Cyclic Peptides Derived From At Least Five Amino Acids And Containing Only Normal Peptide Links (c07k-7/64) Patents (Class 930/DIG546)
  • Patent number: 6011010
    Abstract: Kalahide F. of formula I below, may be isolated from a secoglossan. The compound may be used in the manufacture of pharmaceutical compositions or in the treatment of tumors or viral conditions.
    Type: Grant
    Filed: September 25, 1997
    Date of Patent: January 4, 2000
    Assignee: Pharma Mar, s.a.
    Inventors: Paul J Scheuer, Mark T Hamann, Dolores G. Gravalos
  • Patent number: 5834586
    Abstract: Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives.
    Type: Grant
    Filed: July 25, 1994
    Date of Patent: November 10, 1998
    Assignee: Pharma Mar, S.A.
    Inventors: Kenneth L. Rinehart, Anna M. Lithgow-Bertelloni
  • Patent number: 5753618
    Abstract: The invention provides a pharmaceutical composition containing a somatostatin analogue, and its use in the treatment of breast cancer. The pharmaceutical composition preferably contains lactic acid in addition to the somatostatin analogue and is better tolerated when administered by injection.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 19, 1998
    Assignee: Novartis Corporation
    Inventors: Thomas Cavanak, Alan Harris
  • Patent number: 5677419
    Abstract: Analogs of porcine Vasoactive Intestinal Peptide are disclosed. The analogs have been cyclized by the covalent attachment, via an amide bond, of the side-chain carboxy terminus of one amino acid in the peptide chain to the side-chain amino terminus of another amino acid in the peptide chain. The claimed compounds are useful for the treatment of asthma.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: October 14, 1997
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Robert Bolin, Margaret O'Donnell
  • Patent number: 5668105
    Abstract: Compounds represented by the formula (Seq ID Nos. 1-6) ##STR1## wherein all substituents are fully defined, are disclosed. These compounds exhibit utilities as antibiotic and antifungal agents and for the treatment and prevention of Pneumocystis infections.
    Type: Grant
    Filed: March 12, 1996
    Date of Patent: September 16, 1997
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Frances A. Bouffard, Milton L. Hammond
  • Patent number: 5646245
    Abstract: An improved process for the preparation of side chain derivatives of cyclohexapeptidyl lipopeptides represented by the formula ##STR1## wherein R.sup.1 is fully defined, is disclosed.
    Type: Grant
    Filed: May 16, 1996
    Date of Patent: July 8, 1997
    Inventors: James M. Balkovec, Frances A. Bouffard, James F. Dropinski, Akinlolu A. Adefarati, Jan S. Tkacz
  • Patent number: 5552521
    Abstract: There is disclosed a novel process for preparing aza cyclohexapeptides of the formula ##STR1## where all variables are defined herein.
    Type: Grant
    Filed: February 10, 1995
    Date of Patent: September 3, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Kevin M. Belyk, Dean R. Bender, Regina M. Black, David L. Hughes, William Leonard
  • Patent number: 5516757
    Abstract: There are disclosed novel semi-synthetic lipopeptides of the formula (Seq. ID Nos. 1-6) ##STR1## wherein the substituents are defined herein, which show utility as antifungal and anti-Pneumocystis agents. Pharmaceutical compositions containing said compounds are also disclosed.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: May 14, 1996
    Assignee: Merck & Co., Inc.
    Inventor: James M. Balkovec
  • Patent number: 5516756
    Abstract: The present invention is directed to novel aza cyclohexapeptide compounds of the formula ##STR1## where all substituents are defined herein, which are useful as antifungal agents and for the treatment of Pneumocystis carinii infections. Compositions containing the compounds of the invention are also disclosed.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: May 14, 1996
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Frances A. Bouffard, James F. Dropinski
  • Patent number: 5514651
    Abstract: The present invention relates to aza cyclohexapeptide compounds of the formula (Seq ID Nos. 1-10) ##STR1## which may be useful as antibiotics, antifungal agents and for the treatment of Pneumocystis carinii infections.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: May 7, 1996
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Frances A. Bouffard, James F. Dropinski
  • Patent number: 5514650
    Abstract: Ceretain aza cyclohexapeptide compounds have been found to have superior antibiotic properties. Novel processes for their preparation are also described.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: May 7, 1996
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Regina M. Black, Frances A. Bouffard
  • Patent number: 5430018
    Abstract: Certain aminoalkyl substituted amides which have a cyclohexapeptidyl group and which are found to have antibiotic activity with physical properties suitable for use in therapeutic compositions are described.
    Type: Grant
    Filed: October 17, 1991
    Date of Patent: July 4, 1995
    Assignee: Merck & Co., Inc.
    Inventor: Robert A. Zambias
  • Patent number: 5378804
    Abstract: Aza cyclohexapeptide compounds are disclosed with a nitrogen attached to the cyclohexapeptide ring at the 5-carbon of the 4-hydroxyornithine component. Such compounds are represented by the formula: ##STR1## The compounds are disclosed as having antifungal, antiprotozoal and anti-Pneumocystis carinii activity.
    Type: Grant
    Filed: March 16, 1993
    Date of Patent: January 3, 1995
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Regina M. Black, Frances A. Bouffard
  • Patent number: 5360788
    Abstract: This invention relates to personal care compositions, and, more specifically, to a composition comprising a pyrithione salt or acid, a basic lipopeptide, and a suitable carrier. The pyrithione plus the lipopeptide provide antimicrobial efficacy to the personal care composition. The personal care composition is useful in a variety of dermatological items, such as soaps, shampoos, and skin care medicaments.
    Type: Grant
    Filed: November 10, 1992
    Date of Patent: November 1, 1994
    Assignee: Olin Corporation
    Inventor: John D. Nelson
  • Patent number: 5348940
    Abstract: Certain propionitrile compounds which have a cyclohexapeptidyl nucleus and which are found to have antibiotic activity with physical properties suitable for use in therapeutic compositions are described. A novel process for their preparation is also described.
    Type: Grant
    Filed: September 3, 1992
    Date of Patent: September 20, 1994
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Robert A. Zambias
  • Patent number: 5130414
    Abstract: A new and demonstratably active cyclo-octapeptide is isolated from the South Pacific Ocean Hymeniacidon sp. and structurally elucidated. The substance, herein denominated Hymenistatin 1, demonstrated utility by inhibiting tumor growth when measured by the National Cancer Institute P388 leukemia cell line (ED.sub.50 =3.5 .mu.g/mL).
    Type: Grant
    Filed: November 30, 1989
    Date of Patent: July 14, 1992
    Assignee: Arizona Board of Regents, a body corporate of Arizona State University
    Inventor: George R. Pettit
  • Patent number: 5114918
    Abstract: Cyclic pentapeptides of the formula:cyclo (-X.sup.1 -X.sup.2 -X.sup.3 -X.sup.4 -X.sup.5 -) (I)wherein X.sup.n (n=1-5) represents amino acid residues. These compounds are useful as hypotensive drugs.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: May 19, 1992
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaru Nishikibe, Masaki Ihara, Mitsuo Yano