With All Amino Acids In L-form (c07k-7/66a) Patents (Class 930/DIG548)
  • Cytotoxic and antiviral compound
    Patent number: 6011010
    Abstract: Kalahide F. of formula I below, may be isolated from a secoglossan. The compound may be used in the manufacture of pharmaceutical compositions or in the treatment of tumors or viral conditions.
    Type: Grant
    Filed: September 25, 1997
    Date of Patent: January 4, 2000
    Assignee: Pharma Mar, s.a.
    Inventors: Paul J Scheuer, Mark T Hamann, Dolores G. Gravalos
  • Cyclic vasoactive peptide analogs
    Patent number: 5677419
    Abstract: Analogs of porcine Vasoactive Intestinal Peptide are disclosed. The analogs have been cyclized by the covalent attachment, via an amide bond, of the side-chain carboxy terminus of one amino acid in the peptide chain to the side-chain amino terminus of another amino acid in the peptide chain. The claimed compounds are useful for the treatment of asthma.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: October 14, 1997
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Robert Bolin, Margaret O'Donnell
  • Aza cyclohexapeptide compounds
    Patent number: 5668105
    Abstract: Compounds represented by the formula (Seq ID Nos. 1-6) ##STR1## wherein all substituents are fully defined, are disclosed. These compounds exhibit utilities as antibiotic and antifungal agents and for the treatment and prevention of Pneumocystis infections.
    Type: Grant
    Filed: March 12, 1996
    Date of Patent: September 16, 1997
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Frances A. Bouffard, Milton L. Hammond
  • Process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
    Patent number: 5646245
    Abstract: An improved process for the preparation of side chain derivatives of cyclohexapeptidyl lipopeptides represented by the formula ##STR1## wherein R.sup.1 is fully defined, is disclosed.
    Type: Grant
    Filed: May 16, 1996
    Date of Patent: July 8, 1997
    Inventors: James M. Balkovec, Frances A. Bouffard, James F. Dropinski, Akinlolu A. Adefarati, Jan S. Tkacz
  • Process for preparing certain aza cyclohexapeptides
    Patent number: 5552521
    Abstract: There is disclosed a novel process for preparing aza cyclohexapeptides of the formula ##STR1## where all variables are defined herein.
    Type: Grant
    Filed: February 10, 1995
    Date of Patent: September 3, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Kevin M. Belyk, Dean R. Bender, Regina M. Black, David L. Hughes, William Leonard
  • Aza cyclohexapeptide compounds
    Patent number: 5516756
    Abstract: The present invention is directed to novel aza cyclohexapeptide compounds of the formula ##STR1## where all substituents are defined herein, which are useful as antifungal agents and for the treatment of Pneumocystis carinii infections. Compositions containing the compounds of the invention are also disclosed.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: May 14, 1996
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Frances A. Bouffard, James F. Dropinski
  • Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
    Patent number: 5516757
    Abstract: There are disclosed novel semi-synthetic lipopeptides of the formula (Seq. ID Nos. 1-6) ##STR1## wherein the substituents are defined herein, which show utility as antifungal and anti-Pneumocystis agents. Pharmaceutical compositions containing said compounds are also disclosed.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: May 14, 1996
    Assignee: Merck & Co., Inc.
    Inventor: James M. Balkovec
  • Aza cyclohexapeptide compounds
    Patent number: 5514650
    Abstract: Ceretain aza cyclohexapeptide compounds have been found to have superior antibiotic properties. Novel processes for their preparation are also described.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: May 7, 1996
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Regina M. Black, Frances A. Bouffard
  • Aza cyclohexapeptide compounds
    Patent number: 5514651
    Abstract: The present invention relates to aza cyclohexapeptide compounds of the formula (Seq ID Nos. 1-10) ##STR1## which may be useful as antibiotics, antifungal agents and for the treatment of Pneumocystis carinii infections.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: May 7, 1996
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Frances A. Bouffard, James F. Dropinski
  • Cyclohexapeptide with basic nitrogen containing alkylamide groups
    Patent number: 5430018
    Abstract: Certain aminoalkyl substituted amides which have a cyclohexapeptidyl group and which are found to have antibiotic activity with physical properties suitable for use in therapeutic compositions are described.
    Type: Grant
    Filed: October 17, 1991
    Date of Patent: July 4, 1995
    Assignee: Merck & Co., Inc.
    Inventor: Robert A. Zambias
  • Aza cyclohexapeptide compounds
    Patent number: 5378804
    Abstract: Aza cyclohexapeptide compounds are disclosed with a nitrogen attached to the cyclohexapeptide ring at the 5-carbon of the 4-hydroxyornithine component. Such compounds are represented by the formula: ##STR1## The compounds are disclosed as having antifungal, antiprotozoal and anti-Pneumocystis carinii activity.
    Type: Grant
    Filed: March 16, 1993
    Date of Patent: January 3, 1995
    Assignee: Merck & Co., Inc.
    Inventors: James M. Balkovec, Regina M. Black, Frances A. Bouffard