Search Patents
  • MULTISPECIFIC ANTIBODIES AGAINST CD40 AND CD137
    Publication number: 20210317225
    Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
    Type: Application
    Filed: June 11, 2021
    Publication date: October 14, 2021
    Inventors: Isil ALTINTAS, David SATIJN, Rik RADEMAKER, Paul PARREN, Friederike GIESEKE, Ugur SAHIN
  • Monoclonal Antibodies for Treatment of Cancer
    Publication number: 20170058044
    Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer.
    Type: Application
    Filed: September 6, 2016
    Publication date: March 2, 2017
    Inventors: Ugur Sahin, Michael Koslowski, Özlem Türeci
  • MULTISPECIFIC ANTIBODIES AGAINST CD40 AND CD137
    Publication number: 20220033510
    Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
    Type: Application
    Filed: June 28, 2021
    Publication date: February 3, 2022
    Inventors: Isil ALTINTAS, David SATIJN, Rik RADEMAKER, Paul PARREN, Friederike GIESEKE, Ugur SAHIN
  • MULTISPECIFIC ANTIBODIES AGAINST CD40 AND CD137
    Publication number: 20200247899
    Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
    Type: Application
    Filed: April 22, 2020
    Publication date: August 6, 2020
    Inventors: Isil ALTINTAS, David SATIJN, Rik RADEMAKER, Paul PARREN, Friederike GIESEKE, Ugur SAHIN
  • Compositions and Methods for Diagnosis and Treatment of Cancer
    Publication number: 20180037632
    Abstract: The present invention relates to the diagnosis and treatment of cancerous diseases, in particular cancerous diseases expressing Seprase (Fap-alpha; fibroblast activation protein alpha). More particularly, the invention concerns peptides targeting Seprase.
    Type: Application
    Filed: March 15, 2016
    Publication date: February 8, 2018
    Inventors: Ugur Sahin, Joycelyn Wüstehube-Lausch, Markus Fiedler, Matin Daneschdar, Hans-Ulrich Schmoldt
  • MODIFICATION OF RNA, PRODUCING AN INCREASED TRANSCRIPT STABILITY AND TRANSLATION EFFICIENCY
    Publication number: 20170009244
    Abstract: It was the object of the present invention to provide RNA with increased stability and translation efficiency and means for obtaining such RNA. It should be possible to obtain increased grades of expression by using said RNA in gene therapy approaches.
    Type: Application
    Filed: July 22, 2016
    Publication date: January 12, 2017
    Inventors: Ugur Sahin, Silke Holtkamp, Ozlem Tureci, Sebastian Kreiter
  • METHODS FOR CHARACTERIZING LOSS OF ANTIGEN PRESENTATION
    Publication number: 20200140945
    Abstract: This invention relates to methods for screening for a genotype for loss of antigen presentation via MHC class I in a subject and/or respectively detecting a subject's increased risk of resistance against immunotherapy such as against vaccination.
    Type: Application
    Filed: June 1, 2018
    Publication date: May 7, 2020
    Inventors: Ugur SAHIN, Martin SUCHAN, Barbara SCHRÖRS, Martin LÖWER, Petra OEHM
  • ANTIBODIES USEFUL IN CANCER DIAGNOSIS
    Publication number: 20220162302
    Abstract: The invention relates to antibodies directed against an epitope located within the C-terminal portion of CLDN6 which are useful, for example, in diagnosing cancer and/or in determining whether cancer cells express CLDN6.
    Type: Application
    Filed: February 7, 2022
    Publication date: May 26, 2022
    Inventors: Rita MITNACHT-KRAUS, Stefan WÖLL, Korden WALTER, Özlem TÜRECI, Ugur SAHIN
  • Modification of RNA, Producing an Increased Transcript Stability and Translation Efficiency
    Publication number: 20190062762
    Abstract: It was the object of the present invention to provide RNA with increased stability and translation efficiency and means for obtaining such RNA. It should be possible to obtain increased grades of expression by using said RNA in gene therapy approaches.
    Type: Application
    Filed: September 27, 2018
    Publication date: February 28, 2019
    Applicant: BioNTech AG
    Inventors: Ugur Sahin, Silke Holtkamp, Ozlem Tureci, Sebastian Kreiter
  • ANTIBODIES AGAINST CLAUDIN 18.2 USEFUL IN CANCER DIAGNOSIS
    Publication number: 20180319891
    Abstract: The invention relates to antibodies directed against an epitope located within the C-terminal portion of CLDN18.2 which are useful, for example, in diagnosing cancer and/or in determining whether cancer cells express CLDN18.2.
    Type: Application
    Filed: July 17, 2018
    Publication date: November 8, 2018
    Inventors: Ugur Sahin, Ozlem Tureci, Rita Mitnacht-Kraus, Stefan Woll
  • ANTIBODIES AGAINST CLAUDIN 18.2 USEFUL IN CANCER DIAGNOSIS
    Publication number: 20160333109
    Abstract: The invention relates to antibodies directed against an epitope located within the C-terminal portion of CLDN18.2 which are useful, for example, in diagnosing cancer and/or in determining whether cancer cells express CLDN18.2.
    Type: Application
    Filed: August 3, 2016
    Publication date: November 17, 2016
    Inventors: Ugur Sahin, Ozlem Tureci, Rita Mitnacht-Kraus, Stefan Woll
  • Monoclonal Antibodies for Treatment of Cancer
    Publication number: 20130156782
    Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer.
    Type: Application
    Filed: December 11, 2012
    Publication date: June 20, 2013
    Inventors: Ugur Sahin, Michael Koslowski, Ozlem Tureci
  • ANTIBODIES USEFUL IN CANCER DIAGNOSIS
    Publication number: 20200199221
    Abstract: The invention relates to antibodies directed against an epitope located within the C-terminal portion of CLDN6 which are useful, for example, in diagnosing cancer and/or in determining whether cancer cells express CLDN6.
    Type: Application
    Filed: September 5, 2018
    Publication date: June 25, 2020
    Inventors: Rita MITNACHT-KRAUS, Stefan WÖLL, Korden WALTER, Özlem TÜRECI, Ugur SAHIN
  • USE OF RNA FOR REPROGRAMMING SOMATIC CELLS
    Publication number: 20210324341
    Abstract: Methods for effecting the de-differentiation of somatic cells to cells having stem cell characteristics, in particular pluripotency, include the steps of introducing RNA encoding factors inducing the de-differentiation of somatic cells into the somatic cells and culturing the somatic cells allowing the cells to de-differentiate.
    Type: Application
    Filed: April 27, 2021
    Publication date: October 21, 2021
    Inventors: Ugur Sahin, Marco Poleganov, Tim Beissert
  • Modification of RNA, Producing an Increased Transcript Stability and Translation Efficiency
    Publication number: 20100129877
    Abstract: It was the object of the present invention to provide RNA with increased stability and translation efficiency and means for obtaining such RNA. It should be possible to obtain increased grades of expression by using said RNA in gene therapy approaches.
    Type: Application
    Filed: September 28, 2006
    Publication date: May 27, 2010
    Inventors: Ugur Sahin, Silke Holtkamp, Ozlem Tureci, Sebastian Kreiter
  • CORONAVIRUS VACCINE
    Publication number: 20240000921
    Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses.
    Type: Application
    Filed: June 26, 2023
    Publication date: January 4, 2024
    Inventors: Alexander Muik, Asaf Poran, Kena Anne Swanson, Qi Yang, Hui Cai, Ugur Sahin, Kayvon Modjarrad
  • LNP COMPOSITIONS COMPRISING RNA AND METHODS FOR PREPARING, STORING AND USING THE SAME
    Publication number: 20230414747
    Abstract: The present disclosure relates generally to the field of lipid nanoparticle (LNP) compositions comprising RNA, methods for preparing and storing such compositions, and the use of such compositions in therapy.
    Type: Application
    Filed: November 15, 2021
    Publication date: December 28, 2023
    Inventors: Steffen Panzner, Ugur Sahin, Jorrit-Jan Krijger, Kaushik Thanki, Bakul Subodh Bhatnagar, Ramin Darvari, Sumit Luthra, Serguei A. Tchessalov
  • Monoclonal Antibodies for Treatment of Cancer
    Publication number: 20100111975
    Abstract: The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer.
    Type: Application
    Filed: March 14, 2008
    Publication date: May 6, 2010
    Inventors: Ugur Sahin, Michael Koslowski, Ozlem Tureci
  • Identification of tumor-associated markers for diagnosis and therapy
    Patent number: 10253373
    Abstract: The present technology relates to genetic products the expression of which is associated with cancer diseases. The present technology also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: April 9, 2019
    Assignee: BIONTECH AG
    Inventors: Ugur Sahin, Özlem Türeci, Michael Koslowski
  • METHODS AND COMPOSITIONS FOR STIMULATING IMMUNE RESPONSE
    Publication number: 20200197508
    Abstract: The present invention relates to methods and compositions for stimulating an immune response. In particular, the present invention relates to immunostimulatory RNA molecules comprising sequences derived from an Influenza A virus nucleoprotein-encoding RNA molecule that act as adjuvants and/or immunostimulatory agents to enhance host immune responses.
    Type: Application
    Filed: March 21, 2018
    Publication date: June 25, 2020
    Inventors: Mahjoub Bihi, Ugur Sahin, Mustafa Diken, Thorsten Klamp
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