Medical Device Coating Patents (Class 977/931)
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Devices for thermally induced transformations controlled by irradiation of functionalized fullerenes
Patent number: 9011309Abstract: An electromagnetic radiation activated device comprises a property changing material and at least one functionalized fullerene that upon irradiation of the functionalized fullerenes with electromagnetic radiation of one or more frequencies a thermally activated chemical or physical transformation occurs in the property changing material. The thermal activated transformation of the property changing material is triggered by the heating or combustion of the functionalized fullerenes upon their irradiation. The device can include a chemical agent that is embedded in the property changing material and is released when the material is heated by the functionalized fullerenes upon irradiation.Type: GrantFiled: May 12, 2011Date of Patent: April 21, 2015Assignee: University of Florida Research Foundation, Inc.Inventors: Vijay Krishna, Karl Zawoy, Brij M. Moudgil, Benjamin L. Koopman, Nathanael Ian Stevens, Kevin William Powers -
Patent number: 8999369Abstract: Methods and devices relating to polymer-bioceramic composite implantable medical devices, such as stents are disclosed. A suspension solution is formed including a fluid, a biodegradable polymer, and bioceramic particles. The biodegradable polymer and particles are precipitated from the suspension to form a mixture. A composite is formed by combining the mixture with another polymer and a scaffolding is formed from the composite.Type: GrantFiled: August 7, 2013Date of Patent: April 7, 2015Assignee: Abbott Cardiovascular Systems Inc.Inventors: David C. Gale, Yunbing Wang, Syed Faiyaz Ahmed Hossainy, Bin Huang, Garth L. Wilkes, Vincent J. Gueriguian
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Publication number: 20140364712Abstract: Devices and methods relate to inducing or promoting hemostasis. The hemostasis device may include a support layer having a first surface and an opposing second surface. The device may include a layer, the layer disposed on the first surface. The layer may include a target surface configured to contact a target site. The layer may include a monolayer of about 100% graphene or may include laser-reduced graphene oxide. The device may include a sensor configured to measure a level of hemostasis of the target site. The methods relate to a method of manufacturing a hemostatic device including a monolayer of graphene or a layer of laser-reduced graphene oxide.Type: ApplicationFiled: March 4, 2013Publication date: December 11, 2014Applicant: EMORY UNIVERSITYInventors: Wilbur A. Lam, Anton Sidorov, Zhigang JIang
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Patent number: 8834902Abstract: A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold.Type: GrantFiled: March 9, 2012Date of Patent: September 16, 2014Assignee: Q3 Medical Devices LimitedInventor: Eric K. Mangiardi
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Patent number: 8808268Abstract: A method and composition for hyperthermally diagnosing and monitoring treatment of cells with photoacoustic sound and nanoparticles.Type: GrantFiled: April 25, 2012Date of Patent: August 19, 2014Inventor: Gholam A. Peyman
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Patent number: 8795251Abstract: A method and composition for hyperthermally treating tumor cells in a patient under conditions that affect tumor stem cells and tumor cells. In one embodiment, the method provides a synergetic effect with chemotherapy.Type: GrantFiled: June 19, 2012Date of Patent: August 5, 2014Inventor: Gholam A. Peyman
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Publication number: 20130340771Abstract: A post operative amputated lower leg limb protective and promotive healing device including a supportive section having a first end and an opposite second end; and an open framework protective section releasably securable to at least one end of the supportive section. The open framework protective section forms a plurality of openings to allow airflow therethrough in all directions and is configured to insure no physical contact by the protective section with the amputated lower leg limb. The open framework protective section is non-weight bearing.Type: ApplicationFiled: June 26, 2012Publication date: December 26, 2013Applicant: MILSPORT MEDICAL PRODUCTS, LLCInventor: Samuel L. Morris, III
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Patent number: 8586072Abstract: According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.Type: GrantFiled: November 9, 2007Date of Patent: November 19, 2013Assignee: Boston Scientific Scimed, Inc.Inventors: Jan Weber, Aiden Flanagan, Tim O'Connor, Barry J. O'Brien, John Clarke, David McMorrow
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Patent number: 8574315Abstract: The present invention relates to structures that contain one or more fiber and/or nanofiber structures where such structures can be formed on a wide variety of structures or surfaces (e.g., asperities, flat surfaces, angled surface, hierarchical structures, etc.). In one embodiment, the present invention relates to a process for forming one or more fibers, nanofibers or structures made therefrom on a wide variety of structures or surfaces (e.g., asperities, flat surfaces, angled surface, hierarchical structures, etc.). In another embodiment, the present invention relates to a process for forming one or more fibers, nanofibers or structures made therefrom on a wide variety of structures or surfaces (e.g., asperities, flat surfaces, angled surface, hierarchical structures, etc.) where such fibers and/or structures are designed to sequester, carry and/or encapsulate one or more substances.Type: GrantFiled: May 9, 2007Date of Patent: November 5, 2013Assignee: The University of AkronInventors: Darrell Reneker, Tao Han, Daniel Smith, Camden Ertley, Joseph W. Reneker
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Patent number: 8535704Abstract: The present invention is a molecular nano film formed on a surface of an implantable medical device to provide a barrier to tissue attachment. The film comprises self-assembling cross-linking molecules.Type: GrantFiled: December 29, 2005Date of Patent: September 17, 2013Assignee: Medtronic, Inc.Inventor: Zhongping Yang
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Publication number: 20130236498Abstract: A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold.Type: ApplicationFiled: March 9, 2012Publication date: September 12, 2013Inventor: Eric K. Mangiardi
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Publication number: 20130156935Abstract: Processes for coating medical devices are provided herein. The processes include heating a surface of the particles used to form the coating as the particles are being applied to the medical device. The resulting coating has improved adherence to the medical device, and does not require the use of solvents and/or water, obviating the need for any steps that otherwise might be required to remove these solvents and/or water. Sufficient adherence of the particles to the medical device may also occur without the need for heating the substrate used to form the medical device.Type: ApplicationFiled: December 14, 2011Publication date: June 20, 2013Inventors: Rachit Ohri, Phillip Blaskovich, Lan Pham, David Giusti, Valentino Tramontano
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Patent number: 8454984Abstract: Methods for making antimicrobial resins and for forming coatings comprising antimicrobial resins on substrate surfaces are disclosed. The methods involve providing a mixture comprising about 15 weight % to about 80 weight % of a hydrophilic acrylic oligomer, about 10 weight % to about 80 weight % of a multifunctional acrylic monomer, about 5 weight % to about 40 weight % of an adhesion-promoting acrylic or vinyl monomer, and about 0.1 weight % to about 15 weight % of a metal salt; and exposing the mixture to a radiation source to cure at least a portion of the mixture, thereby forming an antimicrobial resin.Type: GrantFiled: September 11, 2012Date of Patent: June 4, 2013Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Vadim V. Krongauz, Dustin C. Cawthon, Michael Tung-Kiung Ling
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Publication number: 20130110217Abstract: An electrode lead of a pacemaker includes a metal conductive core, a carbon nanotube film, and an insulator. The metal conductive core defines an extending direction. The carbon nanotube film at lest partially surrounds the metal conductive core and is electrically insulated from the metal conductive core. The insulator is located between the metal conductive core and the carbon nanotube film. The carbon nanotube film includes a plurality of carbon nanotubes substantially extending along the extending direction of the metal conductive core. A bared part is defined at one end of the electrode lead. A pacemaker using the above mentioned electrode lead is also disclosed.Type: ApplicationFiled: June 20, 2012Publication date: May 2, 2013Applicants: HON HAI PRECISION INDUSTRY CO., LTD., TSINGHUA UNIVERSITYInventors: LIANG LIU, LI FAN, WEN-MEI ZHAO, CHEN FENG, YU-QUAN WANG, LI QIAN
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Publication number: 20130046375Abstract: Coatings, devices and methods are provided, wherein the contacting surface of a medical device with at least one contacting surface for contacting a bodily fluid or tissue, wherein long-lasting and durable bioactive agents or functional groups are deposited on the contacting surface through a unique two-step plasma coating process with deposition of a thin layer of plasma coating using a silicon-containing monomer in the first step and plasma surface modification using a mixture of nitrogen-containing molecules and oxygen-containing molecules in the second step. The two-step plasma coating process enables the implantable medical device to prevent both restenosis and thrombosis under clinical conditions. The invention also relates to surface treatment of metallic and polymeric biomaterials used for making of medical devices with significantly improved clinical performance and durability.Type: ApplicationFiled: November 1, 2011Publication date: February 21, 2013Inventor: Meng Chen
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Publication number: 20130004557Abstract: Methods for making antimicrobial resins and for forming coatings comprising antimicrobial resins on substrate surfaces are disclosed. The methods involve providing a mixture comprising about 15 weight % to about 80 weight % of a hydrophilic acrylic oligomer, about 10 weight % to about 80 weight % of a multifunctional acrylic monomer, about 5 weight % to about 40 weight % of an adhesion-promoting acrylic or vinyl monomer, and about 0.1 weight % to about 15 weight % of a metal salt; and exposing the mixture to a radiation source to cure at least a portion of the mixture, thereby forming an antimicrobial resin.Type: ApplicationFiled: September 11, 2012Publication date: January 3, 2013Applicants: BAXTER INTERNATIONAL INC.Inventors: Vadim V. Krongauz, Dustin C. Cawthon, Michael Tung-Kiung Ling
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Publication number: 20120330212Abstract: A pressure-sensitive adhesive bandage with a magnetically-released triggering mechanism is provided. The pressure-sensitive bandage may include a backing for providing support for the pressure-sensitive adhesive bandage. Additionally, the pressure-sensitive bandage may include a pressure-sensitive adhesive applied to the backing, which may include microcapsules. The microcapsules may include a silica-based shell, a core confined within the silica-based shell that includes oil, and a plurality of magnetic particles that may be positioned in at least one of the silica-based shell and the core. The plurality of magnetic particles may be configured to cause the silica-based shell to release the oil from the core when a magnetic force is exerted on the plurality of magnetic particles.Type: ApplicationFiled: June 22, 2012Publication date: December 27, 2012Applicant: WESTPATCH, LLCInventors: Joseph T. Persyn, Michael J. Rubal, Robert Windschauer, James S. Weston
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Publication number: 20120328681Abstract: The present invention relates to protecting a human from an infection using a disinfecting agent as described herein and a method for use thereof, more particularly to a rare earth-containing device for protecting a wound and a method for use thereof.Type: ApplicationFiled: September 10, 2012Publication date: December 27, 2012Applicant: MOLYCORP MINERALS, LLCInventors: Carl R. Hassler, John L. Burba, Charles Whitehead, Joe Pascoe
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Publication number: 20120202043Abstract: An antimicrobial composite structure including: a polymeric material, the material having a first exterior surface expanded to fibrils and nodes, a second exterior surface and an interior portion between the exterior surfaces; and nanoparticles present in the interior portion adjacent the first exterior surface but not in the interior portion adjacent the second exterior surface. The nanoparticles can be silver nanoparticles and the polymeric material may be an expanded fluoropolymer material such as expanded polytetrafluoroethylene.Type: ApplicationFiled: January 17, 2012Publication date: August 9, 2012Inventors: Nathan G. Bonn-Savage, Jon N. Neese
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Publication number: 20120183674Abstract: A process for depositing nanoparticles on a surface. The process includes the steps of: providing a sol including a volatile non-aqueous liquid and nanoparticles suspended in the non-aqueous liquid; processing the sol to form a plurality of droplets; depositing the plurality of droplets on a surface; and evaporating the non-aqueous liquid from the surface leaving a residue of nanoparticles. The liquid can be selected from heptane, chloroform toluene, and hexane and mixtures thereof and the nanoparticles are desirably silver nanoparticles. The plurality of droplets may be formed by a spray process. The surface may be selected from a particular area, region, portion, or dimension of a medical device, device material, packaging material or combinations thereof. The residue of nanoparticles desirably provides antimicrobial properties.Type: ApplicationFiled: December 23, 2011Publication date: July 19, 2012Inventors: Nathan G. Bonn-Savage, Jon N. Neese
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Patent number: 8193406Abstract: A bandage that includes a material, which can be breathable, having a first surface, and a plurality of superhydrophobic particles attached to the first surface. The plurality of superhydrophobic particles ranging in size from about 100 nanometers to about 10 micrometers. The superhydrophobic particles including a protrusive material defining a plurality of nanopores and a plurality of spaced apart nanostructures that define an external boundary of the hydrophobic particles. The nanopores providing a flow through porosity. The first surface can be rendered superhydrophobic by the attached superhydrophobic particles. The material can have a second surface opposite the first surface that is hydrophilic. The superhydrophobic particles can be adhered to the first surface by a binder. Also included is a method of making the bandages described herein.Type: GrantFiled: November 19, 2008Date of Patent: June 5, 2012Assignee: UT-Battelle, LLCInventors: John T. Simpson, Brian R. D'Urso
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DEVICES FOR THERMALLY INDUCED TRANSFORMATIONS CONTROLLED BY IRRADIATION OF FUNCTIONALIZED FULLERENES
Publication number: 20120123182Abstract: An electromagnetic radiation activated device comprises a property changing material and at least one functionalized fullerene that upon irradiation of the functionalized fullerenes with electromagnetic radiation of one or more frequencies a thermally activated chemical or physical transformation occurs in the property changing material. The thermal activated transformation of the property changing material is triggered by the heating or combustion of the functionalized fullerenes upon their irradiation. The device can include a chemical agent that is embedded in the property changing material and is released when the material is heated by the functionalized fullerenes upon irradiation.Type: ApplicationFiled: May 12, 2011Publication date: May 17, 2012Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION. INC.Inventors: VIJAY KRISHNA, Karl Zawoy, Brij M. Moudgil, Benjamin L. Koopman, Nathanael Ian Stevens, Kevin William Powers -
Publication number: 20120093909Abstract: In one aspect, the present invention provides coated metal substrates which, in some embodiments, demonstrate one or more advantageous chemical and/or mechanical properties.Type: ApplicationFiled: June 17, 2010Publication date: April 19, 2012Inventor: Ahmed El-Ghannam
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Publication number: 20120070650Abstract: Disclosed are biomedical implants comprising surface-modified metal particles and biodegradable polymers; its use for suppressing inflammation; and a method for preparing a biomedical material, comprising: (a) modifying surface of basic metal particles with a polymer to obtain surface-modified metal particles; and (b) mixing the surface-modified metal particles with a biodegradable polymer, followed by manufacturing a biodegradable biomedical implant, or coating the resulting mixture on a conventional biomedical implant.Type: ApplicationFiled: January 6, 2011Publication date: March 22, 2012Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Dong Keun Han, Kwi Deok Park, Jong Hee Kang, Bong Soo Lee, Ji Yeon Choi, Chang Hun Kum
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Publication number: 20120016297Abstract: Under one aspect, an interventional device includes a balloon having a flexible wall. The flexible wall includes a composition including between 0.005 wt. % and 0.20 wt. % of carbon nanotubes dispersed in a polymer. Under another aspect, a method of making an interventional device includes contacting a plurality of polymer particles with a plurality of nanotubes; extruding the polymer particles and the nanotubes to form a composition comprising the polymer and the nanotubes; and blow-casting the composition into a balloon.Type: ApplicationFiled: March 18, 2011Publication date: January 19, 2012Inventors: Peter John D'Aquanni, Mark C. Bates, Kent Stalker, Jason Phillips
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Publication number: 20120010599Abstract: In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned) to exhibit nanostructured surfaces that promote osseointegration and bone-bonding for, e.g., joint (e.g., knee, hip and shoulder) replacements, bone or tooth reconstruction and/or implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as primary or ancillary drug delivery devices. In alternative embodiments, the invention provides biocompatible nanostructures that promote osseointegration and bone-bonding for enhanced cell and bone growth and e.g., for in vitro and in vivo testing, restorative and reconstruction procedures, implants and therapeutics.Type: ApplicationFiled: July 6, 2011Publication date: January 12, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Sungho JIN, Garrett SMITH, Chulmin CHOI
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Publication number: 20110306699Abstract: Methods of forming antimicrobial polymeric materials comprising metallic nanoparticles are disclosed. Such methods generally comprise: combining a metal-containing material with a resin in situ; and curing the resin in the presence of a metal-containing material. Antimicrobial polymeric materials formed by said methods are also disclosed.Type: ApplicationFiled: June 16, 2011Publication date: December 15, 2011Applicant: The Board of Regents of the University of Texas SystemInventors: Kyumin Whang, H. Ralph Rawls, Barry Norling
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Patent number: 8057901Abstract: The invention relates to a carbon nanotube composite material, to methods of its production and to uses of such composite material.Type: GrantFiled: May 13, 2005Date of Patent: November 15, 2011Assignee: Sony Deutschland GmbHInventors: William E. Ford, Jurina Wessels, Akio Yasuda, Jack Barger
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Publication number: 20110152751Abstract: Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.Type: ApplicationFiled: November 10, 2010Publication date: June 23, 2011Inventors: Ralph G. Dacey, JR., Roderick A. Hyde, Muriel Y. Ishikawa, Jordin T. Kare, Eric C. Leuthardt, Nathan P. Myhrvold, Dennis J. Rivet, Michael A. Smith, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, JR., Victoria Y. H. Wood
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Patent number: 7959940Abstract: Methods and devices relating to polymer-bioceramic composite implantable medical devices are disclosed.Type: GrantFiled: May 30, 2006Date of Patent: June 14, 2011Assignee: Advanced Cardiovascular Systems, Inc.Inventors: David C. Gale, Yunbing Wang, Syed Faiyaz Ahmed Hossainy, Bin Huang, Garth L. Wilkes, Vincent J. Gueriguian
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Patent number: 7939092Abstract: Described is an implantable medical material comprising a malleable, cohesive, shape-retaining putty including mineral particles, insoluble collagen fibers and soluble collagen. The medical material can be used in conjunction with biologically active factors such as osteogenic proteins to treat bone or other tissue defects in patients.Type: GrantFiled: February 1, 2006Date of Patent: May 10, 2011Assignee: Warsaw Orthopedic, Inc.Inventors: William F. McKay, Steve Peckham, Jeffrey L. Scifert
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Publication number: 20110076315Abstract: The present application discusses techniques and structures that incorporate calcium salts in the luminal surface of grafts. In an embodiment, a graft, stent-graft or TIPS may incorporate bio-compatible calcium salt, which is essentially non-osteoinductive in nature, on the surfaces of the implantable device.Type: ApplicationFiled: June 8, 2006Publication date: March 31, 2011Applicant: C.R Bard, Inc.Inventors: R. Michael Casanova, Chandrashekhar P. Pathak
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Patent number: 7894914Abstract: Electrodes for tissue stimulation and sensing can comprise a support with nanostructures disposed on the support. Pairs of the electrodes can be placed in close proximity to one another. When electrical energy is supplied to the electrodes, an electrical field (and possibly an electrical current) can be established between the nanostructures on the electrodes. The nanostructures may have cells disposed thereon, for example myocardial cells, myocardial progenitor cells, neural cells and/or stem cells. In addition, the electrodes can be arranged in arrays.Type: GrantFiled: August 28, 2007Date of Patent: February 22, 2011Assignee: Cardiac Pacemakers, Inc.Inventors: Jeffrey E. Stahmann, Rodney W. Salo, Jihong Qu
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Publication number: 20110030885Abstract: In accordance with certain embodiments of the present disclosure, a process of forming a prosthetic device is provided. The process includes forming a dispersion of polymeric nanofibers, a fiberizing polymer, and a solvent, the dispersion having a viscosity of at least about 50,000 cPs. A tubular frame is positioned over a tubular polymeric structure. Nanofibers from the dispersion are electrospun onto the tubular frame to form a prosthetic device. The prosthetic device is heated.Type: ApplicationFiled: August 9, 2010Publication date: February 10, 2011Applicant: ZEUS, INC.Inventors: Bruce L. Anneaux, Robert L. Ballard
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Publication number: 20100318187Abstract: A method for producing a polymeric surface-structured substrate includes: (a) preparing a first precursor substrate that is nanostructured on at least one surface with inorganic nanoparticles, (b) coating a hardenable substrate material for a second substrate different from the first precursor substrate material onto the nanostructured surface of the precursor substrate, wherein the hardenable substrate material includes cross-linkable monomeric, oligomeric or polymeric starting components for producing a polymeric substrate, (c) hardening the hardenable substrate material to obtain a polymeric substrate, and (d) separating the precursor substrate from the polymeric substrate as a result of which a polymeric substrate nanostructured with nanoparticles and including a polyurethane is obtained.Type: ApplicationFiled: June 11, 2010Publication date: December 16, 2010Applicant: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.Inventors: Sebastian Kruss, Joachim P. Spatz, Raquel Martin
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Patent number: 7824462Abstract: A composition for use as a prosthetic biomaterial and associated method. The biomaterial exhibits cytocompatibility, mechanical functionality and osteoblast adhesion between the implant and interfacing surface. The biomaterial is metallic, has a grain size less than about 500 nanometers and has a surface roughness of less than about 800 nm rms.Type: GrantFiled: March 26, 2004Date of Patent: November 2, 2010Assignee: Purdue Research FoundationInventors: Thomas J. Webster, Jeremiah U. Ejiofor
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Patent number: 7767652Abstract: Medical devices and methods for reducing localized fibrosis at the site of the medical device.Type: GrantFiled: July 18, 2005Date of Patent: August 3, 2010Assignee: Medtronic, Inc.Inventor: Marc Hendriks
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Patent number: 7689291Abstract: A lead includes a lead body extending from a lead proximal end portion to a lead distal end portion and having an intermediate portion therebetween, one or more tissue sensing/stimulation electrodes disposed along the lead body, one or more terminal connections disposed along the lead proximal end portion. The lead further includes one or more conductors contained within the lead body extending between the tissue sensing/stimulation electrodes and the terminal connections, and a fibrous matrix coating is disposed onto at least a portion of the lead body and/or sensing/stimulation electrodes.Type: GrantFiled: May 1, 2006Date of Patent: March 30, 2010Assignee: Cardiac Pacemakers, Inc.Inventors: Jeannette C. Polkinghorne, Xiangchun Jiang, Daniel J. Cooke
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Patent number: 7596415Abstract: The present invention relates generally to medical devices; in particular and without limitation, to unique electrodes and/or electrical lead assemblies for stimulating cardiac tissue, muscle tissue, neurological tissue, brain tissue and/or organ tissue; to electrophysiology mapping and ablation catheters for monitoring and selectively altering physiologic conduction pathways; and, wherein said electrodes, lead assemblies and catheters optionally include fluid irrigation conduit(s) for providing therapeutic and/or performance enhancing materials to adjacent biological tissue, and wherein each said device is coupled to or incorporates nanostructure or materials therein. The present invention also provides methods for fabricating, deploying, and operating such medical devices.Type: GrantFiled: January 20, 2005Date of Patent: September 29, 2009Assignee: Medtronic, Inc.Inventors: Scott J. Brabec, Kenneth C. Gardeski, Suping Lyu, James A. Coles, Jr., Christopher M. Hobot
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Publication number: 20090198117Abstract: Embodiments of the invention provide analyte sensors having nanostructured electrodes as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a carbon nanotube electrode and a analyte limiting membrane that modulates the ability of a analyte to contact the carbon nanotube electrode.Type: ApplicationFiled: January 28, 2009Publication date: August 6, 2009Applicant: MEDTRONIC MINIMED, INC.Inventors: Kenneth W. Cooper, Ratnakar Vejella, Gopikrishnan Soundararajan, Rajiv Shah
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Publication number: 20090162643Abstract: This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices.Type: ApplicationFiled: February 26, 2009Publication date: June 25, 2009Applicant: Nanosys, Inc.Inventors: Robert S. Dubrow, L. Douglas Sloan
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Publication number: 20090123521Abstract: According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.Type: ApplicationFiled: November 9, 2007Publication date: May 14, 2009Applicant: Boston Scientific Scimed, Inc.Inventors: Jan Weber, Aiden Flanagan, Tim O'Connor, Barry J. O'Brien, John Clarke, David McMorrow
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Publication number: 20090104242Abstract: Self-organized niobium oxide nanocones with nano-sized tips are prepared by anodization of niobium in the presence of an electrolyte such as hydrofluoric acid (HF) (aq.). Dimensions and integrity of the bulk nanostructures formed are strongly dependent on potential, temperature, electrolyte composition, and anodization times. Accordingly, the morphology, topology, uniformity and bioactivity of the niobium oxide nanostructures formed can be readily adjusted by adjusting these anodization parameters. A bioactive form of crystalline niobium oxide is formed by anodizing niobium metal in the presence of an electrolyte that includes HF and at least one salt such as Na2SO4 or NaF. One property of bioactive niobium oxide formed by anodizing niobium metal in the presence of HF (aq.) is its ability to interact with hydroxylapatite.Type: ApplicationFiled: July 28, 2006Publication date: April 23, 2009Applicant: INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATIInventor: Robert L. Karlinsey
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Publication number: 20090093881Abstract: The present disclosure is directed to modified metal materials for implantation and/or bone replacement, and to methods for modifying surface properties of metal substrates for enhancing cellular adhesion (tissue integration) and providing antimicrobial properties. Some embodiments comprise surface coatings for metal implants, such as titanium-based materials, using (1) electrochemical processing and/or oxidation methods, and/or (2) laser processing, in order to enhance bone cell-materials interactions and achieve improved antimicrobial properties. One embodiment comprises the modification of a metal surface by growth of in situ nanotubes via anodization, followed by electrodeposition of silver on the nanotubes. Other embodiments include the use of LENS™ processing to coat a metal surface with calcium-based bioceramic composition layers. These surface treatment methods can be applied as a post-processing operation to metallic implants such as hip, knee and spinal devices as well as screws, pins and plates.Type: ApplicationFiled: October 6, 2008Publication date: April 9, 2009Applicant: Washington State UniversityInventors: Amit Bandyopadhyay, Susmita Bose
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Publication number: 20090076430Abstract: A bandage that includes a material, which can be breathable, having a first surface, and a plurality of superhydrophobic particles attached to the first surface. The plurality of superhydrophobic particles ranging in size from about 100 nanometers to about 10 micrometers. The superhydrophobic particles including a protrusive material defining a plurality of nanopores and a plurality of spaced apart nanostructures that define an external boundary of the hydrophobic particles. The nanopores providing a flow through porosity. The first surface can be rendered superhydrophobic by the attached superhydrophobic particles. The material can have a second surface opposite the first surface that is hydrophilic. The superhydrophobic particles can be adhered to the first surface by a binder. Also included is a method of making the bandages described herein.Type: ApplicationFiled: November 19, 2008Publication date: March 19, 2009Inventors: JOHN T. SIMPSON, BRIAN R. D'URSO
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Publication number: 20090047318Abstract: Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed.Type: ApplicationFiled: August 16, 2007Publication date: February 19, 2009Applicant: Abbott Cardiovascular Systems Inc.Inventors: Florian Niklas Ludwig, Syed Faiyaz Ahmed Hossainy, Katsuyuki Murase, Li Zhao, Irina Astafieva
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Publication number: 20080306584Abstract: Implantable medical devices adapted to erodibly release delivery media for local and regional treatment are disclosed.Type: ApplicationFiled: June 5, 2007Publication date: December 11, 2008Inventor: Pamela Kramer-Brown
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Publication number: 20080154245Abstract: It is contemplated that the current invention may comprise applications utilizing nano-materials, such as but not limited to, superhydrophobic nano-materials, or carbon based nano-materials which may be applied in a spray, wipe on, powder, manufactured into the material or surface of durable medical equipment, devices, prosthetics and so forth.Type: ApplicationFiled: December 19, 2007Publication date: June 26, 2008Inventor: James Jay Martin
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Publication number: 20080085326Abstract: This invention discloses novel antimicrobial materials comprising of nanocrystalline metal, metal oxide, and active oxygen species in a permeable structure. It also discloses the compositions of the inventive material enriched with different active oxygen species. The inventive material showed a strong antimicrobial ability over a wide spectrum of microbies. The average log-reduction value was eight within five minutes. The inventive materials can remain sterile in air over more than two months. The methods used to prepare this inventive material are disclosed.Type: ApplicationFiled: October 4, 2006Publication date: April 10, 2008Inventor: Hai Xiong Ruan
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Patent number: 7344617Abstract: This invention provides novel nanofibers and nanofiber structures which posses adherent properties, as well as the use of such nanofibers and nanofiber comprising structures in the coupling and/or joining together of articles or material.Type: GrantFiled: March 14, 2006Date of Patent: March 18, 2008Assignee: Nanosys, Inc.Inventor: Robert Dubrow