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  • Microfluidic Biological Extraction Chip
    Publication number: 20100112667
    Abstract: A microfluidic cartridge for isolating biological molecules having a capture chamber containing functionalized solid supports maintained in a fluidized state provides reduced pressure drops and bubble formation during microfluidic extraction. The cartridge may include an electric field lysis chamber and/or a chemical lysis chamber. The electric-field lysis chamber may comprise an electrically insulating structure arranged between two opposing planar electrodes.
    Type: Application
    Filed: November 3, 2008
    Publication date: May 6, 2010
    Applicant: CFD RESEARCH CORPORATION
    Inventors: Shivshankar Sundaram, Balabhaskar Prabhakarpandian, Kapil Pant, Yi Wang
  • Microfluidic assay in idealized microvascular network for selection and optimization of drug delivery vehicles to simulated tumors
    Patent number: 9453252
    Abstract: An apparatus for assaying a tumor drug delivery vehicle and or drug can include an idealized microvascular network (IMN) of one or more interconnected idealized flow channels in fluid communication through a porous wall with a tissue space (e.g., idealized tissue space) containing animal cells and means for quantifying drug delivery through the IMN to the animal cells.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: September 27, 2016
    Assignee: CFD RESEARCH CORPORATION
    Inventors: Balabhaskar Prabhakarpandian, Kapil Pant, Charles Joseph Garson
  • Apparatus and method for gelling liquefied gasses
    Patent number: 8047703
    Abstract: A method and apparatus for gelling liquid propane and other liquefied gasses includes a temperature controlled churn mixer, vacuum pump, liquefied gas transfer tank, and means for measuring amount of material entering the mixer. The apparatus and method are particularly useful for the production of high quality rocket fuels and propellants.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: November 1, 2011
    Assignee: CFD Research Corporation
    Inventors: Adam Elliott, Roberto DiSalvo, Phillip Shepherd, Ryan Kosier
  • Electrically conductive ink and uses thereof
    Patent number: 8685286
    Abstract: The present disclosure provides an electrode including an electrically conductive ink deposited thereon comprising: a nano-scale conducting material; a binding agent; and an enzyme; wherein said ink is essentially solvent free. In one embodiment, the ink includes at least one of a mediator, a cross-linking agent and a substrate as well. In one further embodiment, the electrode provided herein is used in a battery, fuel cell or sensor.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: April 1, 2014
    Assignee: CFD Research Corporation
    Inventors: Vojtech Svoboda, Jianjun Wei, Sameer Singhal
  • Enzyme Catalyzed Oxidation of Hydrocarbons
    Publication number: 20150050566
    Abstract: The present disclosure provides a method of generating electricity from a long chain hydrocarbon, said method comprising contacting the liquid non-polar substrate with a plurality of enzymes, wherein at least one enzyme is non-electric current/potential enzyme that functions as a catalyst for chemical reaction transforming a first substrate or byproduct to a second substance that can be used with an additional electric current/potential generating enzyme.
    Type: Application
    Filed: April 25, 2014
    Publication date: February 19, 2015
    Applicant: CFD Research Corporation
    Inventors: Yevgenia Ulyanova, Shelley Minteer, Sameer Singhal, Vojtech Svoboda, Jianjun Wei
  • Synthetic microfluidic microvasculature network
    Patent number: 8175814
    Abstract: A synthetic microfluidic microvasculature network and associated methods mimic the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing particle adhesion and drug delivery are described with applications in the optimization of drug delivery and microvascular treatments and in describing disease mechanisms that affect the microvasculature.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: May 8, 2012
    Assignee: CFD Research Corporation
    Inventors: Balabhaskar Prabhakarpandian, Shivshankar Sundaram, Kapil Pant
  • Synthesis of carbon nanotubes by selectively heating catalyst
    Patent number: 7794797
    Abstract: The present invention is a catalytic chemical vapor deposition method and apparatus for synthesizing carbon nanotubes and/or carbon nanofibers (CNTs) on a substrate by selectively heating a catalyst for CNT synthesis on or near the surface of the substrate. Selective heating of the catalyst is achieved using an exothermic oxidation reaction on the surface of the catalyst. Selective heating of the catalyst prevents heating of the substrate and enables the synthesis of CNTs on temperature sensitive substrates.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: September 14, 2010
    Assignee: CFD Research Corporation
    Inventor: Aleksey V. Vasenkov
  • CYBERSECURITY SYSTEMS AND METHODS FOR PROTECTING, DETECTING, AND REMEDIATING CRITICAL APPLICATION SECURITY ATTACKS
    Publication number: 20230262077
    Abstract: The present invention includes systems and methods for providing cybersecurity to web-enabled applications for protection of critical software and host systems. The present invention is operable to build a Hidden Markov model of an application using automated analysis of code and documentation in order to characterize potential state and state transitions. The present invention is also operable to use additional data such as timing and proximity to assess incoming data. Incoming messages are then assigned a trust score based on Bayesian calculations.
    Type: Application
    Filed: November 8, 2022
    Publication date: August 17, 2023
    Applicant: CFD Research Corporation
    Inventor: Brian Gene Palmer
  • Advanced Multipurpose Pseudospark Switch
    Publication number: 20080238325
    Abstract: The present invention provides a pseudospark switch that overcomes the aforementioned limitations of existing pseudospark switches and proved e-beams for applications such as FELs, pulsed lasers, X-ray machines, and radar. The improvement in e-beam quality is obtained by inductively ionizing gas inside the hollow cathode chamber (HCC), prior to main gap breadkown using a HCC that incorporates a spiral induction coil. The gas in the hollow cathode chamber is ionized by the discharge of an auxiliary capacitor bank through the spiral coil that forms the back surface of the HCC.
    Type: Application
    Filed: March 29, 2007
    Publication date: October 2, 2008
    Applicant: CFD RESEARCH CORPORATION
    Inventor: Stelu Deaconu
  • Microfluidic Assay for Characterization of the Leukocyte Adhesion Cascade
    Publication number: 20100112550
    Abstract: An apparatus and method for identifying and screening for agents affecting the leukocyte adhesion cascade (LAC) encompassing rolling, adhesion and migration comprises an optically clear, plastic microfluidic chip comprising flow channels with diameters in the range of 10-500 ?m. The flow channels are coated with endothelial cells and at least a portion of the flow channels contains 1-30 ?m sized openings, optionally filled with a native or synthetic extracellular matrix, that allow leukocyte migration into one or more tissue spaces.
    Type: Application
    Filed: November 4, 2009
    Publication date: May 6, 2010
    Applicant: CFD RESEARCH CORPORATION
    Inventor: Shivshankar Sundaram
  • Enzyme catalyzed oxidation of hydrocarbons
    Patent number: 9509009
    Abstract: The present disclosure provides a method of generating electricity from a long chain hydrocarbon, said method comprising contacting the liquid non-polar substrate with a plurality of enzymes, wherein at least one enzyme is non-electric current/potential enzyme that functions as a catalyst for chemical reaction transforming a first substrate or byproduct to a second substance that can be used with an additional electric current/potential generating enzyme.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: November 29, 2016
    Assignee: CFD Research Corporation
    Inventors: Yevgenia Ulyanova, Shelley Minteer, Sameer Singhal, Vojtech Svoboda, Jianjun Wei
  • Constant Volume Rocket Motor
    Publication number: 20080098711
    Abstract: The present invention is a constant volume rocket motor that uses a non-detonating constant-volume, bipropellant combustion process in pulse-mode operation. Opening and closing of the combustion chamber exhaust outlet is controlled by an actuated reciprocating thrust valve (RTV). Fuel enters the combustion chamber at low pressure with the RTV closed. The valve opens after or during combustion when combustion chamber pressure is at or near maximum. The motor has applications in reaction control systems and attitude control systems in spacecraft.
    Type: Application
    Filed: October 27, 2006
    Publication date: May 1, 2008
    Applicant: CFD Research Corporation
    Inventors: Roberto DiSalvo, Mark Ostrander, Adam Elliott
  • Miniaturized electrothermal flow induced infusion pump
    Patent number: 9283597
    Abstract: A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems such as biochips. The self-regulating infusion pump is useful for the administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: March 15, 2016
    Assignee: CFD Research Corporation
    Inventors: Sivaramakrishnan Krishnamoorthy, Guiren Wang, Jianjun Feng, Yi Wang
  • Microfluidic assay for characterization of the leukocyte adhesion cascade
    Patent number: 8380443
    Abstract: An apparatus and method for identifying and screening for agents affecting the leukocyte adhesion cascade (LAC) encompassing rolling, adhesion and migration comprises an optically clear, plastic microfluidic chip comprising flow channels with diameters in the range of 10-500 ?m. The flow channels are coated with endothelial cells and at least a portion of the flow channels contains 1-30 ?m sized openings, optionally filled with a native or synthetic extracellular matrix, that allow leukocyte migration into one or more tissue spaces.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: February 19, 2013
    Assignee: CFD Research Corporation
    Inventors: Balabhaskar Prabhakarpandian, Kapil Pant, Shivshankar Sundaram
  • Negative pressure, bi-directional nasal aerosol delivery
    Patent number: 8191552
    Abstract: A method and apparatus for nasal drug delivery comprises a first tube in fluid communication with a means for generating a negative pressure and a second tube in fluid communication with an aerosol. The first tube is contacted with one nostril, the said second tube is contacted with the other nostril, and a negative pressure is applied to the first tube, producing a negative pressure within a nasal cavity and causing the aerosol to be drawn into the nasal passages and to deposit on an internal nasal surface.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: June 5, 2012
    Assignees: CFD Research Corporation, Centers For Disease Control and Prevention
    Inventors: Andrzej Przekwas, Vincent Harrand, Mark Papania
  • Methods and compositions for treatment of cancer
    Patent number: 11667666
    Abstract: In an aspect, the disclosure pertains to inhibitors of ANGPTL4; synthesis methods for making disclosed compounds; pharmaceutical compositions comprising disclosed compounds; methods of treating disorders of uncontrolled cellular proliferation, e.g., a cancer; and methods of treating a disease associated with an ANGPTL4 dysfunction using disclosed compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: June 6, 2023
    Assignee: CFD RESEARCH CORPORATION
    Inventor: Anuj Singhal
  • Compositions and methods for mitigating aflatoxin B1-induced liver injury
    Patent number: 11364239
    Abstract: A method for providing a therapy to a subject that has been exposed to an Aflatoxin B1 can include administering a compound having a structure of Formula 1 to the subject after exposure to the Aflatoxin B1: wherein: R1, R2, R3, R4, R5 and/or R6 are each individually a chemical moiety and n is 1, 2, 3, 4, or 5. The compound can be Amprenavir or a derivative thereof, prodrug thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof. The prodrug can be Amprenavir phosphate.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: June 21, 2022
    Assignee: CFD RESEARCH CORPORATION
    Inventor: Narender Singh
  • Self-Cleaning and Mixing Microfluidic Elements
    Publication number: 20100008183
    Abstract: Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.
    Type: Application
    Filed: September 2, 2009
    Publication date: January 14, 2010
    Applicant: CFD RESEARCH CORPORATION
    Inventors: Sivaramakrishnan Krishnamoorthy, Jianiun Feng
  • Nanoscale Surface Plasmonics Sensor with Nanofluidic Control
    Publication number: 20110168559
    Abstract: A microfluidically-controlled transmission mode nanoscal surface plasmonics sensor device comprises one or more arrays of aligned nanochannels in fluid communication with inflowing and outflowing fluid handling manifolds that control the flow of fluid through the array(s). Fluid comprising a sample for analysis is moved from an inlet manifold, through the nanochannel array, and out through an exit manifold. The fluid may also contain a reagent used to modify the interior surfaces of the nanochannels, and/or a reagent required for the detection of an analyte.
    Type: Application
    Filed: January 11, 2010
    Publication date: July 14, 2011
    Applicants: CFD RESEARCH CORPORATION, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Jianjun Wei, Sameer Singhal
  • Synthetic microfluidic microvasculature network
    Patent number: 7725267
    Abstract: The present invention is a synthetic microfluidic microvasculature network and associated methods. The synthetic microfluidic microvasculature network mimics the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing particle adhesion and drug delivery are also described. The invention has many uses including the optimization of drug delivery and microvascular treatments and in describing disease mechanisms that affect the microvasculature such as inflammation, diabetes and hypertension.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: May 25, 2010
    Assignee: CFD Research Corporation
    Inventors: Balabhaskar Prabhakarpandian, Shivshankar Sundaram, Kapil Pant
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