Abstract: In one aspect of the present invention is a substrate comprising multiple, independently controllable electrochromic zones, wherein each of the electrochromic zones share a common, continuous bus bar. In one embodiment, of the electrochromic zones are not completely isolated from each other. In another embodiment, each of the electrochromic zones have the same surface area. In another embodiment, each of the electrochromic zones have a different surface area.
Abstract: Peptides derived from Sarcoma antigen 1 (SAGE1), complexes comprising such peptides bound to recombinant MHC molecules, and cells presenting said peptide in complex with MHC molecules are described. Also provided are binding moieties that bind to the peptides and/or complexes described. Such moieties are useful for the development of immunotherapeutic reagents for the treatment of diseases such as cancer.
Abstract: Process for the industrial synthesis of the compound of formula (I):
and its addition salts.
Application to the synthesis of tianeptine and its pharmaceutically acceptable salts.
Type:
Grant
Filed:
March 29, 2001
Date of Patent:
August 27, 2002
Assignee:
Les Laboratories Servier
Inventors:
Jacky Blanchard, Hugues Turbe, Daniel Brigot
Abstract: The invention relates to compounds of general formula (I):
in which R, R1, R2, X and Y are as defined in the description, their geometrical and/or optical isomers, and their addition salts with a pharmaceutically-acceptable acid or base, as well as to medicaments containing the same.
Type:
Grant
Filed:
June 4, 1999
Date of Patent:
May 15, 2001
Assignee:
Adir et Compagnie
Inventors:
Christian Marazano, Delphine Compere, Bhupesh Chandra Das, Jean Lepagnol
Abstract: The invention concerns novel indole piperazine derivatives of Formula (I):
It also concerns a method for preparing said compounds and their use as therapeutically active substances, in particular for treating or preventing diseases related to the dysfunction of 5 -HT1-like receptors.
Abstract: The present invention relates to novel peptides derived from Sarcoma antigen 1 (SAGE1), complexes comprising such peptides bound to recombinant MHC molecules, and cells presenting said peptide in complex with MHC molecules. Also provided by the present invention are binding moieties that bind to the peptides and/or complexes of the invention. Such moieties are useful for the development of immunotherapeutic reagents for the treatment of diseases such as cancer.
Abstract: The invention relates to compound of the general formula (I):
R—O—A (I)
wherein:
R represents the radical of formula (II):
A is as defined in the description,
and medicinal products containing the same which are useful in treating or in preventing cancer.
Type:
Grant
Filed:
December 14, 2000
Date of Patent:
October 23, 2001
Assignee:
Adir et Compagnie
Inventors:
Ying Li, Feng Shan, Jin Ming Wu, Guangshao Wu, Jian Ding, Jianxian Han, Ghanem Atassi, Pierre Renard
Abstract: An improved bathtub liner. The bathtub liner includes resilient pads encapsulated by a covering having a smooth continuous surface which detachably adheres to the inner surfaces of a bathtub and resists shear forces which tend to cause the continuous surface to slide over the inner surfaces of the bathtub. The bathtub liner includes a bottom pad shaped to cause water to flow under the force of gravity down the pad toward the bathtub drain when the tub is being emptied of water.
Abstract: The proposed iterative method concurrently calculates maximum likelihood estimated values for the channel coefficients (h0, . . . , hL; ?h) and the DC offset (d; ?d) on the basis of a training sequence (TSC) in a TDMA mobile communications system. The SAGE algorithm leads to two recursion formulae, by means of which the iterative calculation of estimated values for the channel coefficients (ho, . . . , hL; ?h) and for the DC offset (d; ?d) is provided.
Type:
Application
Filed:
July 29, 2005
Publication date:
March 9, 2006
Inventors:
Ralf Heddergott, Claudiu Krakowski, Martin Kruger
Abstract: Methods, systems and apparatus for automated extraction, purification, and processing of nucleic acids from biological samples are presented. In some embodiments, hydrogel supports are used to immobilize particulate biological input samples and extract nucleic acids during operations. The use of hydrogel facilitates automated sample processing on robotic liquid handling systems. Devices, methods, and systems are also provided for electrophoretic sample preparation.
Type:
Application
Filed:
November 15, 2018
Publication date:
May 23, 2019
Applicants:
SAGE SCIENCE, INC., SAGE SCIENCE, INC.
Inventors:
Ezra S. ABRAMS, Danny YUN, Todd J. BARBERA, Douglas Grosvenor SABIN, T. Christian BOLES
Abstract: The invention concerns a coal tar extract with reduced polycyclic aromatic hydrocarbon and benzo(a)pyrene content and a method for obtaining same using two sequentially linked distillation systems. The invention also concerns cosmetic and dermatological preparations containing said resulting coal tar extract.
Abstract: The invention concerns novel ary1-{4-fluoro-4-[(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl}-methanone derivatives of formula(1) wherein X is a hydrogen, fluorine or chlorine atom useful as medicines in particular having antidepressant, analgesic, anxiolytic and neuroprotective effects.
Type:
Grant
Filed:
May 29, 2001
Date of Patent:
September 10, 2002
Assignee:
Pierre Fabre Medicament
Inventors:
Bernard Vacher, Bernard Bonnaud, Wouter Koek
Abstract: The invention relates to a compound of formula (I):
wherein:
A represents pyridine, pyridinium or piperidine
R1, R2, R3 and R4 are as defined in the description
R5 represents hydrogen, a nitrogen-containing heterocycle or a group of
R6 represents hydrogen or linear or branched (C1-C6)alkyl.
and medicinal products containing the same which are useful in treating pain or deficiencies in memory.
Type:
Grant
Filed:
May 4, 2000
Date of Patent:
November 27, 2001
Assignee:
Adir et Compagnie
Inventors:
Otto Meth-Cohn, Chu-Yi Yu, Pierre Lestage, Marie-Cécile Lebrun, Daniel-Henri Caignard, Pierre Renard
Abstract: The present invention relates to a process for the preparation of high-grade chloramine by the action of commercial eau de Javelle of 100 chlorometric degrees on a solution of ammonia in the presence of ammonium chloride. According to this process, the chloramine is obtained having a content greater than or equal to 2 mol L−1, that is to say, greater than or equal to 10.3%. The process can be carried out continuously or discontinuously.
Abstract: The invention relates to compounds of formula (I):
wherein:
R1, R2 and R3 are as defined in the description,
X is as defined in the description,
Y represents an oxygen atom, a sulphur atom, a C(H)q group, SO or SO2,
n is equal to from 0 to 5,
A represents a NR5R6 group,
and medicinal products containing the same which are useful in treating or in preventing melatoninergic disorders.
Type:
Grant
Filed:
November 12, 1999
Date of Patent:
November 6, 2001
Assignee:
Adir et Compagnie
Inventors:
Gérald Guillaumet, Marie-Claude Viaud, Ahmed Mamai, Isabelle Charton, Pierre Renard, Caroline Bennejean, Béatrice Guardiola, Philippe Daubos
Abstract:
The present invention relates to novel [(2-substituted-5-[3-thienyl])-benzyl]-[2-([2-isopropoxy-5-fluoro]-phenoxy)-ethyl]-amine derivatives having formula (1) and the use thereof as medicaments, especially anti-psychotic medicaments.
Type:
Grant
Filed:
September 28, 2001
Date of Patent:
July 9, 2002
Assignee:
Pierre Fabre Medicament
Inventors:
Bernard Vacher, Stéphane Cuisiat, Wouter Koek
Abstract: An apparatus for repair of a defect in an electronic energy control device may include a position indicating means for indicating a position at which to fixedly position a mounting unit relative to a portion of an electronic energy control device including a defect to be repaired, where the device is fixed in position. An imaging and repair assembly of the apparatus has an optical imaging range and a laser repair range. When the mounting unit is mounted to a support surface to fixedly position the mounting unit at the position indicated by the position indicating means and the imaging and repair assembly is attached to the mounting unit, the portion of the electronic energy control device is within the imaging range and the repair range.
Abstract: The proposed iterative method concurrently calculates maximum likelihood estimated values for the channel coefficients (h0, . . . , hL; ?h) and the DC offset (d; ?d) on the basis of a training sequence (TSC) in a TDMA mobile communications system. The SAGE algorithm leads to two recursion formulae, by means of which the iterative calculation of estimated values for the channel coefficients (h0, . . . , hL; ?h) and for the DC offset (d; ?d) is provided.
Type:
Grant
Filed:
July 29, 2005
Date of Patent:
March 4, 2008
Assignee:
Infineon Technologies AG
Inventors:
Ralf Heddergott, Claudiu Krakowski, Martin Krüger
Abstract: Compound of formula (I):
wherein:
n represents 2 or 3,
R1 represents optionally substituted alkyl, cycloalkyl or optionally substituted phenyl,
R2 represents amino, optionally substituted amidino, optionally substituted guanidino or optionally substituted isothioureido,
Ar represents aryl or heteroaryl,
X1 represents hydroxy or optionally substituted amino,
isomers thereof, and also salts thereof with a pharmaceutically acceptable acid or base, and which
medicinal products containing the same/are useful as trypsin-related serine protease inhibitors.
Type:
Grant
Filed:
May 2, 2000
Date of Patent:
September 11, 2001
Assignee:
Adir et Compagnie
Inventors:
Guillaume De Nanteuil, Philippe Gloanec, Tony Verbeuren, Alain Rupin