With Sample Supply To Analyzer Patents (Class 73/864.21)
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Patent number: 12025631Abstract: An automatic sample introduction device includes a needle, a sample loop, a mixer and a suction injection switch mechanism. The mixer is provided between the needle and the sample loop. The suction injection switch mechanism sequentially sucks first and second fluids into the sample loop through the needle and the mixer and injects the first and second fluids held in the sample loop into a predetermined injection port. A chromatograph includes the automatic sample introduction device having the above-mentioned configuration, an analysis column and a detector. The analysis column is connected to the injection port of the automatic sample introduction device, and the detector is connected to the analysis column.Type: GrantFiled: May 28, 2018Date of Patent: July 2, 2024Assignee: SHIMADZU CORPORATIONInventors: Takashi Inoue, Makoto Ogaito
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Patent number: 11982599Abstract: A sample collector for extracting a particulate material specimen from a container includes a needle for puncturing the container and capturing an amount of specimen inside a chamber in mechanical communication with the needle. A spring-loaded continuously and progressively retractable and extendable sheath protects the tip of the needle from inadvertent contact with a human user and encloses the puncture site on the container during collection. A preliminary screening test for illicit substances can be conducted on part of the collected specimen to determine whether the container should be confiscated. Part of the collected specimen can be preserved for later confirmatory testing.Type: GrantFiled: August 30, 2020Date of Patent: May 14, 2024Inventors: Roger J. Malcolm, Stuart Hersey
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Patent number: 11965863Abstract: A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.Type: GrantFiled: November 29, 2022Date of Patent: April 23, 2024Assignee: Waters Technologies CorporationInventors: Sylvain Gilles Cormier, Joseph D. Antocci, Francis Patrick Tracey, Charles H. Phoebe, Jr.
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Patent number: 11921091Abstract: A sample injection device is used to inject a sample into a chromatograph and includes a flow vial, a sampling needle and one or more than one sample dissolution devices. A sample is supplied to the flow vial. The sample that has been supplied to the flow vial is collected by the sampling needle and injected into the chromatograph. At least one of ultrasonic waves, an electric field and a magnetic field is used, so that dissolution of a sample to be injected into the chromatograph is promoted by one or more than one sample dissolution devices.Type: GrantFiled: February 28, 2020Date of Patent: March 5, 2024Assignee: Shimadzu CorporationInventors: Yusuke Nagai, Yosuke Iwata
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Patent number: 11630392Abstract: In a chemical liquid container replacement device D2 configured to replace a chemical liquid container 50, multiple chemical liquid containers 50 respectively connected to base end sides of chemical liquid supply paths configured to supply chemical liquids, and a nozzle attachment/detachment device 61 is configured to attach/detach the base end side of the chemical liquid supply path with respect to the chemical liquid container 50 of a container arrangement section 60. A loading/unloading port 62 loads a new chemical liquid container 50 for performing a liquid process on a substrate W and unloads a completely used chemical liquid container 50. A container transfer device 7 unloads the completely used chemical liquid container 50 from the container arrangement section 60 toward the loading/unloading port 62 and loads the new chemical liquid containers 50 from the loading/unloading port 62 toward the container arrangement section 60.Type: GrantFiled: October 29, 2019Date of Patent: April 18, 2023Assignee: TOKYO ELECTRON LIMITEDInventor: Tsunenaga Nakashima
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Patent number: 11614428Abstract: A method for collecting a sample for sample analysis includes drawing a first portion of the sample into a sample storage portion of a chromatography system while the chromatography system is in a first configuration. The method further comprising switching the chromatography system to a second configuration; sealing an end of a sample pick-up needle and draining a portion of a liquid from the second tubing; switching the chromatography system to a third configuration; drawing a second portion of the sample into the sample storage portion of the chromatography system; switching the chromatography system to an injection configuration; and fluidly connecting the sample storage portion to the chromatography column and supplying the first portion of the sample and the second portion of the sample from the sample storage portion to the chromatography column.Type: GrantFiled: April 6, 2020Date of Patent: March 28, 2023Assignee: Dionex Softron GmbHInventor: Christoph Hollnagel
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Patent number: 11161065Abstract: A liquid chromatography system, includes a fluidic flow path, a chromatography column located in the fluidic flow path, a filtration device located in the fluidic flow path before the chromatography column, the filtration device including a housing having a fluidic inlet, a fluidic outlet, wherein at least a portion of the fluidic flow path is located between the fluidic inlet and the fluidic outlet and at least one filter disposed in the portion of the fluidic flow path, wherein the at least one filter is made of a micromachined material. Liquid chromatography filtration methods are further disclosed.Type: GrantFiled: April 5, 2019Date of Patent: November 2, 2021Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Kevin D. Wyndham, Moon Chul Jung, Abhijit Tarafder, Wade P. Leveille, Sr.
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Patent number: 11112390Abstract: An online sample manager of a liquid chromatography system includes a fluidic tee having a first inlet port, a second inlet port, and an outlet port. A diluent pump moves diluent from a diluent source to the first inlet port of the fluidic tee. A valve has a fluidic intake port connected to a process source for acquiring a process sample therefrom. A pumping system moves the acquired process sample from the valve into the second inlet port of the fluidic tee where the process sample merges with the diluent arriving at the first inlet port to produce a diluted process sample that flows out from the outlet port of the fluidic tee.Type: GrantFiled: February 10, 2011Date of Patent: September 7, 2021Assignee: WATERS TECHNOLOGIES CORPORATIONInventor: Sylvain Cormier
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Patent number: 10908173Abstract: A sample measurement apparatus according to one or more embodiments includes a processing unit that aspirates a sample inside a sample container and measures the sample; a transfer unit that includes a holder to hold the sample container, and that picks up the sample container from a rack capable of storing the sample containers at storage positions on a row and transfers the sample container to the processing unit; and a detection unit that is attached to the holder and is movable integrally with the holder, and that detects whether or not there is the sample container at each of the storage positions.Type: GrantFiled: May 11, 2017Date of Patent: February 2, 2021Assignee: SYSMEX CORPORATIONInventors: Mitsuo Yamasaki, Tomonori Okazaki, Noriyuki Nakanishi, Takahiro Saino
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Patent number: 10408729Abstract: A nephelometric turbidimeter for measuring a turbidity of a liquid sample in a transparent sample cuvette. The nephelometric turbidimeter includes a cuvette chamber housing with a cuvette chamber having the transparent sample cuvette arranged therein, and a drying apparatus. The drying apparatus includes a cuvette chamber inlet opening which vents the cuvette chamber, a cuvette chamber outlet opening which de-vents the cuvette chamber, an air circulator which circulates air from the cuvette chamber outlet opening to the cuvette chamber inlet opening, and a drying body. The drying body is provided as a container of a hygroscopic agent defined by a drying substance which is arranged in a drying path between the cuvette chamber outlet opening and the cuvette chamber inlet opening so that air flows through the drying body.Type: GrantFiled: November 19, 2015Date of Patent: September 10, 2019Assignee: HACH LANGE GMBHInventors: Manfred Battefeld, Hans-Joachim Kumpch, Axel Leyer, Bas De Heij, Clemens Hanschke, Michael Kueppers, Andreas Jonak, Elk Fricke, Heinz Rudde, Markus Hahn, Markus Lenhard, Rolf Uthemann, Sebastian Minke, Andreas Golitz, Bernd Gassner, Frank Steinhauer, Lothar Heidemanns, Andreas Mitreiter
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Patent number: 9810604Abstract: Provided is a sample injection device for flow-type analysis including a cylindrical needle (27) which penetrates through an upper wall and a lower wall of a sample injection portion (22) of a carrier-liquid channel through ring-like sealing members (25, 26). The needle (27) includes an inner hole (41) which is closed on a side of a lower end of the needle (27) and open on an outer peripheral surface as a horizontal hole (42). The needle moving unit (44) induces the needle (27) to move downward so that the horizontal hole (42) faces an inside of a sample vessel (40) to draw the sample to the inside of the needle (27). Then the moving unit (44) induces the needle (27) to move upward so that the horizontal hole (42) faces an inside of the sample injection portion (22) to inject the sample in the inside of the needle (27). At an intermediate position, washing liquid is discharged from the horizontal hole (42) of the needle (27), and the washing liquid is recovered via a discharge path (15).Type: GrantFiled: March 27, 2014Date of Patent: November 7, 2017Assignee: Sekisui Medical Co., Ltd.Inventors: Takuya Yotani, Takayuki Oka, Hideki Muraki
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Patent number: 9523699Abstract: An apparatus and methods for dispensing sample holders for use in an automated sample analyzer is disclosed herein. The apparatus for dispensing sample holders includes a rotating carousel for housing stack of sample holders. Stacks of sample holders from the rotating carousel are fed into a chute where sample holders contact a set of rotating members having helical threads thereon. The helically threaded rotating members engage the sample containers and separate each sample holder from the remaining sample holders in the stack by rotation of the helically threaded rotating members. The sample holder can then be transferred for use in an automated sample analyzer.Type: GrantFiled: June 21, 2013Date of Patent: December 20, 2016Assignee: Biokit, S.A.Inventors: Mark Talmer, Paul C. Dahlstrom
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Patent number: 9480428Abstract: This assembly includes: a transportable support; a strip attached to the support and including an application area for applying the sample and at least one reagent required for the analysis; a piercing member for piercing the skin and a blood vessel; and a container for collecting, storing and returning the sample of human or animal blood. The piercing member is inserted into the container. The tip is connected to the support. The container is connected to the support in a removable manner between a storage configuration and a use configuration, in which the container is placed close to the application area.Type: GrantFiled: October 3, 2012Date of Patent: November 1, 2016Assignee: BIOMERIEUXInventors: Bruno Colin, Cécile Paris, Michel Goudard
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Patent number: 9352313Abstract: A device used to test the analyte in a liquid sample includes a test chamber used to contain test components, a collecting chamber used to collect liquid sample, a piston chamber between the test chamber and the collecting chamber, a piston and an opening. The piston has two positions in the piston chamber, i.e. the first position and the second position. When the piston is in the first position, liquid can flow between the piston cavity and the collecting chamber through the opening; during the piston's move from the first position to the second position, the opening is sealed by the piston, wherein while the opening is sealed by the piston, the liquid is released from the piston cavity to the test chamber. This device can help to precisely quantify a liquid sample, with higher accuracy in the tests and higher comfort during the operations.Type: GrantFiled: June 27, 2014Date of Patent: May 31, 2016Assignee: Hangzhou Ditu Technology Co., Ltd.Inventor: Jielin Dai
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Patent number: 9261524Abstract: The invention relates to a positioning device for a sample distribution apparatus, such as a pipetting apparatus, providing a first part, at which a sample transport device can be arranged, a second part, at which a sample holder can be arranged, wherein the first part and the second part are arranged moveable in relation to each other between a first position and an adjusted target position of the first and second part for performing a positioning motion, such that a sample can be conveyed towards the sample holder by the positioning motion. The automated change of the target position assists for achieving an error-free positioning and sample distribution. A corresponding method for the automatical change of a position of a first part relative to a second part using the positioning device, is also claimed.Type: GrantFiled: January 26, 2011Date of Patent: February 16, 2016Assignee: Eppendorf AGInventors: Boris Von Beichmann, Uwe Mellenthin, Rainer Disselbach
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Patent number: 9163618Abstract: An apparatus, system, and process of converting a standard, high performance liquid chromatography (HPLC) flow path to a flow path suitable for supercritical fluid chromatography (SFC) are described. This reversible technique is applied to a variety of flow configurations including binary, high pressure solvent mixing systems and quaternary, low pressure solvent mixing systems than can be conventionally operated or automated. The technique is generally applied to the fields of supercritical fluid chromatography and high pressure liquid chromatography, but users skilled in the art will find utility for any flow system where pressurization components must be periodically applied to and removed from both ends of a flow stream in an automated manner.Type: GrantFiled: June 22, 2012Date of Patent: October 20, 2015Assignee: Agilent Technologies, Inc.Inventors: Edwin E. Wikfors, Kimber D. Fogelman, Terry A. Berger
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Patent number: 9028756Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.Type: GrantFiled: August 30, 2013Date of Patent: May 12, 2015Assignee: Sysmex CorporationInventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
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Patent number: 9016146Abstract: A method for injecting a sample being analyzed into the injection tube of a measurement cell which includes an injection opening and a punch. The sample is introduced into a syringe including a plunger, and the syringe is closed by an expendable cap having a male end closed by a strikable closure. The syringe is secured to the support of an injection station aligned with the injection opening, and a pusher displaces the syringe by vertical translation from an upper position to a lower position with the punch perforating the closure of the cap to inject the sample from the syringe into the injection tube.Type: GrantFiled: June 30, 2011Date of Patent: April 28, 2015Assignee: Instrumentation Scientifique de LaboratoireInventors: Cleris Hervé, Marie Patrick
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Patent number: 8850905Abstract: An automated sampler for sampling contaminants that are dissolved in water. An empty, sealed first vial is placed at a first sampling station with a dual-port needle, and a mechanical syringe pump displaces a programmable volume of gas from the first vial. A sealed second vial having a field sample of water with dissolved contaminants, typically without a headspace region, is placed at a second sampling station, with a dual-port needle. The syringe pump extracts an aqueous volume from the second vial, then transfers the aqueous volume into the first vial. This is all done without exposing the field sample to any external gasses or other compounds, and without opening the seal of the field sample to atmosphere. The sample in the first vial is heated, and an aliquot of headspace from the first vial is then injected into an analyzer device for identification and quantification.Type: GrantFiled: March 8, 2012Date of Patent: October 7, 2014Assignee: EST Analytical, Inc.Inventor: Douglas A. Meece
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Patent number: 8783121Abstract: A blood collecting apparatus includes a cleaning solution piping. The cleaning solution piping feeds into a flow path a heparin solution which is a liquid other than blood to be measured, in order to return the blood present in the flow path to a catheter disposed upstream of a blood inlet of the flow path. Thus, the blood having flowed into the flow path in an amount more than is necessary for blood collection, which corresponds to a portion returned to the upstream catheter of the blood to be measured present in the flow path, can be used in a next blood collection. As a result, the amount of collected blood can be reduced. The liquid to be measured is separated apart by means of a gas, and the flow path is cleaned in a way to leave no impurities in the flow path, thereby preventing impurities from mixing into the liquid to be measured.Type: GrantFiled: March 19, 2009Date of Patent: July 22, 2014Assignees: Shumadzu Corporation, National Institute of Radiological SciencesInventors: Nobuya Hashizume, Keishi Kitamura, Takahiro Nishimoto, Yuichi Kimura, Chie Seki, Iwao Kanno
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Patent number: 8731709Abstract: A sample processing apparatus comprising: a plurality of sample processing units, each processing a sample contained in a sample container; a transport apparatus that transports a sample rack holding a sample container to at least any one of the plurality of sample processing units; a rack feeding section that receives a sample rack and feeds the received sample rack to a transport line of the transport apparatus; and a controller configured to instruct the transport apparatus, according to a quantity of sample racks received by the rack feeding section, to transport a sample rack fed by the rack feeding section to either (a) a sample processing unit which can accept a subsequent sample rack more rapidly than any other sample processing unit or (b) a sample processing unit having a lower processing load than any other sample processing unit. Also, a sample rack transporting method.Type: GrantFiled: December 27, 2010Date of Patent: May 20, 2014Assignee: Sysmex CorporationInventors: Hiroo Tatsutani, Tomoyuki Asahara, Nobuyoshi Yamakawa
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Patent number: 8701508Abstract: An analyzer comprising: a first measurement unit for measuring samples; a second measurement unit; and a transportation device operable to transport a plurality of sample containers accommodated in a first rack and containing samples and a plurality of sample containers accommodated in a second rack and containing samples, to the first measurement unit and the second measurement unit, wherein the transportation device comprises a first transportation section operable to transport the plurality of sample containers on the first rack to the first measurement unit and the second measurement unit by transporting the first rack on a transport path, and a second transportation section operable to transport the plurality of sample containers on the second rack to the first measurement unit and the second measurement unit by transporting the second rack on the transport path independently from movement of the first rack, is disclosed. A transportation device is also disclosed.Type: GrantFiled: December 17, 2012Date of Patent: April 22, 2014Assignee: Sysmex CorporationInventors: Yuichi Hamada, Kunio Ueno
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Patent number: 8691148Abstract: The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.Type: GrantFiled: May 17, 2012Date of Patent: April 8, 2014Assignee: Hitachi High-Technologies CorporationInventors: Hideyuki Yanami, Isao Yamazaki, Masaaki Hanawa, Hitoshi Otake
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Patent number: 8683879Abstract: A sample injecting device is provided for reducing carryover. The sample injecting device includes the following mode: a needle is set at a low descending speed when sample is injected into an injection port in a total-volume injection manner by the sample injecting device. When the needle is in contact with the injection port, the needle is set at a low speed, thereby increasing the accuracy of the position of the needle relative to an injection hole and decreasing friction between the needle and the injection hole. Contaminants present in the injection hole are prevented from easily flowing from the injection hole into an analyzing flow path, so as to achieve an excellent low carryover.Type: GrantFiled: February 17, 2011Date of Patent: April 1, 2014Assignee: Shimadzu CorporationInventor: Masami Tomita
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Patent number: 8679421Abstract: A dispensing device and an analyzer capable of improving dispensing accuracy as well as improving jamming detection accuracy can be realized by having a short distance between a syringe and a suction tip. The dispensing device 10 includes an upper fixed unit 10A, a lower movable unit 10B which is connected to the upper fixed unit 10A, the movable unit being relatively movable with respect to the upper fixed unit 10A, and a Z-axis movement mechanism 55Z which moves the upper fixed unit to and fro. A syringe 4 and a plunger 13 are held by the upper fixed unit 10A. A tip nozzle 8 is attached to the lower movable unit 10B. An interior space of the syringe 4 and an interior space of the tip nozzle 8 are connected with each other by a connection tube 1 having flexibility.Type: GrantFiled: July 15, 2010Date of Patent: March 25, 2014Assignee: Hitachi High-Technologies CorporationInventors: Minoru Sano, Kazutoshi Onuki, Yoshiyuki Shoji, Isao Yamazaki
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Patent number: 8573073Abstract: A method and a device for transferring a microscopic, isolated sample, particularly a membrane-supported micro-dissected specimen, from an object table to an analysis arrangement, with a suction apparatus comprising a nano-suction means with a suction tube and a terminal membrane and a vacuum/overpressure unit which can be coupled to the nano-suction means for sucking or blowing the sample onto or from the terminal membrane; and a carrier apparatus for carrying the nano-suction means, which can be moved by means of an associated positioning unit for positioning the nano-suction means exactly in a sample removal position for sucking the sample onto the terminal membrane and in a sample release position for blowing the sample from the terminal membrane. A micro-dissection system, comprising such a device and a method for the production of a nano-suction means that is used in such a device.Type: GrantFiled: July 23, 2010Date of Patent: November 5, 2013Assignee: Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fur Gesundheit und Umwelt GmbHInventors: Stefan Thalhammer, Norbert Hohn, Albert Zink, Wolfgang Heckl
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Patent number: 8545760Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.Type: GrantFiled: September 28, 2007Date of Patent: October 1, 2013Assignee: Sysmex CorporationInventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
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Patent number: 8522628Abstract: A liquid sample introducing apparatus capable of executing a process with high reliability and high speed is realized. An injection valve includes a sample storage loop connected to a mobile phase flow passage for supplying a sample to a detector of a liquid chromatograph apparatus. A sample is sucked in a needle through a valve and a pipe by a syringe, being introduced to the sample storage loop, being supplied to the mobile phase flow passage. A washing solution from a washing solution bottle is supplied to the needle by a washing unit through the valve and the pipe to wash the inner wall of the needle. The washing solution from the washing solution bottle is supplied to a washing tank by the washing unit through the valve and a pipe to wash the external wall of the needle in the washing tank.Type: GrantFiled: October 20, 2010Date of Patent: September 3, 2013Assignee: Hitachi High-Technologies CorporationInventors: Yoshiaki Seki, Kimihiko Ishii, Mitsuhiko Ueda, Katsutoshi Shimizu, Hiroshi Suzuki
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Patent number: 8474336Abstract: The invention relates to a method for depositing samples in modules, in particular, in kits, in addition to an adapter. The inventive adapter (1) is embodied in such a manner that an injection needle can be received in a liquid-tight manner. It is connected in a liquid-tight manner to the low-lying module or kit (20) and enables a continuous flow of samples.Type: GrantFiled: April 25, 2006Date of Patent: July 2, 2013Assignee: Atoll GmbHInventors: Juergen Hubbuch, Tim Schroeder, Pierre Beugre, Matthias Wiendahl
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Patent number: 8413490Abstract: The present invention relates generally to an apparatus for obtaining a sample underwater. In one embodiment, the apparatus includes a syringe pump comprising a plurality of syringes, a sampling probe coupled to the syringe pump for collecting the sample underwater and an analyzer module coupled to the syringe pump.Type: GrantFiled: September 11, 2009Date of Patent: April 9, 2013Assignee: SRI InternationalInventors: Ryan J. Bell, R. Timothy Short, Strawn K. Toler, Bill Huzar
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Patent number: 8384026Abstract: An atmospheric pressure ion source probe assembly (10) includes an outer casing assembly (14) adapted for attachment to an atmospheric pressure ion source chamber of a mass spectrometer and a docking probe (12) for detachable connection to the outer casing. The arrangement is such that in its docked condition or position the probe extends through, and in sealing engagement with the outer casing. In this docked condition or position, a sample holder (28) carried by the docking probe (12) is presented within the ion chamber. When the docking probe is detached from the outer casing the casing can be sealed off relative to the ion source chamber.Type: GrantFiled: January 25, 2011Date of Patent: February 26, 2013Assignee: Micromass UK LimitedInventors: Ronan O'Malley, Hilary Jamieson Major, Matthew James Henderson, Richard William Jarrold, Richard Barrington Moulds
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Patent number: 8371181Abstract: A continuous flow syringe pump includes a first syringe configured for at least one of loading or dispensing at least one fluid, a second syringe configured for at least one of loading or dispensing the at least one fluid, and a first valve connected to the first syringe and the second syringe. The continuous flow syringe pump also includes a second valve connected to the first valve. The continuous flow syringe pump further includes at least one outlet connected to the first valve. The at least one outlet is configured to alternate output of the at least one fluid between the first syringe and the second syringe in a substantially continuous operation.Type: GrantFiled: December 21, 2009Date of Patent: February 12, 2013Assignee: Elemental Scientific, Inc.Inventor: Daniel R. Wiederin
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Patent number: 8356525Abstract: An analyzer comprising: a first measurement unit for measuring samples; a second measurement unit; and a transportation device operable to transport a plurality of sample containers accommodated in a first rack and containing samples and a plurality of sample containers accommodated in a second rack and containing samples, to the first measurement unit and the second measurement unit, wherein the transportation device comprises a first transportation section operable to transport the plurality of sample containers on the first rack to the first measurement unit and the second measurement unit by transporting the first rack on a transport path, and a second transportation section operable to transport the plurality of sample containers on the second rack to the first measurement unit and the second measurement unit by transporting the second rack on the transport path independently from movement of the first rack, is disclosed. A transportation device is also disclosed.Type: GrantFiled: March 6, 2009Date of Patent: January 22, 2013Assignee: Sysmex CorporationInventors: Yuichi Hamada, Kunio Ueno
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Patent number: 8347743Abstract: A specimen processing device comprising: first and second units for processing specimens; a conveyance unit for conveying a specimen rack in a first direction from a first position where the specimen is retrieved by the first unit to a second position where the specimen is retrieved by the second unit, and a second direction opposite to the first position; a detector common to the first and second units for executing a detection process with respect to the sample containers; and a conveyance controller controlling the conveyance unit to convey some sample containers of the detected sample containers executed with the detection process to the first position, and to convey the other sample containers of the detected sample containers to the second position, the some sample containers and the other sample containers being held by a common rack, is disclosed. A specimen processing method is also disclosed.Type: GrantFiled: May 7, 2010Date of Patent: January 8, 2013Assignee: Sysmex CorporationInventors: Yuichi Hamada, Takaaki Nagai, Masaharu Shibata
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Patent number: 8342044Abstract: Various embodiments disclose a flow cytometric apparatus comprising a flow chamber to be passed through by a sample in a row in sequence, a sample storage means for metering and storing the sample, a sample syringe for driving the sample into the flow chamber, a syringe-type injection-suction device comprising a sheath liquid syringe and a liquid-path switching means connected with it, and a control unit for controlling the operations of the sample syringe and the syringe-type the injection-suction means. In a sample charging stage, the injection-suction means feeds the sample into the sample storage means so that the sample is temporarily stored in it in a ready-to-use state, and in a sheath-liquid injection stage, the injection-suction means feeds the sheath liquid into the flow chamber to form a sheath flow. A flow cytometric method performed by the flow cytometric apparatus is also disclosed.Type: GrantFiled: February 8, 2010Date of Patent: January 1, 2013Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.Inventors: Bingqiang Zhao, Quan Gan, Chengwei Sun
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Publication number: 20120285268Abstract: Provided is a liquid-sample collecting system and liquid-sample collecting method that can decrease the amount of carryover in the process of collecting a liquid sample while maintaining the efficiency of collecting the liquid sample. A liquid-sample collecting system according to the present invention includes: a sampling needle to be inserted into a sample container, for collecting a liquid sample contained in the sample container; a driver for moving the sampling needle; an input unit for allowing a user enter to information for setting the ascent speed of the sampling needle; an ascent-speed determiner for setting the ascent speed based on the entered information; and a controller for controlling the driver so as to move the sampling needle downward at a predetermined descent speed in a descent phase and upward at the aforementioned ascent speed in an ascent phase.Type: ApplicationFiled: May 3, 2012Publication date: November 15, 2012Applicant: SHIMADZU CORPORATIONInventor: Yoshiaki MAEDA
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Patent number: 8281809Abstract: A flow modulator to control the flow of an aerosol to an aerosol detection and/or monitoring system and other aerosol flow systems includes a chamber having an inlet and an outlet, a diverging section of the chamber beneath the inlet that has a flow divider at the center to divide the aerosol into fractions, a recirculation section in which the divided aerosol fractions are recombined, and a converging section that channels the recombined aerosol fractions to the outlet of the chamber.Type: GrantFiled: August 12, 2011Date of Patent: October 9, 2012Assignee: The United States of America as Represented by the Secretary of the ArmyInventors: Daniel G. Wise, Lawrence J. Hyttinen
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Patent number: 8266973Abstract: After a sampling needle is moved to a position above a sample container, the sampling needle is moved down so that the tip of the sampling needle penetrates a septum, and is then preferably moved down to a position at which the tip of the sampling needle is not brought into contact with a sample contained in the sample container, and then, the sampling needle is once elevated until the sampling needle is pulled out of the septum, and is then again moved down to penetrate the septum until the tip of the sampling needle is inserted into the sample to suck the sample through a suction port of the sampling needle, and then, the sampling needle is moved to a sample injection port of an analyzer to inject the sample into the analyzer.Type: GrantFiled: October 20, 2008Date of Patent: September 18, 2012Assignee: Shimadzu CorporationInventors: Yoshiaki Maeda, Takaaki Fujita
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Patent number: 8234941Abstract: A specimen analyzing apparatus comprising: a detector for detecting component information regarding a component in a specimen contained in each of analyzing containers, the analyzing containers comprising first and second analyzing containers; an analyzing part for analyzing the component information detected by the detector; a transporting device for transporting specimen containers each containing a specimen, the specimen containers comprising first and second specimen containers; an operation mode selector for selecting one of a first operation mode and a second operation mode; a first supplying device for supplying the specimen of a first amount; a second supplying device for supplying the specimen of a second amount grater than the first amount; and a supply controller for controlling the first and second supplying devices in accordance with an operation mode selected by the operation mode selector, is disclosed. A specimen analyzing method is also disclosed.Type: GrantFiled: October 28, 2009Date of Patent: August 7, 2012Assignee: Sysmex CorporationInventors: Kazuya Fukuda, Hiroki Koike, Hironori Katsumi, Takashi Yamato, Masayuki Ikeda, Tsuyoshi Fukuzaki, Daisuke Nakano, Masanori Imazu, Nobuhiro Kitagawa
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Patent number: 8234939Abstract: A sample introduction method for reducing carry-over is provided. After a sample introduction device in a total volume injection method draws a proper amount of a sample solution from a sample container and further draws a solution with the same composition as a mobile phase solution with a needle 24, the needle 24 is inserted into an injection port 25. When flow paths are switched to communicate a liquid feeder, a sample loop 23, the needle 24, the injection port 25, and a separation/detection section, the solution with the same composition as the mobile phase solution is forced into a gap between the injection port 25 and the needle 24. Therefore, the samples squeezed out of a tip section of the needle 24 during the switching of the flow paths are prevented from being forced into the gap between the needle 24 and the injection port 25.Type: GrantFiled: September 24, 2008Date of Patent: August 7, 2012Assignee: Shimadzu CorporationInventors: Yoshiaki Maeda, Shuzo Maruyama, Kenichi Yasunaga
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Patent number: 8197754Abstract: The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.Type: GrantFiled: September 30, 2010Date of Patent: June 12, 2012Assignee: Hitachi High-Technologies CorporationInventors: Hideyuki Yanami, Isao Yamazaki, Masaaki Hanawa, Hitoshi Otake
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Patent number: 8161831Abstract: An analyzer comprising: a first measurement unit; a second measurement unit; a transportation device for transporting samples to at least one measurement unit selected from the first measurement unit and the second measurement unit; and a transportation controller for determining whether or not a sample is transportable to the selected one measurement unit on the basis of at least one of a state notification of the first measurement unit and a state notification of the second measurement unit, wherein the transportation controller controls the transportation device to perform a sample transportation operation of transporting the sample to the selected one measurement unit when the sample is transportable to the selected one measurement unit, and to perform the other transportation operation than the sample transportation operation when the sample is not transportable to the selected one measurement unit, is disclosed. Sample transportation method and a computer program product are also disclosed.Type: GrantFiled: March 6, 2009Date of Patent: April 24, 2012Assignee: Sysmex CorporationInventor: Daigo Fukuma
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Publication number: 20120079896Abstract: A fraction collector comprising a liquid holding means (31) wherein it further comprises a fluid front control arrangement (43) arranged for locating the fluid front at a dispensing nozzle (5) and to control the liquid holding means (31) to keep the fluid front at a predetermined position.Type: ApplicationFiled: June 4, 2010Publication date: April 5, 2012Applicant: GE HEALTHCARE BIO-SCIENCES ABInventor: Hakan Frojdh
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Publication number: 20120073389Abstract: A method for injecting a sample being analyzed into the injection tube of a measurement cell which includes an injection opening and a punch. The sample is introduced into a syringe including a plunger, and the syringe is closed by an expendable cap having a male end closed by a strikable closure. The syringe is secured to the support of an injection station aligned with the injection opening, and a pusher displaces the syringe by vertical translation from an upper position to a lower position with the punch perforating the closure of the cap to inject the sample from the syringe into the injection tube.Type: ApplicationFiled: June 30, 2011Publication date: March 29, 2012Applicant: INSTRUMENTATION SCIENTIFIQUE DE LABORATOIREInventors: Cleris Hervé, Marie Patrick
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Publication number: 20120016264Abstract: The instant invention is directed to devices for the collection of chemical substances from substantially undisturbed natural environs for subsequent identification and quantification.Type: ApplicationFiled: July 13, 2010Publication date: January 19, 2012Inventors: Jeff Weidenhamer, Brian Mohney
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Publication number: 20110290042Abstract: The present invention provides a liquid sample injection device and liquid sample injection method using a total volume injection method, which can prevent clogging of the channel or the needle, or carry-over of analysis components. The present invention is characterized by: moving the tip of a needle 9, before collecting a liquid sample, to an area where a predetermined fluid (for example, air, water, or the like) which reacts with neither the liquid sample nor the mobile phase is present; sucking the given fluid from the tip; and inserting the tip into a vial 15 to suck a predetermined amount of the liquid sample in the vial 15. As a result, a layer of the predetermined fluid is formed between the mobile phase remaining in the needle 9 and the newly sucked liquid sample. Thus, the mobile phase and the liquid sample are prevented from being in contact with each other in the needle 9.Type: ApplicationFiled: May 18, 2011Publication date: December 1, 2011Applicant: SHIMADZU CORPORATIONInventor: Yoshiaki MAEDA
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Publication number: 20110219890Abstract: This invention provides a sample injector for injecting a fixed amount of a sample into a mobile phase medium and discharging the mobile phase medium with the sample. The sample injector includes a first member having a medium passage for supplying the mobile phase medium and a sample passage for supplying the sample and a second member having a discharge passage for discharging the mobile phase medium with the sample to an outside of the injector. The second member is provided in contact with the first member. The first member and the second member are configured to move to a sample charging position and a sample injection position. The sample charging position is for the sample chamber to connect with the sample passage. The sample injection position is for the sample chamber to connect with the medium passage and the discharge passage.Type: ApplicationFiled: March 4, 2011Publication date: September 15, 2011Applicant: CKD CORPORATIONInventors: Hiroshi ITAFUJI, Masayuki KOUKETSU
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Publication number: 20110209565Abstract: A sample injecting device is provided for reducing carryover. The sample injecting device includes the following mode: a needle is set at a low descending speed when sample is injected into an injection port in a total-volume injection manner by the sample injecting device. When the needle is in contact with the injection port, the needle is set at a low speed, thereby increasing the accuracy of the position of the needle relative to an injection hole and decreasing friction between the needle and the injection hole. Contaminants present in the injection hole are prevented from easily flowing from the injection hole into an analyzing flow path, so as to achieve an excellent low carryover.Type: ApplicationFiled: February 17, 2011Publication date: September 1, 2011Applicant: SHIMADZU CORPORATIONInventor: MASAMI TOMITA
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Patent number: 7964142Abstract: A sample analyzer includes a loading section in which a measuring unit is removably set, the measuring unit being adapted to receive a sample; and a control section which analyzes a signal acquired from the sample received in the measuring unit set in the loading section to provide a result of analysis of the sample; wherein the control section judges whether or not the measuring unit is properly set in the loading section.Type: GrantFiled: June 24, 2004Date of Patent: June 21, 2011Assignee: Sysmex CorporationInventors: Kazunori Mototsu, Seido Biwa
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Patent number: 7951597Abstract: The present invention is a pressurized fluid sample injector system consisting of a sample needle, multiport valve, sample loop, metering syringe and a pressure assist pump. The speed of sample transport into the sample loop is increased by pressurizing the fluid in the system and metering the sample into the sample loop. The elevated system pressure allows the fluids to be moved faster than the vapor pressure would normally allow in a system at ambient pressure.Type: GrantFiled: September 15, 2006Date of Patent: May 31, 2011Assignee: Waters Technologies CorporationInventors: James E. Usowicz, Theodore C. Ciolkosz, Russell Keene, Daniel J. McCormick