Pipette Patents (Class 73/863.32)
  • Patent number: 11802853
    Abstract: A sample injection device is provided with a syringe for injecting a sample and an arrangement unit in which plural kinds of cleaning solvents are arranged to clean the syringe. The device is configured to be able to set a cleaning order of the syringe by the plural kinds of cleaning solvents.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: October 31, 2023
    Assignee: Shimadzu Corporation
    Inventors: Daiki Fukushima, Gregory King
  • Patent number: 11143668
    Abstract: A sampler device for gas chromatography includes a first unit that supports and moves a second, single instrument holding unit carrying at least two instruments with respective control plungers for taking/inserting samples to be analyzed, and a third unit that actuates the plungers simultaneously. The first unit is mounted on a base and moves the second and third units along horizontal and vertical directions and between a first and a second station, at least one of which is defined beyond the plan encumbrance of the base. A control unit automatically controls the movement of the first unit between the first station, with the third unit controlled by the control unit to simultaneously take the samples to be analyzed by the two instruments, and the second station, with the third unit controlled by the control unit to simultaneously insert the previously taken samples within two distinct injectors of a gas chromatograph.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: October 12, 2021
    Inventors: Massimiliano Saini Fasanotti, Roberto Taschini, Michela Barbara Gasperini
  • Patent number: 10758909
    Abstract: Pipette tip transfer devices allow for the pick-up of pipette tips from one location and the transfer the pipette tips to another location where the tips can then be released. The pipette transfer device includes a strip plate having a linear array of apertures positioned at a lower end of a frame. An actuator bracket is positioned within and mounted to the frame for reciprocal movements between lowered and raised positions, the actuator bracket carrying a linear array of pick-up pins dependently extending therefrom with each pin being received within a respective aperture of the strip plate.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: September 1, 2020
    Inventor: Thomas A. Hedglin
  • Patent number: 10654037
    Abstract: Disclosed herein are fluid handling devices that include integrated card and pipette tip devices, for use with multichannel liquid dispensing devices.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: May 19, 2020
    Assignee: BIOTIX, INC.
    Inventors: Arta Motadel, Phillip Hairfield, Peter Paul Blaszcak
  • Patent number: 9815053
    Abstract: A handheld multichannel air displacement pipette is modular in construction and includes compliant joints and molded plastic components in place of various machined metal, glass, and ceramic components found in traditional multichannel pipettes. These improvements are made without sacrificing performance in channel-to-channel consistency, accuracy, and precision. The multichannel pipette is inexpensive to manufacture, lightweight, reliable, and easy to assemble and service.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: November 14, 2017
    Assignee: Mettler-Toledo Rainin, LLC
    Inventors: Kent Gordon Moriarty, Christopher Brian Elginsmith, Brian Matthew Husmann
  • Patent number: 9221562
    Abstract: A container filler-inspecting apparatus includes a weight-measuring unit (14) that measures the weight of the container (1) filled with a filler (S1), a sample-extracting unit (12) that extracts a fixed amount of filler (S1) from a tip opening (2) of the container (1), and a sampling unit (13) that performs a sampling operation by wiping off the filler extracted by the sample-extracting unit (12) with a sampling paper sheet.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: December 29, 2015
    Assignee: MITSUBISHI HEAVY INDUSTRIES, LTD.
    Inventor: Toyokazu Uchida
  • Patent number: 9110046
    Abstract: A method of wasting tips in an automated processing module is disclosed, which includes at least three positions for holding sample racks. One of the positions is a tip waste rack position holding a tip waste rack, which includes tip receiving openings. Furthermore, it includes a SWAP rack holding mechanism for temporarily holding a sample rack. The method includes transferring the tip waste rack from the tip waste rack position to an adjacent sample rack position. Once the tip waste rack is placed in the adjacent sample rack position, the error pipette tip is discarded into one of the tip receiving openings of the tip waste rack. Following this, the tip waste rack is transferred back to the tip waste rack position. The sample rack temporarily placed in the SWAP rack holding mechanism is transferred from the SWAP rack holding mechanism to the adjacent sample rack position.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: August 18, 2015
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Andreas Gisler, Robert Huesler, Manu Kottuppallil Mathew, Thomi Merk
  • Patent number: 8920751
    Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: December 30, 2014
    Assignee: Life Technologies Corporation
    Inventors: Kristopher Barbee, Maximilian Carpino, Raymond Alan Wheeling, Nicholas Peter Bajka
  • Patent number: 8900527
    Abstract: A pipetting device is described comprising more than one pipetting unit, wherein said pipetting units are independently movable in Y and Z direction and comprise at least one module arranged in a staggered manner compared to the adjacent pipetting unit.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: December 2, 2014
    Assignee: Roche Molecular Systems Inc.
    Inventors: Alessandro D'Amore, Urs Knecht, Rolf Schneebeli
  • Patent number: 8899118
    Abstract: A pipette receiver and its variations are discussed for use in a multi-channel pipetting device typically used for medical, biological or biochemical research and development. There is a plurality of individual positive air displacement channels that are fitted to individual disposable pipette tips intended to pipette into associated “plates”. These “plates” may be Micro-titer plates, wells or vials each typically containing 96 wells in an 8×12 array usually spaced 9 mm apart. Other common plates contain 384 wells 4.5 mm apart in the same footprint of the 96, or a 1536 well plate fitting the same footprint.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: December 2, 2014
    Inventor: Dan Seguin
  • Patent number: 8900878
    Abstract: A pipetting device having a modular pipetting unit including a pipetting tip for pipetting of fluid samples and a pump conduit for transferring a negative or positive pressure to the pipetting tip is disclosed. The pipetting tip and a portion of the pump conduit adjoining the pipetting tip mutually define a fluid sample conduit for receiving the fluid samples. The modular pipetting unit is detachably attached to an automated positioning device for positioning the modular pipetting unit. A system and method for pipetting of fluid samples using such a pipetting device are also disclosed wherein pipetting of the fluid samples is performed in such a manner that each pipetted fluid sample volume is smaller than a volume of the fluid sample conduit.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: December 2, 2014
    Assignee: Roche Molecular Systems Inc.
    Inventors: Carsten Haack, Thomas Engel, Tobias Holenstein
  • Patent number: 8900526
    Abstract: The present invention relates to a device for manually metering liquids, for example a pipette or a metering button. The device comprises a joint forming a seal between a hollow cylinder and a piston housed inside the cylinder, the piston being moved vertically so as to suck in or expel the liquid. During the metering operation, the joint remains fixed with respect to the movement of the piston and comprises parts formed by portions having dedicated geometric and mechanical characteristics which make it possible to locally optimize the functions of sliding, sealing and fastening in the cylinder.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: December 2, 2014
    Assignee: Socorex Isba S.A.
    Inventor: Jean-Pierre Uldry
  • Patent number: 8877145
    Abstract: A device for generating a drop of a primary liquid is described, including: a reservoir fillable with the primary liquid, a pressure generation device for generating a hydraulic pressure on the primary liquid, at least one inlet channel for introducing a secondary fluid, and a channel having a flow cross-section transverse to a main flow direction, wherein the flow cross-section includes a main region and at least one sub-region extending from the main region, designed such that the primary liquid can be held in the main region by capillary forces, and the secondary fluid can be held in the sub-region by capillary forces, wherein the reservoir is fluidically connected to a first end of the channel via an output opening, and the at least one inlet channel is also fluidically connected to the channel, and wherein the pressure generation device is implemented to apply a hydraulic pressure to the primary liquid, whereby the same is moved along the channel and output at a second end of the channel as free-flying d
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: November 4, 2014
    Assignee: Albert-Ludwigs-Universitaet Freiburg
    Inventors: Tobias Metz, Peter Koltay
  • Patent number: 8877513
    Abstract: The pipetting method is directed to mounting and ejecting a disposable pipette tip. The pipetting system has one or more tip mounting shafts with an upper locking section and a lower sealing section. The upper locking section has outwardly extending lobes spaced around the mounting shaft and located above a stop member. The lower sealing section on the tip mounting shaft is located below the stop. As the mounting shaft is inserted into the collar of the disposable pipette, the collar distorts out of round and engages the lobes on the upper locking section of the tip mounting shaft. Contemporaneously, the lower sealing section of the mounting shaft seals against the barrel of the disposable pipette tip.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: November 4, 2014
    Assignee: Integra Biosciences AG
    Inventors: Gregory Mathus, Terrance Kelly, Richard Cote
  • Patent number: 8844385
    Abstract: The present invention relates to a device and method for separation of proteins and other biomolecules. A preferred use is for sample preparation of crude as well as pre-fractionated samples. In a preferred embodiment, the device of the present invention is a pipette tip having dual channels, one for inlet of sample and one for outlet. The outlet, but not the inlet, channel is provided with sample separation media for separation of a desired biomolecule from a sample. The flow through the sample separation media is unidirectional.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: September 30, 2014
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Nils Norrman, Ronnie Palmgren
  • Patent number: 8784012
    Abstract: Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: July 22, 2014
    Assignee: The General Hospital Corporation
    Inventors: Mehmet Toner, Dino DiCarlo, Jon F. Edd, Daniel Irimia
  • Patent number: 8726745
    Abstract: A device comprising a sampling probe configured to sample a fluid, and an ultrasound sensor coupled to the sampling probe and configured to transmit and receive ultrasound energy, the ultrasound sensor further configured to generate a first signal by receiving ultrasound energy reflected from a fluid surface of the fluid is provided. Fluid handling systems and methods of using the fluid handling devices and systems are also disclosed.
    Type: Grant
    Filed: November 26, 2007
    Date of Patent: May 20, 2014
    Assignee: Perkinelmer Health Sciences, Inc.
    Inventors: Karl R. Heinze, Lee Brady, William J. Austhof
  • Patent number: 8691148
    Abstract: The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: April 8, 2014
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hideyuki Yanami, Isao Yamazaki, Masaaki Hanawa, Hitoshi Otake
  • Patent number: 8685342
    Abstract: A device for receiving and dispensing liquids has a plurality of piston-cylinder units (1, 1?, 1?) which are respectively arranged on a piston plate (2) and a cylinder plate (3). The liquid is received and dispensed by displacing the pistons (1?) in the cylinders (1?) by changing the distance between the plates (2, 3), perpendicularly to the plate planes, by means of a drive mechanism (6) and a plate guiding system. The volume can be determined by an upper abutment (4) and a lower abutment (5), at least one of said abutments being regulatable by a regulating means (8). The device is suitable for handling precise volumes of a larger number of piston-cylinder units (1, 1?, 1?) in a technically simple manner.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: April 1, 2014
    Inventors: Bernd Steinbrenner, Roger Steinbrenner
  • Patent number: 8679421
    Abstract: A dispensing device and an analyzer capable of improving dispensing accuracy as well as improving jamming detection accuracy can be realized by having a short distance between a syringe and a suction tip. The dispensing device 10 includes an upper fixed unit 10A, a lower movable unit 10B which is connected to the upper fixed unit 10A, the movable unit being relatively movable with respect to the upper fixed unit 10A, and a Z-axis movement mechanism 55Z which moves the upper fixed unit to and fro. A syringe 4 and a plunger 13 are held by the upper fixed unit 10A. A tip nozzle 8 is attached to the lower movable unit 10B. An interior space of the syringe 4 and an interior space of the tip nozzle 8 are connected with each other by a connection tube 1 having flexibility.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: March 25, 2014
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Minoru Sano, Kazutoshi Onuki, Yoshiyuki Shoji, Isao Yamazaki
  • Patent number: 8663577
    Abstract: A spotter that includes a plurality of spotting heads, each of the plurality of spotting heads having a discharging portion at a tip portion, the plurality of spotting heads form an m×n array (m, n>1) with m spotting heads arranged lengthwise and n spotting heads arranged crosswise; and a pitch varying mechanism configured to vary an array pitch of the plurality of spotting heads arrayed in a lengthwise direction and an array pitch of the plurality of spotting heads arrayed in a crosswise direction.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: March 4, 2014
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Hiroshi Aoki, Masaki Torimura, Hiroaki Tao, Takashi Ikeda
  • Patent number: 8632735
    Abstract: A system for titrating liquids, with a syringe or tip, comprising a holding device and at least one tag and a metering equipment, comprising an additional holding device for holding the syringe or tip on the holding device, a reading device for reading the tag of the syringe or tip held by the additional holding device, a driving device having a motor, which is detachably coupled with a plunger of the syringe when the same is held by the additional holding device, or which is coupled with a plunger which is arranged in a cylinder which is coupled with the tip via a fluid conduit, when the same is held by the additional holding device, an operating device for operating the metering equipment and a control device, connected with the operating device, the reading device and the driving device, which controls the movement of the plunger depending of the tag of the inserted syringe or tip.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: January 21, 2014
    Assignee: Eppendorf AG
    Inventors: Heinz-Gerhard Kohn, Karl-Friedrich Andres
  • Patent number: 8623298
    Abstract: A syringe comprises a syringe body (12) having an axial inner recess (14) extending in the direction of a longitudinal axis of the syringe body (L), a piston (16) being guided in an axially moveable manner in said inner recess and contributing to the delimitation of a fluid-receiving volume together with a section of a wall (14a) radially delimiting the inner recess (14), and having a needle (24) that can be or is connected to a longitudinal end (12a) of the syringe body (12), wherein the needle (24) has a coupling geometry (28) at the longitudinal end (24a) thereof that is closer to the syringe body, wherein the needle (24) can be connected by said coupling geometry to a counter coupling geometry (30) of the syringe body (12), wherein the geometry composed of the coupling geometry (28) and counter coupling geometry (30) comprises an insertion section (32), which in the assembled state of the syringe (10) is received in a coupling recess (34) of the respectively other geometry, and wherein furthermore safety
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: January 7, 2014
    Assignee: Hamilton Bonaduz AG
    Inventor: Klaus Leckebusch
  • Patent number: 8609040
    Abstract: A system for automatically creating a denaturation curve is disclosed. In accordance with certain embodiments, a movement system including a unit having a plurality of cannulas is used. The cannulas are in fluid communication with a fluid system, which allows the cannulas to draw in and dispense fluid. A measurement system is included which draws fluid from a well into a detector to determine a characteristic of the fluid. A controller is used to control these systems and also to create a denaturation graph from the measured characteristics. In another embodiment, a plurality of formulations may be created using the system.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: December 17, 2013
    Assignee: AVIA Biosystems, LLC
    Inventors: Richard Brown, Burleigh Hutchins, Ernesto Freire
  • Patent number: 8602644
    Abstract: The fabrication and use of a multifunctional micropipette biological sensor for in-situ detection of temperature changes, ion conductivity, and light is described herein.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: December 10, 2013
    Assignee: University of North Texas
    Inventor: Tae-Youl Choi
  • Patent number: 8597595
    Abstract: Systems and apparatus for mixing, cooling, and distributing multiphase fluid mixtures within a reactor, wherein reactor internal apparatus of the present invention provides not only improved fluid mixing and distribution to each underlying catalyst bed surface, but also offers other advantages including: decreased mixing tray height; easier maintenance, assembly and disassembly; and decreased amounts of fabrication material. In an embodiment, fluid may be evenly distributed to a catalyst bed from a fluid distribution unit comprising a nozzle tray including a plurality of nozzles, wherein the nozzles include at least one liquid inlet disposed tangentially to an inner surface of the nozzle.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: December 3, 2013
    Assignee: Chevron U.S.A. Inc.
    Inventors: Zackory S. Akin, Craig R. Boyak, Abdenour Kemoun, Ralph Evan Killen, Krishniah Parimi, Steven Xuqi Song, Steven Alden Souers
  • Patent number: 8585984
    Abstract: A proboscis for use with a diagnostic instrument includes an elongated main body having a proximal end and an opposite distal end, and a lumen extending between the proximal and distal ends. The distal end includes an orifice which is in fluid communication with the lumen. A fluid splash guard is affixed to the main body at the distal end, and provides protection for the orifice and lumen from being clogged with a sample fluid.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: November 19, 2013
    Assignee: IDEXX Laboratories, Inc.
    Inventor: Michael Andrew Brookmire
  • Patent number: 8557197
    Abstract: The invention relates to a radial sliding seal component (10), particularly for use in metering devices, such as syringes, pipetting piston-cylinder arrangements, and the like, comprising a sealing component (12) working together with at least one pretensioning component (14), wherein the sealing component (12) comprises a sealing segment (16) extending in the axial direction and in the circumferential direction, preferably running in the circumferential direction, on which a sealing surface (18) facing in a first radial direction for sealing and sliding contact in at least the axial direction is formed on a working surface extending in the axial direction and in the circumferential direction, preferably running in the circumferential direction, and on which a pretensioning surface (20) extending in a second radial direction opposite to the first is formed for engaging with the pretensioning component (14) for transferring the radial pretensioning force, wherein the pretensioning component (14) comprises a sp
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: October 15, 2013
    Assignee: Hamilton Bonaduz AG
    Inventor: Klaus Leckebusch
  • Patent number: 8557200
    Abstract: An ergonomically designed pipette tip that can be securely mounted to a barrel of a pipetter yet is designed to substantially reduce the axial force necessary to install and eject the pipette tip from the pipetter thus reducing the injuries resulting in repetitive stress injury to the thumb and hand. The new ergonomic pipette tip incorporates a separate sealing member constructed from an elastomer that is coupled to the more rigid and chemically inert elongated tubular member that becomes the receptacle for transferring the fluid sample aspirated by the pipetter. The new elastomeric sealing member allows for greater sealing capability or squeeze between the pipetter barrel and the new pipette tip while lowering the coefficient of friction between the mating parts, thus decreasing the axial ejection forces require to overcome the breakaway friction between the new ergonomic pipette tip and the pipetter.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: October 15, 2013
    Inventor: James C. Smith
  • Patent number: 8529848
    Abstract: A system for preparing biological sample contains a body including a proximal side and a distal side, a plurality of mandrels, a plurality of resilient elements, a plurality of fluid dispensers, and one or more samples. The mandrels are moveably positioned within the body, where each resilient element engages a respective one of the mandrels. Each of the fluid dispensers is configured to engage a distal end of a corresponding one of the mandrels. Each sample comprises a solution containing one or more nucleic acid sequences contained within at least one of the fluid dispensers.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: September 10, 2013
    Inventors: Ronald Danehy, Jorge Fonseca, Jayanthi Prasad
  • Patent number: 8524170
    Abstract: A sealing pipette tip includes features to seal the tip directly against the piston in an air displacement pipette, avoiding the need for a piston seal within the pipette. This configuration reduces potential points of failure, allows the pipette-tip interface to be optimized, and improves liquid handling characteristics of the pipette.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: September 3, 2013
    Assignee: Rainin Instrument, LLC
    Inventor: James S. Petrek
  • Patent number: 8475741
    Abstract: Provided is a droplet discharging device that can precisely dispense large flow rate of droplets and small flow rate of droplets selectively. The droplet discharging device according to the present invention includes a pneumatic discharger for discharging a droplet having a first flow rate, and an electronic pipette for discharging or sucking a droplet having a second flow rate equal to or smaller than the first flow rate. The pneumatic discharger includes, i) a storage chamber for storing a liquid, ii) an air tank connected to the storage chamber through a first air pipe and supplying compressed air to the storage chamber to push the liquid of the storage chamber outside, and iii) a first nozzle connected to the storage chamber through the liquid pipe and receiving the liquid pushed out of the storage chamber to discharge droplets.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: July 2, 2013
    Assignee: Postech Academy-Industry Foundation
    Inventors: Seongjin Cho, Geunbae Lim, Intae Kim
  • Patent number: 8470260
    Abstract: A light beam guided liquid delivery device for tracking the placement of a sample by a liquid delivery device into a receptacle like a milliliter or microliter scale tube, or a microtiter plate, includes a liquid delivery device and a light beam generator. The light beam generator may be positioned on the outside or inside of the liquid delivery device. The light beam generator may be adapted to shoot a light beam below the tip of the liquid delivery device, whereby, a user may track the placement of the tip of the liquid delivery device via the light beam.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: June 25, 2013
    Assignee: University of North Carolina at Charlotte
    Inventors: David Andrew Carr, Jennifer W. Weller
  • Patent number: 8420027
    Abstract: A dosing device for liquids, with a distributor rail and a plurality of dosing units for the liquid that are hydraulically connected to the replaceable distributor rail. Each dosing unit has a valve unit, preferably a suction valve, a discharge valve and a discharge cannula. A piston-cylinder unit is detachably arranged on each valve unit for drawing in and measured discharging of the liquid. Each valve unit has a hydraulic connection element for detachable hydraulic connection to the distributor rail. The distributor rail has an elongate fluid supply line, a supply connection for the liquid being provided on an end of the distributor rail and dosing unit connections being distributed laterally along the length of the rail. Each of the dosing unit connections are detachably coupled to the hydraulic connection elements of the dosing units. The distributor rail is a replaceable part made of a preferably recyclable, injection-moldable plastic.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: April 16, 2013
    Assignee: Brand GmbH + Co KG
    Inventors: Peter H. Mahler, Thomas Stricker, Harry Siebert, Eberhard Albrecht
  • Patent number: 8420014
    Abstract: The present invention is directed to a liquid droplet monitoring and measuring apparatus for use with a liquid dispensing system of the type comprising a nozzle having a liquid dispensing tip and means for delivering the dispensed liquid through the nozzle onto a receiving substrate. Further, the invention provides a method of monitoring and measuring the volume of a liquid droplet as it is being dispensed from a liquid dispensing system comprising a nozzle having a dispensing tip. The main use for the invention is in the fields of drug discovery, genomics, medical diagnostics and other life science-related applications. The invention could also be used in other areas for example in the food industry, cosmetic industry or the chemical industry.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: April 16, 2013
    Assignee: Allegro Research Limited
    Inventors: Igor V. Shvets, Cecilia Franken, Tomasz P. Zawada
  • Patent number: 8413528
    Abstract: The present invention relates to a device and method for separation of proteins and other biomolecules. A preferred use is for sample preparation of crude as well as pre-fractionated samples. In a preferred embodiment, the device of the present invention is a pipette tip having dual channels, one for inlet of sample and one for outlet. The outlet, but not the inlet, channel is provided with sample separation media for separation of a desired biomolecule from a sample. The flow through the sample separation media is unidirectional.
    Type: Grant
    Filed: May 20, 2008
    Date of Patent: April 9, 2013
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Nils Norrman, Ronnie Palmgren
  • Patent number: 8372354
    Abstract: Systems and apparatus for mixing, cooling, and distributing multiphase fluid mixtures within a reactor, wherein reactor internal apparatus of the present invention provides not only improved fluid mixing and distribution to each underlying catalyst bed surface, but also offers other advantages including: decreased mixing tray height; easier maintenance, assembly and disassembly; and decreased amounts of fabrication material. In an embodiment, fluid may be evenly distributed to a catalyst bed from a fluid distribution unit comprising a nozzle tray including a plurality of nozzles, wherein the nozzles include at least one liquid inlet disposed tangentially to an inner surface of the nozzle.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: February 12, 2013
    Assignee: Chevron U.S.A. Inc.
    Inventors: Ralph E. Killen, Craig Boyak, Steven X. Song, Abdenour Kemoun, Steve Souers, Krishniah Parimi, Zackory Akin
  • Patent number: 8372356
    Abstract: A manually directed, multi-channel electronic pipetting system is designed to transfer liquids from a standard multi-well plate, deep-well plate or reservoir into another multi-well plate. The preferred pipetting head includes an array of 96-tip fittings. A deck with at least one but preferably two or more wellplate nesting receptacles holds one or more multi-well plates or reagent reservoirs for access by an array of disposable pipette tips mounted to the pipetting head. The electronic motion control system includes a control handle that is mounted to a load cell, the carriage for the pipetting head and is held in the palm of the user. In use, the user grasps the control handle and operates the system in a manner similar to one using a handheld electronic pipettor.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: February 12, 2013
    Assignee: Integra Biosciences Corp.
    Inventors: Julian Warhurst, Gary Nelson, Richard Cote
  • Patent number: 8367022
    Abstract: A manually directed, electronic multi-channel pipettor uses servo controlled motors to drive a carriage and pipetting head in response to a user's manipulation of a control handle. The pipetting head include an array of tip fittings, e.g. 96. The system includes a check processor to avoid unintended motion in case of system faults or crashes. The system requires substantial force to attach the array of tips, and therefore includes controls that require both of the user's hands be occupied during the tip attachment process.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: February 5, 2013
    Assignee: Integra Biosciences Corp.
    Inventors: Julian Warhurst, Richard Cote
  • Patent number: 8354079
    Abstract: The invention relates to a sealing assembly for a metering device, in particular a multi-channel metering device. The sealing assembly serves to seal pipette tips with respect to the metering device. A multi-channel metering device comprises a multiplicity of openings arranged in one plane. A sealing plate with holes in the grid of the openings abuts this plane. Each pipette tip is provided with an annular collar which has an abutting face and is pressed against the sealing plate by force closure so as to enclose one hole.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: January 15, 2013
    Assignee: CyBio AG
    Inventor: Uwe Naumann
  • Patent number: 8343438
    Abstract: An ergonomically designed pipette tip that can be securely mounted to a barrel of a pipetter yet is designed to substantially reduce the axial force necessary to install and eject the pipette tip from the pipetter. An improved pipette tip that includes the addition of an elastomeric material and cooperative means for insuring uniform interference and depth of penetration of the pipetter barrel as successive barrels are inserted and ejected. Also disclosed is an improved multiple-tip configuration with similar features that can be mounted to multiple barrels of a multi-pipetter as one tip instead of 8 or 12 individual tips. The addition of the elastomeric material allows for better sealing and eliminates alignment issues, high installation and ejection requirements while reducing the hand and thumb forces that due to repeated use will sometimes result in repetitive stress injury.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: January 1, 2013
    Inventor: James C. Smith
  • Patent number: 8327725
    Abstract: There is provided a sample collection container, a sample collection apparatus, and a sample collection method used in a supercritical fluid system capable of collecting a multi-constituent sample contained in a supercritical fluid at low cost and high collection efficiency. The pressure of a supercritical fluid containing a sample is reduced to a pressure close to the atmospheric pressure, and the depressurized supercritical fluid is forced to undergo adiabatic expansion to form gas-phase CO2 containing a liquid component in the form of aerosol. The gas-phase CO2 is fractionated for each constituent of the contained sample, transferred to a probe 60 of Liquid Handler, and dispensed into a large number of collection vials 300 under the atmospheric pressure, each of which is provided with a vial cap 100.
    Type: Grant
    Filed: September 26, 2009
    Date of Patent: December 11, 2012
    Assignee: JASCO Corporation
    Inventor: Takeshi Kanomata
  • Patent number: 8318108
    Abstract: This invention relates to plunger operated liquid dispensers, such as hand held pipettors, which are used to portion liquids. Specifically the invention relates to a reliable removal of a liquid from the liquid dispenser. According to the invention the plunger of the liquid dispenser is arranged into a speeded up movement while removing the liquid. This change in speed is preferably sudden.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: November 27, 2012
    Assignee: Sartorius Biohit Liquid Handling Oy
    Inventors: Osmo Suovaniemi, Pertti Ekholm
  • Patent number: 8273307
    Abstract: The invention relates to a microdispenser (1) for dispensing a liquid sample in a dispensing device, with a sample container (2) for receiving the liquid sample, and with a nozzle (7) for dispensing the sample located in the sample container (2). The microdispenser (1) with the filled sample container (2) can in this case be stored independently of and fluidically separately from the dispensing device, without the sample escaping from the sample container (2) during storage.
    Type: Grant
    Filed: May 29, 2006
    Date of Patent: September 25, 2012
    Assignee: Scienion AG
    Inventors: Holger Eickhoff, Christian Wurzel
  • Patent number: 8268261
    Abstract: A pipette core member is used in a pipette for sampling a sample. This pipette core member includes: a pump body including a reservoir communicated with one suction/discharge port of an electroosmotic flow pump, the electroosmotic flow pump and the reservoir being integrally formed; and a capillary connected to the electroosmotic flow pump and communicated with the other suction/discharge port of the electroosmotic flow pump. The capillary is secured to the pump body.
    Type: Grant
    Filed: November 22, 2007
    Date of Patent: September 18, 2012
    Assignees: Altair Corporation, Nano Fusion Technologies, Inc., Kazusa DNA Research Institute
    Inventors: Mamoru Hirafuji, Ichiro Tominaga, Shigeto Eda, Ichiro Yanagisawa, Osamu Ohara
  • Patent number: 8245586
    Abstract: For aspiration and dispensation of a metering fluid, a pipetting apparatus comprises a work fluid which differs from the former, the work fluid being accommodated in a work space with a variable volume which extends along a channel axis and, with reference to the latter, is formed by a piston-cylinder system at least along an axial section of the channel axis, having a cylinder which delimits the work space along a cylinder section in the radial direction and a piston which delimits the work space in a first axial direction, the cylinder and the piston being arranged so that they can move with respect to each other such that the piston-cylinder system has an axial longitudinal end region for metering, which is open for aspiration and dispensation, and an axial longitudinal end region for work which is closed by the piston, the piston being designed as an outer piston and surrounding the cylinder on the outside in the longitudinal end region for work of the piston-cylinder system.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: August 21, 2012
    Assignee: Hamilton Bonaduz AG
    Inventors: Armin Panzer, Patrick Schelling
  • Patent number: 8236256
    Abstract: A device for automatically aspirating and/or dispensing liquids with precision, comprising a housing having an opening at a lower end with a fixed tip protruding out of the lower end; an interchangeable cartridge disposed inside the housing, the cartridge having a holding frame and a spool of tubing provided in the frame such that one end of the tubing is aligned with the tip; and an actuator enabled to automatically extrude part of the tubing so as to accommodate a preselected volume of liquid, aspirate and/or dispense the liquid through the extruded tubing, and disconnect the extruded tubing from the device.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: August 7, 2012
    Inventor: Thomas Friedlander
  • Patent number: 8201466
    Abstract: A device for use in a multi-channel pipetting system is provided. The device includes a body, a plurality of modules mounted to the body, a plurality of pistons mounted to a piston holder for simultaneous movement of the plurality of pistons in a first direction, and a guidance assembly. Each module includes an orifice connecting to an intake chamber. A piston extends into the intake chamber for movement in the first direction. The guidance assembly includes a first rotating element, a second rotating element, a shaft connecting the first rotating element to the second rotating element, and a first track and a second track extending parallel to the first direction. The shaft extends in a second direction orthogonal to the first direction. The first rotating element is mounted to roll along the first track, and the second rotating element is mounted to roll along the second track simultaneously with the plurality of pistons.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: June 19, 2012
    Assignee: Gilson S. A. S.
    Inventor: Bernard Roussel
  • Patent number: 8202495
    Abstract: An ergonomically designed pipette tip that can be securely mounted to a barrel of a pipetter yet is designed to substantially reduce the axial force necessary to install and eject the pipette tip from the pipetter thus reducing the injuries resulting in repetitive stress injury to the thumb and hand. The new ergonomic pipette tip incorporates a separate sealing member constructed from an elastomer that is coupled to the more rigid and chemically inert elongated tubular member that becomes the receptacle for transferring the fluid sample aspirated by the pipetter. The new elastomeric sealing member allows for greater sealing capability or squeeze between the pipetter barrel and the new pipette tip while lowering the coefficient of friction between the mating parts, thus decreasing the axial ejection forces require to overcome the breakaway friction between the new ergonomic pipette tip and the pipetter.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: June 19, 2012
    Inventor: James C. Smith
  • Patent number: 8197754
    Abstract: The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: June 12, 2012
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hideyuki Yanami, Isao Yamazaki, Masaaki Hanawa, Hitoshi Otake