Abstract: Devices, systems, and methods useful in treating an eye are provided herein. Certain embodiments of the devices, systems, and methods may be particularly suitable in maintaining separation of an anterior capsule and a posterior capsule of an evacuated lens capsule of an eye. Certain embodiments of the devices, systems, and methods may be particularly suitable for reducing scarring in the visual field of an eye having a capsulorhexis, among other things.

Abstract: The present invention pertains to accommodating intraocular lens (AIOL) assemblies including a haptics system for self-anchoring implantation in a human eye's annular ciliary sulcus for retaining an AIOL at a desired position along the human eye's visual axis, and an accommodation measurement implant (AMI) for determining accommodation and accommodation forces in an experimental set-up including an animal's eye.

Abstract: An accommodating intraocular lens comprising a flexible body, a flexible optic which is moveable anteriorly and posteriorly relative to the lens body, and a weakened portion connecting the optic to the body. The body may have extending centration and fixation loops on its distal ends.

Abstract: A flexible intraocular implant for placing in a capsular bag, the implant comprising an optical portion of substantially circular shape that presents an optical axis, and a haptic portion connected to the periphery of the optical portion, said haptic portion comprising: a contact portion constituted by n (n?2) contact elements in the form of circular arcs all having the same radius of curvature and each having an outer edge that is in contact with the equatorial zone of the capsular bag, and n connection elements, each connection element being connected via respective ends to two consecutive contact elements, presenting a deformable curved shape, and presenting stiffness that is much less than that of the contact elements; and n deformable connection arms each connected to the periphery of the optical portion and to a contact element.

Abstract: An accommodating intraocular lens (AIOL) including a biasing mechanism for elastically deforming an elastically deformable shape memory disk-like optical element for affording the AIOL a natural positive diopter strength for near vision. The AIOL is intended to be implanted in a human eye such that relaxation of its ciliary body causes its capsular diaphragm to apply an accommodation force for overcoming the biasing mechanism to reduce the AIOL's natural positive diopter strength for distance vision.

Abstract: A deformable intracapsular implant device for shaping an enucleated lens capsule sac for use in cataract procedures and refractive lensectomy procedures. In one embodiment, the intraocular implant devices rely on thin film shape memory alloys and combine with the post-phaco capsular sac to provide a biomimetic complex that can mimic the energy-absorbing and energy-releasing characteristics of a young accommodative lens capsule. In another embodiment, the capsular shaping body is combined with an adaptive optic. The peripheral capsular shaping body carries at least one fluid-filled interior chamber that communicates with a space in a adaptive optic portion that has a deformable lens surface. The flexing of the peripheral shaping body in response to zonular tensioning and de-tensioning provides an inventive adaptive optics mechanism wherein fluid media flows between the respective chambers “adapts” the optic to increase and decrease the power thereof.

Abstract: An accommodating intraocular lens is provided that having optical parameters that are altered in-situ using forces applied by the ciliary muscles, in which a lens body carries an actuator separating two fluid-filled chambers having either the same index of diffraction or different indices of refraction, actuation of the actuator changing the relative volumes of fluid within an optic element of the lens and altering the optical power of the lens.

Abstract: An accommodating IOL comprises an optic adapted to focus light toward a retina of an eye, and a movement assembly coupled to the eye to provide effective accommodating movement, preferably axial movement, of the optic. At least a portion of the movement assembly is made from a material that is less stiff and/or more resilient than the material used to make the optic. Optionally, an outer ring or support portion made at least partially from either a relatively stiff material such as the material used in the optic or a relatively resilient material such as the material used in the movement assembly is also provided.

Abstract: An accommodating intraocular lens has an anterior portion including an anterior viewing element and an anterior biasing element connected to the anterior viewing element. A posterior portion has a posterior viewing element and a posterior biasing element connected to the posterior viewing element. The anterior and posterior biasing elements are connected at first and second apices. First and second distending members are connected to the posterior portion. The first and second distending members extend to locations significantly anterior of an anterior side of the posterior viewing element.

Abstract: A single-optic accommodative lens system comprising two intraocular elements. The two intraocular elements are designed to be located within the capsular bag to extend depth of focus and/or restore accommodation following extraction of a natural lens. A first intraocular element comprises a circumferential capsular ring having interlock features to couple to and control the dynamic vault response of a second intraocular element. This second intraocular element comprises an intraocular lens (IOL) having an optic and a plurality of haptics and is designed to move axially in response to changes in the geometry of the eye capsule and thus provide a range of accommodative power. The IOL further comprises interlock features complementary to the interlock features of the first intraocular element for coupling the IOL to the capsular ring in a manner that provides for controlled movement of the IOL in response to capsular forces.

Abstract: An accommodating intraocular lens comprising a flexible body, a flexible optic which is moveable anteriorly and posteriorly relative to the lens body, and a weakened portion connecting the optic to the body. The body may have extending centration and fixation loops on its distal ends.

Abstract: An accommodating intraocular lens comprising a flexible body and flexible optic, and a flexible skirt connecting the optic to the body. The body may have extending loop haptics.

Abstract: An intraocular lens for implantation in a capsular bag of an eye includes an optic disposed about an optical axis and a haptic including a protruding portion disposed inside the optic. The optic has an anterior face and an opposing posterior face that are configured to provide a lens power. In response to an ocular force of the eye, the haptic transmits a force that alters one or more of a shape of the optic and an axial thickness of the optic. The protruding portion of the haptic has a refractive index that is equal to a refraction index of the optic for at least one a wavelength within the visible spectrum.

Abstract: An accommodating intraocular lens comprising a flexible body, a flexible optic which is moveable anteriorly and posteriorly relative to the lens body, and hinged portions longitudinally connecting the optic to the body. The body may have extending centration and fixation loops on its distal ends.

Abstract: An intraocular lens for insertion into the capsular bag of an eye contains an optic, an outer periphery, and an outer support structure. The optic has a periphery and centered about an optical axis. The outer periphery is disposed about the optic and configured to engage an equatorial region of the capsular bag of an eye. The outer support structure is disposed along the periphery and spaced from the optic with voids outer support structure and the optic. The intraocular lens further comprises a first intermediate member and a weakened region disposed along the outer periphery between the outer support structure and the first intermediate member. The first intermediate member operably couples the optic and the outer support structure. The weakened region is attached to, and configured to provide relative motion between, the outer support structure and the first intermediate member in response to the ciliary muscle of the eye.

Abstract: Accommodating intraocular lenses and methods of use which account for changes to a capsular bag post-implantation as well as a mismatch is size between the accommodating intraocular lens and capsule.

Abstract: An accommodating intraocular lens system for implantation in a capsular bag of an eye includes an optic component comprising first and second light-transmitting lens elements that define a fluid-filled deformation chamber located between the first and second lens elements. The first and/or second lens elements have an elastic membrane adapted to deform in response to a change in pressure. The elastic membrane includes a first portion having a first deformation response and a second portion having a different second deformation response. The system also includes a refractive fluid filling the deformation chamber and at least one haptic member coupled to the optic component. The haptic member is configured for changing a hydrostatic pressure in the deformation chamber in response to muscle movement in the eye in order to deform the elastic membrane of the first and/or second lens elements, thereby changing the shape and the refractive characteristics of the optic component.

Abstract: Intraocular lens implant (10) for providing accommodation for near vision includes an optic (20) centrally disposed in a flexible membrane (30) and at least one haptic (40) outwardly extending from the flexible membrane. The flexible membrane is adapted in use to facilitate translatable movement of the optic in response to attempted accommodation by the ocular substrate.

Abstract: An intraocular accommodating lens comprising a resilient polymer monolith with a peripheral component that has a Young's modulus and an equilibrium memory shape that imparts to the capsular sac's periphery the natural shape of the capsule in an accommodated state. The intraocular lens includes a central deformable optic that provides accommodated and disaccommodated shapes. The peripheral component is deformable to a disequilibrium, stressed shape in responsive to equatorial tensioning—and is capable of applying restorative forces to move the lens toward the accommodated shape from a disequilibrium disaccommodated shape. In one embodiment, the central optic portion includes a displaceable media than can be displaced by very low forces of zonular excursion, wherein the displaceable media can comprise a very low modulus polymer or an index-matched fluid.

Abstract: An intraocular ring assembly and an artificial lens kit, both of which are usable for implantation in a lens capsule or capsular bag of natural eye. The intraocular ring assembly includes a first ring element having recessions therein, a second ring element, and a biasing element provided between the first and second ring elements. The artificial lens kit comprises such intraocular ring assembly and an intraocular lens to be movably supported in the recessions of the ring assembly in a coaxial relation therewith. A guide element may be provided to assist in rectilinear coaxial movement of the first and second ring elements.

Abstract: In one aspect, the present invention provides an intraocular lens (IOL), which comprises at least two optics disposed in tandem along an optical axis, and an accommodative mechanism that is coupled to at least one of the optics and is adapted to adjust a combined optical power of the optics in response to natural accommodative forces of an eye in which the optics are implanted so as to provide accommodation. At least one of the optics has a surface characterized by a first refractive region, a second refractive region and transition region therebetween, where an optical phase shift of incident light having a design wavelength (e.g., 550 nm) across the transition region corresponds to a non-integer fraction of that wavelength.

Abstract: An accommodative intra-ocular lens deformable between the unaccommodating and accommodating configurations upon the relaxation and contraction of the ciliary muscle. The lens anterior and posterior portions are substantially sealingly joined together about their peripheral edges and define a lens internal volume filled with a substantially incompressible lens internal fluid. Causing a variable internal fluid pressure exerted on the lens inner surfaces. The lens is configured such that radius of curvature of both the central and peripheral sections of the lens anterior portion will decrease upon an increase in internal fluid pressure and increase upon a decrease in internal fluid pressure.

Abstract: An ocular lens has a refractive optics structure formed from a polyisobutylene-based material and a glassy segment that is non-reactive to ocular fluid and that maintains in vivo transparency for a substantial time period. The material has a central elastomeric polyolefinic block and thermoplastic end blocks (such as a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene). The material is preferably flexible such that the refractive optics structure can be folded upon itself and introduced through a small scleral incision. The lens device includes an optic portion and preferably either an annular haptic element or one or more haptic elements adapted to rest within a capsular bag formed by a surgical procedure. A portion of the lens device may be loaded with at least one therapeutic agent that interferes with proliferation of the epithelial cells of the eye to protect against PCO.

Abstract: An intraocular lens comprises an optical element adapted to be implanted within the capsular bag of a human eye. The optical element includes one or more internal layers formed by one or more planes that are moveable relative to one another in order to effect the power of the optical element.

Abstract: An intraocular lens in which deterioration in contrast is suppressed even when the optical axis of the intraocular lens is decentred from the optical axis of the eyeball when the intraocular lens is inserted into the eye while the advantage of a conventional aberration reduction type intraocular lens that the image is seen clearly is sustained by employing such a power distribution as respectively having at least one positive power deviation region (E1) having a power larger than that represented by the reference power distribution and at least one negative power deviation region (E2) having a power smaller than that represented by the reference power distribution in the central region of the intraocular lens assuming that a power distribution being set to cancel the spherical aberration of cornea when the intraocular lens is inserted into the eye is the reference power distribution.

Abstract: This invention relates to intraocular lenses. More particularly, this invention relates to intraocular lenses that have the ability to alter the light refractive power in response to changes in the tension of the ciliary muscle or ciliary body of the eye or any other accommodative forces. Lenses of this invention are generally referred to as interfacial, i.e., lens properties being defined as the interface of two liquids having different refractive indices, refractive accommodating lenses (IRAL).

Abstract: An accommodating intraocular lens having an optic and portions extending from the optic radially outwards preferably with fixation devices at their distal ends, the optic designed such that it has a sharp posterior edge for 360 degrees of its perimeter and the lens designed such that the optic can move forward and backwards with constriction and relaxation of the ciliary muscle.

Abstract: An intraocular lens is disclosed, with an adjustable optic that changes shape in response to a deforming force exerted by the zonules of the eye. A haptic supports the optic around its equator and couples the optic to the capsular bag of the eye. The haptic may include a cap on the anterior and/or posterior surfaces of the lens. The lens may include a force transfer member, such as a hinge, that couples forces from the haptic to the cap, so that a radial force on the haptic changes the curvature of the cap. The haptic and optic may be refractive index-matched. The cap may be made of the haptic material, which is stiffer than the optic material, and can influence the deformation of the lens during accommodation. A cap on the anterior surface may produce an axial movement of the lens in an anterior direction during accommodation. The cap may also protect the surfaces of the optic during handling and installation.

Abstract: A method for prevention of migration of epithelial cells in a capsular bag of an eye of a mammal is provided. The method comprises removing the natural lens of the eye from the capsular bag; introducing an object with at least one sharp edge into the capsular bag, in such a way that said sharp edge contacts the inside of the capsular bag to form a barrier preventing migration of epithelial cells across said barrier; and injecting a lens-forming composition into the capsular bag.

Abstract: The present invention is generally directed to accommodative intraocular lenses (IOLs) that exhibit a dynamic spherical aberration as a function of accommodative power. By way of example, in one aspect, the present invention provides an intraocular lens (IOL) having an anterior optical element, a posterior optical element, and a mechanism for coupling the anterior and posterior elements so as to allow axial movement of those elements relative to one another for providing accommodation when the lens is implanted in a patient's eye. Each of the anterior and the posterior elements includes at least one aspherical surface, where the asphericities of the surfaces are adapted to provide a combined spherical aberration that varies with accommodation.

Abstract: An accommodating intraocular lens having an optic and portions extending from the optic radially outwards preferably with fixation devices at their distal ends, the optic designed such that it has a sharp posterior edge for 360 degrees of its perimeter and the lens designed such that the optic can move forward and backwards with constriction and relaxation of the ciliary muscle.

Abstract: An intraocular accommodating lens comprising a resilient polymer monolith with a peripheral component that has a Young's modulus and an equilibrium memory shape that imparts to the capsular sac's periphery the natural shape of the capsule in an accommodated state. The intraocular lens includes a central deformable optic that provides accommodated and disaccommodated shapes. The peripheral component is deformable to a disequilibrium, stressed shape in responsive to equatorial tensioning—and is capable of applying restorative forces to move the lens toward the accommodated shape from a disequilibrium disaccommodated shape. In one embodiment, the central optic portion includes a displaceable media than can be displaced by very low forces of zonular excursion, wherein the displaceable media can comprise a very low modulus polymer or an index-matched fluid.

Abstract: In one aspect, the present invention provides a two-element ophthalmic lens in which a lateral shift of the elements relative to one another can cause a variation not only in a spherical power provided by the lens but also in spherical aberration exhibited by that lens. In some implementations, the thickness profiles of the two elements are designed such that the variation in spherical aberration is positively correlated with that of the spherical power of the lens.

Abstract: An accommodating intraocular lens is provided, in which optical parameters are altered in-situ using forces applied by the ciliary muscles, and in which a lens body carries an actuator separating two fluid-filled chambers having either the same index of diffraction or different indices of refraction. The actuator causes the relative volumes of fluid within an optic element of the lens to change, thereby altering the optical power of the lens.

Abstract: An intra-ocular artificial lens with variable optical strength, having at least two optical elements, at least two of which are movable relative to each other in a direction extending transversely of the optical axis, wherein the optical elements have a form such that in different positions of the movable optical elements the artificial lens has a different optical strength, wherein the artificial lens has a fixed, positive optical basic strength wherein the variable optical strength caused by the relative movement of the movable elements is added to obtain the total optical strength of the artificial lens. Providing a different form results in the possibility of incorporating the greatest optical power in one of the optical elements. This optical element can then be optimized for the desired optical properties. The remaining optical element or the remaining optical elements can then be dimensioned for variation of the optical strength.

Abstract: An intraocular lens for providing accommodative visions to a subject includes an adjustable optic and a haptic that is operably coupled to the optic. The adjustable optic comprises an optical axis, a central zone disposed about the optical axis, and an annular zone surrounding the central zone. The optic may also comprise additional annular zones disposed about the central zone and the first annular zone. The haptic comprises a transparent portion protruding into the adjustable optic. The intraocular lens has a disaccommodative configuration in which the central zone has a base optical power and an accommodative configuration in which the central zone has an add optical power that is at least about 1 Diopter greater than the base optical power, preferably at least about 2 Diopters greater than the base optical power. In some embodiments, the add optical power is at least 3 Diopters, or even 4 Diopters, greater than the base optical power.

Abstract: An intraocular ring assembly and an artificial lens kit, both of which are usable for implantation in a lens capsule or capsular bag of natural eye. The intraocular ring assembly includes a first ring element having recessions therein, a second ring element, and a biasing element provided between the first and second ring elements. The artificial lens kit comprises such intraocular ring assembly and an intraocular lens to be movably supported in the recessions of the ring assembly in a coaxial relation therewith. A guide element may be provided to assist in rectilinear coaxial movement of the first and second ring elements.

Abstract: Accommodating intraocular (AIOL) assemblies (31) for enabling post implantation in situ manual selective displacement of an AIOL (33) along a human eye's visual axis relative to stationary anchor points. Axial displacement may be over a continuous range or alternatively at discrete axial stopping positions typically from about 100 ?m to about 300 ?m apart. Novels AIOLs designed to be at least partially folded for facilitating insertion into a human eye through a relatively small incision.

Abstract: An accommodating intraocular lens where the optic is moveable relative to the outer ends of the extended portions. The lens comprises an optic made from a flexible material combined with extended portions that are capable of multiple flexions without breaking. The optic has a blended central area of increased power of 1 diopter or less to give the patient a single focal point on wavefront examination after implantation into the eye increasing the depth of focus to aid near vision.

Abstract: The invention provides in one form a macromonomer comprising a polysiloxane copolymer having a backbone structure derived from siloxane monomer units that are substituted or unsubstituted arylsiloxanes, arylalkylsiloxanes, alky(alkyl)siloxanes of the general formula —R1R2SiO— and wherein the terminal groups of the copolymer backbone include crosslinkable groups and wherein pendent from the backbone are at least two crosslinkable groups. The macromonomer may be cured in vivo by ultraviolet or visible light. The invention includes intraocular lenses formed by such macromonomers.

Abstract: An intraocular lens assembly for increased depth of focus has a frame configurated to vault posteriorly in an eye and an optic attached thereto. Pressure from ciliary muscle contraction moves the optic anteriorly to focus the eye for near vision.

Abstract: An accommodating intraocular lens device including a lens portion connected to a plate haptic portion. Preferably, the lens portion is connected to the plate haptic portion by a pair of flexible or resilient arms.

Abstract: An intraocular lens assembly (70) including a lens assembly comprising an interface element adapted for attachment to an ocular structure, the lens assembly comprising a tensing element (76) adapted to expand and contract relative to the lens assembly and apply a tensing force on the ocular structure directed towards an inner volume of the lens assembly.

Abstract: Biocompatible polymers useful in ophthalmic devices such as accommodating intraocular lenses. The polymers have improved resistance to the diffusion of fluid, relatively high refractive indexes, and mechanical properties to allow for deformation upon the application of force.

Abstract: An accommodating intraocular lens comprising a flexible body, a flexible optic which is moveable anteriorly and posteriorly relative to the lens body, and hinged portions longitudinally connecting the optic to the body. The body may have extending centration and fixation loops on its distal ends.

Abstract: An accommodating intraocular lens wherein the optic is moveable relative to the ends of extended haptic portions. The lens comprises an optic made from a flexible material combined with haptics capable of multiple flexions without breaking. Each haptic has in longitudinal cross section two wide and deep hinges to better allow the elastic hinges to “stretch” when the optic is subjected to posterior pressure thus allowing the optic to move forward relative to both the outer and inner ends of the haptics. When this movement is combined with the movement of the optic relative to the outer ends of the haptics, the anterior movement of the whole lens, and a change in shape of the optic, the refractive power of the eye is further enhanced.

Abstract: A movable ophthalmic lens assembly including a carrier placeable on a portion of an eye, and a movable ophthalmic lens with non-zero optic power arranged for movement over a surface of the carrier, wherein the movable ophthalmic lens is responsive to ocular muscular movement so as to move in translatory motion over the surface of the carrier.

Abstract: An accommodating intraocular lens implant for implantation in a human eye, including an optic adapted for coaxial alignment with a vision axis of the human eye, and at least one haptic. The haptic includes an anchor portion for receipt in one of a periphery of a capsular bag of the human eye, a cilairy sulcus of the human eye, and an angle of the anterior chamber of the human eye, and a sinuous portion extending radially from the optic and including a proximal end connected to the optic, a distal end spaced from the optic and connected to the anchor portion, and at least four curves successively connected between the proximal end and the distal end. The sinuous portion is adapted to flex upon ciliary muscle action to move the optic along the vision axis and allow the intraocular lens implant to automatically accommodate.

Abstract: Method and design of a dual-optics accommodating intraocular lens (IOL) for vision correction of adult and pediatric eyes after cataract surgeries are disclosed. For adult eyes, a positive accommodation amplitude greater than 3.5 diopter and preferably 4.0 to 10.0 diopter may be achieved by optimal configurations having the positive-power front-optics moves toward the cornea, whereas the negative power back-optics moves in the opposite direction. In contrast, a negative accommodation is required for pediatric eyes and may be achieved by a reversed configurations. The enhanced efficiency, up to 500%, is proposed by preferred embodiments based on new lens design formulas and calculation steps for the IOL power pre-determined by the measured ocular parameters including the corneal power, IOL position and the vitreous cavity length of the eye.

Abstract: An accommodating intraocular lens having anteriorly and posteriorly movable extended portions, such as T-shaped haptics, extending from a central optic to be implanted within a human eye, and a second optic spaced from the posterior optic. The first optic is intended to be implanted in the capsular bag, and the second optic may be located in the capsular bag, in the sulcus, or in the anterior chamber. The second optic can be spaced from and fixed to the first optic and this lens assembly implanted in the capsular bag.