Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: A picker device having an up-picker mechanism (A) and a down-picker mechanism (B) for increasing and decreasing stitches in knitting a heel portion and a toe portion of hosiery. When the knitting of the heel portion or the toe portion is started, a short butt (2a) of a knitting needle in a knitting level comes in contact with a front end portion (17a or 18a) of an up-picker (17 or 18) as a knitting cylinder alternately rotates forward and backward. The up-picker (17 or 18) is thereby rotated horizontally and a rear end portion (17b or 18b) of the up-picker (17 or 18) is guided by an inclined guide slot (20a or 20b), so that the rear end portion (17b or 18b) is lowered and thus thus the front end portion (17a or 18a) of the up-picker (17 or 18) is raised. The knitting needle (2) is thereby raised from above a stitch cam (9a or 9b) to a position above a center cam (8), whereby the knitting needle (2) is moved to a non-knitting level and thus one stitch is decreased.