Plural Separate Columns Patents (Class 95/86)
  • Patent number: 9347927
    Abstract: A system and method are provided for implementing an advanced monitoring scheme to detect a localized presence of particular target substances, including toxic chemical agents, in a space, and particularly for detecting and monitoring a presence of chemical agents that are absorbed into porous or semi-porous products and surfaces in the space when it is determined that potential chemical agent exposure has occurred. A heated vaporizer inlet apparatus provides a sensor source that is optimized for the detection of less volatile chemical agents, and particular less volatile chemical agents, that have been absorbed by materials with porous compositions or surfaces. The heated vaporizer inlet apparatus is used for heating architectural surfaces that were exposed to chemical agents in an effort to substantially increase a vapor pressure of a target substance disposed on or absorbed in a particular target surface.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: May 24, 2016
    Assignee: Lockheed Martin Corporation
    Inventor: John Wood
  • Patent number: 8968560
    Abstract: Methods and related apparatuses and mixtures are described for chromatographic analysis. The described system includes a pressurized source of a mobile phase and a flow path in fluid communication with the pressurized source such that the mobile phase flows through the flow path. The system also includes an injector in fluid communication with the flow path and downstream of the pressurized source, the injector being configured to inject a sample into the flow path. A first column located downstream of the injector, contains a stationary phase, and forms part of the flow path. A first detector is positioned to detect properties of fluid in the flow path at a location downstream of the injector and upstream from the first column. A second detector is positioned to detect properties of fluid in the flow path at a location downstream of the first column.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: March 3, 2015
    Assignee: Schlumberger Technology Corporation
    Inventor: William H. Steinecker
  • Patent number: 8613215
    Abstract: A method and apparatus for two-dimensional gas chromatography (GC), including a valve having first and second positions (P1, and P2), and first through fourth sample flow paths (FP1-FP4). In P1, a first gas sample is collected from a first dimension GC column via FP1, a first pressure source and a first, second dimension GC column are connected via FP2, a second pressure source and a second, second dimension GC column are connected via FP3, and FP4 is disconnected. In P2, the first sample in FP1 is introduced to the second, second dimension GC column via FP1, with aid of the second pressure source, a second gas sample is collected from the first dimension GC column via FP2, the first pressure source and the first, second dimension GC column via FP4 are connected, and FP3 is disconnected.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: December 24, 2013
    Assignees: Schlumberger Technology Corporation, 3M Innovative Properties Company
    Inventors: Gordon Lambertus, William Steinecker
  • Patent number: 8607615
    Abstract: A two-dimensional gas chromatography system having first and second separation columns, a thermal modulator disposed between the first and second columns and having a plurality of stage channels, and a micro heater monolithically integrated in the thermal modulator. The thermal modulator is operable to trap and focus gas/vapor species within the plurality of stage channels upon cooling and release the gas/vapor species to the second column upon heating by the micro heater.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: December 17, 2013
    Assignee: The Regents of The University of Michigan
    Inventors: Sung Jin Kim, Katsuo Kurabayashi, Kensall D. Wise, Edward T. Zellers, Bruce P. Block
  • Patent number: 8499615
    Abstract: A gas chromatograph comprising two separating devices disposed one behind the other, and through which a material sample is conducted by a carrier gas. A pressure regulator regulates the pressure of the carrier gas introduced into the first separating device. A controllable switching device is arranged between the two separating devices. The switching device contains a main gas path lying between the two separating devices and two auxiliary gas paths, which are connected to the main gas path through connecting gas paths and are both fed with the carrier gas and contain flow resistors and a controllable valve for setting different pressure conditions. The auxiliary gas paths are supplied with the carrier gas through the same pressure regulator to reduce the design and adjustment effort in setting the pressure conditions, where fixed resistors are used for the flow resistors.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: August 6, 2013
    Assignee: Siemens Aktiegesellschaft
    Inventor: Piotr Strauch
  • Publication number: 20130145933
    Abstract: An apparatus for separation of gases from ambient air that has at least one separation column containing an adsorbent with an inlet at a first end and an outlet at a second end, a buffer column containing an adsorbent and having a single inlet at a first end, a vacuum pump, and a valve system that connects the vacuum pump to the outlet at the first end of the separation column, and that connects the outlet at the second end of the separation column to the single inlet at the first end of the buffer column.
    Type: Application
    Filed: February 7, 2013
    Publication date: June 13, 2013
    Applicant: VBOX, INCORPORATED
    Inventor: VBOX, INCORPORATED
  • Patent number: 8426215
    Abstract: A gas chromatograph for analyzing natural gas, with a first separation column (6). A first detector (7) is provided following the first separation column, the first separation column and the first detector operable to separate or detect propane and higher hydrocarbons. A second separation column (8) and a second detector (9) following it are provided to separate or detect carbon dioxide and ethane. A third separation column (10) and a third detector (11) following it are provided to separate or detect nitrogen and methane. A controllable changeover device (12) is provided between the second separation column (8) and the third separation column (10) to discharge eluates following methane. The first, second and third separation columns (6, 8, 10) and the first, second and third detectors (7, 9, 11) are connected in series. At least the first and the second detectors (7, 9) are operable to detect a mixture of substances flowing through them in a non-destructive manner.
    Type: Grant
    Filed: September 28, 2004
    Date of Patent: April 23, 2013
    Assignee: Siemens Aktiengesellschaft
    Inventors: Friedhelm Mueller, Udo Gellert
  • Patent number: 8230719
    Abstract: The present invention is directed to a method for multidimensional gas chromatography for separating the analytes of a complex sample. The method comprises the steps of introducing the sample onto a first column whereby the sample is separated into at least two segments, introducing at least one segment into a heartcut device whereby the segments are selectively separated into at least two heartcut fractions, introducing at least one of the fractions onto a second column whereby at least one fraction is further separated into at least two analytes, introducing at least one analyte from the second column to a gas chromatography connector, introducing the analyte from the connector to a third column, and introducing the analyte from the third column into a detector whereby the analyte is analyzed and identified.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: July 31, 2012
    Assignee: MRIGlobal
    Inventor: Chad Fisher
  • Patent number: 8226825
    Abstract: Systems and methods for performing chromatography separations or analyses are disclosed. The methods are based upon an equilibrium gradient focusing mode in contrast to conventional transient migration-based modes. By matching the migration speed of one or more analyte(s) of interest to the wave speed of a thermal gradient induced to travel along a region in which chromatographic partitioning occurs, significant improvements in detection limits are achieved. In particular, a temperature gradient focusing strategy is described in which analyte(s) of interest are circulated around a continuous chromatography system in order to focus the analyte(s). Also described are various devices and systems that can be used in the methods described herein.
    Type: Grant
    Filed: July 21, 2009
    Date of Patent: July 24, 2012
    Assignee: The United States of America, as represented by the Sectretary of Commerce, The National Institute of Standards and Technology
    Inventor: David J. Ross
  • Patent number: 8114200
    Abstract: A portable multi-dimensional gas chromatograph, the gas chromatograph including a carrier gas container, a regulator fluidly connected to the carrier gas container, a dopant chamber containing a reference chemical, at least one pre-concentrator which is fluidly connected to the regulator and the dopant chamber, a first separation column fluidly connected to the at least one pre-concentrator, a second separation column fluidly connected to the at least one pre-concentrator, a first detector fluidly connected to the first separation column, and a second detector fluidly connected to the second separation column.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: February 14, 2012
    Assignee: VPI Enigineering, Inc.
    Inventors: Sheena Alm, James Bentley, John Blankevoort, Mark Kaspersen, Collin Lewis, Derek Maxwell, Ken Wunner
  • Publication number: 20120017760
    Abstract: An apparatus and method for rapid fractionation of hydrocarbon phases in a sample fluid stream are disclosed. Examples of the disclosed apparatus and method include an assembly of elements in fluid communication with one another including one or more valves and at least one sorbent chamber for removing certain classifications of hydrocarbons and detecting the remaining fractions using a detector. The respective ratios of hydrocarbons are determined by comparison with a non separated fluid stream.
    Type: Application
    Filed: July 21, 2010
    Publication date: January 26, 2012
    Applicant: UT-BATTELLE, LLC
    Inventors: Charles S. Sluder, John M. Storey, Samuel A. Lewis, SR.
  • Publication number: 20100307334
    Abstract: A fluid separation apparatus suitable for separating a mixed fluid with different properties and capable of separating a complex fluid mixture efficiently is provided. The fluid separation apparatus includes a sampling entrance, a first separation column, a second separation column, a bypass line, a detector and a guide multi-channel valve. A mixed fluid flows into the first separation column via the sampling entrance. The second separation column is connected to the first separation column in series and connected to the bypass line in parallel. The detector is connected to the second separation column and the bypass line. The guide multi-channel valve has different modes to control a flow-through status and a closed status between the first separation column and the second separation column, between the first separation column and the bypass line, between the second separation column and the detector, and between the bypass line and the detector.
    Type: Application
    Filed: August 4, 2009
    Publication date: December 9, 2010
    Applicant: National Taiwan University of Science and Technology
    Inventors: Sheng-Chiang Yang, Shih-Chi Lu, Bing-Joe Hwang
  • Patent number: 7823439
    Abstract: The present invention is directed to a method for multidimensional gas chromatography for separating the analytes of a complex sample. The method comprises the steps of introducing the sample onto a first column whereby the sample is separated into at least two segments, introducing at least one segment into a heartcut device whereby the segments are selectively separated into at least two heartcut fractions, introducing at least one of the fractions onto a second column whereby at least one fraction is further separated into at least two analytes, introducing at least one analyte from the second column to a gas chromatography connector, introducing the analyte from the connector to a third column, and introducing the analyte from the third column into a detector whereby the analyte is analyzed and identified.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: November 2, 2010
    Assignee: Midwest Research Institute
    Inventor: Chad Fisher
  • Patent number: 7824471
    Abstract: The present invention provides a chromatographic method for eliminating interference from interfering agents, coming from the gas sample itself or from the system material used to perform the impurities measurements, on impurities to be quantified in a gas sample. The method advantageously relies on the use of an additional valve and an additional sample loop particularly arranged in a G. C. system, and also on an additional supporting gas inlet operatively connected to the system through the additional sample loop for providing the system with a supporting gas comprising at least a predetermined portion of a predetermined active gas that will react with the unwanted interfering impurities, if any, or with the column material to cancel out unwanted active sites. Thus, the method of the present invention can advantageously be used in gas chromatographic systems to improve sensitivity thereof by acting on column separation material.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: November 2, 2010
    Assignee: Panalytique Inc.
    Inventors: Yves Gamache, Andre Fortier
  • Patent number: 7824472
    Abstract: In order to provide a new PSA method which can concentrate simultaneously a strong adsorbate such as xenon and a weak adsorbate such as nitrogen in a high concentration with a high recovery percentage when highly valuable gas such as xenon and krypton contained in the exhaust gas from a semiconductor manufacturing equipment, etc.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: November 2, 2010
    Assignee: Taiyo Nippon Sanso Corporation
    Inventor: Tatsushi Urakami
  • Publication number: 20100186587
    Abstract: A method for the chromatographic separation of components of a multicomponent fluid mix by means of the Simulated Moving Bed method wherein the multicomponent fluid mix and at least one solvent are fed to inflows of a plurality of chambers containing at least one solid substance and connected to each other in series to form a closed loop. An extract stream containing at least one first component separated from the multicomponent fluid mix as well as a raffinate stream containing at least one second component separated from the multicomponent fluid mix are carried out of the chambers through a first and second outflows. At least part of the raffinate stream and/or extract stream carried off at the first and/or second outflows is preliminarily stored and recirculated to the first and/or second inflow of the chambers alternately or simultaneously with the multicomponent fluid mix and/or the solvent within one clock unit.
    Type: Application
    Filed: April 16, 2008
    Publication date: July 29, 2010
    Applicant: Max Planck Gesellschaft zur Foderung der Wissenschaftern e V.
    Inventors: Lars Kessler, Andreas Seidel-Morgenstern
  • Patent number: 7722703
    Abstract: The device has a honeycomb rotor which is rotated and which supports an adsorbant. A seal divides the honeycomb rotor into a desorption zone and at least one other zone including an adsorption zone. The seal has a heat resistant/non flammable portion and an elastic seal portion. The heat resistant portion has a slot cut in a surface which contacts the honeycomb rotor. The elastic seal portion is formed outside of the desorption zone with respect to the heat resistant portion. Desorption air is substantially completely sealed within the desorption zone. The seal may allow for hot (perhaps 300° C.) desorption gas to be used with a rotation type gas adsorption concentration device.
    Type: Grant
    Filed: March 23, 2005
    Date of Patent: May 25, 2010
    Assignee: Seibu Giken Co., Ltd.
    Inventor: Yuji Fujioka
  • Publication number: 20100101411
    Abstract: Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.
    Type: Application
    Filed: May 27, 2009
    Publication date: April 29, 2010
    Inventor: Andrew Tipler
  • Patent number: 7601543
    Abstract: This invention is a method and device for use with multi-dimensional chromatography that utilizes partial modulation. An analyte-bearing sample is subjected to a first dimension of chromatography. Thereafter the separated analyte-bearing sample is diluted with a modulated second carrier such at the analyte-bearing sample is not stopped or its temperature altered. The partially modulated analyte-bearing sample then feeds into a secondary column where the analyte-bearing sample is further separated.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: October 13, 2009
    Assignee: Valco Instruments Co., Inc.
    Inventors: Huamin Cai, Stanley Stearns
  • Patent number: 7527676
    Abstract: A unit for separating an exhaust gas containing PFC gases including CF4 and C2F6 generated in a production process, wherein the exhaust gas is concentrated in a concentration device, and then separated chromatographically in a chromatographic separation device using nitrogen as a carrier gas. The chromatographic separation device is packed with molecular sieve 13X or F-9 or the like. The unit is capable of effectively separating CF4 and C2F6.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: May 5, 2009
    Assignee: Organo Corporation
    Inventors: Yoshinori Tajima, Takashi Futatsuki, Tetsuya Abe, Sadamitsu Tanzawa, Seiji Hiroki
  • Publication number: 20090107331
    Abstract: In order to provide a new PSA method which can concentrate simultaneously a strong adsorbate such as xenon and a weak adsorbate such as nitrogen in a high concentration with a high recovery percentage when highly valuable gas such as xenon and krypton contained in the exhaust gas from a semiconductor manufacturing equipment, etc.
    Type: Application
    Filed: February 23, 2006
    Publication date: April 30, 2009
    Inventor: Tatsushi Urakami
  • Patent number: 7524363
    Abstract: A separation column assembly for a gas chromatograph and the like is provided. The assembly is a self contained unit which allows very rapid heating and cooling of the column.
    Type: Grant
    Filed: May 16, 2006
    Date of Patent: April 28, 2009
    Assignee: Alliant Techsystems Inc.
    Inventors: James Bentley, John Blankevoort, Collin Lewis, Ken Wunner
  • Patent number: 7507586
    Abstract: This invention is a method and device for use with multi-dimensional chromatography that utilizes partial modulation with multiple secondary retention times. An analyte-bearing sample is subjected to a first dimension of chromatography. Thereafter the separated analyte-bearing sample is diluted with a modulated second carrier such at the analyte-bearing sample is not stopped or its temperature altered. The secondary retention time period at which the modulator cycles is variable among multiple secondary retention time periods to prevent loss of resolution with less complex and/or low boiling point compounds and to prevent loss of data with more complex and/or higher boiling point compounds. The partially modulated analyte-bearing sample then feeds into a secondary column where the analyte-bearing sample is further separated.
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: March 24, 2009
    Assignee: Valco Instruments Co., Inc.
    Inventor: Huamin Cai
  • Patent number: 7507273
    Abstract: A scalable technology for purifying ethanol, wherein the vaporization of ethanol is coupled with a chromatographic rectification process comprising feeding a vaporized ethanol/water mix onto a plurality of molecular sieve beds to produce dehydrated ethanol vapor, which can then be condensed to recover purified dehydrated ethanol liquid. The scalable technology process is suitable for farm-scale production of fuel-grade ethanol, having the added benefit of allowing wet distillers grains to be used on-site as live-stock feed. By reducing energy requirements, costs and pollution, the output can be scaled to produce fuel-grade ethanol at quantities of anywhere from about 1000 gallons per year to upwards of hundreds of millions of gallons per year. Particularly beneficial versions utilize a plurality of smaller molecular sieve beds in series and use heat generated during desorption and regeneration of the molecular sieve beds as an energy source to aid in the vaporization step.
    Type: Grant
    Filed: June 20, 2006
    Date of Patent: March 24, 2009
    Assignee: 6Solutions, LLC
    Inventor: Cecil T. Massie
  • Patent number: 7383718
    Abstract: A single stage flow modulator for performing comprehensive chromatography comprises a first chromatographic column, a valve fluidically coupled to at least two fluid conduits, wherein when in a first position, the valve directs a control flow to direct an output of the first chromatographic column to a first detector, and wherein when in a second position, the valve directs a control flow to direct a portion of an output of the first chromatographic column to a second chromatographic column, wherein the portion of the output of the first chromatographic column directed to the second chromatographic column is continuously modulated throughout a sample run.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: June 10, 2008
    Assignee: Agilent Technologies, Inc.
    Inventors: James D McCurry, John V. Seeley
  • Patent number: 7273517
    Abstract: A non-planar microfabricated gas chromatography column comprises a planar substrate having a plurality of through holes, a top lid and a bottom lid bonded to opposite surfaces of the planar substrate, and inlet and outlet ports for injection of a sample gas and elution of separated analytes. A plurality of such planar substrates can be aligned and stacked to provide a longer column length having a small footprint. Furthermore, two or more separate channels can enable multi-channel or multi-dimensional gas chromatography. The through holes preferably have a circular cross section and can be coated with a stationary phase material or packed with a porous packing material. Importantly, uniform stationary phase coatings can be obtained and band broadening can be minimized with the circular channels. A heating or cooling element can be disposed on at least one of the lids to enable temperature programming of the column.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: September 25, 2007
    Assignee: Sandia Corporation
    Inventors: Patrick R. Lewis, David R. Wheeler
  • Patent number: 7260978
    Abstract: A gas chromatography/mass spectrometry system includes two sample introduction parts, a gas chromatography part having two columns, a column oven for housing the two columns in a parallel configuration, an interface part through which an outlet end of each of the two columns is inserted, and a mass spectrometry part. The mass spectrometry part has an ionization chamber to which the outlet ends of the columns inserted through the interface part are connected, a mass separation part, an ion detector, and a vacuum chamber for housing the ionization chamber, the mass separation part, and the detector. Because the outlet ends of the parallel columns are both connected to the ionization chamber, the carrier gas flow and line velocity are the same as though there is one column, thereby avoiding line stagnation. Since analyses can be performed selectively with a single system, results having high reliability and precision can be obtained.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: August 28, 2007
    Assignee: Shimadzu Corporation
    Inventor: Haruhiko Miyagawa
  • Patent number: 7107818
    Abstract: A method for detecting substances or mixtures of substances within a sample in an apparatus for comprehensive two-dimensional gas-chromatographic analysis according to the present invention, comprising the steps of: subjecting the sample to a first separation within a first capillary column; modulating in time the effluents from the first column by means of the subdivision into adjacent fractions of the effluents from the first column and subsequently sending each fraction into a second capillary column, the modulation of the effluents being periodic with a first modulation frequency f1 of the sample; separating each of the fractions in the aforesaid second capillary column; and detecting, at the end of the second capillary column, the effluents by means of periodic sampling by discrete time points at a second frequency f2.
    Type: Grant
    Filed: February 4, 2003
    Date of Patent: September 19, 2006
    Assignee: Thermo Electron S.p.A.
    Inventors: Giacinto Zilioli, Jan Beens
  • Patent number: 7091044
    Abstract: This invention is a method and device for use with multi-dimensional chromatography that utilizes partial modulation. An analyte-bearing sample is subjected to a first dimension of chromatography. Thereafter the separated analyte-bearing sample is diluted with a modulated second carrier such at the analyte-bearing sample is not stopped or its temperature altered. The partially modulated analyte-bearing sample then feeds into a secondary column where the analyte-bearing sample is further separated.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: August 15, 2006
    Assignee: Valco Instruments Co., Inc.
    Inventors: Huamin Cai, Stanley Stearns
  • Patent number: 6840456
    Abstract: An injection valve is provided. A first conduit is disposed between first and second chambers of the valve. An entrance to the first conduit is located within the first chamber. A second conduit is concentrically disposed within the first conduit so that there is a first flow passage between the first and second conduits connecting the first and second chambers. The second conduit has an entrance communicating with the first chamber via the entrance of the first conduit and an exit defining a first outlet port of the valve. A cover opens and closes a first inlet port of the first chamber, and a biasing device biases the cover closed. An actuator moves the cover from the closed position to open the first inlet port.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: January 11, 2005
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Waleed M. Maswadeh, A. Peter Snyder
  • Patent number: 6838288
    Abstract: This invention relates to a modulator for use in gas chromatographic analysis, adopted for alternatively trapping and releasing fractions of solutes in a length of a capillary column within a chromatographic oven, characterized in that it comprises at least one nozzle placed to spray at least one jet in at least one corresponding place along said capillary column length, said nozzle(s) being connected each to a source of liquid CO2 via a related valve, and means for alternatively opening said valve(s) for a predetermined time, to cause a jet of liquid CO2 to impinge for said predetermined time on said column place and to leave the oven atmosphere to heat said column place after said predetermined time. The modulator can be used in a conventional GC system or in a two dimensional GC system, for modulating the analytes fed to the second capillary column.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: January 4, 2005
    Assignee: Thermo Electron S.p.A.
    Inventor: Jan Beens
  • Patent number: 6706535
    Abstract: A gas chromatography system having a computer-controlled venting valve system that delivers pressurized pulses to a column junction point of two series-coupled columns having different stationary-phase chemistries and a method of using the same. Each pressurized pulse causes a differential change in the carrier gas velocities in the two columns, which lasts for the duration of the pressurized pulse. Whereby, the pressurized pulse selectively increases the separation of a component pair that exhibits separation at the exit of the first column, but otherwise co-elutes from the column ensemble.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: March 16, 2004
    Assignee: The Regents of the University of Michigan
    Inventors: Richard Douglas Sacks, Tincuta Maria Veriotti, Megan Ellen McGuigan
  • Patent number: 6706534
    Abstract: A gas chromatography system having a computer-controlled pressure controller that delivers pressurized pulses to a column junction point of two series-coupled columns having different stationary-phase chemistries and a method of using the same. Each pressurized pulse causes a differential change in the carrier gas velocities in the two columns, which lasts for the duration of the pressurized pulse. Whereby, the pressurized pulse selectively increases the separation of a component pair that exhibits separation at the exit of the first column, but otherwise co-elutes from the column ensemble.
    Type: Grant
    Filed: December 10, 2001
    Date of Patent: March 16, 2004
    Assignee: The Regents of the University of Michigan
    Inventors: Richard Douglas Sacks, Tincuta Maria Veriotti, Megan Ellen McGuigan
  • Patent number: 6702989
    Abstract: A gas chromatography system having a computer-controlled venting valve system that delivers pressurized pulses to a column junction point of two series-coupled columns having different stationary-phase chemistries and a method of using the same. Each pressurized pulse causes a differential change in the carrier gas velocities in the two columns, which lasts for the duration of the pressurized pulse. Whereby, the pressurized pulse selectively increases the separation of a component pair that exhibits separation at the exit of the first column, but otherwise co-elutes from the column ensemble.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: March 9, 2004
    Assignee: The Regents of the University of Michigan
    Inventors: Richard Douglas Sacks, Joshua Jonathan Mark Whiting
  • Patent number: 6702874
    Abstract: Using a distillation separator, a gas to be treated is separated into a plurality of gas groups having different boiling points. Then, the specific gases included in each of the plurality of gas groups separated at the first separator and having similar boiling points are separated using a chromatographic separator. In this manner, specific gases can be separated from the gas to be treated containing a plurality of specific gases.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: March 9, 2004
    Assignee: Organo Corporation
    Inventors: Yoshinori Tajima, Takashi Futatsuki
  • Patent number: 6632268
    Abstract: A two-dimensional gas chromatograph with a primary column (14) and dual secondary columns (26, 28) is described. Flow rates in the primary column are less than those in the secondary columns due to an accumulation valve (16). Typically the ratio of second and third column flow capacities combined to primary column flow capacities between about 10 to 1 and 30 to 1. Volatile organic compounds are detected in environmental samples of air water, soil and in body fluids of animals and humans.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: October 14, 2003
    Assignee: Oakland University
    Inventor: John V. Seeley
  • Patent number: 6497138
    Abstract: The present disclosure relates to a gas chromatograph having a plurality of layers or channels. The chromatograph typically comprises an inlet that receives a sample to be analyzed, a column disposed in each of the plurality of chromatograph layers, each column being in fluid communication with and downstream from the inlet and having a stationary phase coating its inner surfaces, and a detector in fluid communication with and downstream from at least one of the columns. In a preferred arrangement, the chromatograph includes a pre-column disposed in each of the chromatograph layers upstream of the columns, each pre-column being in fluid communication with the inlet and having a stationary phase coating its inner surfaces.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: December 24, 2002
    Assignee: Agilent Technologies, Inc.,
    Inventors: Mahmoud Farid Abdel-Rahman, Carl A. Myerholtz
  • Patent number: 6484560
    Abstract: An apparatus and method for selectively concentrating an analyte on an apparatus by evaporating solvent from the analyte. Concentration is performed by heating or by flowing a gas stream over the analyte to evaporate solvent from the analyte. The invention also provides a method to be used in conjunction with the apparatus.
    Type: Grant
    Filed: November 7, 2000
    Date of Patent: November 26, 2002
    Assignee: Agilent Technologies, Inc.
    Inventor: Harry F. Prest
  • Publication number: 20020148353
    Abstract: A two-dimensional gas chromatograph with a primary column (14) and dual secondary columns (26, 28) is described. Flow rates in the primary column are less than those in the secondary columns due to an accumulation valve (16). Typically the ratio of second and third column flow capacities combined to primary column flow capacities between about 10 to 1 and 30 to 1. Volatile organic compounds are detected in environmental samples of air water, soil and in body fluids of animals and humans.
    Type: Application
    Filed: February 4, 2002
    Publication date: October 17, 2002
    Applicant: Oakland University
    Inventor: John V. Seeley
  • Patent number: 6447575
    Abstract: The invention relates to gas chromatography analysis of a sample having components to be investigated and water contained therein, which after thermodesorption is separated and analyzed, the thermodesorbed sample being transferred by a carrier gas into a first polar separation column which retains higher-boiling components and water and passes low-boiling components, the latter being led, past a branching point which leads, on the one hand, to a second polar or non-polar separation column and, on the other hand, to the non-polar separation column, to the non-polar separation column in a fashion excluding access to the second polar or non-polar separation column, after which higher-boiling components and water are transferred to the second polar or non-polar separation column in a fashion excluding access to the non-polar separation column, water being eliminated upstream of the second polar or non-polar separation column by cryofocussing.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: September 10, 2002
    Assignee: Gertstel Systemtechnik GmbH & Co.
    Inventors: Ralf Bremer, Andreas Hoffmann
  • Patent number: 6311544
    Abstract: A flow of a carrier gas through a column is provided. A sample is provided in the column, and a temperature of a longitudinally short portion of the column is raised to a predetermined controlled high temperature at which volatile substances are released from the sample packing and are carried by the carrier gas. The column is cooled on each side of the short portion to a low temperature at which the volatile substances condense or adsorb on the column packing. By continuously moving the heated short portion from an inlet end to an outlet end of the packing in a direction of carrier gas flow the volatile substances selected by the controlled high temperature are released. Four particularly useful and advantageous applications can be identified for the invention. Firstly, it provides an improved gas chromatograph (GC) injector. Secondly, it provides an improved thermal separator or extractor.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: November 6, 2001
    Assignee: Universite de Montreal
    Inventor: Michel Bertrand
  • Patent number: 6237396
    Abstract: Integrated analysis process and device for characterization of hydrocarbons in a petroleum product, in distillation fractions, by simulated distillation. The hydrocarbons of a petroleum sample are characterized without fractional distillation by coupling gas chromatography (GC) with liquid chromatography (LC) techniques. GC simulated distillation (SD) is carried out. The separation column is preceded by a precolumn of the same nature but shorter. At the outlet of the main column, retention means (CT, AC) allow to collect and to store one or more light fractions that are sent each to a GC analytical column (6) allowing detailed analysis of the hydrocarbons, and one or more middle fractions. The remaining heavy fraction is collected at the precolumn outlet. The middle and heavy fractions are characterized by a combined LC-GC chromatography unit. Several interfaces allowing GC-GC-LC-GC coupling are described.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: May 29, 2001
    Assignee: Institut Francais du Petrole
    Inventors: Jean-Pierre Durand, Eric Robert, Véronique Ruffier-Meray
  • Patent number: 6007602
    Abstract: An apparatus and a method are described for forming a chemical modulation of a substance present in a fluid stream, which utilize a movable device, such as a movable heater, to induce changes in the retention of a chemical substance flowing through the modulator tube. The modulator tube has an inlet, a first portion in communication with the inlet, a second portion in communication with said first portion, and an outlet in communication with said second portion. The method involves causing a chemical modulation by moving retention alteration device relative to a modulator tube.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: December 28, 1999
    Assignee: Board of Trustees of Southern Illinois University on Behalf of Southern Illinois University at Carbondale
    Inventors: Edward B. Ledford, Jr., John B. Phillips
  • Patent number: 5904749
    Abstract: A gas chromatographic method utilizes columns having either ascending or descending temperature profiles to effect separation even under column overloading conditions. A fixed ascending temperature profile column allows for good separation of components of a mixture under conditions of column overloading. A mixture to be separated is chromatographed on at least one such column prior to chromatography on a column maintained with a descending temperature profile. This latter column has surprisingly been found to greatly reduce tailing of less volatile species. The invention also includes a variable temperature descending column chromatography to provide an initial ordering of a large quantity of components prior to chomatography on the fixed ascending temperature profile column, or on the serial fixed ascending and descending temperature profile pair of columns.
    Type: Grant
    Filed: January 27, 1994
    Date of Patent: May 18, 1999
    Inventors: Christopher Huk-Shi Chen, Shinn-Der Chang, Chengwen Weng, Yuanming Tang, Ingo Bernd Holzhueter, Samuel Hugh Hawthorne
  • Patent number: 5846292
    Abstract: A gas chromatograph and method of chromatography are provided. Analytes, those compounds to be tested, are extracted from the sample by moving the sample into a column which has a stationary phase along the column walls. The column has two sections which are different in length. The longer section is heated and the analytes move to the shorter section. The longer section is then cooled and the entire column is heated. The device then functions as an analytical column and the analytes move out of the shorter section, through the longer section, and out of the column. A detector placed at the end of the column's longer section detects the presence of the compounds as they exit the column. In an alternate embodiment two separate columns are provided. One column is used as the extraction column and the other is used as the analytical column.
    Type: Grant
    Filed: May 6, 1997
    Date of Patent: December 8, 1998
    Assignee: Board of Supervisors at Louisiana State University & Agricultural & Mechanical College
    Inventor: Edward B. Overton
  • Patent number: 5840953
    Abstract: Tetraethoxysilane is purified by passing impure material through a gas chromatographic separating column at a temperature below the boiling point of the pure tetraethoxysilane. Separation of pure material from impurities occurs on the column, and the pure material is thereafter cooled and collected in a receiver. The purified tetraethoxysilane has 99.999999% purity based on metals content.
    Type: Grant
    Filed: November 16, 1995
    Date of Patent: November 24, 1998
    Assignee: Eagle-Picher Industries, Inc.
    Inventor: Thomas M. Potts
  • Patent number: 5779765
    Abstract: To inject a liquid sample with large volume into a GC column of a gas chromatograph, its volatile portion is evaporated by heat, in a non-selective way, in a vaporization chamber, the vapors thus generated being fed to pre-column located upstream of the GC column and maintained at a lower temperature to that of the vaporization chamber, where such compounds are separated from the solvent vapors, which are unloaded into the atmosphere while the compounds to be analyzed are sent to the GC column.
    Type: Grant
    Filed: July 12, 1996
    Date of Patent: July 14, 1998
    Assignee: Thermoquest Italia S.P.A.
    Inventors: Konrad Grob, Fausto Munari
  • Patent number: 5739806
    Abstract: A process for introducing or displaying the adjustment parameters of a device for coating objects, particularly vehicles and vehicle bodies. The parameters are introduced on or off-line by a personal computer and displayed on the monitor graphically and alphanumerically in a manner which provides a survey of a series of parameters in mutual relationship.
    Type: Grant
    Filed: March 21, 1995
    Date of Patent: April 14, 1998
    Assignee: Cegelec AEG Anlagen-und Automatisierungstechnik GmbH
    Inventors: Hans Hissen, Hans Schumacher
  • Patent number: 5611846
    Abstract: Gas chromatographs are disclosed that may be constructed to be portable, light, rugged, fast, sensitive, and to use only utilities (compressed gas and electricity) that are readily available in the field. The gas chromatographs can also perform novel extractions of analytes from gaseous, liquid, or solid samples. The chromatographs can be truly portable; they can operate with approximately 100 watts of power (at peak power consumption); and they are extremely fast. The chromatographs are not limited just to portable applications, but will also find many uses within laboratories, because they require minimal laboratory bench or other space, because they can operate at high speed, and because they can operate with minimal consumption of utilities (compressed gases, air conditioning, etc.).
    Type: Grant
    Filed: July 19, 1996
    Date of Patent: March 18, 1997
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Edward B. Overton, Kenneth R. Carney
  • Patent number: 5578111
    Abstract: A process is described for the separation of a mixture of substances by sorption of the mixture's components on two different sorption agents, which are individually and independently adjustable in their sorption properties, and is performed in a manner by which the mixture of substances to be separated is introduced into a separation chamber between the surfaces of the sorption agents, and in which the separation chamber is occupied by a gap medium, in which the mixture's components can be dissolved and/or dispersed and/or evaporated, while the phases containing the sorption agents move in opposing directions, and the separated components of the mixture held on the sorption agents are recovered after passage through the separation path. This process is characterized in that the separation chamber is formed by at least two or several hollow, concentrically superimposed cylindrical disks Z.sub.A and Z.sub.B, which are filled with structural elements, and which contain separation media Ph.sub.A and Ph.sub.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: November 26, 1996
    Assignee: Reuter Chemischer Apparatebau GmbH
    Inventor: Karl A. Reuter