Abstract: A solid state molecular sensor having an aperture extending through a thickness of a sensing region is configured with a sensing region thickness that corresponds to the characteristic extent of at least a component of a molecular species to be translocated through the aperture. A change in an electrical characteristic of the sensing region is measured during the molecular species translocation. The sensor can be configured as a field effect transistor molecular sensor. The sensing region can be a region of graphene including an aperture extending through a thickness of the graphene.
Type:
Grant
Filed:
September 12, 2008
Date of Patent:
April 15, 2014
Assignee:
President and Fellows of Harvard College
Inventors:
Charles M. Lieber, Qihua Xiong, Ping Xie, Ying Fang
Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
Type:
Application
Filed:
April 11, 2012
Publication date:
August 2, 2012
Applicant:
President and Fellows of Harvard College
Inventors:
Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
Abstract: A method for controlling electric conduction on nanoscale wires is disclosed. The nanoscale wires are provided with controllable regions axially and/or radially distributed. Controlling those regions by means of microscale wires or additional nanoscale wires allows or prevents electric conduction on the controlled nanoscale wires. The controllable regions are of two different types. For example, a first type of controllable region can exhibit a different doping from a second type of controllable region. The method allows one or more of a set of nanoscale wires, packed at sublithographic pitch, to be independently selected.
Type:
Application
Filed:
July 24, 2003
Publication date:
June 17, 2004
Inventors:
Andre DeHon, Charles M. Lieber, Patrick D. Lincoln, John E. Savage
Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
Type:
Application
Filed:
July 13, 2006
Publication date:
July 21, 2011
Applicant:
President and Fellows of Harvard College
Inventors:
Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
Type:
Application
Filed:
November 21, 2005
Publication date:
May 22, 2008
Applicant:
President and Fellows of Harvard College
Inventors:
Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
Abstract: A carbon-based tip for scanning probe microscopy. The tip used in microscopy to reveal chemical characteristics of a sample includes a structure of the formula:X--(L--M).sub.nin which n is 1 to 100, X is a carbon-based nanotube, L is a linking group bonded at an end of the carbon-based nanotube, and M is a molecular probe bonded to the linking group.
Type:
Grant
Filed:
June 4, 1999
Date of Patent:
December 12, 2000
Assignee:
President and Fellows of Harvard College
Inventors:
Charles M. Lieber, Stanislaus S. Wong, Adam T. Woolley, Ernesto Joselevich
Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
Type:
Grant
Filed:
April 11, 2012
Date of Patent:
June 25, 2013
Assignee:
President and Fellows of Harvard College
Inventors:
Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
Type:
Application
Filed:
March 29, 2004
Publication date:
September 30, 2004
Applicant:
President and Fellows of Harvard University
Inventors:
Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
Type:
Grant
Filed:
December 11, 2001
Date of Patent:
October 31, 2006
Assignee:
President & Fellows of Harvard College
Inventors:
Charles M. Lieber, Hongkun Park, Qingqiao Wei, Yi Cui, Wenjie Liang
Abstract: A process utilizing a supported metal catalyst, a volatile species source, and a carbon source has been developed to produce carbide nanorods with diameters of less than about 100 nm and aspect ratios of 10 to 1000. The volatile species source, carbon source, and supported metal catalyst can be used to produce carbide nanorods in single run, batch, and continuous reactors under relatively mild conditions. The method employs a simple catalytic process involving readily available starting materials.
Type:
Grant
Filed:
March 7, 1997
Date of Patent:
December 7, 1999
Assignee:
President and Fellows of Harvard College
Abstract: An apparatus and methods for a sublithographic programmable logic array (PLA) are disclosed. The apparatus allows combination of non-restoring, programmable junctions and fixed (non-programmable) restoration logic to implement any logic function or any finite-state machine. The methods disclosed teach how to integrate fixed, restoration logic at sublithographic scales along with programmable junctions. The methods further teach how to integrate addressing from the microscale so that the nanoscale crosspoint junctions can be programmed after fabrication.
Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
Type:
Grant
Filed:
March 29, 2004
Date of Patent:
May 15, 2012
Assignee:
President and Fellows of Harvard College
Inventors:
Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
Abstract: There is provided a method for sensing the translocation of a molecule through a nanopore. In the method, there is directed to an inlet of a nanopore a molecule that is disposed in a first ionic solution of a first ionic concentration. The molecule is caused to translocate through the nanopore from the inlet of the nanopore to an outlet of the nanopore and into a second ionic solution of a second ionic concentration that is different than the first ionic concentration. An electrical potential, local to that ionic solution, of the first and second ionic solutions, which has a lower ionic concentration, is measured while the molecule is caused to translocate through the nanopore.
Type:
Grant
Filed:
June 7, 2017
Date of Patent:
October 8, 2019
Assignee:
President and Fellows of Harvard College
Abstract: Various aspects of the present invention generally relate to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample, and systems and methods of immobilizing entities such as reaction entities relative to nanoscale wires. In one aspect, a nucleic acid, such as DNA, may be immobilized relative to a nanoscale wire, and in some cases, grown from the nanoscale wire. In certain embodiments, the nucleic acid may interact with entities such as other nucleic acids, proteins, etc., and in some cases, such interactions may be reversible. As an example, an enzyme such as telomerase may be allowed to bind to DNA immobilized relative to a nanoscale wire. The telomerase may extend the length of the DNA, for instance, by reaction with free deoxynucleotide triphosphates in solution; additionally, various properties of the nucleic acid may be determined, for example, using electric field interactions between the nucleic acid and the nanoscale wire.
Type:
Application
Filed:
May 25, 2005
Publication date:
November 30, 2006
Inventors:
Charles Lieber, Fernando Patolsky, Gengfeng Zheng
Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
Type:
Grant
Filed:
November 21, 2005
Date of Patent:
July 15, 2008
Assignee:
President and Fellows of Harvard College
Inventors:
Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
Abstract: The present invention generally relates to nanoscale wires and, in particular, to probes comprising nanoscale wires for use in determining properties such as electrical and/or chemical properties, e.g., for insertion into biological tissue, such as the brain. The probe may be formed from relatively flexible materials such as polymers, and in some cases, the probes may comprises nanoscale wires or other electronic components. The probe may be cooled to a temperature that causes the probe to harden, e.g., to a temperature below a glass transition temperature, prior to insertion, to facilitate the insertion of the probe into the tissue.
Type:
Application
Filed:
December 2, 2014
Publication date:
October 20, 2016
Applicant:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Abstract: The present invention generally relates to nanoscale wires for use in determining analytes suspected to be present in a sample, especially in connection with determining information about a sample containing, or suspected of containing, two or more analytes. For example, the invention can involve a competitive, uncompetitive, or non-competitive binding assay including a nanoscale wire to a sample containing a species able to interact with the retain entity to produce a product, where the sample also contains or is suspected of containing a second species able to interact with the reaction entity to prevent production of the product resulting from interaction of the first species and the reaction entity. Based upon determination of production of the product, determination of the second species in the sample can be made.
Type:
Application
Filed:
June 15, 2005
Publication date:
November 15, 2007
Applicant:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventors:
Wayne Wang, Chuo Chen, Keng-Hui Lin, Ying Fang, Charles Lieber
Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
Type:
Grant
Filed:
December 20, 2005
Date of Patent:
February 6, 2007
Assignee:
President and Fellows of Harvard College
Inventors:
Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
Abstract: There is provided a method for sensing the translocation of a molecule through a nanopore. In the method, there is directed to an inlet of a nanopore a molecule that is disposed in a first ionic solution of a first ionic concentration. The molecule is caused to translocate through the nanopore from the inlet of the nanopore to an outlet of the nanopore and into a second ionic solution of a second ionic concentration that is different than the first ionic concentration. An electrical potential, local to that ionic solution, of the first and second ionic solutions, which has a lower ionic concentration, is measured while the molecule is caused to translocate through the nanopore.
Type:
Application
Filed:
June 7, 2017
Publication date:
September 21, 2017
Applicant:
President and Fellows of Harvard College
Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
Type:
Grant
Filed:
October 24, 2001
Date of Patent:
August 24, 2004
Assignee:
President & Fellows of Harvard College
Inventors:
Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim