version, the blood-permeable portion is defined by bare metal with fenestrations defined therein, and the impermeable portion is formed from polymeric material. The permeable and impermeable portions of the stent are sized, shaped, and located so that, when positioned in the blood vessel to be treated, the impermeable portion is in operative proximity to an aneurysm, dissection, or other area to be treated, and the permeable, bare metal portion is in operative proximity to other blood vessels which need to receive blood from the blood vessel being treated. An aortic valve replacement includes multiple flanges that can be seated in the sinuses of valsalva.Type: ApplicationFiled: February 15, 2008Publication date: April 8, 2010Applicant: EMORY UNIVERSITYInventor: Omar Lattouf
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Patent number: 7686844Abstract: Prosthetic valves for implantation in a body vessel are provided. Prosthetic valves according to the invention comprise first and second frame members and a graft member at least partially disposed between the first and second frame members. The graft member forms a valve that permits fluid flow through the body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction.Type: GrantFiled: July 30, 2004Date of Patent: March 30, 2010Assignee: Cook IncorporatedInventors: Brian C. Case, Thomas A. Osborne, Jacob A. Flagle, Fred T. Parker
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Patent number: 7682648Abstract: A method is provided for forming a polymeric coating on a stent. The method can comprise applying a prepolymer or a combination of prepolymers to the stent and initiating polymerization to form a polymeric coating on the stent. The coating material can optionally contain a biologically active agent or combination of agents.Type: GrantFiled: November 3, 2003Date of Patent: March 23, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Ni Ding, Deborra Sanders Millare, Syed F. A. Hossainy
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Patent number: 7682385Abstract: Method and apparatus implementing and using techniques for controlling flow in a body lumen, including use of an implantable medical device. The device includes a membrane implantable in a body lumen and invertibly deformable between a first position and a second position. The membrane is invertible in response to the direction of fluid flow through the lumen and can be deformable by fluid flow in the body lumen.Type: GrantFiled: July 3, 2006Date of Patent: March 23, 2010Assignee: Boston Scientific CorporationInventor: Sally C. Thornton
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Patent number: 7678144Abstract: The invention relates to a prosthetic valve for regulating fluid flow through a body lumen. The valve includes a frame and a valve member comprising at least one semi-rigid leaflet and at least one flexible leaflet. The at least one semi-rigid leaflet comprises a first portion and a second portion, the first portion attached to the frame and the second portion free of the frame. The at least one semi-rigid leaflet is slanted in a retrograde direction from the second portion to the first portion. The at least one flexible leaflet comprises a first portion and a second portion, the first portion attached to the frame and the second portion free of the frame. The at least one flexible leaflet is slanted in a retrograde direction from the first portion to the second portion when at rest.Type: GrantFiled: January 25, 2008Date of Patent: March 16, 2010Assignee: Cook IncorporatedInventors: Frances Kristen Bailey, Brian C. Case, Ram H. Paul, Jr.
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Publication number: 20100063577Abstract: Methods of implanting a prosthetic valve in a body vessel are provided. A first expandable frame member is delivered to and deployed at a point of treatment in a body vessel. A second expandable frame member is delivered to the point of treatment. The second expandable frame member has an attached graft member that forms a valve adapted to permit fluid flow through the body vessel in a first direction and to substantially prevent fluid flow through the body vessel in a second, opposite direction. After deployment of the first expandable frame member, the second expandable frame member is deployed at the point of treatment such that the second frame member is positioned radially inward of the first frame member within said body vessel to form a prosthetic valve.Type: ApplicationFiled: November 18, 2009Publication date: March 11, 2010Applicant: COOK INCORPORATEDInventors: Brian C. Case, Thomas A. Osborne, Jacob A. Flagle, Fred T. Parker
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Publication number: 20100057194Abstract: A prosthetic heart or venous valve, the valve including a central tissue structure with multiple tissue lobes extending from a common central area, wherein each of the lobes includes a longitudinal slot. The valve further includes a plurality of leaflets, each extending from the central tissue structure and positioned between two adjacent lobes, wherein each of the leaflets has a free end spaced from the central tissue structure, and also has a compressible and expandable stent frame with a plurality of extending arms, wherein each of the extending arms of the stent frame is positioned at least partially within one of the longitudinal slots of the central tissue structure.Type: ApplicationFiled: November 13, 2009Publication date: March 4, 2010Inventor: Timothy R. Ryan