Abstract: A method of manipulating and/or investigating cellular bodies (9) is provided. The method comprises the steps of: providing a sample holder (3) comprising a holding space (5) for holding a fluid medium (11); providing a sample (7) comprising one or more cellular bodies (9) in a fluid medium (11) in the holding space (5); generating an acoustic wave in the holding space exerting a force (F) on the sample (7) in the holding space (5). The method further comprises providing the holding space (5) with a functionalised wall surface portion (17) to be contacted by the sample (7) and the sample (7) is in contact with the functionalised wall surface portion (17) during at least part of the step of application of the acoustic wave. A system and a sample holder (3) are also provided.

Abstract: This disclosure relates generally to detection of concentration of micro and nano particles in a fluid environment. An acoustic transmitter array is selective coated with polymer and receiver array is deployed at a random location in a conduit. The acoustic transmitter array on the conduit is insonified at a predetermined frequency to obtain a plurality of reflected signals. A plurality of key features pertinent to the conduit are extracted from the plurality of reflected signals to obtain a plurality of acoustic signals. A correlation model is configured by inputting, at least one feature associated with the pre-processed acoustic signals. A known concentrations of nano and micro particles are trained with an artificial neural network algorithm and calibrated with ground truth data. The location of the transmitter array and receiver array and the correlation model are finalized for detecting concentration of the particular micro and nano particles in the fluid environment.

Abstract: A magnetic sensor elastometry device (MSED) and a method to perform the whole blood thromboelastography assay. It contains key components, including sample cuvette, detecting head, rotating disc, optical motion detector, and etc; and measures viscoelasticity of whole blood samples. The device optically monitors the physical motion of the magnetically driven rotating disc immersed in the blood sample. The thromboelastograph is recorded by the optical motion detector reading high pulse counts through a gated time window passing through the rotating disc. The device also includes a microcontroller and its embedded firmware to perform the functions of driving the rotating magnetic disc, generating high-frequency pulses, controlling the data pulse time window, as well as handling the user's interface, data analysis, and maintaining communication with an external computer.

Abstract: A blood-sampling tube with a first fluid-receiving chamber for receiving a fluid is described, where the first fluid-receiving chamber may be connected to at least one fluid channel that has a sensor device for measuring at least one biochemical function of the fluid passed through the fluid channel, where the measured biochemical function of the fluid may be read out from the sensor device via a data interface of the blood-sampling tube.

Abstract: Methods and devices for cell or tissue culture are provided. One aspect provides a bioreactor having a gas permeable, closed-loop chamber for cell or tissue culture, and an oscillating means for moving the gas permeable, closed-loop chamber bidirectionally along an axis horizontal to an axis normal to the closed-loop chamber to force convection of cells and fluid in the gas permeable, closed-loop chamber. The bioreactor optionally includes a tissue engineering scaffold, an inlet means, an outlet means, and integrated sensors. Another aspect provides a bioreactor having a plurality of gas permeable, closed-loop chambers for cell or tissue culture. Methods of culturing cells and producing tissue constructs are also provided.

Abstract: The present application provides apparatus and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator. Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.

Abstract: A system and method for controlling a mixing system at a peak energy efficiency point, maximum response point or reduced sound generation point based on displacement, velocity, acceleration or jerk operating conditions.

Abstract: The invention relates to a method for determining haemostasis parameters by measuring vibration parameters of a resonator having a measuring surface which contacts a platelet containing sample fluid. The invention is characterized by the analysis of the characteristic of a vibration parameter over time, based on which the platelet function will then be assessed and a distinction will be made between the presence of an adhesion disorder or that of an aggregation disorder.

Abstract: The present application provides apparatus (300, 400) and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator (108, 109, 110). Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.

Abstract: A system and a method for monitoring a building material are disclosed. The system and the method provide a comprehensive monitoring throughout a manufacturing and an application process and provide a real time data feedback relating to the physical characteristics of the building material. The system and method include mixing a predetermined amount of taggant particles with a predetermined volume of at least one component of the building material in order to comprehensively monitor a mix ratio and segregation of the building material during manufacturing and application.

Abstract: A method and device for blood hemostasis analysis is disclosed. A blood sample is displaced to reach a resonant state. The resonant frequency of the blood sample is determined before, during and after a hemostasis process. The changes in the resonant frequency of the blood sample are indicative of the hemostasis characteristics of the blood sample.

Abstract: A method is provided for measuring the agglomerative state of asphaltenes in oil by applying an acoustic signal to the oil, detecting the scattered acoustic energy and using this detected signal to determine the relative particle size distribution of the asphaltene particles in the oil and/or their state of agglomeration. A method for controlling the agglomerative state of the asphaltenes which is based on the acoustic measurement technique is also provided.

Abstract: A sensor for sensing one or more properties of a vehicle fluid has a tuning fork resonator adapted to contact the fluid. The tuning fork resonator comprises two tines and is operable to oscillate so that the two tines move in opposite phase at a frequency of less than 1 MHz while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. In another aspect, a sensor includes a substrate and a flexural resonator on the substrate and adapted to contact the fluid. Circuitry for operation of the resonator is on the substrate. The resonator is adapted to receive an input signal and to oscillate while contacting the fluid to generate a resonator response indicative of one or more properties of the fluid. One suitable application for the invention is monitoring the condition of a vehicle engine oil.

Abstract: A sample retention apparatus for use in a device for measuring hemostasis. The device for measuring hemostasis may include a sample articulation apparatus including a guide shaft coupled for articulating motion to a drive motor, a sample carrier secured to and axially moveable along the guide shaft between a sample ready position, a sample testing position and a sample ejection position. The sample carrier therefore articulates in unison with the articulating motion of the guide shaft. A measuring apparatus may include a sensing column. The sample retention apparatus may include a sample cup defining a volume within which a sample may be disposed. The sample cup may be adapted to be operably positioned within an aperture formed within the sample carrier. The sample testing apparatus may also include a sample pin that is engageable with the sensing column. The sample pin may include a tip portion for extending into the sample cup.

Abstract: A method for analyzing a fluid contained within a machine, comprising the steps of providing a machine including a passage for containing a fluid; placing a sensor including a mechanical resonator in the passage; operating the resonator to have a portion thereof translate through the fluid; and monitoring the response of the resonator to the fluid in the passage. A preferred sensor includes a tuning fork resonator.

Abstract: A method is provided for measuring the agglomerative state of asphaltenes in oil by applying an acoustic signal to the oil, detecting the scattered acoustic energy and using this detected signal to determine the relative particle size distribution of the asphaltene particles in the oil and/or their state of agglomeration. A method for controlling the agglomerative state of the asphaltenes which is based on the acoustic measurement technique is also provided.

Abstract: A method and device for monitoring and controlling a pharmaceutical, chemical or food process, in which the biological activity and/or the bio-mass of micro-organisms in the process is monitored, and in which the state of the process is detected by monitoring viscosity and/or aggregate size and/or content of a dispersion of proteins, crystalline particles or fat droplets that are processed, respectively. The micro-organisms and/or bio-molecules produced in the process, and the proteins, crystals particles or fat droplets being processed are monitored by means of acoustic spectroscopy.

Abstract: A method and device for monitoring and controlling a pharmaceutical, chemical or food process, in which the biological activity and/or the bio-mass of micro-organisms in the process is monitored, and in which the state of the process is detected by monitoring viscosity and/or aggregate size and/or content of a dispersion of proteins, crystalline particles or fat droplets that are processed, respectively. The micro-organisms and/or bio-molecules produced in the process, and the proteins, crystals particles or fat droplets being processed are monitored by means of acoustic spectroscopy.

Abstract: The invention relates to a method for measuring the aggregation or agglutination of platelets, where a reaction mixture is mixed in a first reaction phase, and is mixed less vigorously or not at all in a second reaction phase following the first, and the measurement is preferably carried out in the second reaction phase.

Abstract: An apparatus for determining elasticity characteristics of a thin-film layer. The apparatus comprises a sensor element having a base magnetostrictive element at least one surface of which is at least partially coated with the thin-film layer. The thin-film layer may be of a variety of materials (having a synthetic and/or bio-component) in a state or form capable of being deposited, manually or otherwise, on the base element surface, such as by way of eye-dropper, melting, dripping, brushing, sputtering, spraying, etching, evaporation, dip-coating, laminating, etc. Among suitable thin-film layers for the sensor element of the invention are fluent bio-substances, thin-film deposits used in manufacturing processes, polymeric coatings, paint, an adhesive, and so on.

Abstract: A method and apparatus are provided for measuring hemostasis. The apparatus includes a torque sensing column having a torque sensing element and a drive ring disposed around a body of the column and in registration with the column so as to allow rotation of the drive ring around a longitudinal axis of the column. The apparatus further includes a first guide shaft rigidly secured to the drive ring, the guide shaft extending parallel to the longitudinal axis of the column and a cup holder movably attached to the guide shaft, allowing the cup holder to move parallel to the longitudinal axis of the column. The apparatus also includes a sample cup adapted to engage the cup holder on a outer surface and the torque sensing element of the torque sensing column on an inner surface.

Abstract: A method and apparatus are provided for measuring hemostasis. The apparatus includes a torque sensing column having a torque sensing element and a drive ring disposed around a body of the column and in registration with the column so as to allow rotation of the drive ring around a longitudinal axis of the column. The apparatus further includes a first guide shaft rigidly secured to the drive ring, the guide shaft extending parallel to the longitudinal axis of the column and a cup holder movably attached to the guide shaft, allowing the cup holder to move parallel to the longitudinal axis of the column. The apparatus also includes a sample cup adapted to engage the cup holder on a outer surface and the torque sensing element of the torque sensing column on an inner surface.

Abstract: A device and method for performing blood coagulation assays, particularly prothrombin times and activated partial thromboplastin times and other clotting parameters are disclosed. The device comprises a disposable strip (containing a sample inlet for sample delivery, a capillary channel for driving force, and a reaction chamber with an appropriate dry reagent for a specific assay) and a piezoelectric sensor. The device could also include a heating element for temperature control, and a magnetic bender. The magnetic bender is driven by an electromagnetic field generator and is attached onto a piezoelectric film in contact with the blood sample. Electric signal generated at the piezo film is characterized by its frequency and amplitude due to the movement of the attached metal film.

Abstract: A transducer for use in a viscoelastic analyzer of the type in which a mechanical probe member is immersed in a fluid or gel and driven to impart a desired oscillating motion to such fluid or gel whose viscoelastic properties are to be determined including means for restricting motion of the probe member of the transducer in all directions except the direction of desired oscillation motion.