Bioelectrical Patents (Class 977/925)
  • Patent number: 8888969
    Abstract: Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: November 18, 2014
    Assignee: The Governing Council of the University of Toronto
    Inventors: Leyla Soleymani, Zhichao Fang, Shana Kelley, Edward Sargent, Bradford Taft
  • Publication number: 20140220145
    Abstract: An improved method for stimulating electrical activity in an eye is provided. Provided is a technique for implanting small, nanometer-sized photoactive devices into an eye to improve electrical activity within an eye or mitigate degradation of electrical response in damaged eyes.
    Type: Application
    Filed: April 9, 2014
    Publication date: August 7, 2014
    Applicant: The Regents of the University of Colorado, a Body Corporate
    Inventors: Jeffrey Olson, Naresh Mandava
  • Patent number: 8788033
    Abstract: An energy-releasing carbon nanotube transponder comprising a nanocapacitor connected to at least one carbon nanotube and method of using same are described. An adjustable amount of electric energy is stored within the nanocapacitor so that the energy-releasing carbon nanotube transponder delivers either a biologically destructive or a biologically non-destructive electrical charge to target cells in response to biological, chemical or electrical stimuli. An optional biocompatible coating onto the outer surface of the carbon nanotube transponder improves cellular targeting, cellular binding or body tolerance towards the carbon nanotube transponder. Optionally, a molecular label attached to at least one carbon nanotube allows for in vivo tracking of the carbon nanotube transponder.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: July 22, 2014
    Assignee: Rush University Medical Center
    Inventor: Marvin A. Rossi
  • Patent number: 8626258
    Abstract: A self-adhering sensor for non-invasively attaching to a portion of a skin is provided. The sensor comprises a biocompatible substrate, and an array of solid nanoelectrodes coupled to the biocompatible substrate and configured to self-adhere to the skin. Also provided is a sensor for attaching to a portion of a skin, where the sensor comprises an array of solid electrodes configured to self-adhere to the skin, where each of the solid structures comprises a stem and one or more projections extending out from the stem, where both the stem and the projections are solid. The stem comprises a mechanical stopper to control the extent of penetration of the solid electrodes into the skin. The sensor further comprises an electrolyte coating disposed on one or more of the solid structures.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: January 7, 2014
    Assignee: General Electric Company
    Inventors: Shankar Chandrasekaran, Nikhil Subhashchandra Tambe, Donald Eugene Brodnick
  • Publication number: 20130289687
    Abstract: Electrically conductive nanowires incorporated within scaffolds enhance tissue growth, bridge the electrically resistant pore walls and markedly improve electrical communication between adjacent cardiac cell bundles. Integration of conducting nanowires within 3D scaffolds should improve the therapeutic value of cardiac patches. Examples demonstrate efficacy of gold nanowires in alginate matrices seeded with cardiomyocytes.
    Type: Application
    Filed: December 28, 2011
    Publication date: October 31, 2013
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Children's Medical Center Corporation
    Inventors: Tal Dvir, Daniel S. Kohane, Robert S. Langer, Brian Timko
  • Publication number: 20130281795
    Abstract: A wearable remote electrophysiological monitoring system. The system includes a garment having at least one nanostructured, textile-integrated electrode attached thereto; a control module in electrical communication with the at least one nanostructured, textile-integrated sensor; and a remote computing system in communication with the control module.
    Type: Application
    Filed: April 18, 2012
    Publication date: October 24, 2013
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventor: Vijay K. Varadan
  • Patent number: 8562660
    Abstract: Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization and enhance function of such cells. The cells include retinal and other excitable cells.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: October 22, 2013
    Inventor: Gholam A. Peyman
  • Publication number: 20130248380
    Abstract: The present disclosure provides for a biosensor comprising a graphene electrode linked to a biosensing element by a linker, the biosensing element bonded to a flexible substrate. The graphene electrode has a first end and a second end, such that the first end may be a positive terminal and the second end a negative terminal. An electrical voltage may be applied to the positive and negative terminals to measure an electrical current response in proportion to a lactate concentration on the biosensing element. In embodiments, the biosensing element is an enzyme. By way of example, the biosensing element may be LOD.
    Type: Application
    Filed: March 26, 2013
    Publication date: September 26, 2013
    Applicant: Utah State University
    Inventor: Yue Cui
  • Publication number: 20130216996
    Abstract: Grafting M13 bacteriophage into an array of poly(3,4-ethylenedioxythiophene) (PEDOT) nanowires generated hybrids of conducting polymers and replicable genetic packages (rgps) such as viruses. The incorporation of rgps into the polymeric backbone of PEDOT occurs during electropolymerization via lithographically patterned nanowire electrodeposition (LPNE). The resultant arrays of rgps-PEDOT nanowires enable real-time, reagent-free electrochemical biosensing of analytes in physiologically relevant buffers.
    Type: Application
    Filed: October 3, 2011
    Publication date: August 22, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Gregory A. Weiss, Reginald M. Penner, Jessica A. Arter, David K. Taggart, Keith C. Donavan
  • Publication number: 20130157335
    Abstract: The present invention relates to a biomemory device, comprising (a) a substrate; and (b) a heterolayer comprising a protein having a redox potential and an inorganic particle; wherein the heterolayer is immobilized on the substrate. By applying inorganic particles, the present invention provides a biomemory device capable of enhancing low current signals detected electron transfer between biomolecules and substrates up to at least five (5) times greater signals. The present invention is capable of controlling the redox states with help of redox potentials of proteins depending on applied potential. The present invention provides a new-concept biomemory device as an information storage device based on the principle of electron transfer of a naturally occurring biomolecule.
    Type: Application
    Filed: August 1, 2012
    Publication date: June 20, 2013
    Applicant: Industry-University Cooperation Foundation Sogang University
    Inventors: Jeong Woo Choi, Taek Lee, Jun Hong Min
  • Patent number: 8460351
    Abstract: Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization and enhance function of such cells. The cells include retinal and other excitable cells.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: June 11, 2013
    Inventor: Gholam A. Peyman
  • Publication number: 20130110212
    Abstract: An electrode lead of a pacemaker includes a lead wire. The lead wire includes at least one sub-lead wire and an electrode head electrically connected with the lead wire. The sub-lead wire includes a core wire structure and a carbon nanotube composite structure wound around the core wire structure. The pacemaker includes a pulse generator and the electrode lead electrically connected to the pulse generator.
    Type: Application
    Filed: June 20, 2012
    Publication date: May 2, 2013
    Applicants: HON HAI PRECISION INDUSTRY CO., LTD., Tsinghua University
    Inventors: CHEN FENG, LI QIAN, YU-QUAN WANG, LIANG LIU, WEN-MEI ZHAO, LI FAN
  • Publication number: 20130109905
    Abstract: A pacemaker is provided. The pacemaker includes a pulse generator and an electrode line connecting with the pulse generator. The electrode line includes at least one conductor. The at least one conductor includes at least one carbon nanotube wire having a plurality of radioactive particles therein.
    Type: Application
    Filed: June 20, 2012
    Publication date: May 2, 2013
    Applicants: HON HAI PRECISION INDUSTRY CO., LTD., TSINGHUA UNIVERSITY
    Inventors: LI QIAN, CHEN FENG, WEN-MEI ZHAO, LI FAN, YU-QUAN WANG, LIANG LIU
  • Publication number: 20130110215
    Abstract: An electrode lead of a pacemaker includes at least one lead wire. The at least one lead wire includes at least one conductive core, a first insulating layer coated on an outer surface of the at least one conductive core, at least one carbon nanotube yarn spirally wound on an outer surface of the first insulating layer, and a second insulating layer coated on the surface of the at least one carbon nanotube yarn. One end of the at least one conductive core protrudes from the first insulating layer to form a naked portion. The at least one carbon nanotube yarn includes a number of carbon nanotubes joined end to end by van der Waals attractive forces. A pacemaker includes a pulse generator and the electrode lead electrically connected with the pulse generator.
    Type: Application
    Filed: June 20, 2012
    Publication date: May 2, 2013
    Applicants: HON HAI PRECISION INDUSTRY CO., LTD., TSINGHUA UNIVERSITY
    Inventors: LI FAN, LIANG LIU, CHEN FENG, LI QIAN, YU-QUAN WANG, WEN-MEI ZHAO
  • Publication number: 20130110217
    Abstract: An electrode lead of a pacemaker includes a metal conductive core, a carbon nanotube film, and an insulator. The metal conductive core defines an extending direction. The carbon nanotube film at lest partially surrounds the metal conductive core and is electrically insulated from the metal conductive core. The insulator is located between the metal conductive core and the carbon nanotube film. The carbon nanotube film includes a plurality of carbon nanotubes substantially extending along the extending direction of the metal conductive core. A bared part is defined at one end of the electrode lead. A pacemaker using the above mentioned electrode lead is also disclosed.
    Type: Application
    Filed: June 20, 2012
    Publication date: May 2, 2013
    Applicants: HON HAI PRECISION INDUSTRY CO., LTD., TSINGHUA UNIVERSITY
    Inventors: LIANG LIU, LI FAN, WEN-MEI ZHAO, CHEN FENG, YU-QUAN WANG, LI QIAN
  • Publication number: 20130109986
    Abstract: An electrode lead of a pacemaker includes a lead wire. The lead wire includes at least one sub-lead wire and an electrode head. The sub-lead wire includes a core wire structure, a first insulating layer and a carbon nanotube composite structure. The first insulating layer coats on an outer surface of the core wire structure. The carbon nanotube composite structure is wound around an outer surface of the core wire structure. The electrode head is disposed on an end of the lead wire and electrically connected with the core wire structure of the sub-lead wire. The pacemaker includes a pulse generator and the electrode lead electrically connected to the pulse generator.
    Type: Application
    Filed: June 20, 2012
    Publication date: May 2, 2013
    Applicants: HON HAI PRECISION INDUSTRY CO., LTD., Tsinghua University
    Inventors: LIANG LIU, CHEN FENG, LI QIAN, YU-QUAN WANG, LI FAN, WEN-MEI ZHAO
  • Publication number: 20130110216
    Abstract: An electrode lead of a pacemaker includes a metal conductive core and a carbon nanotube film. The metal conductive core defines an extending direction. The carbon nanotube film wraps around the metal conductive core. The carbon nanotube film includes a plurality of carbon nanotubes extending substantially along the extending direction of the metal conductive core. A bared part is defined at one end of the electrode lead. A pacemaker using the above mentioned electrode lead is also disclosed.
    Type: Application
    Filed: June 20, 2012
    Publication date: May 2, 2013
    Applicants: HON HAI PRECISION INDUSTRY CO., LTD., TSINGHUA UNIVERSITY
    Inventors: YU-QUAN WANG, LI QIAN, LIANG LIU, CHEN FENG, LI FAN, WEN-MEI ZHAO
  • Publication number: 20130090542
    Abstract: The present disclosure provides robust implantable micro-component electrodes that can be used in a variety of medical devices. The medical device may be a neural probe that can monitor or stimulate neural activity in an organism's brain, spine, nerves, or organs, for example. The micro-component electrode has a small physical profile, with ultra-thin dimensions, while having high strength and flexibility. The micro-electrode has an electrically conductive core material, e.g., carbon. The surface of the core material includes one or more electrically conductive regions coated with an electrically conductive material and one or more non-conductive regions having an electrically non-conductive biocompatible polymeric coating. Implantable devices having such micro-components are capable of implantation in an organism for very long durations.
    Type: Application
    Filed: June 16, 2011
    Publication date: April 11, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Daryl R. Kipke, Takashi Daniel Yoshida Kozai, Nick Langhals, Joerg Lahann, Nicholas A. Kotov, Xiaopei Deng, Paras Patel
  • Patent number: 8409263
    Abstract: Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization of such cells. The cells include retinal and other sensory cells, muscle cells, and nerve cells.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: April 2, 2013
    Inventor: Gholam A. Peyman
  • Patent number: 8399751
    Abstract: The invention relates to imparting photoreactivity to target cells, e.g., retinal cells, by introducing photoresponsive functional abiotic nanosystems (FANs), nanometer-scale semiconductor/metal or semiconductor/semiconductor hetero-junctions that in this case include a photovoltaic effect. The invention further provides methods of making and using FANs, where the hetero-junctions bear surface functionalization that localizes them in cell membranes. Illumination of these hetero-junctions incorporated in cell membranes generates photovoltages that depolarize the membranes, such as those of nerve cells, in which FANs photogenerate action potentials. Incorporating FANs into the cells of a retina with damaged photoreceptor cells reintroduces photoresponsiveness to the retina, so that light creates action potentials that the brain interprets as sight.
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: March 19, 2013
    Assignee: University of Southern California
    Inventors: Siyuan Lu, Anupam Madhukar, Mark S. Humayun
  • Patent number: 8388668
    Abstract: Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization of such cells. The cells include retinal and other sensory cells, muscle cells, and nerve cells.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: March 5, 2013
    Inventor: Gholam A. Peyman
  • Publication number: 20120238848
    Abstract: Embodiments of the present invention relate to a system and method for practicing spectrophotometry using light emitting nanostructures. Specifically, embodiments of the present invention include a physiologic sensor comprising a sensor body configured for placement adjacent pulsatile tissue of a patient, a first light emitting nanostructure device configured to emit light at a first wavelength through the pulsatile tissue, a second light emitting nanostructure device configured to emit light at a second wavelength through the pulsatile tissue, and a light detector configured to detect the light at the first wavelength and the light at the second wavelength after dispersion through the pulsatile tissue.
    Type: Application
    Filed: June 1, 2012
    Publication date: September 20, 2012
    Applicant: Nellcor Puritan Bennett LLC
    Inventors: Gilbert Hausmann, Michael P. O'Neil, Paul Mannheimer
  • Patent number: 8246799
    Abstract: Devices and methods for detecting the length of analytes and/or sequencing analytes are provided in which two or more electrical signals are obtained as an analyte traverses a nanopore or fluidic channel. Detection of the relative position of probes hybridized to a biomolecule and/or the length of the analyte (e.g., a biomolecule) rely on detection events to determine a distance associated with the biomolecule. Multiple signals may be obtained (e.g., as functions of time) corresponding to a plurality of detector volumes at known locations along a fluidic channel through which the biomolecule passes, and the distances may be determined from the multiple signals.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: August 21, 2012
    Assignee: Nabsys, Inc.
    Inventors: John S. Oliver, Petre Ianakiev
  • Publication number: 20120209344
    Abstract: An energy-releasing carbon nanotube transponder comprising a nanocapacitor connected to at least one carbon nanotube and method of using same are described. An adjustable amount of electric energy is stored within the nanocapacitor so that the energy-releasing carbon nanotube transponder delivers either a biologically destructive or a biologically non-destructive electrical charge to target cells in response to biological, chemical or electrical stimuli. An optional biocompatible coating onto the outer surface of the carbon nanotube transponder improves cellular targeting, cellular binding or body tolerance towards the carbon nanotube transponder. Optionally, a molecular label attached to at least one carbon nanotube allows for in vivo tracking of the carbon nanotube transponder.
    Type: Application
    Filed: March 15, 2012
    Publication date: August 16, 2012
    Inventor: Marvin A. Rossi
  • Publication number: 20120197364
    Abstract: The present invention provides a novel photoelectrical device for efficient transmission of electrical signals to a neuron. This photoelectrical device comprises one or more charging units for coupling to and stimulating one or more neurons by charge, the charging unit comprising: a nanostructure-based electrode having a surface, which has a predetermined developed surface area for coupling to a neuron and which carries a plurality of photosensitive regions (e.g. quantum dots) interfacing with a biocompatible macromolecule for tuning the relative energy levels between the photosensitive regions and the electrode, as well as for directing the spatial polarity of charge separation the surface being thereby electrically chargeable and dischargeable in response to light excitation of the photosensitive regions, the charges stimulating the neuron when coupled to the surface.
    Type: Application
    Filed: July 20, 2010
    Publication date: August 2, 2012
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Uri Banin, Shlomo Yitzchaik, Ori Cheshnovsky, Yael Hanein, Evelyne Sernagor
  • Publication number: 20120142016
    Abstract: A nanopore device capable of single molecule detection is described. The nanopores are formed in thin, rigid membranes and modified by a sputtered metal that forms an overhang during application. The overhang causes the pore to be narrower in a certain region, allowing passage of only a single molecule through the pore at a time, or binding to a biomolecule on the pore to be detected by a change in ionic current flow through the nanopore. Embodiments include a silicon nitride membrane formed on a silicon substrate and having a nanopore drilled with a focused ion beam system, followed by gold sputtering onto the membrane. Devices are formed with one or more nanopores and chambers having electrodes on either side of the nanopore.
    Type: Application
    Filed: September 27, 2007
    Publication date: June 7, 2012
    Inventors: Mostafa Ronaghi, Amir Ali Haj Hossein Talasaz, Ronald W. Davis
  • Publication number: 20120121712
    Abstract: Piezoelectric nanotransducers for use in an in vivo treatment of cell stimulation through electrical stimulation are described. The nanotransducers are localized in a target site, and an electrical stimulus is induced in the same site through external stimulation of the nanotransducers by ultrasonic waves.
    Type: Application
    Filed: April 14, 2010
    Publication date: May 17, 2012
    Inventors: Gianni Ciofani, Vittoria Raffa, Serena Danti, Arianna Menciassi, Paolo Dario, Mario Petrini, Alfred Cuschieri
  • Publication number: 20120101022
    Abstract: The aqueous self-assembly of oligopeptide-flanked ?-conjugated molecules into discrete one-dimensional nanostructures is described. Unique to these molecules is the fact that the ?-conjugated unit has been directly embedded within the peptide backbone by way of a synthetic amino acid with ?-functionality that is compatible with standard Fmoc-based peptide synthesis or by way of a diacid or other bis(electrophile) that can covalently cross-link peptide chains presented on a synthesis support. The peptide-based molecular designs enforce intimate ?-? communication within the aggregates after charge-screening and self-assembly, making these nanostructures attractive for optical or electronic applications in biological environments. In other embodiments, a convenient method to incorporate ?-electron units into peptides that assemble into amyloid-like supramolecular polymers is disclosed.
    Type: Application
    Filed: April 2, 2010
    Publication date: April 26, 2012
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: John Dayton Tovar, Stephen Robert Diegelmann, Brian D. Wall, Geeta Sophie Vadehra
  • Publication number: 20110275947
    Abstract: Aspects according to the present invention provide a method and implant suitable for implantation inside a human body that includes a power consuming means responsive to a physiological requirement of the human body, a power source and a power storage device. The power source comprises a piezoelectric assembly that is configured to generate an electrical current when flexed by the tissue of the body and communicate the generated current to the power storage device, which is electrically coupled to the power source and to the power consuming means.
    Type: Application
    Filed: March 7, 2011
    Publication date: November 10, 2011
    Applicant: Board of Regents, The University of Texas System
    Inventors: Marc D. Feldman, Shaochen Chen, Li-Hsin Han, Carlos A. Aguilar, Arturo A. Ayon, C. Mauli A Grawal, David M. Lighthart, Devang N. Patel, Steven R. Bailey, Brian A. Korgel, Doh C. Lee, Tushar Sharma, Christopher J. Ellison, Xiaojing Zhang
  • Publication number: 20110270153
    Abstract: The present invention provides methods for stimulating cells using quantum dots. In addition, the present invention provides methods for treating a variety of clinical conditions using stimulation of quantum dots to induce cell stimulation and/or function.
    Type: Application
    Filed: January 12, 2010
    Publication date: November 3, 2011
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventor: Jefferey Olson
  • Patent number: 7960025
    Abstract: The invention relates to nanoparticles of noble metals, having a controlled microstructure which leads to the appearance of ferromagnetic behaviour in said nanoparticles, thereby enabling the use of very small magnets (<5 nm) in a range in which standard ferromagnetic metals behave as superparamagnetic entitles (disappearance of hysteresis cycle). The inventive nanoparticles can be used, for example, to reduce the dimensions in magnetic recordings, as well as in biomedicine as tools for biomolecule recognition, nuclear magnetic resonance imaging, drug-release control or hypothermia treatments.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: June 14, 2011
    Assignees: Consejo Superior De Investigaciones Cientificas, Universidad Complutense De Madrid
    Inventors: M' AsunciĆ³n Fernandez Camacho, Rocio Litran Ramos, Teresa Cristina Rojas Ruiz, Juan Carlos Sanchez Lopez, Antonio Hernando Grande, Patricia Crespo Del Arco, Blanca Sampedro Rozas
  • Publication number: 20110091974
    Abstract: A conductive substrate for introducing a nucleic acid into a cell, which comprises a carbon nanotube with a carboxyl group, and a nucleic acid, the carbon nanotube and the nucleic acid being loaded on an electrode substrate with a cationic surface.
    Type: Application
    Filed: February 18, 2008
    Publication date: April 21, 2011
    Applicant: KYOTO UNIVERSITY
    Inventors: Hiroo Iwata, Yuuki Inoue
  • Publication number: 20110066219
    Abstract: The present invention relates to conducting polymer nanowires and their use in a brain-machine interface which is secure, robust and minimally invasive. In accordance with a first aspect of the present invention, a vascular-based brain-machine interface comprising conducting polymer nanowires is disclosed.
    Type: Application
    Filed: September 28, 2010
    Publication date: March 17, 2011
    Inventors: Rodolfo R. Llinas, Ian W. Hunter, Bryan P. Ruddy
  • Publication number: 20110046466
    Abstract: Generally, embodiments of the invention relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of one or more components, improved stability, and improved response time of the sensor by inclusion of a nanomaterial, such as inert inorganic nanomaterials, where the components are disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
    Type: Application
    Filed: August 19, 2009
    Publication date: February 24, 2011
    Inventors: Benjamin J. Feldman, Tianmei Ouyang, Zenghe Liu, Brian Cho
  • Patent number: 7818065
    Abstract: The present invention relates to conducting polymer nanowires and their use in a brain-machine interface which is secure, robust and minimally invasive. In accordance with a first aspect of the present invention, a vascular-based brain-machine interface comprising conducting polymer nanowires is disclosed.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: October 19, 2010
    Assignees: New York University, Massachusetts Institute of Technology
    Inventors: Rodolfo R. Llinas, Ian W. Hunter, Bryan P. Ruddy
  • Publication number: 20100189710
    Abstract: A method includes positioning an effective amount of a thermal target material at a treatment site of a patient. The treatment site, that is, the location of the thermal target material, comprises a location adjacent to biological tissue to be treated. The thermal target material includes carbon molecules preferably in a carrier fluid. Regardless of the particular structure of the carbon, the carbon molecules in the material heat very rapidly in response to incident microwave radiation and radiate heat energy. The heat energy radiated from an effective amount of the thermal target material when subjected to an effective quantity of microwave energy causes localized heating around the thermal target material. This localized heating may be applied for therapeutic purposes. However, the microwave radiation necessary to produce therapeutically effective heating is insufficient to cause cellular damage in the biological tissue by direct absorption in the tissue.
    Type: Application
    Filed: January 28, 2009
    Publication date: July 29, 2010
    Inventors: Anthony S. Wagner, Mark DeSantis
  • Publication number: 20100185260
    Abstract: An improved method for stimulating electrical activity in an eye is provided. The invention provides a technique for implanting small, nanometer-sized photoactive devices into an eye to improve electrical activity within an eye or mitigate degradation of electrical response in damaged eyes.
    Type: Application
    Filed: February 28, 2008
    Publication date: July 22, 2010
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventor: Jeffrey Olson
  • Patent number: 7759063
    Abstract: Disclosed herein is an article comprising a nucleic acid-carbon nanotube molecular composite in selective communication with at least one of a plurality of material phases; the selective communication being the result of an affinity of functional groups present in the nucleic acid-carbon nanotube molecular composite for the at least one of the plurality of material phases; the material phases being at least a part of a substrate; the nucleic acid-carbon nanotube molecular composite comprising at least one of i) a nucleic acid disposed on a functionalized carbon nanotube; ii) a functionalized nucleic acid disposed on a carbon nanotube; and iii) a functionalized nucleic acid disposed on a functionalized carbon nanotube to form a nucleic acid-carbon nanotube molecular composite.
    Type: Grant
    Filed: August 29, 2007
    Date of Patent: July 20, 2010
    Assignee: International Business Machines Corporation
    Inventors: Jennifer N. Cha, Christine M. Micheel
  • Publication number: 20100106259
    Abstract: The present invention relates to conducting polymer nanowires and their use in a brain-machine interface which is secure, robust and minimally invasive. In accordance with a first aspect of the present invention, a vascular-based brain-machine interface comprising conducting polymer nanowires is disclosed.
    Type: Application
    Filed: March 31, 2006
    Publication date: April 29, 2010
    Applicants: New York University, Massachusetts Institute of Technology
    Inventors: Rodolfo R. Llinas, Ian W. Hunter, Bryan P. Ruddy
  • Publication number: 20100086993
    Abstract: A cell detecting system is herein disclosed, wherein a complex is formed with a first bioactive ligand coupling to a quantum dot and recognizing and coupling to a first receptor of a cell and a second bioactive ligand coupling to a magnetic bead and recognizing and coupling to a second receptor of the cell. The magnet is configured for attracting the complex. A quantum dot measuring system configured for measuring the fluorescence of the complex includes an excitation light source, an optical system, a detecting sensor and a data capturing unit, wherein the detecting sensor includes a photomultiplier tube measuring florescence of the quantum dot excited by the excitation light source. The present invention achieves the goal of specific cell detection with high sensitivity without performing cell incubation. A quantum dot measuring system is also herein disclosed.
    Type: Application
    Filed: November 17, 2008
    Publication date: April 8, 2010
    Applicant: NATIONAL SYNCHROTRON RADIATION RESEARCH CENTER
    Inventors: LEE-JENE LAI, YI-HEUI HSIEH, SHIH-JEN LIU, HSIN-WEI CHEN
  • Publication number: 20090299213
    Abstract: The present invention generally relates to nanobioelectronics and, in some cases, to circuits comprising nanoelectronic elements, such as nanotubes and/or nanowires, and biological components, such as neurons. In one aspect, cells, such as neurons, are positioned in electrical communication with one or more nanoscale wires. The nanoscale wires may be used to stimulate the cells, and/or determine an electrical condition of the cells. More than one nanoscale wire may be positioned in electrical communication with the cell, for example, in distinct regions of the cell. However, the nanoscale wires may be positioned such that they are relatively close together, for example, spaced apart by no more than about 200 nm. The nanoscale wires may be disposed on a substrate, for example, between electrodes, and the cells may be adhered to the substrate, for example, using cell adhesion factors such as polylysine.
    Type: Application
    Filed: March 15, 2007
    Publication date: December 3, 2009
    Applicant: President and Fellows of Harvard College
    Inventors: Fernando Patolsky, Brian P. Timko, Guihua Yu, Charles M. Lieber
  • Patent number: 7596415
    Abstract: The present invention relates generally to medical devices; in particular and without limitation, to unique electrodes and/or electrical lead assemblies for stimulating cardiac tissue, muscle tissue, neurological tissue, brain tissue and/or organ tissue; to electrophysiology mapping and ablation catheters for monitoring and selectively altering physiologic conduction pathways; and, wherein said electrodes, lead assemblies and catheters optionally include fluid irrigation conduit(s) for providing therapeutic and/or performance enhancing materials to adjacent biological tissue, and wherein each said device is coupled to or incorporates nanostructure or materials therein. The present invention also provides methods for fabricating, deploying, and operating such medical devices.
    Type: Grant
    Filed: January 20, 2005
    Date of Patent: September 29, 2009
    Assignee: Medtronic, Inc.
    Inventors: Scott J. Brabec, Kenneth C. Gardeski, Suping Lyu, James A. Coles, Jr., Christopher M. Hobot