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  • Modified organs and cells for xenotransplantation
    Patent number: 8034330
    Abstract: It has been discovered that there are at least two significant antigens present on the cells of animal species such as pigs that elicit an immune or inflammatory response immediately upon implantation into humans or contact with human serum. The first is an ?-galactosyl (Gal) epitope, for example, Gal?(1?3)Gal?(1?4)GlcNac (linear B type 2) or Gal? (1?3)Gal?(1?4)Glc (linear B type 6). The second is an N-glycolylneuraminic acid (NeuGc) structure. By eliminating these epitopes, preferably by genetically engineering the animal so that the epitope is either not produced or is greatly reduced, or by chemical or enzymatic treatment of the animal's cells to remove the epitopes, it is possible to produce organs, tissues and cells suitable for xenotransplantation into humans. Cells can be rendered even more compatible by genetically engineering the animal to express a human complement regulatory protein (inhibitor), such as CD59, on its cells, or to express an excess of a pig complement regulatory protein.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: October 11, 2011
    Assignee: RBC Biotechnology, Inc.
    Inventor: Alex Zhu
  • 4,5-disubstituted-1H-pyrrolo(2,3-f)quinolin-2,7,9-tricarboxylate compound and use thereof
    Patent number: 10807979
    Abstract: A 4,5-disubstituted-1H-pyrrolo(2,3-f)quinolin-2,7,9-tricarboxylate compound, or an analog, or derivative thereof, having a structure of Formula I: R1 and R4 are each independently an atom or group selected from hydrogen, a linear or branched C1-8 alkyl group, a deuterated linear or branched C1-8 alkyl group, an aralkyl group, or a substituted aryl group; R2 is independently an atom or group selected from halogens, a linear or branched C1-8 alkoxy group, or a deuterated linear or branched C1-8 alkoxy group; and R3 is independently an atom or group selected from a linear or branched C1-8 alkoxy group, or a deuterated linear or branched C1-8 alkoxy group. The compound is useful as a reaction intermediate for the synthesis of PQQ. A process in which CAN is used as an oxidant in the synthesis of PQQ in existing patents and literatures is replaced. This makes the process cheaper and more efficient.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: October 20, 2020
    Assignee: SHANGDONG CAMASY BIOTECHNOLOGY CO., LTD.
    Inventors: Jinglin Wang, Song Qin, Zhenqiang Mu, Yang Li
  • Exploiting nutrient deprivation for modulation of glycosylation - research diagnostic, therapeutic, and biotechnology applications
    Publication number: 20180050055
    Abstract: Drug delivery to the cancer cells during its treatment is challenging. Most of the cancer drug cannot reach to the target because of its complex membrane physiology, drug resistance, and mutability. Establishment of a potential target molecule or domain on the cancer cell is the rate limiting step for the successful drug delivery. Cancer is characterized by abnormal energy metabolism shaped by nutrient deprivation that malignant cells experience during various stages of tumor development. This patent demonstrated a new method of establishing a new target domain that could have enormous importance for the drug delivery during cancer treatment. The inventors showed how nutrient-deprived cancer cells become involved in robust membrane glycan display while treating with nucleotide sugar such as sialic acid and that glycosylated membrane domain become a target domain of cancer cell treatment.
    Type: Application
    Filed: August 16, 2016
    Publication date: February 22, 2018
    Inventors: HAFIZ AHMED, HAITHAM A. BADR, KEVIN J. YAREMA
  • SYSTEM AND METHOD FOR PREVENTING AND PREDICTING THE RISK OF POSTURAL DROP
    Publication number: 20220007970
    Abstract: The present invention patent application for a system and method for preventing and predicting the risk of postural drop is in particular aimed at the health innovation sector, hardware engineering, software engineering, medical engineering, biotechnology, and more specifically to the field of wearable electronic systems for preventive medicine. The inventive solution is in the composition of solutions involving method and system enhanced through the use of specific signal processing, providing the clinical environment (4) and daily environment (5) with a low-cost, easy-to-understand solution that can be measured using graphs and numbers, as opposed to the existing clinical approach based on subjective evaluation, or the existing prior art that involves preventing drops exclusively from a motor perspective, and not systemically as recommended by scientific evidence.
    Type: Application
    Filed: October 2, 2019
    Publication date: January 13, 2022
    Inventor: Fabiana Mendes De ALMEIDA
  • Method and system for more effective protein three-dimensional structure prediction
    Publication number: 20040219601
    Abstract: The present invention relates generally to biotechnology and information technology, and in particular, to a subfield known as bioinformatics. A specific aspect of the invention lies in the provision of a new method and system for predicting the three-dimensional structure of proteins. The main focus in this patent application is on the development of a globally optimal and practically efficient threading algorithm based on an alignment model incorporating pairwise interaction preferences explicitly, and allowing variable gaps by using an integer programming approach. Integer programming formulation can fully exploit the abovementioned special features of the pairwise interaction preferences. It allows one to use the existing powerful linear programming packages together with a branch and bound algorithm to rapidly arrive at the optimal alignment. This is the first time that integer programming and linear programming has been applied to protein threading.
    Type: Application
    Filed: January 2, 2004
    Publication date: November 4, 2004
    Inventors: Jinbo Xu, Ming Li
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