The Polynucleotide Confers Resistance To Heat Or Cold (e.g., Chilling, Etc.) Patents (Class 800/289)
  • Patent number: 11396529
    Abstract: The present invention relates to an isolated peptide, an anti-cancer medicinal composition including the same and a method of specifically reducing or inhibiting activities of cancer cells using the same. The isolated peptide including a TAT basic domain conjugated to a GABARAPL2 H2 domain can specifically reduce or inhibit an activity of cancer cells, thereby being applied to the anti-cancer medicinal composition and the method of specifically reducing or inhibiting activities of cancer cells using the same.
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: July 26, 2022
    Assignee: NATIONAL SUN YAT-SEN UNIVERSITY
    Inventor: Chih-Wen Shu
  • Patent number: 11174288
    Abstract: Disclosed are peptides comprising an amphiphilic backbone and a cationic heparin-binding motif peptide. The peptides can be used in methods of antimicrobial treatment.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: November 16, 2021
    Assignee: Northeastern University
    Inventors: Run Chang, Keerthana Subramanian, Mian Wang, Thomas J. Webster
  • Patent number: 11072798
    Abstract: Methods comprising DNA constructs and polynucleotides of functional transcription factors for improving photosynthetic capacity, biomass and/or grain yield and stress tolerance in various crop and model plants, dicots and monocots with the C3 or C4 photosynthetic pathways are described herein.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: July 27, 2021
    Assignee: YIELD 10 BIOSCIENCE, INC.
    Inventors: Madana M. R. Ambavaram, Mariya Somleva
  • Patent number: 11066677
    Abstract: The present disclosure describes genetically-modified plants having enhanced tolerance to multiple abiotic stressors, such as extreme temperatures (heat or cold) and/or drought. Abiotic stress tolerance is enhanced by ectopic expression of a heterologous glutaredoxin. Abiotic stress tolerance (particularly drought) is also enhanced by inhibited function, activity, or expression of an endogenous glutaredoxin. Methods of producing such genetically-modified plants are also disclosed.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: July 20, 2021
    Assignees: Kansas State University Research Foundation, Baylor College of Medicine
    Inventors: Sunghun Park, Frank White, Jungeun Park, Kendal Hirschi, Ning-Hui Cheng
  • Patent number: 11008583
    Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding ADP-glucose pyrophosphorylase small subunit (AGPaseSS) proteins, polypeptides encompassing AGPaseSS proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: May 18, 2021
    Assignee: Benson Hill, Inc.
    Inventor: Benjamin Neil Gray
  • Patent number: 10947553
    Abstract: The present invention relates to isolated nucleic acid molecules and their corresponding encoded polypeptides. The present invention further relates to the uses of these nucleic acid molecules and polypeptides. For example, the nucleic acid molecules and polypeptides could be used in making enzymes or used to make plants, plant cells, plant materials or seeds of a plant having such modulated growth or phenotype characteristics that are altered with respect to wild type plants grown under similar conditions.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: March 16, 2021
    Assignee: Ceres, Inc.
    Inventors: Vyacheslav Brover, Timothy J. Swaller, Kenneth A. Feldmann, Maxim Troukhan
  • Patent number: 10907172
    Abstract: The invention relates to methods of producing a desired phenotype in a plant by manipulation of gene expression within the plant. The method relates to means to increase expression level of a bHLH subgroup 1b gene expression or activity, wherein a desired phenotype such as increased heat tolerance relative to a wild type control plant following heat stress results in reduced flower abortion and increased yield. Included are plants produced by said methods. The invention also relates to nucleic acid sequences and constructs useful such methods and methods of generating and isolating plants having increased expression of a bHLH subgroup 1b expression or activity.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: February 2, 2021
    Assignee: Performance Plants, Inc.
    Inventors: Jiangxin Wan, Yafan Huang
  • Patent number: 10889854
    Abstract: Present invention disclosed a novel method for detecting and quantifying target DNA from the biological sample. It provides a method of amplification of DNA sequences with loop-mediated isothermal amplification (LAMP) and its easy and accurate detection and quantification by electrochemiluminescence (ECL) technique. The target LAMP DNA is bound electrostatically with [Ru(bpy)3]+2 on the carbon electrode surface, and an ECL reaction is triggered by tripropylamine (TPrA) to yield luminescence. This is a highly sensitive strategy for the detection of sequence-specific DNA from different biological samples at picogram levels. The target DNA of Sus scrofa (pork) meat was detected as low as 1 pg/?L (3.43×10?1 copies/?L) and for Bacillus subtilis DNA samples the detection limit of 10 pg/?L (2.2×103 copies/?L) was achieved.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: January 12, 2021
    Assignee: UNIVERSITI BRUNEI DARUSSALAM
    Inventors: Sharmili Roy, Minhaz Uddin Ahmed
  • Patent number: 10851385
    Abstract: The present invention provides a transgenic corn event MON87460, and cells, seeds, and plants comprising DNA diagnostic for the corn event. The invention also provides compositions comprising nucleotide sequences that are diagnostic for MON87460 in a sample, methods for detecting the presence of MON87460 event polynucleotides in a sample, and probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of MON87460 in a sample. The present invention also provides methods of breeding with MON87460 to produce water deficit tolerance corn plants.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: December 1, 2020
    Assignee: Monanto Technology LLC
    Inventors: Kim A. Beazley, Paolo Castiglioni, Mark A. Dizigan, Rebecca A. Kelly, John A. Korte, Amanda Rock, Christine Voyles
  • Patent number: 10829777
    Abstract: Isolated polynucleotides having a nucleic acid sequence at least 80% homologous to SEQ ID NO:1, 3, 5, 7, 9, 11, 158, 159, 160, 161, 162-204, 206-211, 214-287 and/or encoding polypeptides having an amino acid sequence at least 80% homologous to SEQ ID NO: 2, 4, 6, 8, 10, 12, 13-56, 58-63, 66-121, 141-156 or 157 are provided. Also provided are methods of utilizing same for increasing the tolerance of a plant to abiotic stresses and/or increasing the biomass, vigor and/or yield of a plant.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: November 10, 2020
    Assignee: Evogene Ltd.
    Inventors: Hagai Karchi, Gil Ronen, Rodrigo Yelin, Larisa Rabinovich
  • Patent number: 10584348
    Abstract: This invention is intended to increase biomass production through suppression of expression of a gene functioning in relation to intracellular vesicular transport or inhibition of functions of a protein encoded by such gene. To this end, expression of a gene encoding the coatomer adapter zeta subunit is suppressed, the coatomer adapter zeta subunit is inhibited, expression of a gene encoding the clathrin adaptor small (sigma) subunit is suppressed, or the clathrin adaptor small (sigma) subunit is inhibited.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: March 10, 2020
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Satoshi Kondo, Chikara Ohto, Hiroki Sugimoto, Nobuhiko Muramoto, Tomoko Tanaka, Norihiro Mitsukawa, Ritsuko Yogo
  • Patent number: 10533184
    Abstract: Nucleic acid constructs are provided. These constructs comprise any of the, nucleic acid sequences at least 85% identical to nucleotide sequences selected from the group consisting of SEQ ID NOs: 68, 1, 4, 5, 8, 9, 11, 13, 16, 19, 20, 23, 24, 27, 30, 32, 37, 42, 49, 50, 51, 53, 54, 55, 56, 57, 58, 64, 69, 70, 73, 77, 78, 79, 80, 84, 86, 87, 93, 94, 98, 101, 102, 103, 104, 105, 106, 107, 108 and 109 and a promoter sequence capable of directing transcription of said nucleic acid sequence in a host cell. Also provided are transgenic plants expressing these nucleic acid constructs and methods of using same.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: January 14, 2020
    Assignee: Evogene Ltd.
    Inventors: Rodrigo Yelin, Avi Shoshan, Evgenia Gold, Sharon Ayal, Hagai Karchi
  • Patent number: 10494643
    Abstract: The present invention relates to a method of increasing resistance against fungal pathogens of the family Phacosporaceae in plants and/or plant cells. This is achieved by increasing the expression of an OCP3 protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells. Furthermore, the invention relates to transgenic plants, plant parts, and/or plant cells having an increased resistance against fungal pathogens, in particular, pathogens of the family Phacopsoraceae, and to recombinant expression vectors comprising a sequence that is identical or homologous to a sequence encoding an OCP3 protein.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 3, 2019
    Assignee: BASF PLANT SCIENCE COMPANY GMBH
    Inventors: Holger Schultheiss, Nadine Tresch
  • Patent number: 10435372
    Abstract: Compounds (A) can be used for increasing the yield of useful plants or crop plants with respect to their harvested plant organs, wherein the Compound (A) is selected from compounds of the formula (I) or salts thereof, in which (R1)n is n radicals R1 where the R1 are identical or different and are each halogen or (C1-C4)-haloalkyl, n is an integer from 1 to 3, R2 is hydrogen, (C1-C6)-alkyl, (C1-C4)-alkoxy-(C1-C4)-alkyl, (C3-C6)-cycloalkyl, tri-(C1-C4)-alkyl-silyl or tri-(C1-C4)-alkyl-silylmethyl, R3 is hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl or (C3-C6)-cycloalkyl, and R4 is hydrogen or (C1-C12)-alkyl, preferably mefepyr-diethyl (Compound (A1)]
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: October 8, 2019
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Erwin Hacker, Stefan Lehr, Georg Bonfig-Picard, Martin Hess, Frank Ziemer, Mathias Schmidt, Martin Jeffrey Hills, Udo Bickers, Juan Pedro Ruiz-Santaella Moreno
  • Patent number: 10428345
    Abstract: The present invention provides a transgenic corn event MON87460, and cells, seeds, and plants comprising DNA diagnostic for the corn event. The invention also provides compositions comprising nucleotide sequences that are diagnostic for MON87460 in a sample, methods for detecting the presence of MON87460 event polynucleotides in a sample, and probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of MON87460 in a sample. The present invention also provides methods of breeding with MON87460 to produce water deficit tolerance corn plants.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: October 1, 2019
    Assignee: Monsanto Technology LLC
    Inventors: Kim A. Beazley, Paolo Castiglioni, Mark A. Dizigan, Rebecca A. Kelly, John A. Korte, Amanda Rock, Christine Voyles
  • Patent number: 10383295
    Abstract: The present invention is in the field of plant breeding and drought tolerance. More specifically, the invention includes a method for breeding corn plants containing one or more markers that are associated with tolerance to low water conditions. Markers provided herein include markers genetically linked to proteins comprising cold shock domains, such as the CSD1 and CSD2 proteins. The invention further includes germplasm and the use of germplasm containing at least one marker associated with drought tolerance for introgression into elite germplasm in a breeding program, thus producing drought resistant germplasm. Other embodiments of this invention include transgenic drought tolerant corn plants and corn plant cells, and methods of detecting drought tolerance genes and chromosome regions associated with drought tolerance in a plant genome.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: August 20, 2019
    Assignee: Monsanto Technology LLC
    Inventors: Paul S. Chomet, Nancy M. Houmard, Hongwu Jia, Michael R. Kerns, Mark E. Leibman
  • Patent number: 10314307
    Abstract: The present invention is directed to the treatment of crop plants with 3?-methyl-(S)-abscisic acid, 3?-propargyl-(S)-abscisic acid, and/or salts thereof in order to improve the plants' environmental stress tolerance.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: June 11, 2019
    Assignee: VALENT BIOSCIENCES LLC
    Inventors: Franklin Paul Silverman, Gary T. Wang, Kimberly Ann Falco, Derek D. Woolard, Dale O. Wilson, Jr., Daniel C. Leep, Gregory D. Venburg
  • Patent number: 10316068
    Abstract: This disclosure provides methods and compositions related to microbial gene expression. In one aspect, a synthetic polypeptide having a xylose import activity.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: June 11, 2019
    Assignee: The Regents of the University of California
    Inventors: Aindrila Mukhopadhyay, Amanda Reider Apel, Mario Ouellet, Jay D. Keasling
  • Patent number: 10287604
    Abstract: A technique by which the production of plant biomass can be significantly increased is provided. A protein phosphatase 2C gene having 3 consensus sequences comprising the amino acid sequences shown in SEQ ID NOS: 1-3 from the N-terminal side in such order is over-expressed.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: May 14, 2019
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Satoshi Kondo, Chikara Ohto, Norihiro Mitsukawa, Nobuhiko Muramoto, Kenichi Ogawa, Hiroki Sugimoto, Tomoko Tanaka, Madoka Yonekura
  • Patent number: 10287318
    Abstract: The invention relates to novel peptides, polypeptides or proteins which bind specifically to brain cells and/or to the spinal cord. The peptides, polypeptides, or proteins can be components of a viral capsid and can be used to lead a recombinant viral vector selectively to the brain and/or spinal cord after systemic administration to a subject and to ensure tissue-specific expression of one or more transgenes there. The invention also relates to a recombinant viral vector, preferably an AAV vector, which comprises a capsid containing at least one of the claimed peptides, polypeptides, or proteins and which comprises at least one transgene packaged in the capsid. Said viral vector can be used, in particular for the therapeutic treatment of a disease or disorder of the brain and/or spinal cord. The invention further relates to cells and pharmaceutical compositions that comprise the viral vector according to the invention.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: May 14, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Jakob Körbelin, Stefan Michelfelder, Martin Trepel
  • Patent number: 10273497
    Abstract: Polynucleotides incorporated into nucleic acid constructs have been introduced into plants and were ectopically expressed. The encoded polypeptides of the invention have been shown to confer at least one regulatory activity and confer earlier flowering, longer floral organ retention, increased cold tolerance, greater tolerance to water deprivation, altered carbon-nitrogen balance sensing, increased low nitrogen tolerance, and/or increased tolerance to hyperosmotic stress as compared to a control plant.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: April 30, 2019
    Assignees: Mendel Biotechnology, Inc., Monsanto Technology LLC
    Inventors: Jose Luis Riechmann, Oliver J. Ratcliffe, T. Lynne Reuber, Katherine Krolikowski, Jacqueline E. Heard, Omaira Pineda, Cai-Zhong Jiang, Robert A. Creelman, Roderick W. Kumimoto, Paul S. Chomet
  • Patent number: 10233460
    Abstract: The present invention relates to isolated nucleic acid molecules and their corresponding encoded polypeptides able confer the trait of improved plant size, vegetative growth, growth rate, seedling vigor and/or biomass in plants challenged with saline conditions. The present invention further relates to the use of these nucleic acid molecules and polypeptides in making transgenic plants, plant cells, plant materials or seeds of a plant having plant size, vegetative growth, growth rate, seedling vigor and/or biomass that are improved in saline conditions with respect to wild-type plants grown under similar conditions.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: March 19, 2019
    Assignee: Ceres, Inc.
    Inventors: Fasong Zhou, Kenneth A. Feldmann, Julissa Sosa
  • Patent number: 10214748
    Abstract: Provided are isolated polypeptides which are at least 80% homologous to SEQ ID NO: 474-643, 645-679, 681-755, 757-760, 4806-6390, 6395-6396, 6401-6895, 6897-7249, 7251-7685, 7687-7693, 7695-7700, 7702-7708, 7710-7796, 7798-7816, 7818, 7820-7837, 7839-7840, 7842-7861, 7863-8134, 8136-8163 or 8164, isolated polynucleotides which are at least 80% identical to SEQ ID NOs: 1-170, 172-267, 269-424, 426-473, 761-2486, 2489-2494, 2496-4803 or 4804, nucleic acid constructs comprising same, transgenic cells expressing same, transgenic plants expressing same and method of using same for increasing yield, harvest index, abiotic stress tolerance, growth rate, biomass, vigor, oil content, photosynthetic capacity, seed yield, fiber yield, fiber quality, fiber length, and/or nitrogen use efficiency of a plant.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: February 26, 2019
    Assignee: Evogene Ltd.
    Inventors: Ilya Pankratov, Hagai Karchi
  • Patent number: 10214749
    Abstract: Isolated polynucleotides having a nucleic acid sequence at least 80% homologous to SEQ ID NO:1, 3, 5, 7, 9, 11, 158, 159, 160, 161, 162-204, 206-211, 214-287 and/or encoding polypeptides having an amino acid sequence at least 80% homologous to SEQ ID NO: 2, 4, 6, 8, 10, 12, 13-56, 58-63, 66-121, 141-156 or 157 are provided. Also provided are methods of utilizing same for increasing the tolerance of a plant to abiotic stresses and/or increasing the biomass, vigor and/or yield of a plant.
    Type: Grant
    Filed: September 5, 2016
    Date of Patent: February 26, 2019
    Assignee: Evogene Ltd.
    Inventors: Hagai Karchi, Gil Ronen, Rodrigo Yelin, Larisa Rabinovich
  • Patent number: 10208316
    Abstract: Provided are methods of increasing nitrogen use efficiency, fertilizer use efficiency, yield, growth rate, vigor, biomass, oil content and/or abiotic stress tolerance of a plant by expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence encoding a polypeptide at least 80% identical to SEQ ID NO: 2560, 2557, 184, 238, 188, 154-156, 158-161, 163-183, 185-187, 189-197, 200-237, 239-264, 266-269, 1351, 1365-1425, 1429-1457, 1459, 1461-1730, 1735, 1739-2397, 2533-2541, 2544-2556, 2558, 2559, 2561-2562 or 2563. Also provided are isolated polynucleotides and polypeptides which can be used to increase nitrogen use efficiency, fertilizer use efficiency, yield, growth rate, vigor, biomass, oil content and/or abiotic stress tolerance of a plant of a plant.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: February 19, 2019
    Assignee: Evogene Ltd.
    Inventors: Basia Judith Vinocur, Sharon Ayal, Alex Diber, Eyal Emmanuel, Gil Ronen, Michael Gang, Dotan Dimet, Hagai Karchi, Yoav Herschkovitz
  • Patent number: 10106814
    Abstract: Head smut is one of the most devastating diseases in maize, causing severe yield loss worldwide. The present invention describes the fine-mapping of a major QTL conferring resistance to head smut. Markers useful for breeding, and methods for conferring head smut resistance are described. Nucleic acid sequence from the genetic locus conferring head smut resistance is disclosed. Genes encoding proteins conferring head smut resistance are disclosed.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: October 23, 2018
    Assignees: E I DU PONT DE NEMOURS AND COMPANY, CHINA AGRICULTURAL UNIVERSITY
    Inventors: Mingliang Xu, Bailin Li, Kevin Fengler, Qing Chao, Yongsheng Chen, Xianrong Zhao, Jing Zhao
  • Patent number: 10030056
    Abstract: An agent for preventing and/or treating HIV and other viral infections. The agent in particular comprises at least one peptide, including an amino acid sequence, which is suitable for preventing fibrils associated with Alzheimer's disease, and/or homologs, fractions and parts thereof, so as to treat and/or prevent HIV and/or other viral infections.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: July 24, 2018
    Assignee: Forschungszentrum Juelich GmbH
    Inventors: Susanne Aileen Funke, Dieter Willbold, Heiner Schaal, Marek Widera
  • Patent number: 10006043
    Abstract: The present invention relates to isolated nucleic acid molecules and their corresponding encoded polypeptides able confer the trait of improved plant size, vegetative growth, growth rate, seedling vigor and/or biomass in plants challenged with saline and/or oxidative stress conditions. The present invention further relates to the use of these nucleic acid molecules and polypeptides in making transgenic plants, plant cells, plant materials or seeds of a plant having plant size, vegetative growth, growth rate, seedling vigor and/or biomass that are improved in saline and/or oxidative stress conditions with respect to wild-type plants grown under similar conditions.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: June 26, 2018
    Assignee: Ceres, Inc.
    Inventors: Fasong Zhou, Kenneth A. Feldmann, Julissa Sosa
  • Patent number: 9988640
    Abstract: Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the disclosure provides a transcription factor that negatively regulates alkaloid biosynthesis, such as nicotine biosynthesis.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: June 5, 2018
    Assignee: 22nd Century Limited, LLC
    Inventors: Jonathan Page, Andrea T. Todd
  • Patent number: 9920328
    Abstract: The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3? termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: March 20, 2018
    Assignee: Ceres, Inc.
    Inventors: Nickolai Alexandrov, Vyacheslav Brover, Kenneth A. Feldmann, Vladimir Makarov, Timothy J. Swaller, Gregory Nadzan, Peter Mascia, Maxim Troukhan, Joel Rarang, James Burns, Kyle Vos Strache
  • Patent number: 9862964
    Abstract: The invention relates to transgenic plants exhibiting dramatically enhanced growth rates, greater seed and fruit/pod yields, earlier and more productive flowering, more efficient nitrogen utilization, increased tolerance to high salt conditions, and increased biomass yields. In one embodiment, transgenic plants engineered to over-express both glutamine phenylpyruvate transaminase (GPT) and glutamine synthetase (GS) are provided. The GPT+GS double-transgenic plants of the invention consistently exhibit enhanced growth characteristics, with T0 generation lines showing an increase in biomass over wild type counterparts of between 50% and 300%. Generations that result from sexual crosses and/or selfing typically perform even better, with some of the double-transgenic plants achieving an astounding four-fold biomass increase over wild type plants.
    Type: Grant
    Filed: September 5, 2016
    Date of Patent: January 9, 2018
    Assignees: Los Alamos National Security, LLC, University of Maine System Board of Trustees
    Inventors: Pat J. Unkefer, Penelope S. Anderson, Thomas J. Knight
  • Patent number: 9856492
    Abstract: A nucleic acid expression vector comprising a nucleic acid sequence encoding a dominant negative T3SS protein is disclosed. The nucleic acid expression vector further comprising a cis acting regulatory element capable of driving transcription of the nucleic acid sequence in a plant cell. Moreover, the dominant negative T3SS protein mediates assembly of a dysfunctional needle complex.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: January 2, 2018
    Assignee: Futuragene Israel Ltd.
    Inventors: Hanan Stein, Dror Avisar
  • Patent number: 9809622
    Abstract: A tumor-targeting peptide is disclosed. This tumor-targeting peptide comprises a typical motif with the general formula of: XX(Y/F) (D/E) (D/E) XX. The motif is selectively connected with 1-3 amino acids at the C-terminal and/or N-erminal. X represents any one of the twenty natural amino acids or the D type amino acids. The present invention also discloses that the peptide can not only target tumor vessels and tumor cells but also penetrate them and thus can be applied in tumor diagnosis and therapy.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: November 7, 2017
    Assignee: Sun Yat-Sen University Cancer Center
    Inventors: Musheng Zeng, Xing Zhang, Jun Wang, Guokai Feng, Mengqing Zhang, Qian Zhong
  • Patent number: 9803213
    Abstract: Environmental stress resistance is imparted to a plant or the environmental stress resistance of a plant is improved. Environmental stress resistance is imparted to a plant by changing the expression level of the tyrosine phosphatase gene (At1g71860).
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: October 31, 2017
    Assignees: TOYOTA JIDOSHA KABUSHIKI KAISHA, OKAYAMA PREFECTURE
    Inventors: Satoshi Kondo, Chikara Ohto, Kenichi Ogawa, Kenji Henmi
  • Patent number: 9765355
    Abstract: The present invention relates to isolated nucleic acid molecules and their corresponding encoded polypeptides able confer the trait of improved plant size, vegetative growth, growth rate, seedling vigor and/or biomass in plants challenged with saline and/or oxidative stress conditions. The present invention further relates to the use of these nucleic acid molecules and polypeptides in making transgenic plants, plant cells, plant materials or seeds of a plant having plant size, vegetative growth, growth rate, seedling vigor and/or biomass that are improved in saline and/or oxidative stress conditions with respect to wild-type plants grown under similar conditions.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: September 19, 2017
    Assignee: Ceres, Inc.
    Inventors: Fasong Zhou, Kenneth A. Feldmann, Julissa Sosa
  • Patent number: 9695217
    Abstract: Described herein are small peptide domains and consensus sequences that bind small target molecules of industrial importance, e.g., metals such as nickel, ? carotene, and isoflavones such as genistein. Also described are fusion proteins containing such binding domains fused to proteins or to peptide domains like GST or CBD that bind other ligands and can be used to immobilize the target binding domain on a support. One class of fusion proteins that is useful in industrial settings are fusions that contain concatemers of target binding domains, which increases the binding equivalents per molecule.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: July 4, 2017
    Assignees: Iowa State University Research Foundation, Inc., Archer-Daniels-Midland Company
    Inventors: Thomas P. Binder, Aragula Gururaj Rao, Yasufumi Yamamoto, Paul D. Hanke
  • Patent number: 9637756
    Abstract: The present invention relates to isolated nucleic acid molecules and their corresponding encoded polypeptides able confer the trait of improved plant size, vegetative growth, growth rate, seedling vigor and/or biomass in plants challenged with saline conditions. The present invention further relates to the use of these nucleic acid molecules and polypeptides in making transgenic plants, plant cells, plant materials or seeds of a plant having plant size, vegetative growth, growth rate, seedling vigor and/or biomass that are improved in saline conditions with respect to wild-type plants grown under similar conditions.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: May 2, 2017
    Assignee: Ceres, Inc.
    Inventors: Fasong Zhou, Kenneth A. Feldmann, Julissa Sosa
  • Patent number: 9598688
    Abstract: A method of generating a protein with an improved functional property, the method comprising: (a) identifying at least one Target amino acid Residue in a first protein, wherein said Target amino acid Residue is associated with said functional property; (b) comparing at least one homologous second protein from the same or a different phylogenetic branch as the first protein with the first protein and identifying at least one Variant amino acid Residue between the first protein and the second protein; (c) selecting at least one Candidate amino acid Residue from the Variant amino acid Residue identified in (b) on the basis of said Candidate amino acid Residue affecting said Target amino acid Residue with respect to said functional property; (d) forming at least one Candidate Mutant protein in silico or producing at least one Candidate Mutant protein in vitro in which said at least one Candidate amino acid Residue from the second protein substitutes a corresponding residue in the first protein; and (e) screeni
    Type: Grant
    Filed: April 10, 2009
    Date of Patent: March 21, 2017
    Assignee: The Australian National University
    Inventors: Jill E. Gready, Babu Kannappan
  • Patent number: 9518266
    Abstract: The present invention provides polynucleotides and related polypeptides of the ZmARGOS gene family. The invention provides genomic sequence for the ZmARGOS genes. ZmARGOS is responsible for controlling plant growth, organ size and yield in crop plants.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: December 13, 2016
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Wesley Bruce, Mei Guo, Rajeev Gupta, Mary Rupe, Carl Simmons
  • Patent number: 9493786
    Abstract: The present invention provides a transgenic soybean comprising event MONS87712 that expresses a B-box zinc-finger protein 32 (BBX32) and exhibits increased yield. The invention also provides cells, plant parts, seeds, plants, commodity products related to the event, and DNA molecules that are unique to the event and were created by the insertion of transgenic DNA into the genome of a soybean plant. The invention further provides methods for detecting the presence of said soybean event nucleotide sequences in a sample, and probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of said soybean event.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: November 15, 2016
    Assignee: Monsanto Technology LLC
    Inventors: Robert H. Cole, John A. Korte, John R. LeDeaux, Melissa Compton Spears, Kunsheng Wu
  • Patent number: 9453238
    Abstract: The invention relates to methods of producing a desired phenotype in a plant by manipulation of gene expression within the plant. The method relates to means which inhibit the level of PK220 gene expression or activity, wherein a desired phenotype such as increased water use efficiency relative to a wild type control plant. The invention also relates to nucleic acid sequences and constructs useful such methods and methods of generating and isolating plants having decreased PK220 expression or activity.
    Type: Grant
    Filed: June 12, 2009
    Date of Patent: September 27, 2016
    Assignee: Performance Plants, Inc.
    Inventors: Jiangxin Wan, Yafan Huang, Shujun Yang, Monika Kuzma
  • Patent number: 9422545
    Abstract: A vaccine and method of vaccination for conferring immunity to Q fever is described. The vaccine comprises a polypeptide with a sequence of SLTWHKHELHRK (SEQ ID NO: 7) (m1E41920) or SPPWHKHELHRK (SEQ ID NO: 8) (m1E44), or at least 90% identity to m1E41920 or m1E44. Constructs are also provided for use in vaccination and treatment of Q fever. A method to identify and generate new vaccines to prevent diseases caused by intracellular Gram-negative bacteria is also described.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: August 23, 2016
    Assignee: The Curators of the University of Missouri
    Inventor: Guoquan Zhang
  • Patent number: 9376668
    Abstract: The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor is also described. The method includes providing a fagopyritol synthase, providing a substrate comprising a galactosy donor and a galactosy acceptor, and combining the fagopyritol synthase with the substrate under conditions effective produce a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: June 28, 2016
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Ralph L. Obendorf, Takashi Ueda
  • Patent number: 9365871
    Abstract: A fungal ?-amylase is provided from Aspergillus clavatus (AcAmy1). AcAmy1 has an optimal pH of 4.5 and is operable at 30-75° C., allowing the enzyme to be used in combination with a glucoamylase in a saccharification reaction. This obviates the necessity of running a saccharification reaction as a batch process, where the pH and temperature must be readjusted for optimal use of the ?-amylase or glucoamylase. AcAmy1 also catalyzes the saccharification of starch substrates to an oligosaccharide composition significantly enriched in DP2 and (DP1+DP2) compared to the products of saccharification catalyzed by an ?-amylase from Aspergillus kawachii. This facilitates the utilization of the oligosaccharide composition by a fermenting organism in a simultaneous saccharification and fermentation process, for example.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: June 14, 2016
    Assignee: Danisco US Inc.
    Inventors: Jing Ge, Ling Hua, Martijn Silvan Scheffers, Zhongmei Tang, Marco Van Brussel-Zwijnen, Casper Vroemen, Bo Zhang, Kathleen A. Clarkson, Jacquelyn A. Huitink, Paula Johanna Maria Teunissen
  • Patent number: 9328353
    Abstract: Provided are isolated polynucleotides which comprise a nucleic acid sequence at least 80% identical to SEQ ID NO: 321, 1-320, 322-480, 793-2945 or 2946; isolated polypeptides which comprise an amino acid sequence at least 80% homologous to SEQ ID NO: 517, 481-516, 518-792, 2947-4662 or 4663, nucleic acid constructs comprising same, transgenic cells and plants expressing same and methods of using same for increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: May 3, 2016
    Assignee: Evogene Ltd.
    Inventors: Eyal Emmanuel, Hagai Karchi
  • Patent number: 9277762
    Abstract: The present disclosure is directed to plants that display an improved oil quantity phenotype or an improved meal quality phenotype due to altered expression of an IMQ nucleic acid. The disclosure is further directed to methods of generating plants with an improved oil quantity phenotype or improved meal quality phenotype.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: March 8, 2016
    Assignee: Agrigenetics, Inc.
    Inventors: John P. Davies, Hein Tsoeng (Medard) Ng, D. Ry Wagner
  • Patent number: 9249422
    Abstract: The present invention relates to methods and compositions for the expression of protein. Embodiments of methods may comprise the cleavage and repair of a nucleotide sequence encoding a highly expressed protein leading to a reduction in the expression of the highly expressed protein.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: February 2, 2016
    Assignee: Dow AgroSciences LLC
    Inventors: Joseph F. Petolino, Qihua C. Cai, Weiting W. Ni
  • Patent number: 9222102
    Abstract: A means for inhibiting the bolting and flowering of sugar beet plant, including an isolated nucleic acid, a vector or mobile genetic element which can be used to produce a sugar beet, in which stem elongation post-vernalization is inhibited. Further, a transgenic sugar beet plant comprising the nucleic acid, vector or mobile genetic element, in which bolting and flowering is inhibited after vernalization, a method for producing such transgenic sugar beet plant, and a process for the inhibition of bolting and flowering of sugar beet plant.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: December 29, 2015
    Assignee: KWS SAAT SE
    Inventors: Josef Kraus, Andreas Menze, David Wurbs
  • Patent number: 9193766
    Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: November 24, 2015
    Assignee: Genentech, Inc.
    Inventors: Robert A. Lazarus, Yingnan Zhang, Weiru Wang
  • Patent number: 9181314
    Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mTOR activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: November 10, 2015
    Assignee: Intrexon Corporation
    Inventors: Thomas David Reed, Amy H. Atzel