Gelling Or Coagulation Patents (Class 73/64.41)
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Patent number: 11851965Abstract: Disclosed are methods, systems, and devices for measuring and otherwise processing core samples. In some embodiments, a method includes containing a core sample in a containment vessel including dynamically adjusting pressure within the containment vessel to maintain a phase of fluid within the core sample. Pressure is reduced within the containment vessel. During pressure or following reduction, one or more properties of the fluid in the core sample are measured.Type: GrantFiled: October 22, 2020Date of Patent: December 26, 2023Assignee: Halliburton Energy Services, Inc.Inventors: Donald Clifford Westacott, Christopher Michael Jones, Anthony Herman van Zuilekom
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Patent number: 11644401Abstract: An apparatus is for use in viscoelastic analysis, for example in coagulation testing of sample liquids, such as blood and/or its elements. In the apparatus for use in viscoelastic analysis, the rotating means are provided below the cup, pin and cup receiving element. A capacitive detection means and temperature control devices may be used in the apparatus for use in viscoelastic analysis. A method of performing viscoelastic analysis, e.g. coagulation analysis, on a sample may use the devices and apparatuses.Type: GrantFiled: January 26, 2017Date of Patent: May 9, 2023Inventor: Harald Leyser
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Patent number: 10517415Abstract: Trays for tray tables that prevent liquid spilled on a top surface of the trays from spreading over edges of the trays. A casing having a top surface with at least one aperture through the top surface, a receptacle within the casing positioned below the aperture in the top surface configured to receive an absorbent pad that can be removably positioned in the receptacle below the aperture to be in communication with the top surface of the tray. Spilled liquids can be guided toward the aperture in the top surface and absorbed in the absorbent pad within the casing. The absorbent pad may be a superabsorbent material. The top surface can have a superhydrophobic coating.Type: GrantFiled: January 18, 2017Date of Patent: December 31, 2019Assignee: The Boeing CompanyInventor: Pawel Kajak
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Patent number: 9983106Abstract: A compressive load is exerted with a test apparatus across a rock sample that has a specified length-to-diameter ratio. A strain on the rock sample is measured during the compressive loading with a strain gauge. A mechanical property of the rock sample is determined based at least in part on the compressive load. An elastic property of the rock sample is determined based at least in part on the measured strain and the compressive load.Type: GrantFiled: March 20, 2017Date of Patent: May 29, 2018Assignee: Saudi Arabian Oil CompanyInventors: Yanhui Han, Bitao Lai, Hui-Hai Liu, Hui Li
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Patent number: 9128017Abstract: This disclosure is directed to a cap for obtaining a target analyte from a suspension. The cap introduces a magnetic field or a magnetic gradient to the tube to draw the target analyte bound to a particle to the cap. In one aspect, a cap includes a magnetic insert and a receiving piece. The magnetic insert includes a stopper and a magnet extending from the stopper; and, the receiving piece, which is configured to hold the magnetic insert, includes a receiving stopper and a sheath. The sheath may include imaging slides on opposite sides of the sheath. In another aspect, the cap may include a stopper and an embedded magnet. The cap may include an analysis piece on a bottom end of the stopper. In yet another aspect, the cap may include a fluid compartment and a filter at a bottom end of the stopper.Type: GrantFiled: March 14, 2014Date of Patent: September 8, 2015Assignee: RARECYTE, INC.Inventors: Daniel Campton, Jackie Lynn Stilwell, Arturo Ramirez, Jennifer Chow
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Patent number: 9103816Abstract: The present invention is to present a blood sample analyzing apparatus, comprising: an aspirator for aspirating a blood sample to be used for measurement; a coagulation determiner for determining whether the blood sample is coagulated or not; and an aspirating controller for controlling an operation of the aspirator based on a determination result by the coagulation determiner.Type: GrantFiled: July 21, 2009Date of Patent: August 11, 2015Assignee: Sysmex CorporationInventors: Tokihiro Kosaka, Koichi Okubo
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Patent number: 9034264Abstract: The present application provides apparatus and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator. Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.Type: GrantFiled: August 22, 2014Date of Patent: May 19, 2015Assignee: Highland Biosciences LimitedInventor: Richard Day
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Patent number: 8999243Abstract: A blood coagulation analysis device and method in which information relating to the coagulability of blood is evaluated based on a change generated in a permittivity measured in a coagulation process of the blood due to addition of a substance that activates or inactivates platelets to the blood.Type: GrantFiled: March 7, 2014Date of Patent: April 7, 2015Assignee: Sony CorporationInventors: Yoshihito Hayashi, MarcAurele Brun, Shinji Omori, Yoichi Katsumoto, Kazumasa Sato
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Patent number: 8877510Abstract: A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable to the cell such that one end of the at least one electrode wire pair forms a sensor unit for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair within the blood sample and that the opposite end of the at least one electrode wire pair forms a plug portion being connectable directly to the plug for an electrical connection of the sensor unit to an analyzer.Type: GrantFiled: November 22, 2013Date of Patent: November 4, 2014Assignee: F. Hoffmann-La Roche AGInventors: Andreas Calatzis, Ben Krüger, Marc Wittwer
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Patent number: 8845968Abstract: The present application provides apparatus (300, 400) and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator (108, 109, 110). Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.Type: GrantFiled: December 27, 2007Date of Patent: September 30, 2014Assignee: Highland Biosciences LimitedInventor: Richard Day
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Patent number: 8772039Abstract: Device, method, and computer program product for determining a material parameter of a blood coagulation cascade based on parameters of light diffused at a biofluid sample. In one example, the biofluid sample includes a blood sample. Laser light scattered by the sample is collected by the optical system in reflection and/or transmission mode. An image of the sample in so collected light is formed, and data representing fluctuations of laser speckle intensity with is processed to derive numerical descriptors associated with blood coagulation and fibrinolysis. In a specific case, such numerical descriptors are derived based on temporal dynamic of a viscoelastic characteristic of the blood sample.Type: GrantFiled: May 9, 2012Date of Patent: July 8, 2014Assignee: The General Hospital CorporationInventor: Seemantini K. Nadkarni
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Patent number: 8759108Abstract: In order to provide a reagent kit for detecting LA which can clearly separate a lupus anticoagulant (LA)-positive specimen group from an LA-negative specimen group, it is configured that the reagent kit for detecting LA contains a first clotting time-measuring reagent and a second clotting time-measuring reagent and at least one of the first clotting time-measuring reagent and the second clotting time-measuring reagent contains alkali metal salt. The presence or absence of LA can be determined using the kit.Type: GrantFiled: February 28, 2012Date of Patent: June 24, 2014Assignee: Sysmex CorporationInventors: Masahiro Okuda, Kazuyo Yoshida, Osamu Kumano
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Patent number: 8735163Abstract: A blood coagulation system analyzing method includes acquiring information relating to the coagulability of blood based on a change generated in a complex permittivity spectrum measured in a coagulation process of the blood due to addition of a substance that activates or inactivates platelets to the blood.Type: GrantFiled: February 23, 2012Date of Patent: May 27, 2014Assignee: Sony CorporationInventors: Yoshito Hayashi, MarcAurele Brun, Shinji Omori, Yoichi Katsumoto, Kazumasa Sato
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Patent number: 8703495Abstract: A blood coagulation detection device includes a micro channel unit, an optical signal unit, an opto-electronic conversion circuit, an amplifier circuit, and a filter circuit. The micro channel unit has a sample detection area. The optical signal unit transmits a reference light to the micro channel unit so as to form a message light. The opto-electronic conversion circuit receives the message light and converts the message light into an electrical signal. The amplifier circuit is electrically connected to the opto-electronic conversion circuit for amplifying the electrical signal. The filter circuit is electrically connected to the amplifier circuit for filtering the amplified electrical signal.Type: GrantFiled: July 6, 2012Date of Patent: April 22, 2014Assignee: National Cheng Kung UniversityInventors: Kung-Chia Young, Song-Jeng Huang, Chin-Lung Yang
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Patent number: 8697449Abstract: An optical blood coagulation monitor and method. The monitor has a blood sample holder, a laser with its output light directed through the blood sample, a two-dimensional detector that is able to detect light at the laser light wavelength and that has a detector output, optics for imaging onto the detector laser light that is forward scattered by the blood, and a data analysis system, responsive to the detector output, that is adapted to analyze the detected light to provide information on time-resolved coagulation and clotting properties of the blood.Type: GrantFiled: March 30, 2012Date of Patent: April 15, 2014Assignee: Spectral Sciences, Inc.Inventors: Brian Gregor, Rama Bansil, Julian D. Spring
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Patent number: 8617468Abstract: An assembly for testing platelet aggregation including an electrode subassembly that is mounted in a cuvette subassembly for use with relatively small samples containing platelets.Type: GrantFiled: October 18, 2011Date of Patent: December 31, 2013Assignee: Chrono-Log CorporationInventors: Andrew Roth, Nicholas J. Veriabo
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Patent number: 8600299Abstract: The disclosed embodiments include a method, system, and device for conducting ultrasound interrogation of a medium. The novel method includes transmitting a non-beamformed or beamformed ultrasound wave into the medium, receiving more than one echoed ultrasound wave from the medium, and converting the received echoed ultrasound wave into digital data. The novel method may further transmit the digital data. In some embodiments, the transmitting may be wireless. The novel device may include transducer elements, an analog-to-digital converter in communication with the transducer elements, and a transmitter in communication with the analog-to-digital converter. The transducers may operate to convert a first electrical energy into an ultrasound wave. The first electrical energy may or may not be beamformed. The transducers also may convert an echoed ultrasound wave into a second electrical energy.Type: GrantFiled: November 10, 2006Date of Patent: December 3, 2013Assignee: Siemens Medical Solutions USA, Inc.Inventors: Kevin S. Randall, Jodi Schwartz Klessel, Anthony P. Lannutti, Joseph A. Urbano
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Patent number: 8591816Abstract: A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable to the cell such that one end of the at least one electrode wire pair forms a sensor unit for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair within the blood sample and that the opposite end of the at least one electrode wire pair forms a plug portion being connectable directly to the plug for an electrical connection of the sensor unit to an analyzer.Type: GrantFiled: February 17, 2011Date of Patent: November 26, 2013Assignee: F. Hoffmann-La Roche AGInventors: Andreas Calatzis, Ben Krüger, Marc Wittwer
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Patent number: 8584513Abstract: Disclosed are methods of determining the effectiveness of an asphaltene deposition inhibitor in oilfield applications. Such methods typically comprising the steps of introducing an oil well fluid into a microfluidic/millifluidic system; introducing a mixture of an asphaltene deposition inhibitor and carrier into the microfluidic/millifluidic system; introducing a precipitating agent, typically comprising heptane, into the microfluidic/millifluidic system; and optionally introducing toluene into the microfluidic/millifluidic system; then observing the presence or absence of asphaltene aggregation within the microfluidic/millifluidic system.Type: GrantFiled: February 24, 2011Date of Patent: November 19, 2013Assignee: Rhodia OperationsInventors: Lawrence A. Hough, Jean-Christophe Castaing, Gary Woodward, Ruela Talingting Pabalan, Floryan De Campo
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Patent number: 8586368Abstract: Methods, systems, and computer readable media for using actuated surface-attached posts for assessing biofluid rheology are disclosed. According to one aspect, a method for testing properties of a biofluid specimen includes placing the specimen onto a micropost array having a plurality of microposts extending outwards from a substrate, wherein each micropost includes a proximal end attached to the substrate and a distal end opposite the proximal end, and generating an actuation force in proximity to the micropost array to actuate the microposts, thereby compelling at least some of the microposts to exhibit motion. The method further includes measuring the motion of at least one of the microposts in response to the actuation force and determining a property of the specimen based on the measured motion of the at least one micropost.Type: GrantFiled: June 25, 2010Date of Patent: November 19, 2013Assignee: The University of North Carolina at Chapel HillInventors: Richard Superfine, Richard Chasen Spero, Adam Richard Shields, Benjamin Aaron Evans, Briana Lee Fiser
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Publication number: 20130233536Abstract: A testing system and method for evaluating the time required for shutting in a well after packing fractures in the well with a proppant having curable resin. At the well site, a sample of the proppant is compressed and heated in a portable unit. While the sample is being heated and compressed, its properties are being monitored to determine if the resin in the proppant has cured. Recording the time required for the proppant to cure provides an indication of how long to shut in the well after packing the fractures with the proppant. The portable unit includes a gas to fluid intensifier for compressively stressing the sample and a heat source for heating the sample. Sensors adjacent the proppant sample monitor the properties.Type: ApplicationFiled: March 7, 2013Publication date: September 12, 2013Applicant: SAUDI ARABIAN OIL COMPANYInventors: Mohammad H. Alqam, Hazim Husain Abass, Hussain A. Al-Shammary, Edwin T. Caliboso
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Patent number: 8507282Abstract: When assessing the start time of the limulus reaction between biogenous biologically active substances and LAL and using the reaction start time to determine the concentration of the biogenous biologically active substances, in order to exclude the influence of progressive changes which occur regardless of the conditions of the limulus reaction, the strength of transmitted light or scattered light in the liquid mixture of the measurement sample and LAL is detected, the variation (delta) in the transmittance or number of gel particles is acquired at set intervals, and the time when the variation (delta) crosses a threshold value is taken as the reaction start time. Furthermore, the time intervals when acquiring the abovementioned delta are not uniform, and either change over time from the start of measurement as defined by a time function, or multiple sequences with differing time intervals are prepared in advance.Type: GrantFiled: March 12, 2010Date of Patent: August 13, 2013Assignee: Kowa Company, Ltd.Inventors: Katsumi Yabusaki, Takuya Hara, Yuka Sugiura
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Patent number: 8499620Abstract: A gum substance monitoring apparatus for inexpensively and easily estimating and detecting adhesion and deposition of a gum substance produced in a fuel gas onto a combustor and fuel gas supply piping extending to the combustor, includes: detection piping branched from the fuel gas supply piping configured to supply to the combustor with the fuel gas for allowing a part of the fuel gas as a sample gas to pass therethrough; and a gum substance detecting device provided on the detection piping and configured to detect an extent of adhesion of the gum substance produced in the fuel gas, the gum substance detecting device including a simulated passage member having a simulated passage for passage of the sample gas therethrough which is formed by simulating fuel gas piping of the fuel gas supply piping extending in a portion subject to gum substance monitoring which is located downstream of a branch point at which the detection piping is branched from the fuel gas supply piping, the gum substance detecting deviceType: GrantFiled: March 30, 2007Date of Patent: August 6, 2013Assignee: Kawasaki Jukogyo Kabushiki KaishaInventors: Masaaki Sako, Hideaki Ota
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Patent number: 8465978Abstract: Methods and devices for conducting platelet aggregation analysis. A method for conducting platelet aggregation analysis by a cartridge device, including providing a blood sample in the cartridge device, stirring the blood sample within the cartridge device, measuring the electrical impedance between electrodes to obtain measured electrical impedance values, comparing measured electrical impedance values, discarding and repeating the measurements of the electrical impedance in case a variation of the measurements is outside a predetermined threshold range, or reporting the measured electrical impedance values in case the variation of the measurements is within the predetermined threshold range. Reported measured electrical impedance values indicate platelet aggregation in a blood sample.Type: GrantFiled: February 17, 2011Date of Patent: June 18, 2013Assignee: F. Hoffmann-la Roche AGInventors: Andreas Calatzis, Ben Krüger, Marc Wittwer
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Patent number: 8460938Abstract: A blood analyzing device (100) comprises a holder (110) for receiving a cuvette (20) with a blood sample (30). The device (100) induces a movement of the blood cells in the sample (30) by applying a field (230) over the cuvette (20). A detector (130) detects, based on output light from the blood sample (30) originating from a light source (120), a change in the induced movement of the cells caused by an increase in viscosity of the blood due to an aggregation and/or coagulation process. A processor (140) processes the detector reading and generates a signal representative of the hemostasis function of the tested blood.Type: GrantFiled: March 31, 2009Date of Patent: June 11, 2013Inventor: Tommy Forsell
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Patent number: 8448499Abstract: The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid.Type: GrantFiled: December 17, 2009Date of Patent: May 28, 2013Assignee: C A Casyso AGInventors: Axel Schubert, José Javier Romero-Galeano, Max Kessler
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Patent number: 8445287Abstract: Methods and apparatus are disclosed for determining new anticoagulant therapy factors for monitoring oral anticoagulant therapy to help prevent excessive bleeding or deleterious blood clots that might otherwise occur before, during or after surgery. The inventive methods and apparatus provide an International Normalization Ratio (INR) based on a coagulation reaction with a blood sample of a living being. Embodiments include methods and apparatus for determining an anticoagulant therapy factor without requiring use of a mean normal prothrombin time determination or an ISI, and may be carried out with the patient sample and a coagulation reagent, where the coagulation reagent may be selected from a number of coagulation reagents.Type: GrantFiled: March 7, 2011Date of Patent: May 21, 2013Assignee: WADA, Inc.Inventors: Wallace E. Carroll, R. David Jackson
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Patent number: 8383045Abstract: The present invention is directed to a measuring unit, for measuring characteristics of a sample liquid, comprising a support member, having at least one upper bearing arm, with an upper bearing unit, at least one lower bearing arm, with a lower bearing unit, and a base, for being attachable to a respective measuring system; a shaft, having shaft toes and being rotatably supported about a rotation axis, by said upper bearing unit, and said lower bearing unit, wherein said upper bearing unit, said lower bearing unit, and said shaft toes form toe bearings, respectively; an interface member, having a detecting element, and a drive element, said interface member, being fixed on said shaft, and being connected to a coupling shaft, with a probe connector section, for measuring characteristics of said sample liquid; wherein said interface member, and the coupling shaft, are coaxially aligned with said shaft.Type: GrantFiled: January 15, 2010Date of Patent: February 26, 2013Assignee: C A Casyso AGInventors: Axel Schubert, José Javier Romero-Galeano, Max Kessler
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Patent number: 8372343Abstract: Embodiments of the present invention relate to multiple coagulation test cartridges and methods of using such cartridges. In one embodiment the cartridge is a disposable single-use cartridge for use in evaluating blood clotting. The cartridge includes multiple containers, such as tubes, each of which includes one or more coagulation affecting substances. The containers can be pre-filled with substances in amounts suitable for use with a single patient's blood sample. The cartridge may include one or more containers, each of which has multiple sections, or volumes, each section storing a different coagulation affecting substance. In another embodiment the cartridge is used in a method for determining at least one appropriate coagulation affecting substance for modifying a patient's coagulation status using a multiple coagulation test system.Type: GrantFiled: December 7, 2007Date of Patent: February 12, 2013Inventor: Sheldon Goldstein
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Patent number: 8357539Abstract: An activated partial thromboplastin time measuring reagent, including a first reagent containing a phospholipid and an activator and a second reagent containing a herparin neutralizer and a calcium salt is disclosed. An activated partial thromboplastin time measuring method, and a determination method for determining a presence or absence of a blood coagulation inhibitor are also disclosed.Type: GrantFiled: December 22, 2010Date of Patent: January 22, 2013Assignee: Sysmex CorporationInventors: Kazuyo Yoshida, Masahiro Okuda
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Patent number: 8322195Abstract: An apparatus and a method for measuring the coagulation characteristics of a test liquid (1), in particular of a blood sample, is provided. According to the present invention standardized geometrical dimensions of a cup (2) and a respective pin (3) are modified for receiving maximum elasticity signal per volume test liquid without resulting in irreversible inelastic effects. In particular, the test liquid gap (8) between the cup (2) and the pin (3) is reduced, the diameter of the cup (2) and the pin (3) are increased and/or the geometry of test liquid accommodating portions (7; 10; 10?) are optimized for increasing the ratio between signal amplitude and a needed amount of test liquid (1) compared to standardized equipment.Type: GrantFiled: December 18, 2007Date of Patent: December 4, 2012Assignee: C A Casyso AGInventors: Martin Glauner, Axel Schubert, Max Kessler
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Publication number: 20120291532Abstract: A method of determining a condition of clot carryout from a sample container containing a sample fluid is disclosed. During aspiration of a fluid sample (e.g., blood), a level sensor, such as a capacitance sensor, is used to measure ascending and descending liquid level readings. A difference between the ascending and descending liquid level readings may be compared to a predetermined threshold. Non-ideal conditions, such as a clot carryout condition wherein a clot is carried out of the sample container on the exterior surface of the probe may be detected thereby. Systems and apparatus for carrying out the method are provided, as are other aspects.Type: ApplicationFiled: January 21, 2011Publication date: November 22, 2012Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.Inventors: Alexander Vidlak Evers, Bridgett Angela Harris, Alexander Openstone, Jeffrey Kenneth Parmer
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Patent number: 8236568Abstract: A method and device for blood hemostasis analysis is disclosed. A blood sample is displaced to reach a resonant state. The resonant frequency of the blood sample is determined before, during and after a hemostasis process. The changes in the resonant frequency of the blood sample are indicative of the hemostasis characteristics of the blood sample.Type: GrantFiled: June 1, 2007Date of Patent: August 7, 2012Assignee: Coramed Technologies, LLCInventor: Hans Kautzky
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Patent number: 8076144Abstract: A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit preparation of an individualized assessment of ischemic event risk and individualized treatment of a subject.Type: GrantFiled: January 21, 2011Date of Patent: December 13, 2011Assignee: Cora Healthcare, Inc.Inventor: Eli Cohen
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Patent number: 8008086Abstract: A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit evaluation of hemostasis therapies including anticoagulation therapies such as direct thrombin inhibition therapies.Type: GrantFiled: May 24, 2007Date of Patent: August 30, 2011Assignee: Cora Healthcare, Inc.Inventors: Eli Cohen, Roslyn Cohen
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Patent number: 7939329Abstract: A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit preparation of an individualized assessment of ischemic event risk and individualized treatment of a subject.Type: GrantFiled: October 26, 2009Date of Patent: May 10, 2011Assignee: Cora Healthcare, Inc.Inventor: Eli Cohen
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Patent number: 7901629Abstract: A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable to the cell such that one end of the at least one electrode wire pair forms a sensor unit for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair within the blood sample and that the opposite end of the at least one electrode wire pair forms a plug portion being connectable directly to the plug for an electrical connection of the sensor unit to an analyser.Type: GrantFiled: December 16, 2003Date of Patent: March 8, 2011Assignee: Dynabyte Informationssysteme GmbHInventors: Andreas Calatzis, Ben Krüger, Marc Wittwer
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Patent number: 7879615Abstract: A method and device for blood hemostasis analysis is disclosed. A blood sample is displaced to reach a resonant state. The resonant frequency of the blood sample is determined before, during and after a hemostasis process. The changes in the resonant frequency of the blood sample are indicative of the hemostasis characteristics of the blood sample.Type: GrantFiled: June 22, 2006Date of Patent: February 1, 2011Assignee: Coramed Technologies, LLCInventor: Hans Kautzky
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Patent number: 7867771Abstract: The present invention provides a reagent for measuring clotting time including a nonionic surfactant, a nickel ion and a tissue factor. A method for stabilizing a tissue factor, and use of a nonionic surfactant and a nickel salt for stabilizing a tissue factor are also disclosed.Type: GrantFiled: March 28, 2008Date of Patent: January 11, 2011Assignee: Sysmex CorporationInventors: Masahiro Okuda, Kazuyo Yoshida
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Patent number: 7770455Abstract: The present invention relates to methods, systems, and instruments (10) for monitoring, detecting or measuring one or more acoustic emissions of a foam. The detected emission(s) may then be used to generate a response, such as one to control an associated process.Type: GrantFiled: March 16, 2005Date of Patent: August 10, 2010Assignee: Tribo Flow Separations, LLCInventor: John M. Stencel
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Patent number: 7767458Abstract: A method is disclosed of assaying circulating microparticles contained in a sample of whole blood or blood plasma from a patient to determine the patient's ability to generate thrombin or Factor Xa as blood-clotting factors, wherein the circulating microparticles are microparticles of platelets, endothelial cells, monocytes, and smooth muscle cells, which carry on their surfaces both negatively charged phospholipids as well as tissue factor. The results of the assay may be used to determine the ability of the patient to generate thrombin or Factor Xa as blood clotting factor based upon the circulating microparticles.Type: GrantFiled: February 22, 2006Date of Patent: August 3, 2010Assignee: Technoclone Gesellschaft m.b.H.Inventor: Bernd Binder
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Patent number: 7767459Abstract: A method for determining prothrombin time of a plasma or whole blood sample includes measuring prothrombin time for at least two different dilutions for a test sample to determine tmin or INRmin. The prothrombin time for at least two different dilutions for normal plasma is measured to determine tmin or INRmin values for normal plasma. Next, tPivka or INRPivka values are calculated by subtracting the value for normal plasma from the value for the test sample. The Pivka corrected prothrombin time for the test sample is calculated by subtracting tPivka or INRPivka from the prothrombin time measured for the test sample.Type: GrantFiled: March 20, 2006Date of Patent: August 3, 2010Inventor: Juha Horsti
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Patent number: 7754489Abstract: A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit preparation of an individualized assessment of ischemic event risk and individualized treatment of a subject.Type: GrantFiled: December 31, 2008Date of Patent: July 13, 2010Assignee: Cora Healthcare, Inc.Inventor: Eli Cohen
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Patent number: 7745223Abstract: To increase the adhesion strength of coagulated blood on a surface by increasing the surface interaction of blood-inherent components like fibrin/fibrinogen and thrombocytes it is described to treat the surface by exposing it to ionized atoms or molecules. The surface treatment according to the invention is applied on plastic disposables used in blood diagnostics (e.g. hemostasis analysis) as well as medical implants like artery sealings. The improved blood clot adhesion results in higher diagnostic security due to reduced measurement failure (e.g., for patients with increased thrombocyte content) and in better significance of special tests (e.g., hyperfibrinolysis diagnosis).Type: GrantFiled: August 10, 2005Date of Patent: June 29, 2010Assignee: C A Casyso AGInventors: Axel Schubert, Stefan Wurlitzer, Andreas Calatzis, Martin Glauner
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Patent number: 7745224Abstract: The present invention lies in the field of coagulation diagnosis and relates to a procedure for the standardization of coagulation tests, where calibrators are used to which a discrete standard coagulation time is assigned. The procedure is particularly suitable for the standardization of prothrombin time, activated partial thromboplastin time, thrombin time, ecarin time or batroxobin time.Type: GrantFiled: June 15, 2006Date of Patent: June 29, 2010Assignee: Siemens Healthcare Diagnostics Products GmbHInventors: Norbert Zander, Matthias Wilkens
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Patent number: 7732213Abstract: A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit evaluation of a patient hemostasis condition.Type: GrantFiled: December 7, 2006Date of Patent: June 8, 2010Assignee: CoraMed Healthcare, Inc.Inventors: Eli Cohen, Roslyn Cohen
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Publication number: 20100115952Abstract: A gum substance monitoring apparatus (10) for inexpensively and easily estimating and detecting adhesion and deposition of a gum substance produced in a fuel gas onto a combustor (3) and fuel gas supply piping (4) extending to the combustor (3), includes: detection piping (11) branched from the fuel gas supply piping (4) configured to supply to the combustor (3) with the fuel gas for allowing a part of the fuel gas as a sample gas to pass therethrough; and a gum substance detecting device (12) provided on the detection piping (11) and configured to detect an extent of adhesion of the gum substance produced in the fuel gas, the gum substance detecting device (12) including a simulated passage member (15) having a simulated passage (15A) for passage of the sample gas therethrough which is formed by simulating fuel gas piping of the fuel gas supply piping (4) extending in a portion subject to gum substance monitoring which is located downstream of a branch point (C1) at which the detection piping (11) is brancheType: ApplicationFiled: March 30, 2007Publication date: May 13, 2010Applicant: KAWASAKI PLANT SYSTEMS KABUSHIKI KAISHAInventors: Masaaki Sako, Hideaki Ota
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Patent number: 7588942Abstract: A whole-blood-based substitute composition that is useful in coagulation assays as a standard, reference, control, calibrator, linearity verifier, or training material is prepared by combining a red blood cell lysate that is free of plasma, leukocytes, and platelets with a platelet-free plasma of human origin and an antimicrobial agent.Type: GrantFiled: August 4, 2006Date of Patent: September 15, 2009Assignee: Bio-Rad Laboratories, Inc.Inventors: Timothy Ho, James Cole, Alireza Ebrahim
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Patent number: 7544514Abstract: The present subject matter concerns methods for determining platelet medicated clot formation. Specifically, the subject matter provides a method for determining platelet-medicated clot formation in a blood sample. The method may include obtaining sample of blood, and optionally mixing same with an anti-coagulant in an amount effective to inhibit clot formation. Additionally, the method may include mixing the sample in a vessel with a minute amount of an initiator to obtain a mixed sample, the amount being effective to initiate coagulation. The method may further include rotating the mixed sample inside the vessel, whereby shear forces are developed at the surface of the vessel in a manner and for a time sufficient to allow adhesion of platelets at the surface of the vessel. In addition, the method may include determining clot formation at the surface of the adherent platelets.Type: GrantFiled: December 27, 2004Date of Patent: June 9, 2009Assignees: Ramot at Tel-Aviv University Ltd.Inventor: Sanford N. Gitel
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Patent number: 7437913Abstract: Novel methods and devices comprising magnetic particles for detecting or monitoring the coagulation state of a sample are provided.Type: GrantFiled: November 25, 2003Date of Patent: October 21, 2008Assignee: Inverness Medical Switzerland GmbHInventors: Nasr-Eddine Djennati, Jonathan Andrew Fuller, Robert Andrew Porter, David Scott