Plural Separate Columns Patents (Class 95/86)
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Patent number: 11016066Abstract: A gas analysis device suited for e.g. medical analysis of exhaled breath from a subject. A gas inlet receives a gas sample to a flow path for guiding the gas sample to two or more gas separators, e.g. gas chromatography columns, with respective molecule selectivity properties which are different. One or more detectors, each with a sensor, are arranged to generate respective responses to outputs from the two or more gas separators. A communication module generate output data in response to the respective responses from the one or more detectors, e.g. data indicative of selected molecules in the gas sample, e.g. data indicative of one or more diseases identified as a result of identified biomarkers in the gas sample. The device is suitable as a compact device, e.g. a handheld breath analysis device, since the use of a plurality of gas separators allows use of very molecule specific gas separators which can be implemented with a small size. E.g.Type: GrantFiled: June 12, 2017Date of Patent: May 25, 2021Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Tamara Mathea Elisabeth Nijsen, Johannes Weda
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Patent number: 10254258Abstract: A two-dimensional chromatogram creator creates a two-dimensional chromatogram based on data collected by a comprehensive two-dimensional GC/MS analysis. An extraction condition conformity determiner determines whether or not each MS/MS spectrum obtained through the analysis conforms to a compound extraction condition previously stored in a storage section, such as the presence of a specific peak on the MS/MS spectrum. Each spectrum which conforms to the condition is extracted. This spectrum is most likely to reflect a partial structure of a compound in which an analysis operator is interested. Accordingly, a condition conformity information superposing displayer displays a marker whose appearance varies according to the compound extraction condition, at a position corresponding to the retention time of the extracted spectrum on the two-dimensional chromatogram.Type: GrantFiled: October 21, 2013Date of Patent: April 9, 2019Assignee: SHIMADZU CORPORATIONInventor: Shinichi Yamaguchi
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Patent number: 9347927Abstract: A system and method are provided for implementing an advanced monitoring scheme to detect a localized presence of particular target substances, including toxic chemical agents, in a space, and particularly for detecting and monitoring a presence of chemical agents that are absorbed into porous or semi-porous products and surfaces in the space when it is determined that potential chemical agent exposure has occurred. A heated vaporizer inlet apparatus provides a sensor source that is optimized for the detection of less volatile chemical agents, and particular less volatile chemical agents, that have been absorbed by materials with porous compositions or surfaces. The heated vaporizer inlet apparatus is used for heating architectural surfaces that were exposed to chemical agents in an effort to substantially increase a vapor pressure of a target substance disposed on or absorbed in a particular target surface.Type: GrantFiled: June 14, 2013Date of Patent: May 24, 2016Assignee: Lockheed Martin CorporationInventor: John Wood
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Patent number: 8968560Abstract: Methods and related apparatuses and mixtures are described for chromatographic analysis. The described system includes a pressurized source of a mobile phase and a flow path in fluid communication with the pressurized source such that the mobile phase flows through the flow path. The system also includes an injector in fluid communication with the flow path and downstream of the pressurized source, the injector being configured to inject a sample into the flow path. A first column located downstream of the injector, contains a stationary phase, and forms part of the flow path. A first detector is positioned to detect properties of fluid in the flow path at a location downstream of the injector and upstream from the first column. A second detector is positioned to detect properties of fluid in the flow path at a location downstream of the first column.Type: GrantFiled: December 6, 2007Date of Patent: March 3, 2015Assignee: Schlumberger Technology CorporationInventor: William H. Steinecker
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Patent number: 8613215Abstract: A method and apparatus for two-dimensional gas chromatography (GC), including a valve having first and second positions (P1, and P2), and first through fourth sample flow paths (FP1-FP4). In P1, a first gas sample is collected from a first dimension GC column via FP1, a first pressure source and a first, second dimension GC column are connected via FP2, a second pressure source and a second, second dimension GC column are connected via FP3, and FP4 is disconnected. In P2, the first sample in FP1 is introduced to the second, second dimension GC column via FP1, with aid of the second pressure source, a second gas sample is collected from the first dimension GC column via FP2, the first pressure source and the first, second dimension GC column via FP4 are connected, and FP3 is disconnected.Type: GrantFiled: December 14, 2009Date of Patent: December 24, 2013Assignees: Schlumberger Technology Corporation, 3M Innovative Properties CompanyInventors: Gordon Lambertus, William Steinecker
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Patent number: 8607615Abstract: A two-dimensional gas chromatography system having first and second separation columns, a thermal modulator disposed between the first and second columns and having a plurality of stage channels, and a micro heater monolithically integrated in the thermal modulator. The thermal modulator is operable to trap and focus gas/vapor species within the plurality of stage channels upon cooling and release the gas/vapor species to the second column upon heating by the micro heater.Type: GrantFiled: October 18, 2010Date of Patent: December 17, 2013Assignee: The Regents of The University of MichiganInventors: Sung Jin Kim, Katsuo Kurabayashi, Kensall D. Wise, Edward T. Zellers, Bruce P. Block
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Patent number: 8499615Abstract: A gas chromatograph comprising two separating devices disposed one behind the other, and through which a material sample is conducted by a carrier gas. A pressure regulator regulates the pressure of the carrier gas introduced into the first separating device. A controllable switching device is arranged between the two separating devices. The switching device contains a main gas path lying between the two separating devices and two auxiliary gas paths, which are connected to the main gas path through connecting gas paths and are both fed with the carrier gas and contain flow resistors and a controllable valve for setting different pressure conditions. The auxiliary gas paths are supplied with the carrier gas through the same pressure regulator to reduce the design and adjustment effort in setting the pressure conditions, where fixed resistors are used for the flow resistors.Type: GrantFiled: November 24, 2009Date of Patent: August 6, 2013Assignee: Siemens AktiegesellschaftInventor: Piotr Strauch
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Publication number: 20130145933Abstract: An apparatus for separation of gases from ambient air that has at least one separation column containing an adsorbent with an inlet at a first end and an outlet at a second end, a buffer column containing an adsorbent and having a single inlet at a first end, a vacuum pump, and a valve system that connects the vacuum pump to the outlet at the first end of the separation column, and that connects the outlet at the second end of the separation column to the single inlet at the first end of the buffer column.Type: ApplicationFiled: February 7, 2013Publication date: June 13, 2013Applicant: VBOX, INCORPORATEDInventor: VBOX, INCORPORATED
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Patent number: 8426215Abstract: A gas chromatograph for analyzing natural gas, with a first separation column (6). A first detector (7) is provided following the first separation column, the first separation column and the first detector operable to separate or detect propane and higher hydrocarbons. A second separation column (8) and a second detector (9) following it are provided to separate or detect carbon dioxide and ethane. A third separation column (10) and a third detector (11) following it are provided to separate or detect nitrogen and methane. A controllable changeover device (12) is provided between the second separation column (8) and the third separation column (10) to discharge eluates following methane. The first, second and third separation columns (6, 8, 10) and the first, second and third detectors (7, 9, 11) are connected in series. At least the first and the second detectors (7, 9) are operable to detect a mixture of substances flowing through them in a non-destructive manner.Type: GrantFiled: September 28, 2004Date of Patent: April 23, 2013Assignee: Siemens AktiengesellschaftInventors: Friedhelm Mueller, Udo Gellert
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Patent number: 8230719Abstract: The present invention is directed to a method for multidimensional gas chromatography for separating the analytes of a complex sample. The method comprises the steps of introducing the sample onto a first column whereby the sample is separated into at least two segments, introducing at least one segment into a heartcut device whereby the segments are selectively separated into at least two heartcut fractions, introducing at least one of the fractions onto a second column whereby at least one fraction is further separated into at least two analytes, introducing at least one analyte from the second column to a gas chromatography connector, introducing the analyte from the connector to a third column, and introducing the analyte from the third column into a detector whereby the analyte is analyzed and identified.Type: GrantFiled: April 27, 2010Date of Patent: July 31, 2012Assignee: MRIGlobalInventor: Chad Fisher
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Patent number: 8226825Abstract: Systems and methods for performing chromatography separations or analyses are disclosed. The methods are based upon an equilibrium gradient focusing mode in contrast to conventional transient migration-based modes. By matching the migration speed of one or more analyte(s) of interest to the wave speed of a thermal gradient induced to travel along a region in which chromatographic partitioning occurs, significant improvements in detection limits are achieved. In particular, a temperature gradient focusing strategy is described in which analyte(s) of interest are circulated around a continuous chromatography system in order to focus the analyte(s). Also described are various devices and systems that can be used in the methods described herein.Type: GrantFiled: July 21, 2009Date of Patent: July 24, 2012Assignee: The United States of America, as represented by the Sectretary of Commerce, The National Institute of Standards and TechnologyInventor: David J. Ross
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Patent number: 8114200Abstract: A portable multi-dimensional gas chromatograph, the gas chromatograph including a carrier gas container, a regulator fluidly connected to the carrier gas container, a dopant chamber containing a reference chemical, at least one pre-concentrator which is fluidly connected to the regulator and the dopant chamber, a first separation column fluidly connected to the at least one pre-concentrator, a second separation column fluidly connected to the at least one pre-concentrator, a first detector fluidly connected to the first separation column, and a second detector fluidly connected to the second separation column.Type: GrantFiled: June 11, 2010Date of Patent: February 14, 2012Assignee: VPI Enigineering, Inc.Inventors: Sheena Alm, James Bentley, John Blankevoort, Mark Kaspersen, Collin Lewis, Derek Maxwell, Ken Wunner
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Publication number: 20120017760Abstract: An apparatus and method for rapid fractionation of hydrocarbon phases in a sample fluid stream are disclosed. Examples of the disclosed apparatus and method include an assembly of elements in fluid communication with one another including one or more valves and at least one sorbent chamber for removing certain classifications of hydrocarbons and detecting the remaining fractions using a detector. The respective ratios of hydrocarbons are determined by comparison with a non separated fluid stream.Type: ApplicationFiled: July 21, 2010Publication date: January 26, 2012Applicant: UT-BATTELLE, LLCInventors: Charles S. Sluder, John M. Storey, Samuel A. Lewis, SR.
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Publication number: 20100307334Abstract: A fluid separation apparatus suitable for separating a mixed fluid with different properties and capable of separating a complex fluid mixture efficiently is provided. The fluid separation apparatus includes a sampling entrance, a first separation column, a second separation column, a bypass line, a detector and a guide multi-channel valve. A mixed fluid flows into the first separation column via the sampling entrance. The second separation column is connected to the first separation column in series and connected to the bypass line in parallel. The detector is connected to the second separation column and the bypass line. The guide multi-channel valve has different modes to control a flow-through status and a closed status between the first separation column and the second separation column, between the first separation column and the bypass line, between the second separation column and the detector, and between the bypass line and the detector.Type: ApplicationFiled: August 4, 2009Publication date: December 9, 2010Applicant: National Taiwan University of Science and TechnologyInventors: Sheng-Chiang Yang, Shih-Chi Lu, Bing-Joe Hwang
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Patent number: 7824471Abstract: The present invention provides a chromatographic method for eliminating interference from interfering agents, coming from the gas sample itself or from the system material used to perform the impurities measurements, on impurities to be quantified in a gas sample. The method advantageously relies on the use of an additional valve and an additional sample loop particularly arranged in a G. C. system, and also on an additional supporting gas inlet operatively connected to the system through the additional sample loop for providing the system with a supporting gas comprising at least a predetermined portion of a predetermined active gas that will react with the unwanted interfering impurities, if any, or with the column material to cancel out unwanted active sites. Thus, the method of the present invention can advantageously be used in gas chromatographic systems to improve sensitivity thereof by acting on column separation material.Type: GrantFiled: March 10, 2006Date of Patent: November 2, 2010Assignee: Panalytique Inc.Inventors: Yves Gamache, Andre Fortier
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Patent number: 7823439Abstract: The present invention is directed to a method for multidimensional gas chromatography for separating the analytes of a complex sample. The method comprises the steps of introducing the sample onto a first column whereby the sample is separated into at least two segments, introducing at least one segment into a heartcut device whereby the segments are selectively separated into at least two heartcut fractions, introducing at least one of the fractions onto a second column whereby at least one fraction is further separated into at least two analytes, introducing at least one analyte from the second column to a gas chromatography connector, introducing the analyte from the connector to a third column, and introducing the analyte from the third column into a detector whereby the analyte is analyzed and identified.Type: GrantFiled: November 15, 2007Date of Patent: November 2, 2010Assignee: Midwest Research InstituteInventor: Chad Fisher
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Patent number: 7824472Abstract: In order to provide a new PSA method which can concentrate simultaneously a strong adsorbate such as xenon and a weak adsorbate such as nitrogen in a high concentration with a high recovery percentage when highly valuable gas such as xenon and krypton contained in the exhaust gas from a semiconductor manufacturing equipment, etc.Type: GrantFiled: February 23, 2006Date of Patent: November 2, 2010Assignee: Taiyo Nippon Sanso CorporationInventor: Tatsushi Urakami
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Publication number: 20100186587Abstract: A method for the chromatographic separation of components of a multicomponent fluid mix by means of the Simulated Moving Bed method wherein the multicomponent fluid mix and at least one solvent are fed to inflows of a plurality of chambers containing at least one solid substance and connected to each other in series to form a closed loop. An extract stream containing at least one first component separated from the multicomponent fluid mix as well as a raffinate stream containing at least one second component separated from the multicomponent fluid mix are carried out of the chambers through a first and second outflows. At least part of the raffinate stream and/or extract stream carried off at the first and/or second outflows is preliminarily stored and recirculated to the first and/or second inflow of the chambers alternately or simultaneously with the multicomponent fluid mix and/or the solvent within one clock unit.Type: ApplicationFiled: April 16, 2008Publication date: July 29, 2010Applicant: Max Planck Gesellschaft zur Foderung der Wissenschaftern e V.Inventors: Lars Kessler, Andreas Seidel-Morgenstern
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Patent number: 7722703Abstract: The device has a honeycomb rotor which is rotated and which supports an adsorbant. A seal divides the honeycomb rotor into a desorption zone and at least one other zone including an adsorption zone. The seal has a heat resistant/non flammable portion and an elastic seal portion. The heat resistant portion has a slot cut in a surface which contacts the honeycomb rotor. The elastic seal portion is formed outside of the desorption zone with respect to the heat resistant portion. Desorption air is substantially completely sealed within the desorption zone. The seal may allow for hot (perhaps 300° C.) desorption gas to be used with a rotation type gas adsorption concentration device.Type: GrantFiled: March 23, 2005Date of Patent: May 25, 2010Assignee: Seibu Giken Co., Ltd.Inventor: Yuji Fujioka
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Publication number: 20100101411Abstract: Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.Type: ApplicationFiled: May 27, 2009Publication date: April 29, 2010Inventor: Andrew Tipler
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Patent number: 7601543Abstract: This invention is a method and device for use with multi-dimensional chromatography that utilizes partial modulation. An analyte-bearing sample is subjected to a first dimension of chromatography. Thereafter the separated analyte-bearing sample is diluted with a modulated second carrier such at the analyte-bearing sample is not stopped or its temperature altered. The partially modulated analyte-bearing sample then feeds into a secondary column where the analyte-bearing sample is further separated.Type: GrantFiled: August 18, 2005Date of Patent: October 13, 2009Assignee: Valco Instruments Co., Inc.Inventors: Huamin Cai, Stanley Stearns
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Patent number: 7527676Abstract: A unit for separating an exhaust gas containing PFC gases including CF4 and C2F6 generated in a production process, wherein the exhaust gas is concentrated in a concentration device, and then separated chromatographically in a chromatographic separation device using nitrogen as a carrier gas. The chromatographic separation device is packed with molecular sieve 13X or F-9 or the like. The unit is capable of effectively separating CF4 and C2F6.Type: GrantFiled: June 2, 2004Date of Patent: May 5, 2009Assignee: Organo CorporationInventors: Yoshinori Tajima, Takashi Futatsuki, Tetsuya Abe, Sadamitsu Tanzawa, Seiji Hiroki
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Publication number: 20090107331Abstract: In order to provide a new PSA method which can concentrate simultaneously a strong adsorbate such as xenon and a weak adsorbate such as nitrogen in a high concentration with a high recovery percentage when highly valuable gas such as xenon and krypton contained in the exhaust gas from a semiconductor manufacturing equipment, etc.Type: ApplicationFiled: February 23, 2006Publication date: April 30, 2009Inventor: Tatsushi Urakami
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Patent number: 7524363Abstract: A separation column assembly for a gas chromatograph and the like is provided. The assembly is a self contained unit which allows very rapid heating and cooling of the column.Type: GrantFiled: May 16, 2006Date of Patent: April 28, 2009Assignee: Alliant Techsystems Inc.Inventors: James Bentley, John Blankevoort, Collin Lewis, Ken Wunner
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Patent number: 7507273Abstract: A scalable technology for purifying ethanol, wherein the vaporization of ethanol is coupled with a chromatographic rectification process comprising feeding a vaporized ethanol/water mix onto a plurality of molecular sieve beds to produce dehydrated ethanol vapor, which can then be condensed to recover purified dehydrated ethanol liquid. The scalable technology process is suitable for farm-scale production of fuel-grade ethanol, having the added benefit of allowing wet distillers grains to be used on-site as live-stock feed. By reducing energy requirements, costs and pollution, the output can be scaled to produce fuel-grade ethanol at quantities of anywhere from about 1000 gallons per year to upwards of hundreds of millions of gallons per year. Particularly beneficial versions utilize a plurality of smaller molecular sieve beds in series and use heat generated during desorption and regeneration of the molecular sieve beds as an energy source to aid in the vaporization step.Type: GrantFiled: June 20, 2006Date of Patent: March 24, 2009Assignee: 6Solutions, LLCInventor: Cecil T. Massie
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Patent number: 7507586Abstract: This invention is a method and device for use with multi-dimensional chromatography that utilizes partial modulation with multiple secondary retention times. An analyte-bearing sample is subjected to a first dimension of chromatography. Thereafter the separated analyte-bearing sample is diluted with a modulated second carrier such at the analyte-bearing sample is not stopped or its temperature altered. The secondary retention time period at which the modulator cycles is variable among multiple secondary retention time periods to prevent loss of resolution with less complex and/or low boiling point compounds and to prevent loss of data with more complex and/or higher boiling point compounds. The partially modulated analyte-bearing sample then feeds into a secondary column where the analyte-bearing sample is further separated.Type: GrantFiled: December 19, 2005Date of Patent: March 24, 2009Assignee: Valco Instruments Co., Inc.Inventor: Huamin Cai
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Patent number: 7383718Abstract: A single stage flow modulator for performing comprehensive chromatography comprises a first chromatographic column, a valve fluidically coupled to at least two fluid conduits, wherein when in a first position, the valve directs a control flow to direct an output of the first chromatographic column to a first detector, and wherein when in a second position, the valve directs a control flow to direct a portion of an output of the first chromatographic column to a second chromatographic column, wherein the portion of the output of the first chromatographic column directed to the second chromatographic column is continuously modulated throughout a sample run.Type: GrantFiled: February 21, 2006Date of Patent: June 10, 2008Assignee: Agilent Technologies, Inc.Inventors: James D McCurry, John V. Seeley
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Patent number: 7273517Abstract: A non-planar microfabricated gas chromatography column comprises a planar substrate having a plurality of through holes, a top lid and a bottom lid bonded to opposite surfaces of the planar substrate, and inlet and outlet ports for injection of a sample gas and elution of separated analytes. A plurality of such planar substrates can be aligned and stacked to provide a longer column length having a small footprint. Furthermore, two or more separate channels can enable multi-channel or multi-dimensional gas chromatography. The through holes preferably have a circular cross section and can be coated with a stationary phase material or packed with a porous packing material. Importantly, uniform stationary phase coatings can be obtained and band broadening can be minimized with the circular channels. A heating or cooling element can be disposed on at least one of the lids to enable temperature programming of the column.Type: GrantFiled: February 25, 2005Date of Patent: September 25, 2007Assignee: Sandia CorporationInventors: Patrick R. Lewis, David R. Wheeler
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Patent number: 7260978Abstract: A gas chromatography/mass spectrometry system includes two sample introduction parts, a gas chromatography part having two columns, a column oven for housing the two columns in a parallel configuration, an interface part through which an outlet end of each of the two columns is inserted, and a mass spectrometry part. The mass spectrometry part has an ionization chamber to which the outlet ends of the columns inserted through the interface part are connected, a mass separation part, an ion detector, and a vacuum chamber for housing the ionization chamber, the mass separation part, and the detector. Because the outlet ends of the parallel columns are both connected to the ionization chamber, the carrier gas flow and line velocity are the same as though there is one column, thereby avoiding line stagnation. Since analyses can be performed selectively with a single system, results having high reliability and precision can be obtained.Type: GrantFiled: November 9, 2005Date of Patent: August 28, 2007Assignee: Shimadzu CorporationInventor: Haruhiko Miyagawa
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Patent number: 7107818Abstract: A method for detecting substances or mixtures of substances within a sample in an apparatus for comprehensive two-dimensional gas-chromatographic analysis according to the present invention, comprising the steps of: subjecting the sample to a first separation within a first capillary column; modulating in time the effluents from the first column by means of the subdivision into adjacent fractions of the effluents from the first column and subsequently sending each fraction into a second capillary column, the modulation of the effluents being periodic with a first modulation frequency f1 of the sample; separating each of the fractions in the aforesaid second capillary column; and detecting, at the end of the second capillary column, the effluents by means of periodic sampling by discrete time points at a second frequency f2.Type: GrantFiled: February 4, 2003Date of Patent: September 19, 2006Assignee: Thermo Electron S.p.A.Inventors: Giacinto Zilioli, Jan Beens
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Patent number: 7091044Abstract: This invention is a method and device for use with multi-dimensional chromatography that utilizes partial modulation. An analyte-bearing sample is subjected to a first dimension of chromatography. Thereafter the separated analyte-bearing sample is diluted with a modulated second carrier such at the analyte-bearing sample is not stopped or its temperature altered. The partially modulated analyte-bearing sample then feeds into a secondary column where the analyte-bearing sample is further separated.Type: GrantFiled: August 6, 2004Date of Patent: August 15, 2006Assignee: Valco Instruments Co., Inc.Inventors: Huamin Cai, Stanley Stearns
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Patent number: 6840456Abstract: An injection valve is provided. A first conduit is disposed between first and second chambers of the valve. An entrance to the first conduit is located within the first chamber. A second conduit is concentrically disposed within the first conduit so that there is a first flow passage between the first and second conduits connecting the first and second chambers. The second conduit has an entrance communicating with the first chamber via the entrance of the first conduit and an exit defining a first outlet port of the valve. A cover opens and closes a first inlet port of the first chamber, and a biasing device biases the cover closed. An actuator moves the cover from the closed position to open the first inlet port.Type: GrantFiled: September 11, 2002Date of Patent: January 11, 2005Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Waleed M. Maswadeh, A. Peter Snyder
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Patent number: 6838288Abstract: This invention relates to a modulator for use in gas chromatographic analysis, adopted for alternatively trapping and releasing fractions of solutes in a length of a capillary column within a chromatographic oven, characterized in that it comprises at least one nozzle placed to spray at least one jet in at least one corresponding place along said capillary column length, said nozzle(s) being connected each to a source of liquid CO2 via a related valve, and means for alternatively opening said valve(s) for a predetermined time, to cause a jet of liquid CO2 to impinge for said predetermined time on said column place and to leave the oven atmosphere to heat said column place after said predetermined time. The modulator can be used in a conventional GC system or in a two dimensional GC system, for modulating the analytes fed to the second capillary column.Type: GrantFiled: November 28, 2001Date of Patent: January 4, 2005Assignee: Thermo Electron S.p.A.Inventor: Jan Beens
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Patent number: 6706535Abstract: A gas chromatography system having a computer-controlled venting valve system that delivers pressurized pulses to a column junction point of two series-coupled columns having different stationary-phase chemistries and a method of using the same. Each pressurized pulse causes a differential change in the carrier gas velocities in the two columns, which lasts for the duration of the pressurized pulse. Whereby, the pressurized pulse selectively increases the separation of a component pair that exhibits separation at the exit of the first column, but otherwise co-elutes from the column ensemble.Type: GrantFiled: January 22, 2002Date of Patent: March 16, 2004Assignee: The Regents of the University of MichiganInventors: Richard Douglas Sacks, Tincuta Maria Veriotti, Megan Ellen McGuigan
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Patent number: 6706534Abstract: A gas chromatography system having a computer-controlled pressure controller that delivers pressurized pulses to a column junction point of two series-coupled columns having different stationary-phase chemistries and a method of using the same. Each pressurized pulse causes a differential change in the carrier gas velocities in the two columns, which lasts for the duration of the pressurized pulse. Whereby, the pressurized pulse selectively increases the separation of a component pair that exhibits separation at the exit of the first column, but otherwise co-elutes from the column ensemble.Type: GrantFiled: December 10, 2001Date of Patent: March 16, 2004Assignee: The Regents of the University of MichiganInventors: Richard Douglas Sacks, Tincuta Maria Veriotti, Megan Ellen McGuigan
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Patent number: 6702989Abstract: A gas chromatography system having a computer-controlled venting valve system that delivers pressurized pulses to a column junction point of two series-coupled columns having different stationary-phase chemistries and a method of using the same. Each pressurized pulse causes a differential change in the carrier gas velocities in the two columns, which lasts for the duration of the pressurized pulse. Whereby, the pressurized pulse selectively increases the separation of a component pair that exhibits separation at the exit of the first column, but otherwise co-elutes from the column ensemble.Type: GrantFiled: May 23, 2002Date of Patent: March 9, 2004Assignee: The Regents of the University of MichiganInventors: Richard Douglas Sacks, Joshua Jonathan Mark Whiting
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Patent number: 6702874Abstract: Using a distillation separator, a gas to be treated is separated into a plurality of gas groups having different boiling points. Then, the specific gases included in each of the plurality of gas groups separated at the first separator and having similar boiling points are separated using a chromatographic separator. In this manner, specific gases can be separated from the gas to be treated containing a plurality of specific gases.Type: GrantFiled: November 7, 2001Date of Patent: March 9, 2004Assignee: Organo CorporationInventors: Yoshinori Tajima, Takashi Futatsuki
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Patent number: 6632268Abstract: A two-dimensional gas chromatograph with a primary column (14) and dual secondary columns (26, 28) is described. Flow rates in the primary column are less than those in the secondary columns due to an accumulation valve (16). Typically the ratio of second and third column flow capacities combined to primary column flow capacities between about 10 to 1 and 30 to 1. Volatile organic compounds are detected in environmental samples of air water, soil and in body fluids of animals and humans.Type: GrantFiled: February 4, 2002Date of Patent: October 14, 2003Assignee: Oakland UniversityInventor: John V. Seeley
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Patent number: 6497138Abstract: The present disclosure relates to a gas chromatograph having a plurality of layers or channels. The chromatograph typically comprises an inlet that receives a sample to be analyzed, a column disposed in each of the plurality of chromatograph layers, each column being in fluid communication with and downstream from the inlet and having a stationary phase coating its inner surfaces, and a detector in fluid communication with and downstream from at least one of the columns. In a preferred arrangement, the chromatograph includes a pre-column disposed in each of the chromatograph layers upstream of the columns, each pre-column being in fluid communication with the inlet and having a stationary phase coating its inner surfaces.Type: GrantFiled: October 18, 2000Date of Patent: December 24, 2002Assignee: Agilent Technologies, Inc.,Inventors: Mahmoud Farid Abdel-Rahman, Carl A. Myerholtz
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Patent number: 6484560Abstract: An apparatus and method for selectively concentrating an analyte on an apparatus by evaporating solvent from the analyte. Concentration is performed by heating or by flowing a gas stream over the analyte to evaporate solvent from the analyte. The invention also provides a method to be used in conjunction with the apparatus.Type: GrantFiled: November 7, 2000Date of Patent: November 26, 2002Assignee: Agilent Technologies, Inc.Inventor: Harry F. Prest
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Publication number: 20020148353Abstract: A two-dimensional gas chromatograph with a primary column (14) and dual secondary columns (26, 28) is described. Flow rates in the primary column are less than those in the secondary columns due to an accumulation valve (16). Typically the ratio of second and third column flow capacities combined to primary column flow capacities between about 10 to 1 and 30 to 1. Volatile organic compounds are detected in environmental samples of air water, soil and in body fluids of animals and humans.Type: ApplicationFiled: February 4, 2002Publication date: October 17, 2002Applicant: Oakland UniversityInventor: John V. Seeley
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Patent number: 6447575Abstract: The invention relates to gas chromatography analysis of a sample having components to be investigated and water contained therein, which after thermodesorption is separated and analyzed, the thermodesorbed sample being transferred by a carrier gas into a first polar separation column which retains higher-boiling components and water and passes low-boiling components, the latter being led, past a branching point which leads, on the one hand, to a second polar or non-polar separation column and, on the other hand, to the non-polar separation column, to the non-polar separation column in a fashion excluding access to the second polar or non-polar separation column, after which higher-boiling components and water are transferred to the second polar or non-polar separation column in a fashion excluding access to the non-polar separation column, water being eliminated upstream of the second polar or non-polar separation column by cryofocussing.Type: GrantFiled: December 15, 2000Date of Patent: September 10, 2002Assignee: Gertstel Systemtechnik GmbH & Co.Inventors: Ralf Bremer, Andreas Hoffmann
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Patent number: 6311544Abstract: A flow of a carrier gas through a column is provided. A sample is provided in the column, and a temperature of a longitudinally short portion of the column is raised to a predetermined controlled high temperature at which volatile substances are released from the sample packing and are carried by the carrier gas. The column is cooled on each side of the short portion to a low temperature at which the volatile substances condense or adsorb on the column packing. By continuously moving the heated short portion from an inlet end to an outlet end of the packing in a direction of carrier gas flow the volatile substances selected by the controlled high temperature are released. Four particularly useful and advantageous applications can be identified for the invention. Firstly, it provides an improved gas chromatograph (GC) injector. Secondly, it provides an improved thermal separator or extractor.Type: GrantFiled: August 16, 2000Date of Patent: November 6, 2001Assignee: Universite de MontrealInventor: Michel Bertrand
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Patent number: 6237396Abstract: Integrated analysis process and device for characterization of hydrocarbons in a petroleum product, in distillation fractions, by simulated distillation. The hydrocarbons of a petroleum sample are characterized without fractional distillation by coupling gas chromatography (GC) with liquid chromatography (LC) techniques. GC simulated distillation (SD) is carried out. The separation column is preceded by a precolumn of the same nature but shorter. At the outlet of the main column, retention means (CT, AC) allow to collect and to store one or more light fractions that are sent each to a GC analytical column (6) allowing detailed analysis of the hydrocarbons, and one or more middle fractions. The remaining heavy fraction is collected at the precolumn outlet. The middle and heavy fractions are characterized by a combined LC-GC chromatography unit. Several interfaces allowing GC-GC-LC-GC coupling are described.Type: GrantFiled: December 21, 1999Date of Patent: May 29, 2001Assignee: Institut Francais du PetroleInventors: Jean-Pierre Durand, Eric Robert, VĂ©ronique Ruffier-Meray
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Patent number: 6007602Abstract: An apparatus and a method are described for forming a chemical modulation of a substance present in a fluid stream, which utilize a movable device, such as a movable heater, to induce changes in the retention of a chemical substance flowing through the modulator tube. The modulator tube has an inlet, a first portion in communication with the inlet, a second portion in communication with said first portion, and an outlet in communication with said second portion. The method involves causing a chemical modulation by moving retention alteration device relative to a modulator tube.Type: GrantFiled: June 12, 1998Date of Patent: December 28, 1999Assignee: Board of Trustees of Southern Illinois University on Behalf of Southern Illinois University at CarbondaleInventors: Edward B. Ledford, Jr., John B. Phillips
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Patent number: 5904749Abstract: A gas chromatographic method utilizes columns having either ascending or descending temperature profiles to effect separation even under column overloading conditions. A fixed ascending temperature profile column allows for good separation of components of a mixture under conditions of column overloading. A mixture to be separated is chromatographed on at least one such column prior to chromatography on a column maintained with a descending temperature profile. This latter column has surprisingly been found to greatly reduce tailing of less volatile species. The invention also includes a variable temperature descending column chromatography to provide an initial ordering of a large quantity of components prior to chomatography on the fixed ascending temperature profile column, or on the serial fixed ascending and descending temperature profile pair of columns.Type: GrantFiled: January 27, 1994Date of Patent: May 18, 1999Inventors: Christopher Huk-Shi Chen, Shinn-Der Chang, Chengwen Weng, Yuanming Tang, Ingo Bernd Holzhueter, Samuel Hugh Hawthorne
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Patent number: 5846292Abstract: A gas chromatograph and method of chromatography are provided. Analytes, those compounds to be tested, are extracted from the sample by moving the sample into a column which has a stationary phase along the column walls. The column has two sections which are different in length. The longer section is heated and the analytes move to the shorter section. The longer section is then cooled and the entire column is heated. The device then functions as an analytical column and the analytes move out of the shorter section, through the longer section, and out of the column. A detector placed at the end of the column's longer section detects the presence of the compounds as they exit the column. In an alternate embodiment two separate columns are provided. One column is used as the extraction column and the other is used as the analytical column.Type: GrantFiled: May 6, 1997Date of Patent: December 8, 1998Assignee: Board of Supervisors at Louisiana State University & Agricultural & Mechanical CollegeInventor: Edward B. Overton
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Patent number: 5840953Abstract: Tetraethoxysilane is purified by passing impure material through a gas chromatographic separating column at a temperature below the boiling point of the pure tetraethoxysilane. Separation of pure material from impurities occurs on the column, and the pure material is thereafter cooled and collected in a receiver. The purified tetraethoxysilane has 99.999999% purity based on metals content.Type: GrantFiled: November 16, 1995Date of Patent: November 24, 1998Assignee: Eagle-Picher Industries, Inc.Inventor: Thomas M. Potts
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Patent number: 5779765Abstract: To inject a liquid sample with large volume into a GC column of a gas chromatograph, its volatile portion is evaporated by heat, in a non-selective way, in a vaporization chamber, the vapors thus generated being fed to pre-column located upstream of the GC column and maintained at a lower temperature to that of the vaporization chamber, where such compounds are separated from the solvent vapors, which are unloaded into the atmosphere while the compounds to be analyzed are sent to the GC column.Type: GrantFiled: July 12, 1996Date of Patent: July 14, 1998Assignee: Thermoquest Italia S.P.A.Inventors: Konrad Grob, Fausto Munari
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Patent number: 5739806Abstract: A process for introducing or displaying the adjustment parameters of a device for coating objects, particularly vehicles and vehicle bodies. The parameters are introduced on or off-line by a personal computer and displayed on the monitor graphically and alphanumerically in a manner which provides a survey of a series of parameters in mutual relationship.Type: GrantFiled: March 21, 1995Date of Patent: April 14, 1998Assignee: Cegelec AEG Anlagen-und Automatisierungstechnik GmbHInventors: Hans Hissen, Hans Schumacher