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  • Constant volume rocket motor
    Patent number: 7631487
    Abstract: The present invention is a constant volume rocket motor that uses a non-detonating constant-volume, bipropellant combustion process in pulse-mode operation. Opening and closing of the combustion chamber exhaust outlet is controlled by an actuated reciprocating thrust valve (RTV). Fuel enters the combustion chamber at low pressure with the RTV closed. The valve opens after or during combustion when combustion chamber pressure is at or near maximum. The motor has applications in reaction control systems and attitude control systems in spacecraft.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: December 15, 2009
    Assignee: CFD Research Corporation
    Inventors: Roberto DiSalvo, Mark Ostrander, Adam Elliott
  • Electrically Conductive Ink and Uses Thereof
    Publication number: 20140183416
    Abstract: The present disclosure provides an aqueous based electrically conductive ink, which is essentially solvent free and includes a nano-scale conducting material; a binding agent; and an enzyme. In one embodiment, the ink includes at least one of a mediator, a cross-linking agent and a substrate as well. In one further embodiment, the present disclosure provides electrically conductive ink including a single walled, carboxylic acid functionalized carbon nanotube; 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride and N-hydroxy succinimide (NHS) ester; polyethyleneimine; an aqueous buffer; and glucose oxidase.
    Type: Application
    Filed: March 5, 2014
    Publication date: July 3, 2014
    Applicant: CFD Research Corporation
    Inventors: Vojtech Svoboda, Jianjun Wei, Sameer Singhal, Yevgenia Ulyanova
  • Apparatus and method for gelling liquefied gasses
    Patent number: 7810990
    Abstract: The present invention is a method and apparatus for gelling liquid propane and other liquefied gasses. The apparatus includes a temperature controlled churn mixer, vacuum pump, liquefied gas transfer tank, and means for measuring amount of material entering the mixer. The method uses gelling agents such as silicon dioxide, clay, carbon, or organic or inorganic polymers, as well as dopants such as titanium, aluminum, and boron powders. The apparatus and method are particularly useful for the production of high quality rocket fuels and propellants.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: October 12, 2010
    Assignee: CFD Research Corporation
    Inventors: Adam Elliott, Roberto DiSalvo, Phillip Shepherd, Ryan Kosier
  • Electrically conductive ink and uses thereof
    Patent number: 9994725
    Abstract: The present disclosure provides an aqueous based electrically conductive ink, which is essentially solvent free and includes a nano-scale conducting material; a binding agent; and an enzyme. In one embodiment, the ink includes at least one of a mediator, a cross-linking agent and a substrate as well. In one further embodiment, the present disclosure provides electrically conductive ink including a single walled, carboxylic acid functionalized carbon nanotube; 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride and N-hydroxy succinimide (NHS) ester; polyethyleneimine; an aqueous buffer; and glucose oxidase.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: June 12, 2018
    Assignee: CFD Research Corporation, Inc.
    Inventors: Vojtech Svoboda, Jianjun Wei, Sameer Singhal, Yevgenia Ulyanova
  • Advanced multipurpose pseudospark switch having a hollow cathode with a planar spiral electrode and an aperture
    Patent number: 7579578
    Abstract: The present invention provides a pseudospark switch that overcomes the aforementioned limitations of existing pseudospark switches and proved e-beams for applications such as FELs, pulsed lasers, X-ray machines, and radar. The improvement in e-beam quality is obtained by inductively ionizing gas inside the hollow cathode chamber (HCC), prior to main gap breakdown using a HCC that incorporates a spiral induction coil. The gas in the hollow cathode chamber is ionized by the discharge of an auxiliary capacitor bank through the spiral coil that forms the back surface of the HCC.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: August 25, 2009
    Assignee: CFD Research Corporation
    Inventor: Stelu Deaconu
  • Microfluidic biological extraction chip
    Patent number: 8435465
    Abstract: A microfluidic cartridge for isolating biological molecules having a capture chamber containing functionalized solid supports maintained in a fluidized state provides reduced pressure drops and bubble formation during microfluidic extraction. The cartridge may include an electric field lysis chamber and/or a chemical lysis chamber. The electric-field lysis chamber may comprise an electrically insulating structure arranged between two opposing planar electrodes.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: May 7, 2013
    Assignee: CFD Research Corporation
    Inventors: Shivshankar Sundaram, Balabhaskar Prabhakarpandian, Kapil Pant, Yi Wang
  • Electrically conductive ink and uses thereof
    Patent number: 8703022
    Abstract: The present disclosure provides an aqueous based electrically conductive ink, which is essentially solvent free and includes a nano-scale conducting material; a binding agent; and an enzyme. In one embodiment, the ink includes at least one of a mediator, a cross-linking agent and a substrate as well. In one further embodiment, the present disclosure provides electrically conductive ink including a single walled, carboxylic acid functionalized carbon nanotube; 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride and N-hydroxy succinimide (NHS) ester; polyethyleneimine; an aqueous buffer; and glucose oxidase.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: April 22, 2014
    Assignee: CFD Research Corporation
    Inventors: Vojtech Svoboda, Jianjun Wei, Sameer Singhal
  • High Energy, Low Temperature Gelled Bi-Propellant Formulation Preparation Method
    Publication number: 20120073713
    Abstract: A method for preparing a gelled liquid propane (GLP) composition comprises the introduction of liquid propane into an evacuated mixing vessel containing a gellant and mixing the liquid propane with the gellant. A bi-propellant system comprising GLP is particularly well-suited for outer planet missions greater than 3 AU from the sun and also functions in earth and near earth environments. Additives such as powders of boron, carbon, lithium, and/or aluminum can be added improve performance or enhance hypergolicity. The gelling agent can be silicon dioxide, clay, carbon, or organic or inorganic polymers. The bi-propellant system may be, but need not be, hypergolic.
    Type: Application
    Filed: January 25, 2011
    Publication date: March 29, 2012
    Applicant: CFD RESEARCH CORPORATION
    Inventor: Roberto DiSalvo
  • Multi-chambered cell culture device to model organ microphysiology
    Patent number: 9932550
    Abstract: A cell culture device can include: at least 3 distinct chambers between the top wall and bottom wall. The perimeter walls can include: an internal chamber defined by at least one porous internal wall; one or more boundary layer chambers having at least an inner boundary layer chamber defined by the at least one porous internal wall and at least one porous inner boundary layer wall, the at least one porous internal wall having a plurality of pores fluidically coupling the central internal chamber to the one or more boundary layer chamber; and an outer chamber.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: April 3, 2018
    Assignee: CFD RESEARCH CORPORATION
    Inventors: Balabhaskar Prabhakarpandian, Kapil Pant
  • Multi-chambered cell culture device to model organ microphysiology
    Patent number: 10570360
    Abstract: A method of testing an analyte can include using a cell culture device that includes: at least three distinct chambers between the top wall and bottom wall. The chambers can include: an internal chamber defined by at least one porous internal wall; one or more boundary layer chambers having at least an inner boundary layer chamber defined by the at least one porous internal wall and at least one porous inner boundary layer wall, the at least one porous internal wall having a plurality of pores fluidically coupling the central internal chamber to the one or more boundary layer chamber; and an outer chamber.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: February 25, 2020
    Assignee: CFD RESEARCH CORPORATION
    Inventors: Balabhaskar Prabhakarpandian, Kapil Pant
  • Oxidizer compound for rocket propulsion
    Patent number: 9598323
    Abstract: The present disclosure generally pertains to a rocket propulsion oxidizer compound that is a solution, is a homogenous and stable liquid at room temperature and includes nitrous oxide and nitrogen tetroxide. In addition, an apparatus is provided for burning a fuel and nitrous oxide/nitrogen tetroxide. The apparatus has a combustor, a catalyst, a nitrous oxide/nitrogen tetroxide supply passage for directing the nitrous oxide/nitrogen tetroxide to a contact position with the catalyst, and a fuel supply passage for supplying the fuel to the combustor. The catalyst acts to facilitate decomposition of the nitrous oxide/nitrogen tetroxide, while the combustor burns the fuel, the decomposed nitrous oxide/nitrogen tetroxide and/or nitrous oxide/nitrogen tetroxide decomposed in the reaction.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: March 21, 2017
    Assignee: CFD Research Corporation
    Inventors: Robert L. Sackheim, Joseph R. Herdy
  • Synthetic microfluidic systems for hypoxia
    Patent number: 10775364
    Abstract: A method of inducing ischemia includes: providing a cell culture device having a first cell culture in an internal chamber and a second cell culture in at least one fluid channel and a perfusion modulating system that causes changes in oxygen flow in the internal chamber and/or at least one fluid channel; flowing liquid media having oxygen through the internal chamber and at least one fluid channel of the cell culture device; modulating oxygen perfusion in the internal chamber with the perfusion modulating system by varying and selectively blocking the flow rate of at least one of the liquid media or oxygen through the internal chamber to induce varying levels of ischemia; and assaying for ischemia in the first cell culture.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: September 15, 2020
    Assignee: CFD Research Corporation
    Inventors: Balabhaskar Prabhakarpandian, Kapil Pant
  • Self-cleaning and mixing microfluidic elements
    Patent number: 8147775
    Abstract: Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: April 3, 2012
    Assignee: CFD Research Corporation
    Inventors: Sivaramakrishnan Krishnamoorthy, Jianiun Feng
  • Self-cleaning and mixing microfluidic elements
    Patent number: 7604394
    Abstract: Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: October 20, 2009
    Assignee: CFD Research Corporation
    Inventors: Sivaramakrishnan Krishnamoorthy, Jianjun Feng
  • Thrombectomy Microcatheter
    Publication number: 20080119780
    Abstract: The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.
    Type: Application
    Filed: November 17, 2006
    Publication date: May 22, 2008
    Applicant: CFD Research Corporation
    Inventors: Guiren Wang, Shivshankar Sundaram, Kapil Pant, Jianjun Feng, Peter Storm
  • High energy, low temperature gelled bi-propellant formulation preparation method
    Patent number: 8425700
    Abstract: A method for preparing a gelled liquid propane (GLP) composition comprises the introduction of liquid propane into an evacuated mixing vessel containing a gellant and mixing the liquid propane with the gellant. A bi-propellant system comprising GLP is particularly well-suited for outer planet missions greater than 3 AU from the sun and also functions in earth and near earth environments. Additives such as powders of boron, carbon, lithium, and/or aluminum can be added improve performance or enhance hypergolicity. The gelling agent can be silicon dioxide, clay, carbon, or organic or inorganic polymers. The bi-propellant system may be, but need not be, hypergolic.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: April 23, 2013
    Assignee: CFD Research Corporation
    Inventor: Roberto DiSalvo
  • SYNTHETIC MICROFLUIDIC SYSTEMS FOR TUMOR METASTASIS
    Publication number: 20140255971
    Abstract: A method of assaying metastasis can include: providing a device of one of the embodiments; introducing the at least one cancer cell into the at least one internal chamber or at least one fluid channel; and studying metastasis of the at least one cancer cell. Optionally: introducing cancer cells into a first internal chamber; detecting escape of the cancer cell from the first internal chamber into the fluid channel; detecting migration of the cancer cell through the fluid channel; detecting adhesion of the cancer cell to a coating on the fluid channel; detecting invasion of the cancer cell into a second internal chamber from the fluid channel; or visualizing metastasis of the cancer cell with a visualization device.
    Type: Application
    Filed: March 10, 2014
    Publication date: September 11, 2014
    Applicant: CFD Research Corporation
    Inventors: Balabhaskar Prabhakarpandian, Kapil Pant
  • High energy, low temperature gelled bi-propellant formulation
    Patent number: 7896987
    Abstract: The present invention is a bi-propellant system comprising a gelled liquid propane (GLP) fuel and a gelled MON-30 (70% N2O4+30% NO) oxidizer. The bi-propellant system is particularly well-suited for outer planet missions greater than 3 AU from the sun and also functions in earth and near earth environments. Additives such as powders of boron, carbon, lithium, and/or aluminum can be added to the fuel component to improve performance or enhance hypergolicity. The gelling agent can be silicon dioxide, clay, carbon, or organic or inorganic polymers. The bi-propellant system may be, but need not be, hypergolic.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: March 1, 2011
    Assignee: CFD Research Corporation
    Inventor: Roberto Di Salvo
  • Synthetic microfluidic systems for tumor metastasis
    Patent number: 9933413
    Abstract: A method of assaying metastasis can include: providing a device of one of the embodiments; introducing the at least one cancer cell into the at least one internal chamber or at least one fluid channel; and studying metastasis of the at least one cancer cell. Optionally: introducing cancer cells into a first internal chamber; detecting escape of the cancer cell from the first internal chamber into the fluid channel; detecting migration of the cancer cell through the fluid channel; detecting adhesion of the cancer cell to a coating on the fluid channel; detecting invasion of the cancer cell into a second internal chamber from the fluid channel; or visualizing metastasis of the cancer cell with a visualization device.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: April 3, 2018
    Assignee: CFD Research Corporation
    Inventors: Balabhaskar Prabhakarpandian, Kapil Pant
  • Synthetic microfluidic systems for tumor metastasis
    Patent number: 10641761
    Abstract: A method of assaying metastasis can include: providing a device of one of the embodiments; introducing the at least one cancer cell into the at least one internal chamber or at least one fluid channel; and studying metastasis of the at least one cancer cell. Optionally: introducing cancer cells into a first internal chamber; detecting escape of the cancer cell from the first internal chamber into the fluid channel; detecting migration of the cancer cell through the fluid channel; detecting adhesion of the cancer cell to a coating on the fluid channel; detecting invasion of the cancer cell into a second internal chamber from the fluid channel; or visualizing metastasis of the cancer cell with a visualization device.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: May 5, 2020
    Assignee: CFD Research Corporation
    Inventors: Balabhaskar Prabhakarpandian, Kapil Pant
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