Search Patents
  • Insulated non-halogenated heavy metal free vehicular cable
    Publication number: 20080271909
    Abstract: Described is an insulated non-halogenated, heavy metal free vehicular cable comprising an inner core of a copper based metal wire having a cross sectional area of at least about 0.1 mm2, and an outer insulation, covering the length of the inner core, comprised of a thermoplastic polyphenylene ether composition that has no halogen or heavy metal added thereto, the insulated cable capable of meeting the testing standard ISO 6722.
    Type: Application
    Filed: June 24, 2008
    Publication date: November 6, 2008
    Inventors: Raman V. Chiruvella, Leonard A. Weiner, Eugene W. Yeager, Daniel T. Quinlan, Paul J. Pawlikowski, Edward L. Monroe, Bruce D. Lawrence
  • Thiosemicarbazones as anti-virals and immunopotentiators
    Patent number: 7521062
    Abstract: The present invention is directed to novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, novel methods for treating viral infections, including HCV, by administering the compounds, and novel methods for modulating an immune response by administering the compounds.
    Type: Grant
    Filed: December 29, 2003
    Date of Patent: April 21, 2009
    Assignee: Novartis Vaccines & Diagnostics, Inc.
    Inventors: Paul A. Barsanti, Nathan Brammeier, Anthony Diebes, Liana Marie Lagniton, Simon Ng, Zhi-Jie Ni, Keith B. Pfister, Casey Philbin, Nicholas Valiante, Allan S. Wagman, Weibo Wang, Amy J. Weiner
  • Apparatus for stabilization of high speed optical pulses
    Patent number: 4746193
    Abstract: An optical system including an input pulse source for providing an input optical pulse the intensity of which is sufficiently high to result in stimulated Raman scattering; and a first optical component that spatially disperse the frequency components of the input optical pulse to produce a dispersed beam. A bandpass filter is disposed asymmetrically in the path of the dispersed beam to produce a modified dispersed beam; and a second optical component is disposed in the path of the modified dispersed beam to return the frequency components substantially to the spatially distribution of the input optical pulse.
    Type: Grant
    Filed: November 26, 1986
    Date of Patent: May 24, 1988
    Assignee: Bell Communications Research, Inc.
    Inventors: Jonathan P. Heritage, Andrew M. Weiner
  • Insulated non-halogenated heavy metal free vehicular cable
    Patent number: 7408116
    Abstract: Described is an insulated non-halogenated, heavy metal free vehicular cable comprising an inner core of a copper based metal wire having a cross sectional area of at least about 0.1 mm2, and an outer insulation, covering the length of the inner core, comprised of a thermoplastic polyphenylene ether composition that has no halogen or heavy metal added thereto, the insulated cable capable of meeting the testing standard ISO 6722.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: August 5, 2008
    Assignee: Delphi Technologies, Inc.
    Inventors: Raman V. Chiruvella, Leonard A. Weiner, Eugene W. Yeager, Daniel T. Quinlan, Paul J. Pawlikowski, Edward L. Monroe, Bruce D. Lawrence
  • SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT
    Publication number: 20160244457
    Abstract: The present invention provides novel compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated transporter protein-mediated disease by administering such compounds, and pharmaceutical compositions comprising such compounds. In one embodiment, the invention provides novel pyrazolo[1,5-a]pyrimidine efflux inhibitors that are selective toward ABCG2 over ABCB1.
    Type: Application
    Filed: May 5, 2016
    Publication date: August 25, 2016
    Inventors: Richard Smith Larson, Larry A. Sklar, Bruce S. Edwards, Juan Jacob Strouse, Irena lvnitski-Steele, Hadya M. Khawaja, Jerec Warren Ricci, Jeffrey Aube, Jennifer Elizabeth Golden, TuanIi Yao, Warren S. Weiner, Chad E. Schroeder
  • Hepatitis C virus isolates
    Patent number: 5372928
    Abstract: Two new isolates of the Hepatitis C virus (HCV), J1 and J7, are disclosed. These new isolates comprise nucleotide and amino acid sequences which are distinct from the prototype HCV isolate, HCV1. Thus, J1 and J7 provide new polynucleotides and polypeptides for use, inter alia, in diagnostics, recombinant protein production and vaccine development.
    Type: Grant
    Filed: February 24, 1994
    Date of Patent: December 13, 1994
    Assignees: Chiron Corporation, The Director General of the National Institute of Health of Japan
    Inventors: Tatsuo Miyamura, Izumi Saito, Michael Houghton, Amy J. Weiner, Jang Han, Janice A. Kolberg, Tai-An Cha, Bruce D. Irvine
  • Pallet racking system
    Patent number: 6183176
    Abstract: The invention is a drive-in pallet racking system for a large transportation vehicle like a railcar or truck trailer. The racking system includes a plurality of center posts which define two drive-through passageways along the length of the vehicle. Pallet-supporting rails are mounted on each side of the posts. One rail is mounted to the posts and the other is mounted on the sidewall opposite the posts. The rails are spaced apart so that a forklift can drive in between them. However, the spacing is sufficiently narrow so that the rails can support the edges of the pallet without any intermediate support.
    Type: Grant
    Filed: August 9, 1999
    Date of Patent: February 6, 2001
    Assignee: Cryo-Trans, Inc.
    Inventor: Marvin H. Weiner
  • Insulated non-halogenated heavy metal free vehicular cable
    Patent number: 7687720
    Abstract: Described is an insulated non-halogenated, heavy metal free vehicular cable comprising an inner core of a copper based metal wire having a cross sectional area of at least about 0.1 mm2, and an outer insulation, covering the length of the inner core, comprised of a thermoplastic polyphenylene ether composition that has no halogen or heavy metal added thereto, the insulated cable capable of meeting the testing standard ISO 6722.
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: March 30, 2010
    Assignee: Delphi Technologies, Inc.
    Inventors: Raman V. Chiruvella, Leonard A. Weiner, Eugene W. Yeager, Daniel T. Quinlan, Paul J. Pawlikowski, Edward L. Monroe, Bruce D. Lawrence
  • Methods for detecting Hepatitis C virus using polynucleotides specific for same
    Patent number: 5712088
    Abstract: A new virus, Hepatitis C virus (HCV), which has proven to be the major etiologic agent of blood-borne NANBH, was discovered by Applicant. Reagents for isolating, amplifying, and detecting HCV polynucleotides are provided. These reagents are oligomers containing polynucleotide sequences which are capable of forming hybrid structures with HCV target polynucleotide sequences.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: January 27, 1998
    Assignee: Chiron Corporation
    Inventors: Michael Houghton, Qui-Lim Choo, George Kuo, Amy J. Weiner, Jang Han, Michael Steven Urdea, Bruce Duncan Irvine, Janice A. Kolberg
  • SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT
    Publication number: 20150197526
    Abstract: The present invention provides novel compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated transporter protein-mediated disease by administering such compounds, and pharmaceutical compositions comprising such compounds. In one embodiment, the invention provides novel pyrazolo[1,5-a]pyrimidine efflux inhibitors that are selective toward ABCG2 over ABCB1.
    Type: Application
    Filed: December 31, 2014
    Publication date: July 16, 2015
    Inventors: Richard Smith Larson, Larry A. Sklar, Bruce S. Edwards, Juan Jacob Strouse, Irena Ivnitski-Steele, Hydya M. Khawaja, Jerec Warren Ricci, Jeffrey Aube, Jennifer Elizabeth Golden, Tuanli Yao, Warren S. Weiner, Chad E. Schroeder
  • NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
    Patent number: 5714596
    Abstract: A new virus, Hepatitis C virus (HCV), which has proven to be the major etiologic agent of blood-borne NANBH, was discovered by Applicant. Reagents for isolating, amplifying, and detecting HCV polynucleotides are provided. These reagents are oligomers comprised of polynucleotide sequences which are capable of forming hybrid structures with HCV target polynucleotide sequences.
    Type: Grant
    Filed: March 31, 1993
    Date of Patent: February 3, 1998
    Assignee: Chiron Corporation
    Inventors: Michael Houghton, Qui-Lim Choo, George Kuo, Amy J. Weiner, Jang Han, Michael Steven Urdea, Bruce Duncan Irvine, Janice A. Kolberg
  • Archery sighting device and methods of constructing and utilizing same
    Patent number: 4294017
    Abstract: An archery sighting device which provides adjustment of the angle between an optical sight and an archery bow by sliding movement of a housing for the optical sight along a curved support member. A mounting bracket of the device is affixed to a side surface of the midsection of an archery bow. The curved support member providing angular adjustment of the optical sight has a radius of curvature proportional to the draw length of the archer, thus affording precise adjustment of the angle of the optical sight. A detent positioning arrangement is provided to enable the user to readily adjust the optical sight to the desired setting along the curved support member.
    Type: Grant
    Filed: March 31, 1980
    Date of Patent: October 13, 1981
    Inventors: Robert J. Byrnes, Bruce R. Byrnes
  • Conserved motif of hepatitis C virus E2/NS1 region
    Patent number: 7371386
    Abstract: The hypervariable region (E2HV) of the putative hepatitis C virus (HCV) glycoprotein E2/NS1, between about amino acid 384 to about amino acid 414, is a rapidly evolving region of HCV, and is likely to be under positive immune selection. A newly discovered motif within this hypervariable region is immunogenic and conserved with respect to the character of the amino acids. In many isolates, this motif falls between amino acids 401 to 406 or 407. The discovery of this motif allows for additional materials and methods to treat and diagnose HCV.
    Type: Grant
    Filed: September 18, 2006
    Date of Patent: May 13, 2008
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Amy J. Weiner, Michael Houghton
  • Hepatitis C virus isolate polypeptides
    Patent number: 5856437
    Abstract: Two new isolates of the Hepatitis C virus (HCV), J1 and J7, are disclosed. These new isolates comprise nucleotide and amino acid sequences which are distinct from the prototype HCV isolate, HCV1. Thus, J1 and J7 provide new polynucleotides and polypeptides for use, inter alia, in diagnostics, recombinant protein production and vaccine development.
    Type: Grant
    Filed: November 3, 1994
    Date of Patent: January 5, 1999
    Assignees: Chiron Corporation, The Director General of the National Institute of Health of Japan
    Inventors: Tatsuo Miyamura, Izumi Saito, Michael Houghton, Amy J. Weiner, Jang Han, Janice A. Kolberg, Tai-An Cha, Bruce D. Irvine
  • Genetic constructs and compositions comprising RRE and CTE and uses thereof
    Patent number: 7455841
    Abstract: Genetic constructs that comprise a coding sequence for HIV-1 Rev, and a coding sequence for a desired protein are disclosed. Compositions that comprise at least two nucleic acid molecules in which at least one nucleic acid molecule comprises a coding sequence for HIV-1 Rev, and at least one nucleic acid molecule comprises a coding sequence for a desired protein are disclosed. In such genetic constructs and compositions comprising nucleic acid molecules, the coding sequence for the desired protein comprises at least a portion of coding sequence for an HIV structural protein that includes an RRE and at least one CTE. Methods of inducing an immune response against an immunogen in an individual, methods of delivering proteins to an individual and methods of producing proteins are also disclosed.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: November 25, 2008
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Karuppiah Muthumani
  • Apparatus for dynamically reading/writing multiple object file formats through use of object code readers/writers interfacing with generalized object file format interface and applications programmers' interface
    Patent number: 5740469
    Abstract: An apparatus for allowing a single software Tool (136) to read and write multiple Object File Formats utilize dynamically configurable and loadable Object File Readers (131) and Writers (139). A separate Reader (131) and Writer (139) can be implemented for each different Object File Format and variations thereof. Tools (136) communicate with the Readers (131) and Writers (139) using a Generalized Object File Program Interface (124). This Interface (124) utilizes Data Structures implementing a Generalized Object File Internal Representation (122) and an Applications Programmers Interface (120).
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: April 14, 1998
    Assignee: Motorola Inc.
    Inventors: Weiping Yin, Paul Hancock, Alan Weiner
  • Selective efflux inhibitors and related pharmaceutical compositions and methods of treatment
    Patent number: 9056111
    Abstract: The present invention provides pyrazolo[1,5-a]pyrimidine compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated transporter protein-mediated disease by administering such compounds, and pharmaceutical compositions comprising such compounds. In one embodiment, the invention provides pyrazolo[1,5-a]pyrimidine efflux inhibitors that are selective toward ABCG2 over ABCB1. Compounds and compositions according to the present invention may be used to treat cancer, including drug resistant (DR) and multiple drug resistant (MDR) cancers.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: June 16, 2015
    Assignees: STC.UNM, UNIVERSITY OF KANSAS
    Inventors: Richard Smith Larson, Larry A. Sklar, Bruce S. Edwards, Juan Jacob Strouse, Irena Ivnitski-Steele, Hadya M. Khawaja, Jerec Warren Ricci, Jeffrey Aube, Jennifer Elizabeth Golden, Tuanli Yao, Warren S. Weiner, Chad E. Schroeder
  • Coaxial plasma processing apparatus
    Patent number: 5364488
    Abstract: A plasma processing apparatus for ashing semi-conductors wafers has a vertically elongate cylindrical chamber for generating a plasma for processing a workpiece housed therein with heat applied thereto. The cylindrical chamber has upper and lower open ends closed respectively by upper and lower chamber plates. A cooling coil is positioned above the upper chamber plate. A temperature controller actuates a fan unit to force an air flow over the cooling coil to the upper chamber plate for keeping the temperature in the cylindrical chamber within a predetermined range. The plasma processing apparatus includes inner and outer electrodes disposed inside and outside, respectively, of the cylindrical chamber, and a Radio Frequency generator for generating the plasma between the inner and outer electrodes.
    Type: Grant
    Filed: September 30, 1992
    Date of Patent: November 15, 1994
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Mitsuaki Minato, Akira Uehara, Atsushi Matsushita
  • Resist materials and related processes
    Patent number: 5741629
    Abstract: Polymers suitable for chemically amplified resists based on styrene chemistry are advantageously formed with a meta substituent on the phenyl ring of the styrene moiety. Additionally, polymers for such applications including, but not limited to, meta substituted polymers are advantageously formed by reacting a first monomer having a first protective group with a second monomer having a second protective group. After polymerization, the second protective group is removed without substantially affecting the first protective group. For example, if the first protective group is an alkoxy carbonyl group, and the second protective group is a silyl ether group, treatment with a lower alcohol with trace amounts of acid transforms the silyl group into an OH-moiety without affecting the alkoxy carbonyl group.
    Type: Grant
    Filed: October 15, 1996
    Date of Patent: April 21, 1998
    Assignee: Lucent Technologies Inc.
    Inventors: Edwin Arthur Chandross, Janet Mihoko Kometani, Omkaram Nalamasu, Elsa Reichmanis, Kathryn Elizabeth Uhrich
  • Bone shortening device and method
    Patent number: 10631902
    Abstract: Bone fixation devices and plates are disclosed. The bone fixation device includes a first portion, a second portion, and a third portion. The first portion includes at least one opening. The second portion includes at least one second opening. The third portion is positioned between the first portion and the second portion and is configured to guide the cutting of a bone. The bone fixation plate includes a first plate portion, a second plate portion, and a third plate portion. The first plate portion includes at least one screw hole for receiving a first bone screw. The second plate portion includes at least one slot for receiving a second bone screw. The third plate portion is positioned adjacent to the first and second plate portions and is configured to guide bone cutting A method of altering a bone using the bone fixation devices and plates is also disclosed.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: April 28, 2020
    Assignee: NEXTREMITY SOLUTIONS, INC.
    Inventors: Lon S. Weiner, Stuart D. Katchis, John R. Pepper
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