Abstract: An intraluminal vascular prosthesis assembly, having a hollow cylindrical body with a first end and a second end is provided. The assembly includes, at its first end, a first vascular prosthesis portion, and at its second end, a second vascular prosthesis portion which has only a prosthesis material. The vascular prosthesis assembly has a stent portion which is provided between the first vascular prosthesis portion and the second vascular prosthesis portion, the stent portion being free of prosthesis material to allow fluid flow there through and received within the aortic arch and spanning the brachiocephalic artery, left common carotid artery, and left subclavian artery when placed within the aortic arch of a patient.

Abstract: An aortic prosthesis for the treatment of abdominal aortic aneurysms, wherein the prosthesis is implanted intraluminally and comprises a main body having a generally cylindrical shape with an upper portion intended to be secured firmly above the renal arteries through an anchoring means, a lower portion freely moving at a position within the aneurysm and above the iliac arteries, and an intermediate portion arranged between the upper and lower portions, and the main body comprising a flexible fabric of woven material having a very loose weave in the upper portion so as to allow fluid communication between the interior of the prosthesis and the renal arteries, an intermediate weave in the intermediate portion and a tight weave in the lower portion of the main body.

Abstract: Some of strands of a stent are disposed using a strand made of a platinum alloy material. In the stent (10) formed by helicoidally braiding a plurality of strands, some even-numbered strands among the plurality of strands are disposed using a platinum alloy material.

Abstract: The present application discloses a covered stent and a method for navigating the covered stent to a branch vessel, the covered stent comprising a main body and at least one lateral side branch connected to the main body, wherein the lateral side branch is flexible and expandable. A system of covered stents and a method for interconnecting the covered stents is also disclosed.

Abstract: A nonmodular endograft system for treating aortic aneurysms involving bilateral renal arteries can include a main fabric cover that is sealed, coupled, or integral, with first and second branch fabric covers. The system can be configured so that after the main cover is expanded in the aorta, and after the two branch covers are respectively expanded in the renal arteries such that (i) the first cover ostium is substantially aligned with the first renal ostium, and (ii) the second cover ostium is not substantially aligned with the second renal ostium, then aortic blood flows from the main cover into each of the branch covers.

Abstract: A branched graft method includes securing a first end of a branch graft into a first conduit and subsequently moving the second end into a second conduit. The first conduit may be a branch vessel, such as a renal artery and the second conduit may be a main graft that extends over an aortic aneurysm. The branch graft may be deployed starting at an offset distance from the first end, thereby preventing the deployed portion from insertion into the first conduit and predetermining the insertion length into the target vessel. The first end may then be deployed to secure the first end to the first conduit. A branch graft may be a self-expanding stent graft having one or more ripcords, and/or a serpentine ripcord that enables non-linear deployment of the branch graft, or deployment that does not progress from one end to the opposing end.

Abstract: A primary stent-graft is deployed into a primary vessel to exclude an aneurysm. To maintain perfusion to a branch vessel covered by the primary stent-graft, a gutter filling stent-graft is deployed in parallel to the primary stent-graft. The gutter filling stent-graft includes a balloon that is pressurized and inflated by the patient's own blood thereby sealing any gutters formed around the gutter filling stent-graft. By sealing the gutters, the chance of type I endoleaks, migrations, and overall failure to exclude the aneurysm is minimized.

Abstract: An occlusive device for occluding a target area can include an elongate member having opposing first and second side edges extending longitudinally along the member and a member width. The member can have a collapsed configuration in which the first and second side edges are curled toward each other about a longitudinal axis of the member. Further the member can have an expanded configuration in which the member form a series of loops and the first and second side edges uncurl to be spaced apart from each other.

Abstract: A system for treating a bifurcated vessel that includes a first delivery catheter and a second delivery catheter. The first delivery catheter carries a proximal first stent and a distal second stent. The first delivery catheter also has a first elongate shaft, a proximal first expandable member with the proximal first stent disposed thereover, and a distal second expandable member with the distal second stent disposed thereover. The proximal first expandable member and distal second expandable member are independently expandable of one another. The second delivery catheter carries a third stent. The second delivery catheter also has a second elongate shaft, and a third expandable member with the third stent disposed thereover. The third expandable member is independently expandable of the proximal first expandable member and the distal second expandable member.

Abstract: A thoraco-abdominal branch graft prosthesis includes a lumen main graft component that defines a lumen and at least one main graft wall fenestration. At least one tunnel graft component of the branch graft prosthesis defines at least one tunnel graft fenestration. The tunnel graft component is within the main graft lumen defined by the luminal main graft component. A luminal wall of the tunnel graft component is fixed to the luminal wall of the main graft component. The fenestration of the tunnel graft wall is aligned with the fenestration of the main graft wall. The thoraco-abdominal branch graft prosthesis can be implanted in a patient at a site of a thoraco-abdominal aneurysm.

Abstract: Vaso-occlusive apparatuses, including implants, and methods of using them to treat aneurysms. For example, described herein are expandable vaso-occlusive implants that include one or more soft and expandable braided member coupled to a pushable member such as a coil that maybe inserted and retrieved from within an aneurism using a delivery catheter. In particular, the expandable implants described herein are configured to allow relatively soft and elongate implants to be pushed out of a cannula without binding up within the cannula.

Abstract: A segmented endograft includes at least one positioning segment and at least one main body segment which are separately deployable. The at least one positioning segment and at least one main body segment may be connected one to another. For example, the at least one positioning segment and at least one main body segment may be connected along a portion of a circumference thereof, but unconnected along a remainder of the circumference thereof. The at least one positioning segment overlaps a portion of the at least one main body segment. Deployment systems may include the segmented endograft and the segmented endograft may be deployed according to various methods.

Abstract: Several gastrointestinal surgery procedures are effective as treatments for metabolic disorders such as obesity and diabetes. Minimally invasive procedures including intra-luminal gastrointestinal implants have been proposed to mimic the anatomical, physiological and metabolic changes achieved by these procedures. Many of these designs include long sleeve like elements that prevent contact of food with the walls of the small intestine. It is desirable to have simple delivery systems that can place these implants under endoscopic guidance. However, in order to anchor these sleeve elements safely and reliably, the inventors have previously disclosed anchoring means that anchor the sleeves at the junctions of the stomach and the intestine or the stomach and esophagus.

Abstract: A medical device can include an elongate manipulation member, and a thrombectomy device connected to the elongate manipulation member. The thrombectomy device can have a first configuration and a second configuration, the thrombectomy device being expandable from the first configuration to the second configuration. The thrombectomy device can include an arcuate marker-mounting projection attached to a portion of the thrombectomy device configured to contact a thrombus. A marker can be coupled to, and extending around, the arcuate marker-mounting projection with the marker and the arcuate marker-mounting projection contacting each other at three discrete locations. A method for engaging a thrombus can include advancing a thrombectomy device to a location radially adjacent to a thrombus in a blood vessel.

Abstract: Y-stents and delivery apparatus for delivering the Y-stents include a delivery catheter with an open distal end having two, circumferentially opposed extensions separated by two receiving portions which receive an anatomical junction.

Abstract: A branched stent graft, a convey system comprising thereof and manufacturing method thereof, the branched stent graft includes a main body (100) and a side branch (200), at least a portion of a lowermost stent section of the side branch (200) closest to the main body (100) is not stitched to the cover of the side branch from a lower end to an upper end, the at least a portion of the lowermost stent section is located on a side of the side branch corresponding to a folding direction of the side branch. After deployed, the branched stent graft has an effective supporting force at the base portion of the side branch. In addition, during the deployment of the stent, the side branch can expand to a maximal extent even when the positioning is slightly inaccurate. Further, vascular stenosis or occlusion will not be caused even when subsequent endothelialization occurs.

Abstract: A prosthetic assembly for repairing a target tissue defect within a target vessel region configured includes an exclusion structure sized to substantially bypass target tissue defect, and includes a branch assembly. The branch assembly can include a self-expanding outer branch prosthesis having an inflow region configured to deform to a non-circular cross-sectional-shape when deployed, and a support structure at least partially disposed within the inflow region. The support structure preserves blood flow to the branch vessel while the deformed inflow region inhibits blood leakage between and/or around the prosthetic assembly.

Abstract: Disclosed is a medical device for shaping a vessel accommodated therein in a predetermined form, wherein said vessel includes a vein and an artery which are connected at a artifactual vascular junction thereof. The device includes an external vascular support (100) having at least one vascular support wall for accommodating an exterior vessel wall of a vessel therein when implanted. The support includes an arterial portion (1304) for apposition with said artery when accommodated therein, and/or a venous portion (1302) for apposition with said vein when accommodated therein. The venous portion (1302) and/or said arterial portion (1304) are shaped at a junction thereof to provide a vessel rounding to at least a portion of said vessel junction when in apposition with the latter upon implantation of said device for said vessel shaping. Corresponding methods are also disclosed. Thus dysfunction or failure of a vessel of the artifactual vascular junction may be reduced, minimized, or eliminated.

Abstract: An endoluminal prosthesis system may include a main graft and an extension graft. The main graft may include a tubular main body having a sidewall, open proximal and distal ends, a lumen, and a fenestration in the sidewall. The extension graft may include a tubular extension body, and tubular first and second extension legs. Each of the first and second extension legs may extend from the extension body and include a lumen in fluid communication with the extension body lumen. The extension graft may be deployable within the main graft such that the extension body extends through the fenestration in the sidewall of the main body. Each of the first and second extension legs may extend outward away from the main graft. An auxiliary guide such as an auxiliary cannula and/or auxiliary guide wire may be preloaded in the extension graft and extend through the lumen of each of the second extension leg and the extension body.

Abstract: An iliac branch device includes an iliac septum limb configured to be deployed in the common iliac artery. The iliac septum limb includes a graft material, a proximal end, and a septum. The graft material defines a common iliac lumen extending between the proximal end and the septum, the graft material and the septum defining an internal iliac lumen and an external iliac lumen. The iliac branch device including the iliac septum limb has several modes of adjustability. In addition, the iliac branch device has a relatively small cross-sectional area allowing the iliac branch device to treat relatively small iliac aneurysms in short common iliac arteries. This allows the iliac aneurysms to be treated at very early stages of the disease.

Abstract: Example stent grafts and methods for placement thereof are provided. An example stent graft may include (a) a main body stent graft defining a lumen that has a first end and a second end, (b) a diaphragm coupled to the main body stent graft, where the diaphragm defines at least three openings and (c) at least three stent graft extensions each defining a lumen, where a first end of each of the three stent graft extensions is coupled to one of the three openings.

Abstract: A prosthesis comprising a graft having a tubular body with a wall defining an external surface of the graft and a pouch. The graft further comprises a strip with at least one fenestration, wherein the strip is at least partially contained within the pouch. A window may be formed within the wall, wherein the fenestration is at least partially aligned with the window, thereby forming a channel through the fenestration and the window.

Abstract: The present embodiments provide a stent for use in a medical procedure that comprises a series of proximal apices disposed at a proximal end of the stent and a series of distal apices disposed at a distal end of the stent. In a first embodiment, a first proximal apex comprises a bore for receiving a trigger wire, and a second proximal apex, disposed adjacent to the first proximal apex, comprises at least one barb. In an alternative embodiment, a first proximal apex comprises a first bore and a second, adjacent proximal apex comprises a second bore, such that a single trigger wire may be disposed through the first and second bores to restrain the first and second proximal apices during delivery.

Abstract: Described herein are flexible implantable occluding devices that can, for example, navigate the tortuous vessels of the neurovasculature. The occluding devices can also conform to the shape of the tortuous vessels of the vasculature. In some embodiments, the occluding devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. Some embodiments describe methods and apparatus for adjusting, along a length of the device, the porosity of the occluding device. In some embodiments, the occluding devices allows adequate blood flow to be provided to adjacent structures such that those structures, whether they are branch vessels or oxygen-demanding tissues, are not deprived of the necessary blood flow.

Abstract: A multimodal fiducial marker for registration of multimodal data, including a first portion comprising magnetic material visible in magnetic particle imaging (MPI) data obtained by a magnetic particle imaging method and a second portion comprising a second material visible in image data obtained by another imaging method, which image data is registrable with the MPI data and a corresponding marker arrangement.

Abstract: Systems and methods for treating diseased bodily lumens involving branched lumen deployment sites include a main graft or stent-graft deployable in a main artery and a vent device or stent-graft deployable in a branch artery to maintain blood flow through the main artery and from the main artery to the branch artery. Systems and methods for treating diseased bodily lumens involving branched lumen deployment sites may also include a main graft or stent-graft deployable in the main artery, a chimney graft or stent-graft deployable in both branch artery and the main artery to the branch artery and a gutter-sealing device associated with the chimney graft to prevent flow of blood among the chimney graft, the main graft and a wall of the main artery.

Abstract: A stent graft has a tubular body with a first bifurcation with first and second legs extending from the bifurcation. One of the legs has a further bifurcation to define a side arm. The stent graft can be deployed into the vasculature of a patient with the tubular body being in an aorta of the patient, a first leg extending down an iliac artery, a second leg being directed towards a contralateral iliac artery and the side arm directed to an internal artery of one of the iliac arteries. One of the legs can include a valved aperture to enable the placement of an indwelling catheter therethrough.

Abstract: A prosthesis is disclosed for placement across an ostium opening from a main body lumen to a branch body lumen. The prosthesis comprises a radially expansible support, at least two axially elongate longitudinal members, at least one of which can be fronds, extending from an end of the support, and a circumferential member connected to at least one axially elongate longitudinal member and unconnected to at least one other axially elongate longitudinal member.

Abstract: Medical devices and methods for forming an arteriovenous (AV) fistula include a stent having an arterial tubular portion and vein supporting tongue connected by a pre-shaped connector and a venous frustoconical stent having a distal end for maintaining a take-off angle for the venous portion of the AV fistula. Also disclosed is an angled balloon for assisting with the formation of the AV fistula. The medical devices disclosed herein support an AV fistula formation having a desired take off angle of about 30 degrees, or between about 15 and 45 degrees.

Abstract: A vascular prosthesis is disclosed, comprising a forked tube, having: an inflow tube with an inflow end; a primary distal outflow branch with a primary distal outflow end; and a secondary proximal outflow branch with a secondary proximal outflow end. The two outflow ends are directed in different directions and the two outflow branches in the vicinity of the bifurcation have different cross-sectional areas. Further, the secondary proximal outflow branch is more curved than the primary distal outflow branch, and the secondary proximal outflow branch in the vicinity of the bifurcation has a smaller cross-sectional area than the primary distal outflow branch. Hereby, energy losses at flow bifurcations is adapted to the bypass situation to even out the level of shear stress, thereby avoiding areas with low shear stress and decreasing the tendency for turbulent flow, thus reducing the risk of graftstenosis.

Abstract: A stent assembly (42) adapted for endoluminal placement by endovascular deployment for the treatment of a false lumen (10) associated with a vascular dissection. The stent assembly has a number of self expanding stents (35) connected together to define an elongate substantially cylindrical lumen wall engaging surface. The stents are adapted to provided pressure on the wall of the lumen adjacent to and extending away from a rupture. A deployment device (40) for the stent assembly includes a sheath (48) and a retention and release arrangement (50) to retain the proximal end (37) of the stent graft to the deployment device. Release of the stent assembly is by withdrawal of the sheath before release of its proximal end by the use of a trigger wire (54) of the retention and release arrangement.

Abstract: A radially compliant pressure indicating stent graft is radially compliant from a free stent graft diameter to an expanded stent graft diameter. A radially compliant slant is attached to a graft having stored circumferential length between attachment points. A slant may be expanded and affixed to the graft or the graft may be constricted radially and the stent attached to the constricted graft. The radially compliant stent graft may expand radially to a free graft diameter and the graft may be non-elastic and/or no compliant. As the stent graft approaches the free graft diameter, the force to expand further may increase rapidly.

Abstract: A stent graft (1) including a tubular wall (3) with at least one fenestration (40) including a peripheral (37) reinforcement around at least part of the fenestration. There can also be a tubular extension (15). The side arm includes a stent (19) and a cover (17) and extends from and is in fluid communication with the fenestration and the stent graft. The stent may be a self expanding stent. The ring and/or tubular extension provides better support and sealing for an extension arm. The fenestration (40) can be circular or if towards the ends of the stent graft may be in the form of a U-shape (50) with an open end.

Abstract: A stent graft comprising an elongate main tubular body of a biocompatible graft material is disclosed. The main tubular body comprises a main lumen, a distal end and a proximal end; and an elongate tubular bridge of a biocompatible graft material. The elongate tubular bridge extends around a portion of the main tubular body so as to form a bridging lumen bridging between two circumferentially spaced-apart openings within the main tubular body. The tubular bridge has at least two fenestrations. The tubular bridge comprises concertinaed graft material.

Abstract: A bifurcated graft including a first branch having a first leg graft; a second branch having a second leg graft spaced apart from and not overlapping the first leg graft; and a trunk including a first layer having a first portion, a second portion, and a saddle extending therebetween the first portion and the second portion. Each of the first portion and second portion have opposite side edges that are spaced apart to define a first width. The saddle has opposite sides that are spaced apart to define a second width. The second width of the saddle is less than the first width of each of the first portion and second portion. The saddle extends along a bifurcation between the first leg graft and second leg graft.

Abstract: Methods for accessing the common and internal iliac arteries and delivering and deploying an endovascular graft therein are disclosed. A system including a pre-loaded delivery and deployment device with an extension sheath is described which enables such a method to be practiced is also disclosed.

Abstract: An iliac artery stent graft has a substantially inverted Y shape comprising a second arm terminating in a second end, and first and third arms terminating respectively in a first end and a third end. Each of the arms comprising a tubular graft of biocompatible graft material and the three arms joined being at a junction to allow fluid flow from the second arm into the first and third arms. In use the first end is deployed within the common iliac artery extending towards the external iliac artery, the second end is deployed within the common iliac artery extending towards the iliac bifurcation and the third end is within the common iliac artery and extends towards the internal iliac artery. Each of the three arms are mutually at an angle of approximately 120 degrees to each other. In use the first and second legs form a U shape to allow a deployment device to be smoothly deployed.

Abstract: The present invention provides an electrical block implant sized and shaped for securement at the perimeter of the pulmonary ostium of the left atrium. By utilizing various expandable ring designs and optional anchoring mechanisms, the present invention causes even, circular scarring around the perimeter of the pulmonary ostium, achieving reliable blocking of aberrant electrical signals responsible for atrial fibrillation.

Abstract: A debranching Great vessel stent graft and methods for its use, where the stent graft comprises, a main body stent graft with a first bifurcation defining a first leg and a second leg, the main body stent graft has distal and proximal ends, the main body stent graft has a diameter at the proximal end in the range from about 18 mm to about 28 mm, the first leg and the second leg each have a diameter in the range from about 12 mm to about 18 mm, the distance from the proximal end of the main body to the distal end of the first leg is in the range from about 30 mm to about 50 mm, and the distance from the proximal end of the main body to the distal end of the second leg is in a range from about 50 mm to about 70 mm.

Abstract: According to one aspect, the present invention provides a substantially two-dimensional surgical mesh comprising a base material, a first area having a first characteristic and a second area having a second characteristic that differs from the first characteristic. The surgical mesh may further comprise a third area having a third characteristic that may be the same as or different from the first and second characteristics, and so on.

Abstract: A stent graft leg extension (10) to extend from a bifurcated aortic stent graft into an iliac artery. The stent graft has a tubular body. (12) of a biocompatible graft material and a plurality of self-expanding stents (14) joined to and supporting the tubular body. An uncovered tubular self-expanding stent assembly (26) extends from a first end of the tubular body and is fastened thereto. The uncovered tubular self-expanding stent assembly (26) provides a smooth transition from the leg extension into the iliac artery to reduce the chance of kinks causing problems in the leg extension.

Abstract: The present embodiments provide systems and methods for loading a stent or stent graft onto an introducer for intraluminal deployment. In one example, a system includes an endoluminal prosthesis introducer comprising a stent retaining member engageable with a stent end. The system may also include a loading tool for engaging the stent end on the stent retaining member. The loading tool may include a loading body having a passage extending from a first end to a second end and a slot that extends through the tubular loading body from the passage to an outer surface of the tubular loading body, and the slot may further extend from the second end toward the first end. The stent retaining member may be disposed at least partially within the passage of the loading body, and the slot of the loading body may be rotatable around the stent retaining member.

Abstract: An endoluminal prosthesis system includes a tubular graft having a pocket on the exterior of the graft. The graft further includes a wire extending within a lumen of the graft, with the wire extending through the passageway and into the pocket. An extension prosthesis can be inserted over the wire and into engagement with the pocket and the passageway, where the extension prosthesis can be sealed with the pocket and the passageway to seal the otherwise unused passageway in the graft.

Abstract: Exemplary embodiments of the present invention comprise a stent graft having a first section and a second section, wherein the first section comprises a first longitudinal profile and a first flow lumen and the second section comprises a second longitudinal profile and a second flow lumen. In exemplary embodiments, a hinged connection between the first and second sections is structurally and/or materially configured to isolate or otherwise not transfer bending forces between the first and second sections.

Abstract: Stents and method of inserting a stent into a delivery catheter are disclosed. In a disclosed embodiment, a stent for redirecting blood flow away from an aneurysmal sac is provided. The stent comprises an elongate frame (2) that is radially contractable from a fully radially expanded state to a radially contracted state in a process involving elongation of the frame, wherein: the fully radially expanded state represents the state of the frame at body temperature when no external force is applied to the frame; in the radially contracted state the frame has a maximum lateral dimension that is at least 30% smaller than the maximum lateral dimension of the frame in the fully radially expanded state; and the frame comprises a low porosity region (4) for positioning at the opening to the aneurysmal sac, the low porosity region having a porosity of less than 50% when the frame is in the fully radially expanded state.

Abstract: An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The interventional device has a controlled local areal density of beneficial agent for systemic delivery or delivery to the luminal wall. The local areal density of beneficial agent may be varied along the prosthesis. The interventional device includes overlapping or bifurcated stents having a controlled areal density of beneficial agent.

Abstract: The present disclosure relates to an endoluminal prosthesis, such as a stent graft that includes one or more fenestrations to accommodate endovascular disease, such as an aneurysm in cases where one or more side branches is involved. In one aspect, the prosthesis includes fenestrations that are pivotable to accommodate the dynamic geometry of the aortic branches.

Abstract: A delivery system for an endoluminal device including an introducer, the introducer having a distal end intended to remain outside a patient in use and a proximal end. A stent graft having a first and second end is retained upon the introducer, the stent graft defining a fenestration disposed through a wall of the stent graft between the first and second end. A valve arrangement is disposed within an interior lumen of the stent graft about the fenestration. A retention system including a trigger wire engages and retains the valve arrangement away from the fenestration. The fenestration is in fluid communication with the interior lumen of the stent graft.

Abstract: A valve prosthesis device and methods for deployment is disclose. The device comprises an expandable support stent and a valve assembly comprising a flexible conduit having an inlet end and an outlet, made of pliant material attached to the support beams providing collapsible slack portions of the conduit at the outlet. Flow is allowed to pass through the valve prosthesis device from the inlet to the outlet, but reverse flow is prevented as the collapsible slack portions of the valve assembly collapse inwardly. The device is configured so that retrograde flow will be altered from laminar flow and directed towards the leaflets to effect closing. The device can be deployed in a native heart valve position using a deployment catheter advanced through a body lumen such as a blood vessel, including an aorta.

Abstract: A bioabsorbable, expandable coil bifurcation stent having a first, second, and third segment, in which the second and third segments are extensions of a coiled fiber in the first segment. Also disclosed is a three-segment expandable coil bifurcation stent in which the second and third segments extend from supporting fibers in the first segment. Further disclosed is an expandable bifurcation stent in which supporting fibers in the first segment also support the second and third segments. The three segments are independently adjustable to fit varied geometries.