Abstract: A macula cover having a flexible sheet member and including an contact surface, an outer surface, a perimeter, and an annular stiffener. The sheet member is sized to cover the fovea and the parafoveal area of the macula during retinal surgery.

Abstract: A band that can be implanted into an eye to re-attach a retina. The implanted band exerts a pressure that presses the retina into a globe of the eye. The band has a length that is at least 100 degrees of the circumference of the globe of the eye. The band may be injected into the eye with a syringe type injector.

Abstract: Method and system for processing light signals received by the eye of a human or other animal, where the eye may be compromised or non-functioning. Incident light is received at first and second pixels in a photodetector array and provides a pixel electrical signal representing the received light. Each of an array of carbon nanotube (CNT) towers is connected to a pixel, has a first tower end penetrating a retinal active layer of the animal and has a second tower end positioned to receive to receive and transport the pixel electrical signal to the retinal active layer. The CNT tower may be coated with a biologically active substance or chemically modified to promote neurite connections with the tower. The photoreceptor array can be provide with a signal altering mechanism that alters at least one of light intensity and wavelength intensity sensed by a first pixel relative to a second pixel, to correct for one or more selected eye problems.

Abstract: A band that can be implanted into an eye to re-attach a retina. The implanted band exerts a pressure that presses the retina into a globe of the eye. The band has a length that is at least 100 degrees of the circumference of the globe of the eye. The band may be injected into the eye with a syringe type injector.

Abstract: Improved ophthalmological surgical methods, systems and devices, employing a colorant.

Abstract: Methods and apparatus for modifying membranous tissue, growing cells on modified membranous tissue, and for transplantation of modified tissues and modified tissues with attached cells are provided. In particular, the invention provides methods and apparatus for modifying membranous tissue such as lens capsule tissue and inner limiting membrane tissue, for growing cells such as iris pigment epithelial (IPE) cells and retinal pigment epithelial (RPE) cells on modified membranous tissue, and for modifying membranous tissue and growing cells on biodegradable polymer substrates. A method of modifying membranous tissues comprises depositing micropatterns of biomolecules onto membranous tissue with a contacting surface such as a stamp; other methods include mechanical ablation, photoablation, ion beam ablation, and modification of membranous tissues via the action of proteolytic enzymes.

Abstract: An apparatus facilitating the delivery of electrical stimulation to physiologically excitable retinal nerve cells includes: (a), a receiver/decoder/stimulator comprising a semiconductor integrated circuit and other components hermetically sealed within a capsule, implanted and fixed within the eye of the patient such that it may receive power, and decode information from (b), an externally worn image processor/encoder/transmitter comprising an image detector, an image processor capable of translating the image into an array of discreet pixels of varying intensity, encoding the pixel information into a series of discreet data bursts representing the chosen current amplitude, pulse duration, stimulating electrode or electrodes, and reference electrode or electrodes, and transmitting this data to the receiver/decoder/stimulator through a tuned, inductive communication link such that the system may deliver controlled, charge balanced, diphasic, constant current stimulus pulses to (c), discreet metallic electrodes

Abstract: An artificial retinal device, implanted in the subretinal space of the eye in persons with certain types of retinal blindness, induces artificial vision by electrical stimulation of the remaining viable cells of the retina. The artificial retina device includes a stimulating electrode unit preferably placed in the subretinal space, and a tail-like extension housing a distant electrical return ground electrode unit that may be placed in the vitreous cavity. The stimulating electrode unit includes an array of electrode subunits. Each electrode subunit includes one or more microphotodiodes electrically connected, for example, in series to provide increased voltage and current to its microelectrode. The stimulating electrode unit and the ground return electrode of the ground return electrode unit are preferably disposed on opposite sides of the neuroretina to allow for efficient and high resolution transretinal electrical stimulation of the neuroretinal cells.

Abstract: A process for inhibiting vascular proliferation introduces a composition into the eye inducing posterior vitreous detachment. The composition includes a combination of plasminogen, a collagen crosslinking agent and at least one plasminogen activator selected from the group consisting of urokinase, streptokinase, tissue plasminogen activator, chondroitinase, pro-urokinase, retavase, metaloproteinase, and thermolysin. The composition is introduced into the vitreous in an amount effective to induce crosslinking of the vitreous and to induce substantially complete or partial posterior vitreous detachment from the retina without causing inflammation of the retina. In one embodiment, a gaseous material is introduced into the vitreous before or simultaneously with the composition to compress the vitreous against the retina while the composition induces the posterior vitreous detachment.

Abstract: Neural prosthesis for implantation within an eye. The prosthesis includes a foldable substrate and at least one electronic component supported by the substrate. At least one microchannel is disposed within the substrate. Upon inflation, the foldable substrate will unfold to provide for close contact of the electronic component with neural tissue, thus facilitating surgical implantation through a narrow incision, yet allowing the unfolded device to cover a sufficiently large portion of the patient's retina to provide useful vision.

Abstract: A combination of silicon processing technology advances and increased understanding of the mechanisms underlying phosphene generation in human retinas by surface electrical stimulation has now made it possible to conceive of a chronically implantable retinal prosthesis for the blind which will restore some useful vision to patients over at least several degrees of their former field of view. These thin, strong, and flexible epiretinal devices are constructed of or encapsulated in known biocompatible materials which will have a long working life in the eye's saline environment. The function of the implants is to electrically stimulate the ganglion cell layer at the surface of the retina using controlled current sources. Due to the exceptionally low mass of the implant and its flexible, nearly planar form, patient discomfort and fluid drag caused by the implant minimized.

Abstract: A band that can be implanted into an eye to re-attach a retina. The implanted band exerts a pressure that presses the retina into a globe of the eye. The band has a length that is at least 100 degrees of the circumference of the globe of the eye. The band may be injected into the eye with a syringe type injector.