Specially Adapted For Travel Through Blood Circulatory System Patents (Class 977/905)
  • Patent number: 9005995
    Abstract: The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications. The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations. The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: April 14, 2015
    Assignee: The Johns Hopkins University
    Inventors: David H. Gracias, Timothy Gar-Ming Leong, Hongke Ye
  • Publication number: 20150099919
    Abstract: A system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator is provided. In one embodiment, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.
    Type: Application
    Filed: May 2, 2014
    Publication date: April 9, 2015
    Applicant: Pulse Therapeutics, Inc.
    Inventor: Francis M. Creighton
  • Patent number: 8728529
    Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
    Type: Grant
    Filed: December 29, 2008
    Date of Patent: May 20, 2014
    Assignee: General Electric Company
    Inventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, Jr., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
  • Patent number: 8709829
    Abstract: The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: April 29, 2014
    Assignee: The Johns Hopkins University
    Inventors: David H. Gracias, Timothy Gar-Ming Leong, Hongke Ye
  • Publication number: 20140066762
    Abstract: A method of tracking specific cells in vivo is disclosed. The method of the disclosure includes: providing fluorescent nanoparticles suitable for targeting of specific cells; administering the fluorescent nanoparticles to a subject; providing an X-ray source to irradiate the subject; and determining the distribution and growth of the specific cells by the fluorescent images from the fluorescent nanoparticles and X-ray images of the subject irradiated by the X-ray source.
    Type: Application
    Filed: August 31, 2013
    Publication date: March 6, 2014
    Applicant: ACADEMIA SINICA
    Inventors: Yeu-Kuang Hwu, Chia-Chi Chien, Cheng-Liang Wang
  • Patent number: 8603499
    Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: December 10, 2013
    Assignee: BIND Therapeutics, Inc.
    Inventors: Stephen E. Zale, Mir Mukkaram Ali
  • Patent number: 8603500
    Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: December 10, 2013
    Assignee: BIND Therapeutics, Inc.
    Inventors: Stephen E. Zale, Mir Mukkaram Ali
  • Patent number: 8603501
    Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: December 10, 2013
    Assignee: BIND Therapeutics, Inc.
    Inventors: Stephen E. Zale, Mir Mukkaram Ali
  • Publication number: 20130296631
    Abstract: Disclosed embodiments provide an apparatus and method for brushing plaques from vessels by exposing intraluminal nanoparticles to changing magnetic gradients.
    Type: Application
    Filed: May 7, 2013
    Publication date: November 7, 2013
    Applicant: WEINBERG MEDICAL PHYSICS LLC
    Inventors: Irving N. WEINBERG, Lamar MAIR
  • Patent number: 8507778
    Abstract: Self-assembling multimeric physical models of closed polyhedral structures made of structurally symmetric units, and which mimic the structure and self-assembly characteristics of naturally occurring systems such as viral capsids, are provided. Also provided are methods of creating structurally symmetric units, kits for forming self-assembling physical models of polyhedral structures, and methods of forming the same.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: August 13, 2013
    Inventor: Arthur J. Olson
  • Patent number: 8431143
    Abstract: A titanium dioxide composite is provided that can be stably dispersed in an aqueous solvent and easily administered into a living body, such as human, and allows elimination of the drug efficacy of a pharmaceutical compound supported thereon by light irradiation and a dispersion thereof. A composite is used in which a pharmaceutical compound is bound to titanium dioxide having photocatalytic activity through a hydrophilic polymer. The composite is stable in an aqueous solvent and easily administered into a living body, and adverse drug reactions of the pharmaceutical compound can be reduced by administering the composite into the body and irradiating the composite with a light to photoexcite the titanium dioxide to decompose the pharmaceutical compound in a region where the drug efficacy of the pharmaceutical composition is not required.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: April 30, 2013
    Assignee: Toto Ltd.
    Inventors: Shuji Sonezaki, Koki Kanehira, Yumi Ogami, Toshiaki Banzai, Yoshinobu Kubota
  • Patent number: 8389485
    Abstract: Methods and compositions for delivering agents (e.g., gene silencing agents) and molecules to cells using yeast cell wall particles are presented herein. Embodiments of the invention are particularly useful for the delivery of nucleic acids (e.g., siRNAs) to cells.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: March 5, 2013
    Assignee: University of Massachusetts
    Inventors: Michael P. Czech, Gary R. Ostroff, Myriam Aouadi
  • Patent number: 8329161
    Abstract: Red blood cell-derived vesicles (RDV) as a nanoparticle drug delivery system. The RDV are smaller than one micrometer, capable of encapsulating and delivering an exogenous substance into cells. The substance may be at least one selected from the group consisting of fluorophores, nucleic acids, superparamagnetic compounds and therapeutic agents. The RDV are capable of delivering encapsulated substances into cells including stem cells. The delivered substance within the cell or stem cell may be traced or tracked using a suitable device either in vitro or in vivo.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: December 11, 2012
    Assignee: National Health Research Institutes
    Inventor: Dong-Ming Huang
  • Patent number: 8313422
    Abstract: Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: November 20, 2012
    Assignee: Pulse Therapeutics, Inc.
    Inventor: Francis M. Creighton
  • Patent number: 8273363
    Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: September 25, 2012
    Assignee: Bind Biosciences, Inc.
    Inventors: Stephen E. Zale, Mir Mukkaram Ali
  • Patent number: 8246968
    Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: August 21, 2012
    Assignee: Bind Biosciences, Inc.
    Inventors: Stephen E. Zale, Mir Mukkaram Ali
  • Patent number: 8246917
    Abstract: The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations.
    Type: Grant
    Filed: June 25, 2007
    Date of Patent: August 21, 2012
    Assignee: Johns Hopkins University
    Inventors: David H. Gracias, Timothy Gar-Ming Leong, Hongke Ye
  • Patent number: 8236259
    Abstract: The present invention relates to a nanoscale or microscale container for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the container, with subsequent release of the therapeutic materials in situ, methods of fabricating the container by folding a 2D precursor into the 3D container, and the use of the container in in-vivo or in-vitro applications. The container can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations. The container is coated with a biocompatible metal, e.g. gold, or polymer, e.g. parylene, layer and the surfaces and hinges of the container are made of any metal or polymer combinations.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: August 7, 2012
    Assignee: Johns Hopkins University
    Inventors: David H. Gracias, Barjor Gimi, Zaver M Bhujwalla
  • Patent number: 8236330
    Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: August 7, 2012
    Assignee: Bind Biosciences, Inc.
    Inventors: Stephen E. Zale, Mir Mukkaram Ali
  • Publication number: 20120164231
    Abstract: An artificial oxygen carrier (AOC) for use in the body. A first gas permeable first shell encloses an oxygen carrying agent. The first shell has a second oxygen carrying agent surrounding it, and there is a second gas permeable shell enclosing the second agent. The concentric shells are not subject to turbulent breakup, or chemical decomposition, do not release the agents.
    Type: Application
    Filed: August 24, 2010
    Publication date: June 28, 2012
    Inventors: Agnes Ostafin, Hiroshi Mizukami
  • Patent number: 8182807
    Abstract: The present invention relates to a method for inhibiting reperfusion injury in the brain. The method involve injecting via the carotid artery or jugular vein an antioxidant-loaded nanoparticle. A nanoparticle formulation containing an inert plasticizer is also provided for sustained release of an active agent.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: May 22, 2012
    Assignee: Board of Regents of the University of Nebraska by and on Behalf of the University of Nebraska Medical Center
    Inventors: Vinod D. Labhasetwar, Maram K. Reddy
  • Publication number: 20120121683
    Abstract: Carbon nanotubes with a suspension or colloidal solution of functional nanoparticles and methods for production of carbon nanotubes loaded with functional nanoparticles are provided.
    Type: Application
    Filed: January 12, 2012
    Publication date: May 17, 2012
    Applicant: DREXEL UNIVERSITY
    Inventors: YURY GOGOTSI, GUZELIYA KORNEVA, GENNADY FRIEDMAN
  • Publication number: 20120039989
    Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired. Fusions with targeting peptides direct the fusions to the target, for instance a tumor, where the erythrocyte-binding ligands reduce or entirely eliminate blood flow to the tumor by recruiting erythrocytes to the target.
    Type: Application
    Filed: August 9, 2011
    Publication date: February 16, 2012
    Inventors: Jeffrey A. Hubbell, St├ęphane Kontos, Karen Y. Dane
  • Publication number: 20110217379
    Abstract: There are disclosed magnetic nanoparticles and embolisation compositions comprising the nanoparticles. There are also disclosed methods to make the nanoparticles and embolisation compositions and methods to deliver therapeutic agents to a subject.
    Type: Application
    Filed: March 4, 2011
    Publication date: September 8, 2011
    Applicant: Davis LLP
    Inventors: Yixiang Wang, Ken Cham-Fai Leung, Chris Hon Ki Cheng, Ling Qin
  • Publication number: 20110201994
    Abstract: Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization of such cells. The cells include retinal and other sensory cells, muscle cells, and nerve cells.
    Type: Application
    Filed: April 18, 2011
    Publication date: August 18, 2011
    Inventor: Gholam A. Peyman
  • Patent number: 7910577
    Abstract: Described are injectable formulations of nanoparticulate olanzapine that produce a prolonged duration of action upon administration, and methods of making and using such formulations. The injectable formulations comprise nanoparticulate olanzapine.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: March 22, 2011
    Assignee: Elan Pharma International Limited
    Inventors: Gary Liversidge, Scott Jenkins, Elaine Merisko Liversidge
  • Patent number: 7901674
    Abstract: Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the sane. The blood cells may be red blood cells or blood platelets.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: March 8, 2011
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Timothy C. Nichols, Thomas Fischer, Marjorie S. Read
  • Publication number: 20100215760
    Abstract: The present invention provides solution to the problem involved in delivery of active molecules to nucleus. More particularly, the invention provides intrinsically fluorescent and inherently surface functionalized carbon nanospheres which are non-toxic. Also, these carbon nanospheres [CSP] were adsorbed with CTPB [CSP-CTPB] and the adsorbed CSP-CTPB are permeable to cells with nuclear targeting ability. In addition, the present invention provides a composition, a process to prepare the composition comprising CSP with adsorbed active/therapeutic molecules. Further, the instant invention provides a method for delivering active molecules inside a cell nucleus.
    Type: Application
    Filed: September 30, 2008
    Publication date: August 26, 2010
    Applicant: JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH
    Inventors: Tapas Kumar Kundu, Eswaramoorthy Muthusamy, Ruthrotha Selvi Bharatha Vikru, Dinesh Jagadeesan
  • Publication number: 20100166665
    Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
    Type: Application
    Filed: December 29, 2008
    Publication date: July 1, 2010
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, JR., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
  • Publication number: 20100158805
    Abstract: The present invention provides methods and compositions relating to the labeling of target cells with quantum dots (QDs). Specifically, a delivery system is disclosed based on the use of negatively charged QDs for delivery of a tracking fluorescent signal into the cytosol of target cells via a passive endocytosis-mediated delivery process. In a specific embodiment of the invention the target cell is a stem cell, preferably a mesenchymal stem cell (MSC). Such labeled MSCs provide a means for tracking the distribution and fate of MSCs that have been administered to a subject to promote cardiac repair. The invention is based on the discovery that MSCs can be tracked in vitro for up to at least 6 weeks. Additionally, QDs delivered in vivo can be tracked for up to at least 8 weeks, thereby permitting for the first time, the complete 3-D reconstruction of the locations of all MSCs following administration into a host.
    Type: Application
    Filed: March 21, 2008
    Publication date: June 24, 2010
    Applicants: The Trustees of Columbia University in the City of, The Research Foundation of State University of New York
    Inventors: Ira S. Cohen, Amy Rosen Kontorovich, Peter R. Brink, Glenn Gaudette, Michael R. Rosen, Richard B. Robinson
  • Publication number: 20100055041
    Abstract: Nanotracers for in-situ detection of cancerous gastric tissue include substantially monodisperse polymeric nanoparticles, at least one detectable label incorporated into each particle, and receptor-specific ligands coupled to each nanoparticle. The receptor-specific ligand is selected such that it interacts preferentially with ligand-specific receptors that are overexpressed on cancerous cells.
    Type: Application
    Filed: August 28, 2008
    Publication date: March 4, 2010
    Inventor: Dong June Ahn
  • Publication number: 20090274630
    Abstract: Red blood cell-derived vesicles (RDV) as a nanoparticle drug delivery system. The RDV are smaller than one micrometer, capable of encapsulating and delivering an exogenous substance into cells. The substance may be at least one selected from the group consisting of fluorophores, nucleic acids, superparamagnetic compounds and therapeutic agents. The RDV are capable of delivering encapsulated substances into cells including stem cells. The delivered substance within the cell or stem cell may be traced or tracked using a suitable device either in vitro or in vivo.
    Type: Application
    Filed: March 16, 2009
    Publication date: November 5, 2009
    Applicant: National Health Research Institutes
    Inventor: Dong-Ming HUANG
  • Patent number: 7596415
    Abstract: The present invention relates generally to medical devices; in particular and without limitation, to unique electrodes and/or electrical lead assemblies for stimulating cardiac tissue, muscle tissue, neurological tissue, brain tissue and/or organ tissue; to electrophysiology mapping and ablation catheters for monitoring and selectively altering physiologic conduction pathways; and, wherein said electrodes, lead assemblies and catheters optionally include fluid irrigation conduit(s) for providing therapeutic and/or performance enhancing materials to adjacent biological tissue, and wherein each said device is coupled to or incorporates nanostructure or materials therein. The present invention also provides methods for fabricating, deploying, and operating such medical devices.
    Type: Grant
    Filed: January 20, 2005
    Date of Patent: September 29, 2009
    Assignee: Medtronic, Inc.
    Inventors: Scott J. Brabec, Kenneth C. Gardeski, Suping Lyu, James A. Coles, Jr., Christopher M. Hobot
  • Patent number: 7591831
    Abstract: The present invention provides medical devices comprising nanocomposite materials. By utilizing nanocomposites in the production thereof, the inventive medical devices can be produced with various advantageous properties. Methods of producing the inventive medical devices are also provided. Inasmuch as the inventive devices are expected to provide certain advantages in their use, there is also provide a method of medical care including methods of treatment or diagnosis, wherein the inventive devices are brought into therapeutic contact with a body to be treated or diagnosed thereby.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: September 22, 2009
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Edward Parsonage, Daniel J. Horn, John J. Chen, Paul J. Miller, Douglas A. Devens, Jr., Jan Weber
  • Patent number: 7538329
    Abstract: The presently claimed and disclosed inventions relate, in general, to methods of radiation dosimetry and imaging using scintillation luminescence. More particularly, materials having a scintillation luminescence response to radiation that varies with total radiation dose received can be used for dosimetry monitoring, including, but not limited to nanoparticles for in vivo, real-time dosimetry. Energy-transfer nanocomposite materials as well as methods of making and using such materials in various applications including, but not limited to, in vivo radiation dosimetry and imaging, are disclosed. More particularly, the presently claimed and disclosed inventions relate to nanoparticle scintillation luminescence particles encapsulated in hosts of the general formula BaFX and BaFX:Eu2+ where X=Cl, Br and I.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: May 26, 2009
    Assignee: Nomadics, Inc.
    Inventors: Wei Chen, Shaopeng Wang, Sarah Westcott, Jun Zhang