Search Patents
  • Methods and Compositions for Dengue Virus Vaccines
    Publication number: 20160257719
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: June 26, 2014
    Publication date: September 8, 2016
    Inventors: William MESSER, Ralph BARIC, Aravinda DE SILVA, Boyd YOUNT
  • Multivalent Immunogenic Compositions Against Noroviruses and Methods of Use
    Publication number: 20110070260
    Abstract: The invention provides immunogenic formulations comprising virus-like particles (VLPs) from two or more genoclusters and/or strains of norovirus in a pharmaceutically acceptable carrier. In representative embodiments, the formulation also comprises an adjuvant, for example, a viral adjuvant or CpG. The invention also provides methods of inducing an immune response to one or more noroviruses.
    Type: Application
    Filed: September 3, 2010
    Publication date: March 24, 2011
    Inventors: Ralph S. Baric, Anna LoBue, Robert Edward Johnston, Joseph Thompson, Lisa Lindesmith
  • METHODS AND COMPOSITIONS FOR DENGUE VIRUS VACCINES
    Publication number: 20190225654
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: August 20, 2018
    Publication date: July 25, 2019
    Inventors: William Messer, Ralph Baric, Aravinda de Silva, Boyd Yount
  • PROCESS FOR PACKAGING WINE IN ALUMINUM CANS
    Publication number: 20080014317
    Abstract: A filled two-piece aluminum can contains a wine that has less than 35 ppm of free SO2, less than 300 ppm of chlorides, less than 800 ppm of sulfates, and less than 250 ppm of total sulfur dioxide. The can is sealed with an aluminum closure such that the pressure within the can is at least 25 psi. The inner surface of the aluminum can is coated with a corrosion resistant coating.
    Type: Application
    Filed: September 28, 2007
    Publication date: January 17, 2008
    Inventors: Gregory Stokes, Steven Barics
  • Multi-sided vending machine
    Patent number: 9098959
    Abstract: A vending machine has a housing with a first side and a second side opposite the first side. A first dispensing slot is located at the first side of the housing, and a second dispensing slot is located at the second side of the housing. A central product storage stores product to be dispensed from the vending machine. A product delivery system selectively delivers product from said product storage to the first dispensing slot and said second dispensing slot.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: August 4, 2015
    Inventor: Robert Baric
  • MULTI-SIDED VENDING MACHINE
    Publication number: 20110172813
    Abstract: A vending machine has a housing with a first side and a second side opposite the first side. A first dispensing slot is located at the first side of the housing, and a second dispensing slot is located at the second side of the housing. A central product storage stores product to be dispensed from the vending machine. A product delivery system selectively delivers product from said product storage to the first dispensing slot and said second dispensing slot.
    Type: Application
    Filed: January 11, 2011
    Publication date: July 14, 2011
    Inventor: Robert BARIC
  • Multiple-sided vending machine
    Patent number: 9105144
    Abstract: A vending machine has a housing with a first side and a second side opposite the first side. A first dispensing slot is located at the first side of the housing, and a second dispensing slot is located at the second side of the housing. A central product storage stores product to be dispensed from the vending machine. A product delivery system selectively delivers product from said product storage to the first dispensing slot and said second dispensing slot.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: August 11, 2015
    Inventor: Robert J. Baric
  • Methods and compositions for dengue virus vaccines
    Patent number: 10870682
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: December 22, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: William Messer, Ralph Baric, Aravinda de Silva, Boyd Yount
  • Methods and compositions for dengue virus vaccines
    Patent number: 10053493
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: August 21, 2018
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: William Messer, Ralph Baric, Aravinda de Silva, Boyd Yount
  • METHODS AND COMPOSITIONS FOR DENGUE VIRUS SEROTYPE 4 EPITOPES
    Publication number: 20200155663
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein epitope from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: May 23, 2018
    Publication date: May 21, 2020
    Inventors: Ralph BARIC, Matthew BEGLEY, Douglas WIDMAN, Aravinda DESILVA, Usha NIVARTHI, Boyd YOUNT, Ellen YOUNG
  • METHODS AND COMPOSITIONS FOR RECOMBINANT DENGUE VIRUSES FOR VACCINE AND DIAGNOSTIC DEVELOPMENT
    Publication number: 20170333548
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: November 2, 2015
    Publication date: November 23, 2017
    Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom
  • METHODS AND COMPOSITIONS FOR RECOMBINANT DENGUE VIRUSES FOR VACCINE AND DIAGNOSTIC DEVELOPMENT
    Publication number: 20200230224
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: August 29, 2019
    Publication date: July 23, 2020
    Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom
  • Method and apparatus for a powder metallurgical process
    Patent number: 5812924
    Abstract: A method of producing a green compact which includes the steps of forming a generally homogeneous powder blend of powder components; consolidating the powder blend into a green body wherein the green body includes a flashing; impinging the green body with a fluid stream so as to dislodge the flashing; and removing the dislodged flashing from the surface of the green body.
    Type: Grant
    Filed: November 4, 1997
    Date of Patent: September 22, 1998
    Assignee: Kennametal Inc.
    Inventors: William R. Shaffer, Thomas J. Baric, Daniel Danila, Robert L. Macabobby
  • WINE PACKAGED IN ALUMINIUM CONTAINERS
    Publication number: 20160201019
    Abstract: A method of filling an aluminium container with wine, and a filled aluminium container containing a wine characterised in that the maximum oxygen content of the head space is 1% v/v and the wine prior to filling is micro filtered and dissolved oxygen levels throughout the aluminium container filling process are maintained up to 0.5 mg/L. and final levels of dissolved CO2 are from 50 ppm for white and sparkling wines and from 50 ppm to 400 ppm for red wines, prior to filling the container.
    Type: Application
    Filed: January 15, 2016
    Publication date: July 14, 2016
    Inventors: Gregory John Charles Stokes, Steven John Anthony Barics
  • Compositions of coronaviruses with a recombination-resistant genome
    Patent number: 7618802
    Abstract: The present invention provides a cDNA of a severe acute respiratory syndrome (SARS) coronavirus, recombinant SARS coronavirus vectors, and SARS coronavirus replicon particles. Also provided are methods of making the compositions of this invention and methods of using the compositions as immunogens and/or vaccines and/or to express heterologous nucleic acids.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: November 17, 2009
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ralph S. Baric, Rhonda Roberts, Boyd Yount, Kristopher M. Curtis
  • Methods and compositions for dengue virus serotype 4 epitopes
    Patent number: 11241491
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein epitope from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: February 8, 2022
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ralph Baric, Matthew Begley, Douglas Widman, Aravinda Desilva, Usha Nivarthi, Boyd Yount, Ellen Young
  • BELT TENSIONING METHOD
    Publication number: 20190219138
    Abstract: Provided is an actuator, preferably a linear actuator, including a carriage having a lateral support surface for supporting a first longitudinal section of a belt against lateral deflection and a space adjacent to and longitudinally offset from the lateral support surface for partially surrounding a second longitudinal section of the belt that is deflected relative to the lateral support surface to take up slack and/or tension the belt. By containing the slack within the carriage using the space and the lateral support surface, slack may be removed from the belt or the belt may be tensioned in an easy and cost efficient manner.
    Type: Application
    Filed: March 26, 2019
    Publication date: July 18, 2019
    Inventors: Thomas BARIC, Mike BRIDGES, Adis HALIMIC
  • Methods and compositions for recombinant dengue viruses for vaccine and diagnostic development
    Patent number: 10398768
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: September 3, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Ralph Baric, Douglas Widman, Boyd Yount, Emily Gallichotte, Scott Royal, Aravinda Desilva, Jesica Swanstrom
  • Linear table and simplified assembly method
    Publication number: 20040083933
    Abstract: A linear table includes a slide plate, a base, and pair of bearing assemblies. Each bearing assembly has an inner and outer bearing way, and a rolling element located between the bearing ways. The bearing ways are securely fixed to the slide plate and the base. A precision parallel device and preload fixture are used to align the bearing ways and provide a proper preload on the bearing assemblies without integral preload screws or other preload method, or integral bearing locating shoulders or other such geometry.
    Type: Application
    Filed: August 28, 2003
    Publication date: May 6, 2004
    Inventors: Thomas J. Baric, James K. Monnich, Jeremy F. Mikesell, Mark S. Koster
  • Methods and Compositions for Dengue Virus Epitopes
    Publication number: 20150328303
    Abstract: The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein domain I and domain II hinge region from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
    Type: Application
    Filed: March 15, 2013
    Publication date: November 19, 2015
    Inventors: Aravinda M. De Silva, A. Ruklanthi De Alwis, Wahala M.P.B. Wahala, Ralph H. Baric, William B. Messer, James E. Crowe, Scott A. Smith
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