Material Characteristic Patents (Class 623/23.71)
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Patent number: 12232730Abstract: A method of implanting and securing an implantable flow connector in a body of a patient for providing communication of a first space within the body of the patient with a second space within the body of the patient. The method includes providing a flow connector having a lumen having a first orifice and a second orifice, inserting a retention device into the first space within the body, subsequently inserting the flow connector through an opening in the retention device so the second portion of the flow connector extends into the first space within the body and placing the second space within the body over the retention device.Type: GrantFiled: December 23, 2020Date of Patent: February 25, 2025Assignee: TVA Medical, Inc.Inventors: Michael Paris, Adam Dakin, Todd Polk, Mahesh Krishnamoorthy, Jin Park, Michael Longo, Peter Hinchliffe
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Patent number: 11883565Abstract: Provided is a ureteral stent comprising certain amount of ethylene-vinyl acetate polymer and a certain amount of an additive selected from barium sulfate, bismuth subcarbonate, bismuth oxychloride, a polyolefin elastomer, a thermoplastics elastomer, and a mixture thereof. The provided stent may have multiple layers such as inner layer and outer layer with each layer having different elastic modulus. Also provided is a method of making the aforementioned ureteral stent and a method of using the ureteral stent in treating kidney or bladder related diseases.Type: GrantFiled: March 14, 2018Date of Patent: January 30, 2024Assignee: Gyrus ACMI, Inc.Inventors: Hui Tang, Thomas J. Holman, Judy L Walish
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Patent number: 11298235Abstract: A method for ameliorating joint conditions and diseases and preventing bone hypertrophy can include facilitating cartilage regrowth and preventing bone overgrowth to a damaged bone at a treatment site within a body joint to promote healing. The method can include providing a device having a first section comprising a joint-ward end having an inner surface and an outer surface and fenestrations between the inner and outer surfaces. A second section can include an opposing leading end and a lateral wall extending between the joint-ward end and the leading end. The leading end can be penetrated into the bone to a depth to substantially position: 1) the joint-ward end in a cartilage zone or at a boundary/transition area; and 2) the second section in the bone. Bone overgrowth into the cartilage zone may be prevented within the body joint when the device is positioned at the treatment site.Type: GrantFiled: April 3, 2020Date of Patent: April 12, 2022Assignee: Subchondral Solutions, Inc.Inventor: Derek Dee
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Patent number: 10792129Abstract: The present invention provides, among other things, implants including a biocompatible substrate, wherein the substrate includes a plurality of pores, such as trabecular and/or dodecahedral pores, and wherein said implant is configured as a transcutaneous implant. In some embodiments, provided implants may comprise multiple layers with differing pore densities, geometries, and/or distributions.Type: GrantFiled: February 3, 2016Date of Patent: October 6, 2020Assignee: University of Maine System Board of TrusteesInventors: Kyle J. Spivack, Anne B. Lichtenwalner, James A. Weber, David J. Neivandt, Ian D. Dickey
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Patent number: 10610969Abstract: A fabric cutting system and/or method can include a mandrel having a body and first and second legs, a chuck, the chuck configured to receive either one of the legs or body to rotatingly support the mandrel. The mandrel can be rotated and the fabric mounted on the mandrel can be cut about the leg at a location beyond the end of the other leg. One of the legs can include a leg extension removable from a leg base that when removed allows the other leg to be cut beyond the end of the leg base. The fabric can be cut with a cutting laser, which may be a multi-axis laser, and/or have low power.Type: GrantFiled: August 11, 2017Date of Patent: April 7, 2020Assignee: Atex Technologies Inc.Inventors: Danny Severino, Paul Van Hulle, Timothy Warner
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Patent number: 10161037Abstract: A uniform external field can enhance condensation on a superhydrophobic surface. Jumping droplets on superhydrophobic surfaces accumulate a positive charge which promises the manipulation and control of jumping behavior using external electric fields.Type: GrantFiled: March 19, 2014Date of Patent: December 25, 2018Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Nenad Miljkovic, Daniel John Preston, Ryan Enright, Evelyn N. Wang
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Patent number: 9345486Abstract: A hollow fibrous conduit for promoting regeneration of a severed nerve, comprising a first end for coapting the conduit to a first end of a severed nerve and second end for coapting the conduit to a second end of the severed nerve, the hollow fibrous conduit comprising chitosan-poly(caprolactone) fibers. Methods for making the conduit and methods for using the conduit for nerve regeneration.Type: GrantFiled: March 16, 2009Date of Patent: May 24, 2016Assignee: University of WashingtonInventors: Miqin Zhang, Narayan Bhattarai
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Patent number: 9180028Abstract: The present invention relates generally a manufacturing process which results in a completely hydrogel polymer device that maintains lumen patency which allows for numerous applications. Catheters and stents are particular examples, and their composition, mechanical characteristics, and the significantly unique ability to conduct and allow fluids to pass from one end to the other without physiological rejection, inflammation, or manifestation of complications due to implant or otherwise undesirable outcomes when used for ambulatory and or therapeutic interventions is the purpose of the invention.Type: GrantFiled: September 13, 2011Date of Patent: November 10, 2015Inventor: Scott M. Epstein
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Patent number: 9039963Abstract: A titanium based, ceramic reinforced alloy ingot for use in producing medical implants. An ingot is formed from an alloy having comprising from about 5 to about 35 wt. % niobium, from about 0.5 to about 3.5 wt. % silicon, and from about 61.5 to about 94.5 wt. % of titanium. The alloy has a hexagonal crystal lattice ? phase of from about 20 vol % to about 70 vol %, and a cubic body centered ? crystal lattice phase of from about 30 vol. % to about 80 vol. %. The ingot has an ultimate tensile strength of about 940 MPa or more, and a Young's modulus of about 150 GPa or less. A molten substantially uniform admixture of a niobium, silicon, and titanium alloy is formed, cast into a shape, and cooled into an ingot. The ingot may then be formed into a medical implant and optionally annealed.Type: GrantFiled: October 12, 2012Date of Patent: May 26, 2015Assignee: Pulse Technologies, Inc.Inventors: Andrew E. Fisk, Anatolii Demchyshyn, Mykola Kuzmenko, Sergei Firstov, Leonid Kulak
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Publication number: 20150073564Abstract: Novel bioabsorbable polymeric porous tubes for tissue engineering nerve growth are disclosed. The tubes are made from a bioabsorbable polymeric foam material and have a gradient of pore sizes across the wall thickness of the tubes such that cell growth occurs into the wall of the tubes from the inner surface, while cell growth or entry is not permitted through the outer wall into the tubular wall. The wall is permeable inwardly and outwardly to fluids. A novel method of manufacturing porous nerve tubes is also disclosed.Type: ApplicationFiled: September 10, 2013Publication date: March 12, 2015Applicant: Ethicon, Inc.Inventors: Chandra M. Valmikinathan, Pedro Cruz
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Patent number: 8940357Abstract: A medical device, such as a medical wire, which includes a coating applied to the surface of the medical wire. The coating includes a base layer bonded to the surface of the medical wire and an at least partially transparent low-friction top coat applied to the base layer. The base layer includes heat activated pigments that change color when heated above a color shifting temperature. In one embodiment, the color of the pigment in one area contrasts with the color of the pigment in an adjacent area without otherwise affecting the low-friction surface of the coating. The areas of different color created in locations along the length of the low-friction coated medical wire form markings which, as an example, enable a surgeon to determine the length of the medical wire inserted into a body by observing the markings on the portion of the marked medical wire located exterior to the body.Type: GrantFiled: June 27, 2012Date of Patent: January 27, 2015Assignee: Innovatech LLCInventor: Bruce Nesbitt
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Publication number: 20150012083Abstract: The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.Type: ApplicationFiled: September 24, 2014Publication date: January 8, 2015Inventors: Shannon L.M. Dahl, Laura E. Niklason, Juliana Blum, Justin T. Strader, William E. Tente, Heather L. Prichard, Joseph J. Lundquist
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Patent number: 8920516Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.Type: GrantFiled: January 26, 2010Date of Patent: December 30, 2014Assignees: Cook Biotech Incorporated, Cook Medical Technologies LLCInventors: William A. Cook, Michael C. Hiles, Thomas G. Kozma, Umesh H. Patel
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Patent number: 8920515Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.Type: GrantFiled: October 31, 2007Date of Patent: December 30, 2014Assignees: Cook Biotech Incorporated, Cook Medical Technologies LLCInventors: William A. Cook, Michael C. Hiles, Thomas G. Kozma, Umesh H. Patel
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Patent number: 8840735Abstract: Fatigue damage resistant metal or metal alloy wires have a submicron-scale or nanograin microstructure that demonstrates improved fatigue damage resistance properties, and methods for manufacturing such wires. The present method may be used to form a wire having a nanograin microstructure characterized by a mean grain size that is 500 nm or less, in which the wire demonstrates improved fatigue damage resistance. Wire manufactured in accordance with the present process may show improvement in one or more other material properties, such as ultimate strength, unloading plateau strength, permanent set, ductility, and recoverable strain, for example. Wire manufactured in accordance with the present process is suitable for use in a medical device, or other high end application.Type: GrantFiled: September 18, 2009Date of Patent: September 23, 2014Assignee: Fort Wayne Metals Research Products CorpInventor: Jeremy E. Schaffer
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Patent number: 8834979Abstract: A pouch for forming an implantable artificial organ, including a closed shell provided in a semi-pervious membrane. The pouch further includes a sheet contained within the shell, the sheet including projections on the surface thereof for maintaining a space for cells between the sheet and the shell.Type: GrantFiled: July 6, 2011Date of Patent: September 16, 2014Assignee: Statice SanteInventor: Serge Piranda
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Patent number: 8808392Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.Type: GrantFiled: October 31, 2007Date of Patent: August 19, 2014Assignees: Cook Biotech Incorporated, Cook Medical Technologies LLCInventors: William A. Cook, Michael C. Hiles, Thomas G. Kozma, Umesh H. Patel
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Patent number: 8758374Abstract: The disclosure provides methods for repairing nerves and inhibiting atrophy of a muscle via a side-to side neurorraphy using a bridging element between a first epineurial window on a donor nerve and a second epineurial window on a recipient nerve.Type: GrantFiled: September 15, 2011Date of Patent: June 24, 2014Assignee: University of Utah Research FoundationInventor: Jayant P. Agarwal
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Publication number: 20140141152Abstract: Aspects of the disclosure relate to synthetic tissue or organ scaffolds and methods and compositions for promoting or maintaining their structural integrity. Aspects of the disclosure are useful to prevent scaffold damage (e.g., delamination) during or after implantation into a host. Aspects of the disclosure are useful to stabilize tissue or organ scaffolds that include electrospun fibers.Type: ApplicationFiled: June 26, 2013Publication date: May 22, 2014Applicant: Harvard Apparatus Regenerative TechnologyInventors: Ron Sostek, David Green
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Patent number: 8696760Abstract: Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.Type: GrantFiled: March 1, 2011Date of Patent: April 15, 2014Assignee: Tengion, Inc.Inventors: Timothy A. Bertram, Andrew Bruce, Deepak Jain, Manuel J. Jayo, John W. Ludlow, Darell McCoy, Richard Payne, Namrata D. Sangha, Oluwatoyin A. Knight
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Patent number: 8685081Abstract: The medical stent includes: a main body formed into an approximately tubular shape along a longitudinal axis with a first resin material; an elastic member formed of a second resin material which is larger in flexural modulus than the first resin material, and configured to have one end portion connected to an end portion of the main body and the other end portion formed to extend to the central portion side of the main body along the longitudinal axis and also to direct to the radial direction of the main body; and a treated layer formed between the end portion of the main body and the one end portion of the elastic member and configured to have a functional group for joining the end portion of the main body and the one end portion of the elastic member to each other.Type: GrantFiled: May 30, 2012Date of Patent: April 1, 2014Assignee: Olympus Medical Systems Corp.Inventor: Toshihiro Yamagata
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Publication number: 20140067058Abstract: Described herein are tissue grafts derived from the placental tissue that are reinforced with at least one biocompatible mesh. The tissue grafts possess good adhesion to biological tissues and are useful in wound healing applications. Also described herein are methods for making and using the tissue grafts.Type: ApplicationFiled: August 14, 2013Publication date: March 6, 2014Applicant: MIMEDX GROUP, INC.Inventors: Thomas J. KOOB, Robert TOFE, Elizabeth CHEN
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Publication number: 20140058496Abstract: This disclosure describes decellularized, biologically-engineered tubular grafts and methods of making and using such decellularized, biologically-engineered tubular grafts.Type: ApplicationFiled: February 20, 2013Publication date: February 27, 2014Applicant: Regents of the University of MinnesotaInventors: Robert Tranquillo, Zeeshan Syedain
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Patent number: 8657883Abstract: Valve implant systems positionable within a flow passage, the systems having an inlet, an outlet, and a remotely activatable valve between the inlet and outlet, with the valves being operable to provide intermittent occlusion of the flow path. A remote field is applied to provide thermal or magnetic activation of the valves.Type: GrantFiled: March 23, 2010Date of Patent: February 25, 2014Assignee: UT-Battelle, LLCInventors: Timothy E. McKnight, Anthony Johnson, Kenneth J. Moise, Jr., Milton Nance Ericson, Justin S. Baba, John B. Wilgen, Boyd McCutchen Evans, III
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Patent number: 8632606Abstract: A medical stent comprising a coil formed by winding a wire around an axis, an outer layer formed substantially tubular made from a first resin material, provided on an outer peripheral side of said coil and coaxial to said coil, and an inner layer formed substantially tubular made from a second resin material, provided on an inner peripheral side of said coil and coaxial to said coil.Type: GrantFiled: September 26, 2011Date of Patent: January 21, 2014Assignee: Olympus Medical Systems Corp.Inventor: Toshihiro Yamagata
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Patent number: 8623446Abstract: The invention is directed to an ion plasma deposition (IPD) method adapted to coat polymer surfaces with highly adherent antimicrobial films. A controlled ion plasma deposition (IPD) process is used to coat a metal or polymer with a selected metal/metal oxide. Exposing the coated surface to ultraviolet light significantly improves the antimicrobial properties of the deposited coatings.Type: GrantFiled: October 3, 2006Date of Patent: January 7, 2014Assignee: Metascape LLCInventors: Terrence S. McGrath, Deidre Sewell, Daniel M. Storey
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Publication number: 20130304232Abstract: A tubular structure and method for making a tubular structure are provided, where the tubular structure includes at least one layer of braided strands. In general, at least one portion of the braided strands exhibits a braid pattern of crests and troughs (e.g., a wave pattern, which may include sinusoidal, square, and/or sawtooth waves) along a length of the tubular structure. The wave pattern can be created by rotating the mandrel onto which the tubular structure is braided during the braiding process, such as by angularly oscillating the mandrel about its longitudinal axis or about its transverse axis. As a result, the tubular structures may have increased radial strength, collapse resistance, torque transmission, column strength, and kink resistance. The tubular structures may be used in medical devices, such as stent-grafts, as well as in other medical and non-medical devices, such as in hoses, tubing, filters, and other devices.Type: ApplicationFiled: July 18, 2013Publication date: November 14, 2013Inventor: Sara Jane Gries
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Publication number: 20130144399Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 ?m to 5 ?m thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The application further provides an implantable cage-like apparatus for culturing cells comprising the parylene membrane.Type: ApplicationFiled: January 11, 2013Publication date: June 6, 2013Applicants: University of Southern California, California Institute of TechnologyInventors: California Institute of Technology, University of Southern California
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Patent number: 8449601Abstract: Medical devices including an organic-inorganic composite material, including methods of making the devices, are disclosed.Type: GrantFiled: November 19, 2002Date of Patent: May 28, 2013Assignee: Boston Scientific Scimed, Inc.Inventor: Jan Weber
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Publication number: 20130131828Abstract: The present invention relates to a functionalized semi-permeable membrane composed of a porous biocompatible support pretreated so as to increase the surface energy thereof and characterized in that it comprises at least two layers, each comprising a hydrophilic polymer and at least one biologically active molecule, and to the use thereof in particular for producing a bioartificial organ.Type: ApplicationFiled: May 31, 2011Publication date: May 23, 2013Applicants: Association Pour Les Transferts De Technologie Du Mans, CENTRE EUROPEEN D'ETUDE DU DIABETEInventors: Gilbert Legeay, Séverine Sigrist, Arnaud Coudreuse
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Patent number: 8444700Abstract: An elongate hollow body (1) comprising crystalline cellulose has on an inside wall a plurality of protuberances (3, 4) which extend into a lumen of the hollow body (1). A process for the production of an elongate hollow body (1) comprising crystalline cellulose comprises the steps: preparation of a hollow mold (12); cultivation of cellulose-forming organisms in an interior space formed by the hollow mold (12), in order to allow the hollow body (1) to grow in the interior space; demolding of the hollow mold (12). In the step of demolding the hollow mold (12), at least part of the hollow mold (12) is irreversibly deformed.Type: GrantFiled: February 12, 2008Date of Patent: May 21, 2013Assignee: Bioregeneration GmbHInventor: Günter Bertholdt
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Publication number: 20130084315Abstract: The resorption of a medical implant can be controlled with the use of particles embedded in a resorbable bulk material forming the implant or portion thereof. The implant can be removed from a body of a mammal by natural biological mechanisms after use. The resorption of the implant can involve swelling and/or hydrolyzing of the particles within the implant upon contact with a body fluid such that porosity and flow of fluid within the bulk material of the implant is increased. Resorption of the implant may also involve the use of particles with magnetic properties embedded within the implant such that an applied magnetic field causes the particles to vibrate within the bulk material thereby increasing the porosity and thus the flow of fluid, hence facilitating resorption of the implant. The resorption rate of the implant can be controlled by modulating swelling, hydrolysis, or movement of the embedded particles.Type: ApplicationFiled: November 26, 2012Publication date: April 4, 2013Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventor: Boston Scientific Scimed, Inc.
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Publication number: 20130018454Abstract: The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a micropattern of grooves to which cells adhere and orient along. The exterior surface comprises electrospun microfibers wherein the microfibers provide mechanical properties to the graft. The hybrid graft is capable supporting endothelial cell attachment, endothelial cell alignment, cell proliferation, and maintaining their in vivo function. The graft of the invention can recapitulate the in vivo morphology and function of natural vascular endothelium.Type: ApplicationFiled: November 24, 2010Publication date: January 17, 2013Inventors: Peter I. Lelkes, Mengyan Li, Anat Perets, Pimporn Uttayarat, Robert J. Levy, Russell J. Composto
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Publication number: 20120259348Abstract: A reinforcement device for reinforcing tissues having one or more structural deficiencies includes a longitudinally-extending reinforcing layer for treating the structural deficiency, a plurality of spiked naps distributed across the reinforcing layer and projecting therefrom for adhering to the tissue, and a dissolvable matrix layer covering at least a portion of the reinforcing layer and a portion of the plurality of spiked naps. The matrix layer increases the time before the spiked naps substantially adhere to the tissue, thereby allowing the practitioner additional time to position the reinforcement device.Type: ApplicationFiled: May 20, 2010Publication date: October 11, 2012Inventor: Martin G. PAUL
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Patent number: 8211085Abstract: Therapeutic device intended for the selective cytoreductive treatment of an obstruction in a natural lumen or passage of the human or animal body, said lumen being obstructed by the effect of a local cell proliferation, said device comprising a tubular element, in particular of cylindrical shape, intended to be placed in said natural lumen and sufficiently flexible to conform to said natural lumen, but sufficiently rigid to maintain an artificial channel in said lumen. The tubular element supports lengthwise a medicinal sleeve which is intended to come into line with, and into contact with, the obstruction once the natural lumen has been intubated, and is designed to deliver locally, at least in its outer surface portion, at least one therapeutic agent which is cytoreductive, in particular cytotoxic, through contact with the cells under whose effect said lumen is obstructed.Type: GrantFiled: December 22, 2004Date of Patent: July 3, 2012Inventor: Marian Devonec
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Publication number: 20120065740Abstract: The disclosure provides methods for repairing nerves and inhibiting atrophy of a muscle via a side-to side neurorraphy using a bridging element between a first epineurial window on a donor nerve and a second epineurial window on a recipient nerve.Type: ApplicationFiled: September 15, 2011Publication date: March 15, 2012Inventor: Jayant P. Agarwal
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Patent number: 8106014Abstract: A medical device comprises a tubular body having a lumen and a long axis; and a plurality of silk elements laid substantially parallel along the long axis of the lumen of the tubular body. A method of manufacturing the medical device comprises forming the tubular body and introducing the silk elements into the lumen of the tubular body so as to lie substantially parallel along the long axis of the lumen of the tubular body. The device can be used in a method for the regeneration of nerve cells comprising the implantation of a medical device at a site for regeneration of nerves.Type: GrantFiled: September 8, 2005Date of Patent: January 31, 2012Assignee: Neurotex LimitedInventors: John Priestley, Von King, David Philip Knight, Nicholas James Vavasor Skaer, Jessica Hensman
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Patent number: 8034119Abstract: A medical stent provides an active agent to a patient's body while simultaneously maintaining an open passageway within the body of the patient. The stent includes a first segment, a second segment, a connecting segment disposed between the first and second segments, and the active agent. The active agent may be a hemostatic agent that stops or controls bleeding by coagulation, or any other medical drug, such as, for example an antibiotic or an anticoagulant. When the stent is properly positioned within the patient's urinary system, the first segment is located on one side of the external sphincter and the second segment is located on the other side. The connecting segment is sized to extend through the external sphincter to couple the first and second segments together while not interfering with the normal operation of the external sphincter.Type: GrantFiled: December 23, 2008Date of Patent: October 11, 2011Assignee: Boston Scientific Scimed, Inc.Inventor: Kenneth P. Reever
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Patent number: 8029554Abstract: An endoprosthesis such as a stent is composed of a metal or ceramic, such as Irox, embedded in the stent material.Type: GrantFiled: November 2, 2007Date of Patent: October 4, 2011Assignee: Boston Scientific Scimed, Inc.Inventors: Thomas J. Holman, Liliana Atanasoska
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Patent number: 8002830Abstract: Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.Type: GrantFiled: February 7, 2005Date of Patent: August 23, 2011Assignee: Georgia Tech Research CorporationInventors: Barbara D. Boyan, Stephen J. Kennedy, Zvi Schwartz
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Patent number: 7918897Abstract: Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.Type: GrantFiled: February 12, 2007Date of Patent: April 5, 2011Assignee: Tengion, Inc.Inventors: Timothy A. Bertram, Andrew Bruce, Deepak Jain, Manuel J. Jayo, John W. Ludlow, Darell McCoy, Richard Payne, Namrata D. Sangha
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Patent number: 7909790Abstract: An implantable fluid management device, designed to drain excess fluid from a variety of locations in a living host into a second location within the host, such as the bladder of that host. The device may be used to treat ascites, chronic pericardial effusions, normopressure hydrocephalus, hydrocephalus, pulmonary edema, or any fluid collection within the body of a human, or a non-human mammal.Type: GrantFiled: April 17, 2004Date of Patent: March 22, 2011Assignee: NovaShunt AGInventor: Daniel R. Burnett
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PROSTHESIS FOR PROMOTING THE IN VIVO RECONSTRUCTION OF A HOLLOW ORGAN OR A PORTION OF A HOLLOW ORGAN
Publication number: 20110035023Abstract: The invention relates to a prosthesis for promoting the in vivo reconstruction of a hollow organ or of a portion of a hollow organ, characterized in that it comprises: a biodegradable hollow tubular support membrane comprising at least one biocompatible and biodegradable polymer material, said support membrane being constituted of a porous outer layer and an essentially non-porous inner layer; and a material of living biological origin at the outer surface, and/or within at least one portion of the porous layer of said support member, and/or over the surface of the essentially non-porous layer facing the porous layer, said material of biological origin being chosen in order to allow the in vivo reconstruction of said organ or of said organ portion. The invention relates to a method for producing such a prosthesis and the medical applications thereof, especially for reconstructing at least one portion of a hollow tubular organ, in particular an esophagus.Type: ApplicationFiled: September 1, 2008Publication date: February 10, 2011Inventors: Veronique Maquet, Sandrine Gautier, Very Coulic -
Publication number: 20100331963Abstract: A method of making a hollow organ tissue engineering scaffold for repairing organs. Specifically, the hollow organ tissue engineering scaffold is made from a nonwoven fabric having first and second biocompatible materials, wherein the first material has a lower melting temperature than the first, and the first material is at least partially melted to form the scaffolds.Type: ApplicationFiled: June 30, 2009Publication date: December 30, 2010Inventors: Jackie Donners, Dhanuraj S. Shetty, Mark D. Timmer
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Publication number: 20100298952Abstract: Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties.Type: ApplicationFiled: May 19, 2010Publication date: November 25, 2010Inventors: Rany Busold, Chang Cheng You, Daniel Concagh, Lee Core, Kicherl Ho, Maria Palasis, Upma Sharma, Greg Zugates
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Patent number: 7837645Abstract: An endoscopic device separates ingested food from gastric fluids or gastric fluids and digestive enzymes, to treat obesity. In a particular embodiment a gastric bypass stent comprises a tubular member and two or more stent members defining a lumen. The tubular member has a substantially liquid impervious coating or covering and one or more lateral openings to permit one-way liquid flow.Type: GrantFiled: March 5, 2007Date of Patent: November 23, 2010Assignee: The Trustees of Columbia University in the City of New YorkInventors: Marc Bessler, John D. Allendorf
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Patent number: 7806937Abstract: The invention is directed to compositions and methods for reconstructing artificial female reproductive organs. The constructs and methods of the invention can be used for ameliorating congenital malformations and disorders of female reproductive tract using tissue engineered female reproductive organs, such as the uterus, vagina, cervix, and fallopian tubes. These tissue engineered female reproductive organs can be generated by perfusing cultured cell populations derived from cells of the female reproductive tissues, such as uterine, vaginal, cervical, fallopian tube epithelial cells as well as smooth muscle cells.Type: GrantFiled: November 15, 2002Date of Patent: October 5, 2010Assignee: Children's Medical Center CorporationInventors: Anthony Atala, James J. Yoo
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Patent number: 7789888Abstract: A composite multi-layer material may generally comprise a d-PTFE material combined with an open structured material (either resorbable or non-resorbable) creating a composite multi-layer material. Attachment of the layers may be accomplished by stitching layers of material, exertion of hydraulic or other pressure, application of a biocompatible adhesive or heat, or some combination of the foregoing. Use of a d-PTFE, unexpanded material has multiple alternative uses, including without limitation, placement on the visceral side of a hernia that may minimize or even eliminate the incidence of abdominal adhesions. Alternatively, the material may be used to create tubing sufficient as a graft for treating abdominal aortic aneurysms.Type: GrantFiled: February 14, 2006Date of Patent: September 7, 2010Inventors: Chad M. Bartee, Barry K. Bartee
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Publication number: 20100222894Abstract: An implantable tissue connector (1; 1 a) adapted to be connected to a tubular part of living tissue (70; 80) within a patient's body (100) comprises a conduit (2) and at least one flexible sleeve (10) adapted to axially extend and closely fit around at least part of the outer surface (6) of the conduit. The conduit is inserted into the tubular part of living tissue and the flexible sleeve placed over the tubular part of living tissue. Various alternatives are described of how the living tissue may be prevented form slipping off of the conduit.Type: ApplicationFiled: October 10, 2008Publication date: September 2, 2010Inventor: Peter Forsell
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Publication number: 20100137998Abstract: An esophageal valve comprising a polymeric valve body having an outer support region, at least three valve leaflets, and a main body region extending between the support region and the valve leaflets. The valve has a normally closed configuration in which the valve is closed, an antegrade open configuration in which the valve leaflets are opened in response to an antegrade force to allow flow through the valve and a retrograde open configuration in response to a retrograde force which is substantially larger than the antegrade force.Type: ApplicationFiled: June 19, 2009Publication date: June 3, 2010Applicant: Vysera Biomedical LimitedInventors: Gabriel Sobrino-Serrano, Niall Behan, Anthony O'Halloran