Having Means To Promote Cellular Attachment Patents (Class 623/23.76)
  • Patent number: 10034965
    Abstract: The present disclosure relates to compositions useful in synthetic bone graft applications. Particularly, the disclosure teaches moldable bone graft compositions, methods of making said compositions, and methods of utilizing the same.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: July 31, 2018
    Assignee: Bioventus LLC
    Inventors: John E. Brunelle, Russell L. Cook, Duraid S. Antone
  • Patent number: 9801975
    Abstract: Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: October 31, 2017
    Assignee: AlloSource
    Inventors: Reginald L. Stilwell, Adrian C. Samaniego, Brent Atkinson
  • Patent number: 9744266
    Abstract: Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: August 29, 2017
    Assignee: AlloSource
    Inventors: Reginald L. Stilwell, Adrian C. Samaniego, Brent Atkinson
  • Patent number: 9670443
    Abstract: A method of forming an implantable tissue engineered construct, a bioreactor for forming a tissue engineered construct, and a tissue engineered construct itself are disclosed The method includes seeding a scaffold with cells to form a tissue construct; locating the tissue construct in a space defined by a tissue construct support element; locating the tissue construct support element within a bioreactor; and operating a load applicator of the bioreactor to apply a cyclical compressive mechanical load to the tissue construct, to stimulate the deposition of tissue matrix in the tissue construct, in which the tissue construct, the tissue construct support element and the load applicator are arranged so that the load applicator can at least initially contact both the tissue construct and the tissue construct support element, so that at least part of a total load generated by the load applicator is borne by the tissue construct support element.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: June 6, 2017
    Assignees: UNIVERSITY OF LEEDS, XIROS LIMITED
    Inventors: Scott Finlay, Bahaa Botros Seedhom
  • Patent number: 9642935
    Abstract: There is disclosed a synthetic, composite graft to support robust bone growth. In an embodiment, the synthetic, composite graft includes a synthetic scaffold material including a material resorbable through natural cellular processes; a signaling factor combined with the scaffold material; a cell adherence factor coated on the scaffold material; a quantity of viable bone forming cells adhered to the scaffold; and a matrix substrate binding the scaffold material. There is disclosed a method of forming a synthetic, composite graft to support bone growth for bone grafting. In one embodiment, the method includes providing a synthetic scaffold material including a material resorbable through natural cellular processes; combining a signaling factor with the scaffold material; coating a cell adherence factor on the scaffold material; adhering a quantity of viable bone forming cells to the scaffold; and encasing the scaffold material with a matrix substrate. Other embodiments are also disclosed.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: May 9, 2017
    Inventors: Robert L. Bundy, Kevin P. Armstrong
  • Patent number: 9603626
    Abstract: The invention provides a method and apparatus for cranial fixation following a craniotomy and treatment for increased intracranial pressure. The cranial fixation device comprises of plates attached to the skull with a telescopic screw. The telescopic screw provides constrained movement of the bone flap relative to the skull to accommodate an increase in the intracranial pressure.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: March 28, 2017
    Inventor: Rohit Khanna
  • Patent number: 9539297
    Abstract: The present invention relates to a composition comprising, or consisting of 2-50 mg/ml hyaluronic acid, 0.1-500 mg/ml of biodegradable particles with an average mean particle diameter of 1 nm-500 ?m, 1 pg/ml-10 ?g/ml cytokines, where the concentrations specified are based in each case on the total volume (w/v) of the composition and where the cytokines are enclosed in the biodegradable particles, and to their use in the treatment of cartilage defects, for example traumatic cartilage defects or osteoarthrosis.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: January 10, 2017
    Assignee: CHARITE—UNIVERSITATSMEDIZIN BERLIN
    Inventors: Kristin Andreas, Jochen Ringe, Michael Sittinger
  • Patent number: 9017417
    Abstract: This invention includes a subchondral bone repair system, comprising a structural component and a fluid settable component and an optional non-core component. The fluid settable component may penetrate into any pores of the structural component, and set to a solid, thereby fixing the structural component in place. The fluid settable component will penetrate interporously into the pores of the subchondral bone tissue surrounding the device, beneficially displacing any fluid to reduce edema in the affected bone region. Furthermore, the settable component, once solid is osteoconductive to promote repair and regrowth of bone in the affected region, and will also transmit mechanical force stimuli (such as compressive forces) directed through the structural component, into the adjacent bone tissue, thereby providing appropriate force stimuli necessary for appropriate tissue growth.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: April 28, 2015
    Assignee: Kensey Nash BVF Technology LLC
    Inventors: Gino Bradica, Timothy A. Ringeisen
  • Patent number: 9015922
    Abstract: An implant device for humans or mammals has a body structure having an exposed surface and one or more selected portions of the exposed surface having a bone formation enhancing 3-dimensional pattern. The exposed surface can be on exterior portions of the body structure or internal portions of the body structure or both. The one or more selected portions of the exposed portions having the bone formation enhancing 3-dimensional patterns are in the external exposed surfaces or in the internal exposed surfaces or both internal and external exposed surfaces.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: April 28, 2015
    Assignee: Vivex Biomedical, Inc.
    Inventor: Timothy Ganey
  • Patent number: 9011899
    Abstract: Devices and methods for transplanting cells in a host body are described. The cell comprises a porous scaffold that allows ingrowth of vascular and connective tissues, a plug or plug system configured for placement within the porous scaffold, and a seal configured to enclose a proximal opening in the porous scaffold. The device may further comprise a cell delivery device for delivering cells into the porous scaffold. The method of cell transplantation comprises a two step process. The device is incubated in the host body to form a vascularized collagen matrix around a plug positioned within the porous scaffold. The plug is then retracted from the porous scaffold, and cells are delivered into the vascularized space created within the porous scaffold.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: April 21, 2015
    Assignee: Sernova Corporation
    Inventors: Craig Hasilo, Justin Leushner, Daniel Nicholas Haworth, Simon Shohet, Philip Michael Toleikis, Delfina Maria Mazzuca Siroen
  • Patent number: 8993117
    Abstract: Phosphorus-based coatings having a plurality of phosphate moieties, a plurality of phosphonate moieties, or both, covalently bonded to an oxide surface of an implantable substrate exhibiting one or more of the following characteristics: (a) the surface phosphorus-containing group density of the coated regions of the substrate is at least about 0.1 nmol/cm2; (b) the phosphorus-based coating has a thickness of less than about 10 nm; or (c) the surface phosphorus-containing group density of the coated regions of the substrate is equal to or greater than the surface hydroxyl group density of the oxide surface of the substrate. Implantable devices embodying the coated substrates are also disclosed.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: March 31, 2015
    Assignee: The Trustees of Princeton University
    Inventors: Jeffrey Schwartz, Ellen S. Gawalt, Michael J. Avaltroni
  • Patent number: 8968417
    Abstract: Bioactive implant for myocardial regeneration and ventricular chamber support including an elastomeric microporous membrane. The elastomeric microporous membrane being at least one non-degradable polymer and at least one partially degradable polymer. The non-degradable polymer is selected from polyethylacrylate and polyethylacrylate copolymerized with a hydroxyethylacrylate comonomer. The partially degradable polymer is selected from caprolactone 2-(methacryloyloxy)ethyl ester and caprolactone 2-(methacryloyloxy)ethyl ester copolymerized with ethylacrylate. The elastomeric microporous membrane further includes a nanofiber hydrogel, and cells. The bioactive implant, having one or two helical loops, contributes to the restauration of the heart conical shape.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: March 3, 2015
    Assignees: Institut Quimic de Sarria, Universitad Politecnica de Valencia, Fundacio Institut d'Investigacio Sanitaria Germans Trias Pujol, Association Cardio-Monde
    Inventors: Juan Carlos Chachques, Antonio Bayes Genis, Manuel Monleon Pradas, Carlos Eduardo Semino, Nicole Zur Nieden, Philippe Jenny
  • Patent number: 8945600
    Abstract: Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include administering at least one pharmaceutical agent onto a SEM graft in the skull base of the subject. Also provided are methods of treating a neurological disorder or pain in a subject that include forming a SEM graft in the skull base of the subject and administering at least one pharmaceutical agent onto the SEM graft in the skull base of the subject. Also provided are methods of forming a SEM graft in the skull base of a subject, compositions for administration onto a SEM graft in the skull base or into an endonasal reservoir or endonasal reservoir device in a subject, and devices for administering such compositions onto a SEM graft in the skull base of a subject.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: February 3, 2015
    Assignee: Massachusetts Eye & Ear Infirmary
    Inventor: Benjamin S. Bleier
  • Publication number: 20150018969
    Abstract: A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material.
    Type: Application
    Filed: October 1, 2014
    Publication date: January 15, 2015
    Inventors: Mark Thomas Fulmer, David A. Armbruster, Robert Frigg, Elliott A. Gruskin, Sean Hamilton Kerr
  • Patent number: 8921109
    Abstract: A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro.
    Type: Grant
    Filed: September 19, 2006
    Date of Patent: December 30, 2014
    Assignee: Histogenics Corporation
    Inventors: R. Lane Smith, Laurence J. B. Tarrant, Akihiko Kusanagi, Hans Peter Ingemar Claesson
  • Patent number: 8871267
    Abstract: The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: October 28, 2014
    Assignee: Gel-Del Technologies, Inc.
    Inventor: David B. Masters
  • Patent number: 8864825
    Abstract: The present invention relates to an implant system comprising implantable material in at least partially uncured form, contained in a closed casing, under vacuum and sterilized, and a closed bag containing the casing. The system is characterized in that at least 5% of the surface of the casing comprises sheet-like material having a thickness of 0.05-5 mm and having an original form, the sheet-like material being selected from the group consisting of metallic materials, polymers, bioceramic materials and composites thereof, provided that the material, once deformed from its original form to a changed form, is capable of maintaining that changed form unless subjected to external forces.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: October 21, 2014
    Assignee: Skulle Implants Oy
    Inventor: Pekka Vallittu
  • Patent number: 8822219
    Abstract: A method of treating a biological tissue for biological prostheses includes steps of fixation of the biological tissue via a fixing solution including glutaraldehyde and detoxification of the fixed biological tissue via treatment with a detoxifying solution. The detoxification step includes one or both of eliminating phospholipids via treatment with an elimination solution and a treatment with a detoxifying solution. The elimination solution includes 1,2-octanediol and ethanol. The detoxifying solution includes taurine or homocysteic acid.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: September 2, 2014
    Assignee: Sorin Group Italia S.r.l.
    Inventors: Marina Strasly, Giovanni Rolando
  • Patent number: 8808363
    Abstract: A vascular prosthesis comprising a tubular shaped expandable ECM member and at least one anchoring mechanism. In one embodiment, the anchoring mechanism comprises proximal and distal single or dual-ring anchors. In one embodiment, the anchoring mechanism comprises a multiple-ring anchor. The anchors preferably comprise a biodegradable metal, such as magnesium. The anchors can also comprise a shape memory alloy, such as nitinol, and a cross-linked ECM material. In some embodiments, the ECM member includes a pharmacological agent.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: August 19, 2014
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Michael David Perry, Robert G. Matheny
  • Patent number: 8795710
    Abstract: A laminated, bioimplantable dural graft product is configured for use as both an onlay graft and a suturable graft. The dural graft product is sufficiently pliable so as to sufficiently conform to a curvature of a tissue surface to which it is applied, such as the curved surface of a meningeal membrane. The use of the graft product can have improved properties, including suture retention strength and fluid impermeability. To use the dural graft product as an implant to replace, reinforce or strengthen bodily tissue, or to act as an adhesion barrier, the dural graft is placed in contact with bodily tissue and conforms to the curvature of the bodily tissue. Sutures can be used to maintain the contact between the dural graft and the bodily tissue.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: August 5, 2014
    Assignee: Codman & Shurtleff, Inc.
    Inventors: Robert E. Sommerich, Laurel R. Macomber
  • Patent number: 8790681
    Abstract: This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
    Type: Grant
    Filed: May 23, 2010
    Date of Patent: July 29, 2014
    Assignee: Cartiheal (2009) Ltd.
    Inventors: Nir Altschuler, Razi Vago
  • Patent number: 8778012
    Abstract: An extracellular matrix (ECM) construct having a biodegradable support scaffold that includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein, and at least a first layer of first ECM material disposed on the top surface of the support scaffold.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: July 15, 2014
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G. Matheny
  • Patent number: 8778822
    Abstract: The present invention provides a ceramic porous body for in-vitro and in-vivo use comprising a composition comprising a calcium aluminate (CA) containing phase and optionally at least one of an accelerator, a retarder, a surfactant, a foaming agent, a reactive alumina, water, a fiber, and a biologically active material, and combinations thereof. Ceramic compositions are provides as well as method of using the ceramic compositions and methods of manufacturing a ceramic porous body. The ceramic porous bodies of this invention may be used as artificial bones, joints, in-vitro support structures, and in-vivo support structures for cells, tissues, organs, and nerve growth and regeneration.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: July 15, 2014
    Assignee: Cabertech, Inc.
    Inventor: Kenneth A. McGowan
  • Patent number: 8771353
    Abstract: A method and apparatus for replacing damaged meniscal tissue includes a meniscus implant including a porous body having a plurality of interconnected open micro-pores and one or more open cavities for receiving meniscal tissue. The interconnected micro-pores are arranged to allow fluid to flow into the porous body and are in fluid communication with the one or more open cavities.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: July 8, 2014
    Assignee: Depuy Synthes Products, LLC
    Inventors: Philippe Gedet, Beat Lechmann, Nicolas Bouduban
  • Patent number: 8765039
    Abstract: Bio-implantable textured tubular and sheet structures of un-sintered ePTFE are described. Such micro-textured structures stimulate robust development of beneficial bio-integrative scar attachment to adnexal soft tissues. Methods for texturing one side of an un-sintered extruded ePTFE tube or sheet are also described. A select length of tubing of any thickness or diameter is applied over a matching mandrel and adhesively stabilized thereon by applying intense suction. The texture is made by “RIGDA tooling” into the wall thickness of the material and by removing undesired material by distraction and avulsion tooling and methods assisted by vibration, leaving intact the finished product. Disclosed is an implantable, non-attached, enveloping, conforming and supportive drainage cover for breast and other soft implants.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: July 1, 2014
    Inventor: Walter J. Ledergerber
  • Patent number: 8733274
    Abstract: Inkjet print head dies are directly seated upon an exterior of a tubular member so as to face different directions.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: May 27, 2014
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: David R. Otis, Jr., Jeffrey A. Nielsen, Casey T. Miller, Gerald F. Meehan, Isaac Farr, Joseph W. Dody
  • Patent number: 8728170
    Abstract: A bioerodible conductive tissue scaffold that can provide, e.g., improved tissue growth.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: May 20, 2014
    Assignee: Boston Scientific SciMed, Inc.
    Inventors: Liliana Atanasoska, James Q. Feng, Jan Weber, James Lee Shippy, III
  • Patent number: 8709094
    Abstract: An anti-adhesion sheet for placement upon the anterior wall of a vertebral body, wherein the sheet has a radius of curvature that is less than that of the anterior wall of the vertebral body.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: April 29, 2014
    Assignee: Depuy Synthes Products, LLC
    Inventors: Shawn Stad, Michael J O'Neil
  • Patent number: 8709096
    Abstract: Described herein are tissue repair implants comprising at least a first layer of peritoneal membrane. The first layer of peritoneal membrane can be located adjacent to a second layer of peritoneal membrane and can be in direct contact with the second layer of peritoneal membrane. Additional layers (e.g., a third or fourth layer) can be included. Where more than one layer is present, the layers can be affixed to one another. For example, a first layer of peritoneal membrane can be attached to the second layer of peritoneal membrane by an adhesive bond, suture, or staple. One or more of the peritoneal membranes can be non-crosslinked, partially crosslinked, or substantially fully crosslinked. Any of the layers of peritoneal membrane may be attached to a wall (e.g., an interior or exterior wall) of an abdominal tissue by an adhesive, suture, and/or staples.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: April 29, 2014
    Assignee: Proxy Biomedical Limited
    Inventors: Peter Gingras, Gabriela Voskerician, Michael F. White
  • Publication number: 20140114436
    Abstract: A medical device configured to be at least partially implanted within a host. The medical device includes an outer surface at least a portion of which is impermeable to cells but is permeable to molecules secreted by cells, the outer surface separating a space inside the medical device from a surrounding tissue of the host. The medical device also includes a diffusion sink positioned within the space and configured to cause molecules that are secreted into the tissue by immune cells during a foreign body response (FBR) to diffuse, through random motion, through the portion and into the diffusion sink.
    Type: Application
    Filed: February 17, 2012
    Publication date: April 24, 2014
    Inventors: Patrick A. Tresco, Michael J. Bridge
  • Publication number: 20140114435
    Abstract: The invention relates to medical devices that has a surface configured to promote the migration of cells onto the surface of the medical device. In particular, the surface of the medical device has a noncontiguous pattern of topographical features formed therein or thereon.
    Type: Application
    Filed: March 13, 2013
    Publication date: April 24, 2014
    Inventors: Scott Carpenter, Michael Poor, Julio C. Palmaz
  • Patent number: 8703293
    Abstract: Provided herein re a composition and a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: April 22, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Connie S. Kwok
  • Publication number: 20140094932
    Abstract: The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.
    Type: Application
    Filed: September 25, 2013
    Publication date: April 3, 2014
    Applicant: AXOGEN, INC.
    Inventors: CURT DEISTER, CRYSTAL SIMON
  • Patent number: 8679191
    Abstract: A composite material for positioning in the anatomy to form a selected function therein. The composite may be resorbable over a selected period of time. The composite may allow for selected bone ingrowth as absorption of the composite occurs.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: March 25, 2014
    Assignee: Biomet Manufacturing, LLC
    Inventors: Mark D. Borden, Joseph M. Hernandez, Edwin C. Shors
  • Patent number: 8673338
    Abstract: Provided are methods of delivering at least one pharmaceutical agent to the central nervous system (CNS) of a subject, methods of treating a neurological disorder or pain in a subject that include administering at least one pharmaceutical agent onto a SEM graft in the skull base of the subject. Also provided are methods of treating a neurological disorder or pain in a subject that include forming a SEM graft in the skull base of the subject and administering at least one pharmaceutical agent onto the SEM graft in the skull base of the subject. Also provided are methods of forming a SEM graft in the skull base of a subject, compositions for administration onto a SEM graft in the skull base or into an endonasal reservoir or endonasal reservoir device in a subject, and devices for administering such compositions onto a SEM graft in the skull base of a subject.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: March 18, 2014
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventor: Benjamin S. Bleier
  • Patent number: 8657601
    Abstract: An implant (10) has one or more surfaces (10a, 10b) with a basic or starting surface structure (1a) derived from mechanical working. A topographic modification of the surface structures is arranged on said surface structure or surface structures. The topographic modification can be formed, for example, by means of shot-peening, etching, plasma spraying, chemical action, etc. The topographically modified surface structures support bone-growth-stimulating agent. In a method for producing the implant, three subsidiary methods are used for carrying out the mechanical working, the topographical modification, and the application of the bone-growth-stimulating agent. An important niche in the demand which exists in the field of implants is thus covered in an advantageous manner.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: February 25, 2014
    Assignee: Nobel Biocare Services AG
    Inventor: Jan Hall
  • Patent number: 8652645
    Abstract: The present invention relates generally to an antibacterial coating which is composed of silver, to medical tools and to implants comprising such a coating and to a method as well to an apparatus for the production of such a coating. The medical tools or the dental or orthopaedic implant comprises a metal or metal alloy having a treated surface wherein the treated surface is at least partially converted to an oxide film by plasma electrolytic oxidation using a colloid-dispersed system and wherein the converted surface is partially covered by islands formed by colloid-dispersed silver-particles of the colloid-dispersed system. An Ag—TiO2 coating shows excellent properties in terms of antibacterial efficacy (even against multi-resistant strains), adhesion and biocompatibility. The life-time of an implant in a human body is increased. The antibacterial coating can be used in the field of traumatology, orthopaedic, osteosynthesis and/or endoprothesis, especially where high infection risk exists.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: February 18, 2014
    Assignee: aap Biomaterials GmbH
    Inventors: Elvira Dingeldein, Cyrille Gasqueres, Frank Witte, Amir Eliezer
  • Patent number: 8652215
    Abstract: A scaffold for tissue regeneration is provided. In a preferred embodiment, the scaffold is implantable in a patient in need of nerve or other tissue regeneration and includes a structure which has a plurality of uniaxially oriented nanofibers made of at least one synthetic polymer. Preferably, at least 75% of the nanofibers are oriented within 20 degrees of the uniaxial orientation. The scaffold beneficially provides directional cues for cell and tissue regeneration, presumably by mimicking the natural strategy using filamentous structures during development and regeneration.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: February 18, 2014
    Assignee: Georgia Tech Research Corporation
    Inventors: Ravi V. Bellamkonda, Young-Tae Kim, Satish Kumar, Dasharatham Goud Janagama
  • Patent number: 8628584
    Abstract: A transcutaneous prosthesis includes a first component shaped for implantation into a bone, the first component including flutes or grooves on a surface thereof for deterring rotation of the prosthesis within a bone; a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells; and a third component adapted for location to extend from the skin surface and is adapted to extend directly from the skin surface in use, the third component having a coating of a non-stick material on an outer surface thereof, the coating having a surface energy that is lower than a surface energy of the first and second components and which is low enough to deter bacterial adhesion.
    Type: Grant
    Filed: January 3, 2006
    Date of Patent: January 14, 2014
    Assignee: University College London
    Inventors: Gordon Blunn, Justin Cobb, Allen Goodship, Paul Unwin
  • Patent number: 8597745
    Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: December 3, 2013
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Ted R. Farnsworth, Charles Flynn, Charles F. White
  • Publication number: 20130304174
    Abstract: The present disclosure provides nerve interface devices, such as passive or active nerve caps or regenerative peripheral nerve interface devices (RPNI), for a subject in need thereof. The nerve interface devices include nerve interface cap devices capable of treating, minimizing, or preventing formation of neuromas in severed or damaged nerve endings. Such a nerve interface device includes a housing that may be formed of a scaffold, such as a biotic material or hydrogel, an autograft, and optionally an electrode and/or conducting polymer. The autograft may be free muscle or free skin tissue, which is attached to the nerve ending to permit reinnervation. The present disclosure also provides methods for treating, minimizing, or preventing neuroma formation in a subject having a severed or damaged nerve, especially a peripheral nerve.
    Type: Application
    Filed: July 17, 2013
    Publication date: November 14, 2013
    Inventors: Nicholas B. Langhals, Paul S. Cederna, Melanie G. Urbanchek
  • Patent number: 8556972
    Abstract: A monolithic material including a first region having a first variability of strength and a second region joined to the first region, the second region having a second variability of strength, wherein the monolithic material has a variability of strength less than the first variability of strength of the first region and less than the second variability of strength of the second region.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: October 15, 2013
    Assignee: Sevika Holding AG
    Inventors: Jeffrey D. Gordon, Michael G. Fisher, Paul R. Johnson, Kenneth D. Johannaber
  • Patent number: 8535388
    Abstract: The present invention relates to a novel bone graft and methods for producing said graft. Said bone graft can be used for surgical, plastic and/or cosmetic bone replacement for a patient in need thereof. The bone graft is made of a scaffold or matrix of sheet material having a 3-dimensional pattern of a continuous network of voids and/or indentations for enhancing new bone growth.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: September 17, 2013
    Inventor: Timothy Ganey
  • Patent number: 8518123
    Abstract: A system and method for the repair of damaged tissue and bones, congenitally missing tissue/cosmetic reconstruction of tissue is described. The system has a layered porous structure with a sufficiently large area of exposed pores to promote neo-vascularization as well as bone and tissue formation. The disclosed porous implant system can contain bioactive agents necessary for rapid tissue formation and keep ingrowth of unwanted tissue out of the implant surgical site. The implant can be reinforced with an additional, stronger polymer layer and/or may include an endoskeleton or exoskeleton for dimensional stability.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: August 27, 2013
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Peder Jensen, Alexandru S. Biris
  • Patent number: 8486436
    Abstract: Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: July 16, 2013
    Assignee: Georgia Tech Research Corporation
    Inventors: Barbara D. Boyan, Stephen J. Kennedy, Zvi Schwartz
  • Publication number: 20130172999
    Abstract: Provided herein is a biocompatible implant for meniscus tissue engineering. Particularly, the biocompatible implant comprises a multi-layered crescent-shaped silk fibroin scaffold, in which each layer comprises distinct pore size and/or pore orientation, e.g., to mimic native meniscus complex architecture. Accordingly, the biocompatible implant can be used for repairing any meniscal defect or promoting meniscal regeneration in a subject.
    Type: Application
    Filed: June 9, 2011
    Publication date: July 4, 2013
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Biman B. Mandal
  • Patent number: 8460367
    Abstract: A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: June 11, 2013
    Assignee: OrbusNeich Medical, Inc.
    Inventors: Robert J. Cottone, Jr., Stephen M. Rowland, Sherri Parker
  • Publication number: 20130105348
    Abstract: The invention relates to implantable collagen devices made by seeding at least one elongate collagen construct, e.g., comprising at least one elongate synthetic collagen fiber with a plurality of cells and applying a strain and/or stress to the at least one elongate collagen fiber to induce the cells to differentiate into target phenotypes, e.g., tendon or ligament phenotype cells (and/or fibroblasts), typically with an extracellular matrix of collagen to organize into a tissue on the at least one collagen fiber.
    Type: Application
    Filed: November 2, 2012
    Publication date: May 2, 2013
    Inventor: MiMedx Group, Inc.
  • Patent number: 8414654
    Abstract: An implant device for humans or mammals has a body structure having an exposed surface and one or more selected portions of the exposed surface having a bone formation enhancing 3-dimensional pattern. The exposed surface can be on exterior portions of the body structure or internal portions of the body structure or both. The one or more selected portions of the exposed portions having the bone formation enhancing 3-dimensional patterns are in the external exposed surfaces or in the internal exposed surfaces or both internal and external exposed surfaces.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: April 9, 2013
    Assignee: Amendia, Inc.
    Inventor: Timothy Ganey
  • Patent number: 8409227
    Abstract: The invention relates to a biocompatible neural implant for bridging interruptions or defects in nerves resulting from injuries sustained in an accident or following surgery. Inventive neural implants comprise fibers made from natural or synthetic spider silk and allow interrupted nerves to regenerate across defects such that functional nerve conduction is made possible within a short period of time.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: April 2, 2013
    Assignee: Medizinische Hochschule Hannover
    Inventors: Peter Vogt, Christina Allmeling, Kerstin Reimers