With Heating Or Cooling Patents (Class 95/87)
  • Patent number: 11946912
    Abstract: Techniques disclosed herein can be used to perform a rapid, splitless injection of a sample including SVOCs and VOCs. In some embodiments, a system includes two focusing traps combined in series, one inside of a GC oven and one in a separate oven to concentrate the SVOCs inside of the GC oven and concentrate the VOCs outside of the GC oven. Heating the VOC focusing trap and reversing the flow through both focusers allows splitless injection of compounds boiling from as low as ?100° C. to as high as 600° C. in a single analysis, with a narrow injection bandwidth to optimize both sensitivity and the resolving power of the analyzer.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: April 2, 2024
    Assignee: Entech Instruments Inc.
    Inventor: Daniel B. Cardin
  • Patent number: 11946911
    Abstract: The present invention relates to an analysis system that is applied to rapid automatic analysis and detection of highly lipophilic components and a method for rapidly detecting vitamin D in an oil or fat, or a biological sample. In the present invention, online pretreatment and separation of a sample containing highly lipophilic components in a sample to be analyzed are performed by a multidimensional chromatography system. The multidimensional chromatography system includes a supercritical chromatography part and a reverse phase liquid chromatography part sequentially connected, the reverse phase liquid chromatography part including one or more reverse phase liquid chromatography columns, and the supercritical chromatography part including a supercritical mobile phase, a modifier, and a supercritical packed column.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: April 2, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Yanli Guo, Naoki Hamada, Yuki Hashi
  • Patent number: 11879878
    Abstract: A gas separation system includes a separation column for separating components contained in sample gas, a sample gas supplier fluidly connected to an inlet of the separation column for supplying sample gas to the separation column, a detector fluidly connected to an outlet of the separation column, a collection tube filled with an adsorbent having a property of adsorbing a target component in the sample gas under a condition of a first temperature or less and desorbing the adsorbed target component under a condition of a second temperature or more higher than the first temperature, a temperature adjuster for adjusting a temperature of the collection tube, a collection container for collecting the target component, and a switching mechanism for switching between a state in which the collection tube is connected to an outlet of the detector and a state in which the collection tube is connected to the collection container.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: January 23, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Tasuku Murata, Mitsuru Nishishita, Shigeo Yasui
  • Patent number: 11709149
    Abstract: Examples are directed toward systems and methods relating to collecting and analyzing samples. For example, a system includes a cold trap that directly collects a sample. The cold trap operates to serve as a collection filter while the system draws in a flow across the cold trap. A thermal heater, coupled to the cold trap, flash heats the cold trap to produce a released sample from the cold trap at a release concentration. An analyzer entrains the released sample at the release concentration into a sampling flow of the analyzer for analysis.
    Type: Grant
    Filed: September 7, 2022
    Date of Patent: July 25, 2023
    Assignee: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventors: Barry T. Smith, John Brady, Jeffrey Barber
  • Patent number: 11612874
    Abstract: The invention providing methods of loading and unloading particulate from micorchannels in apparatus that contains multiple microchannels, typically apparatus that is designed to operate with hundreds or thousands of particulate-containing microchannels. Aligning a sonicating head at one end of a set of microchannels provides a particularly effective mode for densifying particulate in microchannels.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: March 28, 2023
    Assignee: Velocys, Inc.
    Inventors: Jeffrey J. Ramler, Anna Lee Tonkovich, Rachid D. Taha, Kai T. P. Jarosch, Robert J. Luzenski, Jeffery D. Slane, Thomas D. Hickey, Sean D. Fitzgerald, Harley D. Freeman, Frederick A. Zenz
  • Patent number: 11406916
    Abstract: The invention is a method for liquid, gaseous or supercritical phase chromatography which involves circulating, on a chromatograph (6) containing a stationary phase, a load (1) comprising components to be separated entrained by a carrier fluid (2), said method being characterized in that it involves: (a) obtaining, at the outlet of the chromatograph, a plurality of chromatographic fractions (3, 4) comprising at least one component of the load and the carrier fluid in a first fluid phase, (b) imposing a change of state on at least one of said chromatographic fractions (3, 4) so as to obtain at least one fraction of purified carrier fluid in a second fluid phase different from the first fluid phase by separating said carrier fluid from the component of the load, (c) imposing a change of state in a reverse direction to that of step (b) on at least one fraction of purified carrier fluid obtained in step (b) so as to obtain at least one fraction of purified carrier fluid in a third fluid phase different to the sec
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: August 9, 2022
    Inventor: Francois Parmentier
  • Patent number: 11088328
    Abstract: A method of analyzing a light-emitting element is provided. The method analyzes an organic semiconductor element including an organic semiconductor layer including one or a plurality of layers between a pair of electrodes.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: August 10, 2021
    Inventors: Sachiko Kawakami, Nozomi Komatsu, Satoshi Seo
  • Patent number: 10478750
    Abstract: Techniques are described for accelerating thermal equilibrium in a chromatographic column. An apparatus comprises a chromatography column, and a plurality of temperature control units in thermal contact with the chromatography column. A method of performing liquid chromatography comprises setting an inlet of a chromatography column to a first temperature using a first temperature control unit in thermal contact with said inlet, setting an outlet of the chromatography column to a second temperature using a second temperature control unit in thermal contact with the outlet, wherein the first temperature is less than the second temperature; and injecting a sample into a liquid stream that flows through the chromatography column after the inlet is set at the first temperature and the outlet is at the second temperature.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: November 19, 2019
    Assignee: Waters Technologies Corporation
    Inventors: Edouard S. P. Bouvier, Joseph Kareh
  • Patent number: 10481136
    Abstract: A temperature controller for simultaneously controlling the temperatures of a plurality of heating elements for use in chromatographic analysis including columns, detectors, valves, transport lines and other components.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: November 19, 2019
    Assignee: Valco Instruments Company, L.P.
    Inventors: Stanley D. Stearns, Huamin Cai, Chris Bishop, Robert Simpson, Chris S. Cowles, Dale Ashworth, Douglas Dailey
  • Patent number: 10481137
    Abstract: A temperature controller for simultaneously controlling the temperatures of a plurality of heating elements for use in chromatographic analysis including columns, detectors, valves, transport lines and other components.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: November 19, 2019
    Assignee: Valco Instruments Company, L.P.
    Inventors: Stanley D. Stearns, Huamin Cai, Chris Bishop, Robert Simpson, Chris S. Cowles, Dale Ashworth, Douglas Dailey
  • Patent number: 10413846
    Abstract: An apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column wherein the insulating member is formed from a vacuum chamber surrounding the chromatography column. Another apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column, wherein the insulating member includes aerogel. Also described is a method of insulating a chromatography column comprising forming a jacket surrounding the chromatography column, and creating a vacuum chamber in an area between the jacket and the chromatography column.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: September 17, 2019
    Assignee: Waters Technologies Corporation
    Inventors: Edouard S.P. Bouvier, Pamela C. Iraneta, Joseph A. Luongo, Joseph A. Jarrell
  • Patent number: 10335759
    Abstract: The invention providing methods of loading and unloading particulate from microchannels in apparatus that contains multiple microchannels, typically apparatus that is designed to operate with hundreds or thousands of particulate-containing microchannels. Aligning a sonicating head at one end of a set of microchannels provides a particularly effective mode for densifying particulate in microchannels.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: July 2, 2019
    Assignee: Velocys, Inc.
    Inventors: Jeffrey J. Ramler, Anna Lee Tonkovich, Rachid Taha, Kai Jarosch, Robert J. Luzenski, Jeffery D. Slane, Thomas Hickey, Sean Fitzgerald, Harley D. Freeman, Frederick A. Zenz
  • Patent number: 10324069
    Abstract: A temperature controller for simultaneously controlling the temperatures of a plurality of heating elements for use in chromatographic analysis including columns, detectors, valves, transport lines and other components.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: June 18, 2019
    Assignee: Valco Instruments Company, L.P.
    Inventors: Stanley D. Stearns, Huamin Cai, Chris Bishop, Robert Simpson, Chris S. Cowles, Dale Ashworth, Douglas Dailey
  • Patent number: 10241092
    Abstract: A gas chromatograph includes a column module for independently adjusting the temperature of a separation column. The column module is held by an oven with the separation column being horizontal. The column module includes the separation column for separating a sample gas into components, a column accommodating member accommodating inside the separation column while surrounding the separation column by a heat insulating member, and including a gap between the separation column and the heat insulating member for air to flow along the separation column, and a heater, provided inside the column accommodating member, for heating the separation column by being in direct or indirect contact with the separation column. The column accommodating member includes an air inlet port for introducing external air into the gap between the separation column and the heat insulating member, and an air outlet port for exhausting air in the gap.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: March 26, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Masaki Kanai, Satoshi Matsuoka, Masanori Nishino, Takahiro Nishimoto
  • Patent number: 10145823
    Abstract: An apparatus for heating a GC column is described. The apparatus includes first and second temperature sensors. Temperature data are used to set power provided to a heating element of the apparatus.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: December 4, 2018
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Paul C Dryden, Sammye Elizabeth Traudt, William H Wilson
  • Patent number: 10126275
    Abstract: Herein is disclosed an inlet liner for use within an injection port of a capillary gas chromatograph. The inlet liner can include a first fused quartz tube and a second fused quartz tube aligned along a common longitudinal axis; the outside surface of the first fused quartz tube affixed to the inside surface of the second fused quartz tube. In certain instances, the tubers are affixed at two points along the longitudinal axis thereby defining a hermetically sealed volume between the outside surface of the first quartz tube and the inside surface of the second fused quartz tube, wherein the hermetically sealed volume entrains a reactive surface.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: November 13, 2018
    Assignee: Cyclone Biosciences LLC
    Inventors: Jason Guth, Stephen E. Griffin, Brian Barr
  • Patent number: 10067101
    Abstract: A gas chromatography (GC) column heating apparatus is described. The GC column heating apparatus includes a first substrate; a heating element disposed over the first substrate; and a second substrate. A gas chromatography (GC) column heating and cooling apparatus is also described. The GC column cooling and heating apparatus includes a housing configured to receive a heating apparatus, the heating apparatus comprising a first side and a second side; a first thermal insulation layer disposed over the first side; a second thermal insulation layer disposed over the second side; and an actuator connected to the housing and configured to move the first and second thermal insulation layers in contact with the first and second sides, respectively, during a heating sequence, and to move the first and second layers of insulation out of contact with the first and second sides, respectively, during a cooling sequence.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: September 4, 2018
    Assignee: AGILENT TECHNOLOGIES
    Inventors: Sammye Elizabeth Traudt, Richard P White, William H Wilson, Paul C Dryden, Jane Ann Leous
  • Patent number: 9423383
    Abstract: Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: August 23, 2016
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Andrew Tipler
  • Patent number: 9034077
    Abstract: A fast gas chromatograph (GC) method and device for obtaining fast gas chromatography analysis, in which a capillary gas chromatography column is inserted into a resistively heated metal tube located mostly outside a heated oven, which serves as a heated transferline to a flexible column that enters a resistively heated metal tube from a gas chromatograph injector and exits into a gas chromatograph detector. The resistively heated metal tube of the fast GC device has an internal diameter that is over twice the external diameter of the GC column so as to enable the insertion of several capillary GC column loops. The process of column insertion into or removal from the heated tube is aided by touching it with an ultrasound vibrating device that remarkably reduces the friction during column insertion into the metal tube heater.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: May 19, 2015
    Assignee: Aviv Amirav
    Inventors: Aviv Amirav, Alexander B. Fialkov
  • Publication number: 20150075374
    Abstract: A system and method for thermal gradient gas chromatography wherein a front or injection end of a column is heated to a higher temperature than a back or detector end to thereby create a thermal gradient having a profile that is substantially monotonically non-increasing and has a positive second derivative, and then providing a heat source to raise the thermal gradient and cause it to remain stationary or to travel through the column while maintaining a desired profile.
    Type: Application
    Filed: September 16, 2014
    Publication date: March 19, 2015
    Inventors: H. Dennis Tolley, Anzi Wang, Samuel E. Tolley, Milton L. Lee
  • Patent number: 8974580
    Abstract: A collimator fixed to the cold jet nozzle of a modulator of a two-dimensional gas chromatograph to aid in the alignment of the cold jet nozzle and loop modulator tube.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: March 10, 2015
    Assignee: ExxonMobil Research and Engineering Company
    Inventor: Frank C. Wang
  • Patent number: 8882894
    Abstract: The invention relates to a vaporization injector for a gas chromatograph, said injector comprising a structure (11) mounted in a detachable manner on the gas chromatograph body and including the sample introduction means, the vaporization chamber and pneumatic connections for feeding the carrier gas to the vaporization chamber and to the septum purge means, as well as pneumatic connections for evacuating the splitted sample and carrier gases.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: November 11, 2014
    Assignee: Thermo Fisher Scientific S.p.A.
    Inventors: Stefano Pelagatti, Eric Phillips, Paolo Magni
  • Patent number: 8607615
    Abstract: A two-dimensional gas chromatography system having first and second separation columns, a thermal modulator disposed between the first and second columns and having a plurality of stage channels, and a micro heater monolithically integrated in the thermal modulator. The thermal modulator is operable to trap and focus gas/vapor species within the plurality of stage channels upon cooling and release the gas/vapor species to the second column upon heating by the micro heater.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: December 17, 2013
    Assignee: The Regents of The University of Michigan
    Inventors: Sung Jin Kim, Katsuo Kurabayashi, Kensall D. Wise, Edward T. Zellers, Bruce P. Block
  • Patent number: 8591630
    Abstract: In a fast gas chromatograph (GC) method and device for obtaining fast gas chromatography analysis, a capillary gas chromatography column is inserted into a resistively heated metal tube located mostly outside a standard gas chromatograph oven, which may serve as a heated transfer line to a flexible column that enters the resistively heated metal tube from its injector and exits into its detector. The fast GC device enables less than one minute full range temperature programming and cooling back analysis cycle time. The fast GC according to one embodiment is combined with mass spectrometry with supersonic molecular beams for the provision of fast analysis cycle time together with highly informative mass spectral information for improved sample analysis and identification.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: November 26, 2013
    Inventors: Aviv Amirav, Alexander B. Fialkov
  • Patent number: 8529672
    Abstract: Methods and systems for cooling gas chromatography ovens that comprise a housing having a fluid entry and a sleeve positioned within the housing to provide a fluid gap between the inner surface of the housing and the outer surface of the sleeve, where the sleeve is coupled to the fluid entry, and where a cooling fluid from the fluid entry traverses the inner layer of the sleeve and thereafter the outer layer of the sleeve via the fluid gap. In one embodiment, the housing includes at least one adjustable fluid exit, and the fluid gap is in fluid communications with the fluid exit(s). The fluid entry and the sleeve can be concentric, and the sleeve can include a heating element. A fan can be positioned to drive the cooling fluid from the fluid entry.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: September 10, 2013
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Jim Botelho, Stephen Pignataro, Jr., John Mezzoni, John H. Vanderhoef
  • Patent number: 8512456
    Abstract: The invention is directed to an oven for use in gas chromatography. In one embodiment, the oven is comprised of a housing that defines an interior chamber within which a substantial portion of a heating element and a radial fan blade are located. The interior chamber also defines a space within which a separation column is located when the oven is in use. The substantial portion of the heating element is located so as to receive air, when the oven is in operation, that is being moved by the radial fan blade in a direction that is substantially perpendicular to the axis of rotation of the blade. The space within which a separation column is located is also defined so as to receive air, when the oven is in operation, that is being moved by the radial fan blade in a direction that is substantially perpendicular to the axis of rotation of the blade.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: August 20, 2013
    Assignee: Wasson-ECE Instrumentation, Inc.
    Inventors: John G. Wasson, Robert J. Wasson
  • Patent number: 8500863
    Abstract: A room temperature trap for the purification and concentration of gaseous methane. The trap utilizes the adsorption and desorption properties of microporous spherical carbon molecular sieves to purify and concentrate radiolabelled methane for application in an automated synthesis module without the need for cryogenic cooling.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: August 6, 2013
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Nicie C. Murphy, Todd L. Graves
  • Patent number: 8408044
    Abstract: Automated systems and methods for processing liquid test samples are generally provided. Automated systems generally include a gas and liquid separator configured for removing at least one volatile component from the test sample, a first trapping vessel in fluid communication with the gas and liquid separator, wherein the first trapping vessel contains a trapping material capable of adsorbing at least one of the at least one volatile component to provide at least one adsorbed component, and a heat source configured to heat the trapping material to a temperature sufficient to release at least one of the at least one adsorbed component from the trapping material to provide at least one released component.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: April 2, 2013
    Assignee: Brooks Rand Inc
    Inventor: Paul Danilchik
  • Patent number: 8404185
    Abstract: A system for pre-concentrating analytes in a sample prior to introduction into a chromatographic column is generally disclosed comprising a housing, an adsorbent disposed in the housing, and first and second conduits having an inlet and an outlet, respectively, for transferring fluid out of and into the housing during adsorption/dry purge and desorption stages, respectively. In some embodiments, the inlet of the first conduit and the outlet of the second conduit are both disposed in one end of the housing and are offset from each other with respect to the adsorbent.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: March 26, 2013
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Andrew Tipler, Richard G Edwards, James E. Botelho
  • Patent number: 8398851
    Abstract: The invention relates to a device and to a method for determining the proportion of fuel in a combustion engine lubricating oil. The device according to the invention comprises a column (12) with at least 22000 theoretical plates and a steady state phase capable of separating the fuel, the oil, the internal standard contained in the oil and the solvent, in which the oil and the internal standard are diluted, and a heating module (120) capable of causing an increase in the temperature of the column (12) at a rate of at least 350° C./min. In the method according to the invention, the column (12) is subjected to determined cycles during which the pressure of the carrier gas and the temperature are varied.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: March 19, 2013
    Assignee: Renault S.A.S.
    Inventors: Laurent Tiquet, Pierrick Rouille
  • Publication number: 20130000485
    Abstract: A flow control system, method and device for performing thermal desorption is provided. In one embodiment, the system includes a first flow path in which gas flows from a first carrier gas inlet, through a first vessel in a first direction at a first flow rate to adsorb analytes on an adsorbent of said first vessel; a second flow path in which gas flows from a second carrier gas inlet, through said first vessel in the first direction at a second flow rate to further adsorb the analytes on the adsorbent of said first vessel; a third flow path in which a carrier gas flows through said first vessel in a second direction to carry desorbed analytes out of said first vessel; and wherein the second flow rate of carrier gas through said first vessel is greater than the first flow rate of carrier gas through said first vessel.
    Type: Application
    Filed: June 29, 2011
    Publication date: January 3, 2013
    Inventors: Andrew Tipler, Greg Johnson, David J. Scott
  • Patent number: 8277544
    Abstract: A thermal modulation device for a gas chromatography (GC) system a cold zone, a first hot zone and a second hot zone, which are located outside of a GC oven of the GC system, and a flexible capillary column. The cold zone includes a thermoelectric cooler assembly. The first hot zone is adjacent a first side of the cold zone, and has a corresponding first heat source. The second hot zone is adjacent a second side of the cold zone, and has a corresponding second heat source. The flexible capillary column includes a first segment, configured to move between the first hot zone and the cold zone in accordance with a modulation frequency, and a second segment, configured to move between the cold zone and the second hot zone in accordance with the modulation frequency.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: October 2, 2012
    Assignee: Agilent Technologies, Inc.
    Inventors: Xiaosheng Guan, Qiang Xu
  • Patent number: 8226825
    Abstract: Systems and methods for performing chromatography separations or analyses are disclosed. The methods are based upon an equilibrium gradient focusing mode in contrast to conventional transient migration-based modes. By matching the migration speed of one or more analyte(s) of interest to the wave speed of a thermal gradient induced to travel along a region in which chromatographic partitioning occurs, significant improvements in detection limits are achieved. In particular, a temperature gradient focusing strategy is described in which analyte(s) of interest are circulated around a continuous chromatography system in order to focus the analyte(s). Also described are various devices and systems that can be used in the methods described herein.
    Type: Grant
    Filed: July 21, 2009
    Date of Patent: July 24, 2012
    Assignee: The United States of America, as represented by the Sectretary of Commerce, The National Institute of Standards and Technology
    Inventor: David J. Ross
  • Patent number: 8167987
    Abstract: Systems and methods for cooling a chromatographic column is disclosed generally, comprising heating a chromatographic column, supplying fluid into the column via the inlet end of the column at an inlet pressure, decreasing the temperature of the column, thereby causing the fluid in the column to contract, and controlling the fluid in the column such that the rate at which the fluid in the column contracts does not exceed the flow rate of the fluid supplied to the column. In certain embodiments, the rate of change of the volume of the fluid in the column as the column temperature decreases is modeled, and the rate of contraction of the gas in the column is estimated therefrom. In some embodiments, the column temperature and/or inlet pressure are controlled by a programmable chromatographic oven.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: May 1, 2012
    Assignee: PerkinElmer LAS, Inc.
    Inventor: Andrew Tipler
  • Patent number: 8114200
    Abstract: A portable multi-dimensional gas chromatograph, the gas chromatograph including a carrier gas container, a regulator fluidly connected to the carrier gas container, a dopant chamber containing a reference chemical, at least one pre-concentrator which is fluidly connected to the regulator and the dopant chamber, a first separation column fluidly connected to the at least one pre-concentrator, a second separation column fluidly connected to the at least one pre-concentrator, a first detector fluidly connected to the first separation column, and a second detector fluidly connected to the second separation column.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: February 14, 2012
    Assignee: VPI Enigineering, Inc.
    Inventors: Sheena Alm, James Bentley, John Blankevoort, Mark Kaspersen, Collin Lewis, Derek Maxwell, Ken Wunner
  • Patent number: 8075768
    Abstract: A liquid chromatograph device was provided wherein operations inside a thermostatic chamber can be safely performed even while a heat block is being heated. The liquid chromatograph device comprises: a thermostatic chamber; outer doors and that are disposed at the front surface of the thermostatic chamber; a heat block; heater for heating said heat block; temperature sensor for the heat block; flowing means for flowing air between the inside and outside of the thermostatic chamber; a control means for controlling the supply of power to the heater based on the result of the temperature sensor; and an inner door between the outer door and the heat block, the inner door comprising a hollow inner door main body, a heat-insulating material that is housed within the inner door so as to form an air chamber between the heat-insulating material and the surface of the outer door of the inner door main body and inlet/outlet slits and that are formed in the inner door main body.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: December 13, 2011
    Assignee: Shimadzu Corporation
    Inventor: Takao Okado
  • Patent number: 8021468
    Abstract: A room temperature trap for the purification and concentration of gaseous methane. The trap utilizes the adsorption and desorption properties of microporous spherical carbon molecular sieves to purify and concentrate radiolabelled methane for application in an automated synthesis module without the need for cryogenic cooling.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: September 20, 2011
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Nicie C. Murphy, Todd L. Graves
  • Patent number: 7984638
    Abstract: A gas chromatograph oven including a housing, a capillary tube and a thermal control assembly. The housing defining a capillary tube receiving space and having at least one outlet port to permit the passage of a fluid from the capillary tube receiving space of the housing. The capillary tube is positioned in the capillary tube receiving space of the housing and has a gas inlet end connectable to a gas injector and a gas detector end connectable to a gas detector. The thermal control assembly is in fluid communication with the capillary tube receiving space of the housing and is connectable to a source of a temperature regulating fluid.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: July 26, 2011
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Robert L. White
  • Patent number: 7928370
    Abstract: An open probe method for sample introduction into a mass spectrometer is disclosed, comprising the steps of: loading a sample holder with sample compounds to be analyzed; heating a probe oven; introducing said sample compounds in said sample holder into said heated probe oven; flowing inert gas into said heated probe oven; vaporizing said sample in said heated probe oven by the combined effect of oven temperature and inert gas flow; entraining said vaporized sample in said inert gas; and, transferring said vaporized sample in inert gas into an ion source of a mass spectrometer; wherein said heated probe oven remains open to the ambient atmosphere during sample introduction and analysis; said inert gas is flowing in said heated probe oven in two directions of a transfer line to a mass spectrometer ion source and to the oven opening; said vaporized sample in inert gas is transferred through a heated transfer line directly into the ionization chamber of an ion source of a mass spectrometer.
    Type: Grant
    Filed: May 21, 2009
    Date of Patent: April 19, 2011
    Assignee: Aviv Amirav
    Inventors: Aviv Amirav, Alexander Gordin
  • Patent number: 7914612
    Abstract: A compliant column sheath assembly for use in a gas chromatograph is provided which includes an open tubular column in the form of a helical coil having a coiled length of between about 5 and 15 cm. The sheath assembly further includes an insulating sheath which surrounds the open tubular column and a frame. When incorporated in a gas chromatograph, the compliant column sheath assembly allows samples to be analyzed in about 2 to 10 seconds.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: March 29, 2011
    Assignee: University of Dayton
    Inventors: Wayne A. Rubey, Richard C. Striebich, Jesse Contreras
  • Patent number: 7806963
    Abstract: An apparatus, system, and method are disclosed for broad spectrum chemical detection. The method includes detecting an ambient temperature and setting a target temperature based on the ambient temperature. The target temperature is a temperature greater than the ambient temperature. The method further includes determining elution data for the target temperature, either by selecting a target temperature at which elution data is available, or by interpolating between available sets of elution data. The method includes setting a preferred target temperature when an external power source is available, when faster sensor response is desired, and when higher resolution data is desired. The method further includes controlling the temperature of gas chromatography (GC) columns within a GC sensor to the target temperature.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: October 5, 2010
    Assignee: Seer Technology, Inc.
    Inventors: Neil S. Arnold, Gary Bodily
  • Patent number: 7691181
    Abstract: A system for controlling the flow rate into a chromatographic column is disclosed generally comprising communicating a fluid to the column through a transfer line, measuring the inlet pressure, determining the outlet pressure, and adjusting the applied pressure until the inlet and outlet pressures produce a desired flow rate for the transfer line outlet. In certain embodiments, the applied pressure is adjusted by controlling a proportional valve. In some embodiments, the outlet pressure is determined by measuring the pressure drop across the transfer line and calculating the outlet pressure from the measured inlet pressure and the pressure drop.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: April 6, 2010
    Assignee: PerkinElmer LAS, Inc.
    Inventors: Andrew Tipler, Richard G Edwards
  • Publication number: 20090314158
    Abstract: A room temperature trap for the purification and concentration of gaseous methane. The trap utilizes the adsorption and desorption properties of microporous spherical carbon molecular sieves to purify and concentrate radiolabelled methane for application in an automated synthesis module without the need for cryogenic cooling.
    Type: Application
    Filed: June 23, 2008
    Publication date: December 24, 2009
    Applicant: Siemens Medical Solutions USA, Inc.
    Inventors: Nicie C. Murphy, Todd L. Graves
  • Patent number: 7572319
    Abstract: An analyte pre-concentrator for gas chromatography is disclosed generally comprising a tube packed with an adsorbent, wherein the tube may serve as the liner of a chromatographic injector, as an adsorbent trap coupled to a chromatographic column, and/or as an adsorbent trap coupled to a headspace sampler. Preferably, a heating device allows the tube to be heated. In a preferred embodiment, the analyte pre-concentrator further comprises a column isolating accessory so that a chromatographic column can be temporarily isolated from substances flowing through the tube.
    Type: Grant
    Filed: December 24, 2007
    Date of Patent: August 11, 2009
    Assignee: PerkinElmer LAS, Inc.
    Inventors: Andrew Tipler, Gary Campbell, Mark Collins
  • Patent number: 7559226
    Abstract: An analytical column includes a coating that absorbs at least one of ultraviolet (UV) and visible (VIS) radiant energy and converts the radiant energy into heat.
    Type: Grant
    Filed: May 16, 2006
    Date of Patent: July 14, 2009
    Assignee: Agilent Technologies, Inc.
    Inventor: Sammye E. Traudt
  • Patent number: 7552617
    Abstract: An automated system for processing a liquid test sample is provided.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: June 30, 2009
    Assignee: Brooks Rand Labs, LLC
    Inventor: Paul Danilchik
  • Patent number: 7534286
    Abstract: Systems and methods for cooling a chromatographic column is disclosed generally, comprising heating a chromatographic column, supplying fluid into the column via the inlet end of the column at an inlet pressure, decreasing the temperature of the column, thereby causing the fluid in the column to contract, and controlling the fluid in the column such that the rate at which the fluid in the column contracts does not exceed the flow rate of the fluid supplied to the column. In certain embodiments, the rate of change of the volume of the fluid in the column as the column temperature decreases is modeled, and the rate of contraction of the gas in the column is estimated therefrom. In some embodiments, the column temperature and/or inlet pressure are controlled by a programmable chromatographic oven.
    Type: Grant
    Filed: June 14, 2006
    Date of Patent: May 19, 2009
    Assignee: PerkinElmer LAS, Inc.
    Inventor: Andrew Tipler
  • Patent number: 7524363
    Abstract: A separation column assembly for a gas chromatograph and the like is provided. The assembly is a self contained unit which allows very rapid heating and cooling of the column.
    Type: Grant
    Filed: May 16, 2006
    Date of Patent: April 28, 2009
    Assignee: Alliant Techsystems Inc.
    Inventors: James Bentley, John Blankevoort, Collin Lewis, Ken Wunner
  • Patent number: 7520920
    Abstract: The present invention discloses a gas chromatograph assembly. In one implementation, the assembly includes a sample injector and a guard column assembly. The guard column assembly includes a guard column connected to and downstream of the sample injector; a jacket with low thermal mass surrounding the guard column; a temperature controlled heater connected to the jacket to control the temperature of the jacket and thereby the temperature of the guard column; and an insulating housing surrounding the jacket. An analytical column is connected to and downstream of the guard column.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: April 21, 2009
    Assignee: Griffin Analytical Technologies
    Inventors: Mark A. Gregory, Garth E. Patterson, Anthony J. Cochran, Jason L. Springston
  • Patent number: 7513936
    Abstract: The gas chromatography (GC) column assembly described herein consists of capillary GC column material, such as fused silica or metal capillary tubing, which is constrained to lie in a flat, ordered, spiral pattern and then encased between two thin opposing surfaces. The resulting column assembly is flat, dimensionally stable and can be very efficiently thermally modulated. The resulting column assembly also takes up very little space, has very little thermal mass, and can be easily and accurately manufactured. The column assembly can be adapted for chromatographic use by affixing it to the surface of a thermal modulator described herein by means of adhesive force or by mechanical compression, and then by attaching the free ends of the exposed column material to the input and output ports of the chromatographic device.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: April 7, 2009
    Inventor: Ned J. Roques