Search Patents
  • METHODS AND COMPOSITIONS FOR DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION (AMI)
    Publication number: 20120208715
    Abstract: Embodiments of the invention utilizes advanced detection methodologies, such as the lab-on-a-chip (LOC) technology, as a cost-effective, efficient, ultra-sensitive rapid method for diagnosing Acute Myocardial Infarction (AMI) in human subjects. In certain aspects, multiple biomarkers of AMI are concurrently detected and measured in serum and saliva to provide a more efficient, sensitive and accurate diagnosis of AMI.
    Type: Application
    Filed: August 20, 2010
    Publication date: August 16, 2012
    Inventors: John T. McDevitt, Craig S. Miller, Jeffrey L. Ebersole, Nicolaos Christodoulides, Pierre N. Floriano
  • ROTATION SENSOR, ROTATION SENSING METHOD, AND APPLICATIONS
    Publication number: 20180252527
    Abstract: A chip-scale ultrasensitive ring laser gyroscope that utilizes the physics of exceptional points. By exploiting the properties of such non-Hermitian degeneracies, the rotation-induced frequency splitting becomes proportional to the square root of the gyration speed (?1/2), thus enhancing the sensitivity to low angular rotations by orders of magnitudes. At its maximum sensitivity limit, the measurable spectral splitting is independent of the radius of the cavity rings involved. Binary and ternary systems and associated methods are described.
    Type: Application
    Filed: October 31, 2017
    Publication date: September 6, 2018
    Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Mercedeh Khajavikhan, Demetrios Christodoulides, Hossein Hodaei, Mohammad Soltani
  • LIGHT MICROSCOPY CHIPS AND DATA ANALYSIS METHODOLOGY FOR QUANTITATIVE LOCALZIED SURFACE PLASMON RESONANCE (LSPR) BIOSENSING AND IMAGING
    Publication number: 20210341474
    Abstract: A method for the spatiotemporal mapping of receptor-ligand binding kinetics in localized surface plasmon resonance (LSPR) imaging using a chip for LSPR imaging having a glass coverslip compatible for use in a standard microscope and at least one array of functionalized plasmonic nanostructures patterned onto the glass coverslip with electron beam nanolithography and projecting a magnified image of the array to a CCD camera and monitoring the binding kinetics of the array. The nanostructures can be regenerated allowing the chip to be used multiple times.
    Type: Application
    Filed: July 17, 2021
    Publication date: November 4, 2021
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers
  • Rotation sensor, rotation sensing method, and applications
    Patent number: 10415970
    Abstract: A chip-scale ultrasensitive ring laser gyroscope that utilizes the physics of exceptional points. By exploiting the properties of such non-Hermitian degeneracies, the rotation-induced frequency splitting becomes proportional to the square root of the gyration speed (?1/2), thus enhancing the sensitivity to low angular rotations by orders of magnitudes. At its maximum sensitivity limit, the measurable spectral splitting is independent of the radius of the cavity rings involved. Binary and ternary systems and associated methods are described.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: September 17, 2019
    Assignee: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Mercedeh Khajavikhan, Demetrios Christodoulides, Hossein Hodaei, Mohammad Soltani
  • BIO-NANO-CHIPS FOR ON-SITE DRUG SCREENING
    Publication number: 20140094391
    Abstract: A bio-nano-chip (BNC) technology that works in connection with non-invasive samples, such as saliva, cheek swab or urine samples that can be easily performed by non-specialists, such as security personnel and police officers is disclosed. The microfluidic system for drug testing includes an analyzer or reader having a housing containing a slot for receiving a cartridge, a drug testing cartridge, a processor having a user interface, an optical or energy sensing means, and a means for moving fluid.
    Type: Application
    Filed: March 21, 2012
    Publication date: April 3, 2014
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: John T. McDevitt, Nicolaos Christodoulides, Pierre N. Floriano, Glennon Simmons
  • NANOSPLASMONIC IMAGING TECHNIQUE FOR THE SPATIO-TEMPORAL MAPPING OF SINGLE CELL SECRETIONS IN REAL TIME
    Publication number: 20140273002
    Abstract: A label-free method for the spatio-temporal mapping of protein secretions from individual cells in real time by using a chip for localized surface plasmon resonance (LSPR) imaging. The chip is a glass coverslip compatible for use in a standard microscope having at least one array of functionalized plasmonic nanostructures patterned onto it. After placing a cell on the chip, the secretions from the cell are spatially and temporally mapped using LSPR imaging. Transmitted light imaging and/or fluorescence imaging may be done simultaneously with the LSPR imaging.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers, James B. Delehanty
  • Bio-nano-chips for on-site drug screening
    Patent number: 9709580
    Abstract: A bio-nano-chip (BNC) technology that works in connection with non-invasive samples, such as saliva, cheek swab or urine samples that can be easily performed by non-specialists, such as security personnel and police officers is disclosed. The microfluidic system for drug testing includes an analyzer or reader having a housing containing a slot for receiving a cartridge, a drug testing cartridge, a processor having a user interface, an optical or energy sensing means, and a means for moving fluid.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: July 18, 2017
    Assignee: William Marsh Rice University
    Inventors: John T. McDevitt, Nicolaos Christodoulides, Pierre N. Floriano, Glennon Simmons
  • NANOPLASMONIC IMAGING TECHNIQUE FOR THE SPATIO-TEMPORAL MAPPING OF SINGLE CELL SECRETIONS IN REAL TIME
    Publication number: 20180038791
    Abstract: A label-free method for the spatio-temporal mapping of protein secretions from individual cells in real time by using a chip for localized surface plasmon resonance (LSPR) imaging. The chip is a glass coverslip compatible for use in a standard microscope having at least one array of functionalized plasmonic nanostructures patterned onto it. After placing a cell on the chip, the secretions from the cell are spatially and temporally mapped using LSPR imaging. Transmitted light imaging and/or fluorescence imaging may be done simultaneously with the LSPR imaging.
    Type: Application
    Filed: October 16, 2017
    Publication date: February 8, 2018
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers, James B. Delehanty
  • CALIBRATING SINGLE PLASMONIC NANOSTRUCTURES FOR QUANTITATIVE BIOSENING
    Publication number: 20140095100
    Abstract: A method for calibrating multiple nanostructures in parallel for quantitative biosensing using a chip for localized surface plasmon resonance (LSPR) biosensing and imaging. The chip is a glass coverslip compatible for use in a standard microscope with at least one array of functionalized plasmonic nanostructures patterned onto it using electron beam nanolithography. The chip is used to collect CCD-based LSPR imagery data of each individual nanostructure and LSPR spectral data of the array. The spectral data is used to determine the fractional occupancy of the array. The imagery data is modeled as a function of fractional occupancy to determine the fractional occupancy of each individual nanostructure.
    Type: Application
    Filed: September 27, 2013
    Publication date: April 3, 2014
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers
  • Efficient mode coupling using ladder fibers
    Patent number: 10277354
    Abstract: An optical fiber system including an optical fiber and an optical grating is provided. The optical fiber is configured to support M mode groups, where differences in effective refractive index between adjacent mode groups are substantially equal. The optical grating is optically coupled to the optical fiber, and has a period inversely proportional to the difference in effective refractive index between adjacent mode groups. The optical grating is configured to couple all adjacent mode groups in the optical fiber.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: April 30, 2019
    Assignees: Futurewei Technologies, Inc., University of Central Florida Research Foundation, Inc.
    Inventors: Guifang Li, Zhihong Li, Demetrios Christodoulides, Huiyuang Liu, He Wen, Mohammadamin Eftekhar, Bin Huang
  • Nanosplasmonic imaging technique for the spatio-temporal mapping of single cell secretions in real time
    Patent number: 9791368
    Abstract: A label-free method for the spatio-temporal mapping of protein secretions from individual cells in real time by using a chip for localized surface plasmon resonance (LSPR) imaging. The chip is a glass coverslip compatible for use in a standard microscope having at least one array of functionalized plasmonic nanostructures patterned onto it. After placing a cell on the chip, the secretions from the cell are spatially and temporally mapped using LSPR imaging. Transmitted light imaging and/or fluorescence imaging may be done simultaneously with the LSPR imaging.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 17, 2017
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers, James B. Delehanty
  • SOLUTION-PROCESSABLE SUPERATOMIC THIN-FILMS
    Publication number: 20210002536
    Abstract: Ionic superatomic materials that can be solution-processed into completely amorphous and homogeneous thin films are disclosed herein. The amorphous materials disclosed herein have tunable compositions and have electrical conductivities of up to 300 siemens per meter, thermal conductivities of 0.05 watt per meter per degree Kelvin, and optical transparencies of up to 92%. Application of these thin-films are also provided herein.
    Type: Application
    Filed: June 30, 2020
    Publication date: January 7, 2021
    Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, CARNEGIE MELLON UNIVERSITY
    Inventors: Colin Nuckolls, Jingjing Yang, Alexander D. Christodoulides, Boyuan Zhang, Qizhi Xu, Amirali Zangiabadi, Christine McGinn, Samuel Peurifoy, Lingyun Dai, Elena Meirzadeh, Michael Steigerwald, Xavier Roy, Ioannis Kymissis, Jonathan A. Malen
  • Nanoplasmonic imaging technique for the spatio-temporal mapping of single cell secretions in real time
    Patent number: 10641705
    Abstract: A label-free method for the spatio-temporal mapping of protein secretions from individual cells in real time by using a chip for localized surface plasmon resonance (LSPR) imaging. The chip is a glass coverslip compatible for use in a standard microscope having at least one array of functionalized plasmonic nanostructures patterned onto it. After placing a cell on the chip, the secretions from the cell are spatially and temporally mapped using LSPR imaging. Transmitted light imaging and/or fluorescence imaging may be done simultaneously with the LSPR imaging.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: May 5, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers, James B. Delehanty
  • Raman amplifier with gain enhancement from optical filtering
    Patent number: 6388800
    Abstract: A fiber Raman amplifier with increased gain and improved pump conversion efficiency is formed by including a high pass optical filter in the amplifier structure. The filter may comprise one or more discrete components, or may be formed as a “distributed” filter along the length of the fiber amplifier. The cut-off frequency for the high pass optical filter is selected to be immediately below the frequency of the input signal to be amplified. When used in an arrangement with multiple input signals, the cutoff frequency is controlled to be immediately below the lowest input signal frequency.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: May 14, 2002
    Assignees: Lucent Technologies Inc., Lehigh University
    Inventors: Demetrios Nicolau Christodoulides, Jean-Marc Pierre Delavaux, Christopher Michael McIntosh, Jean Toulouse
  • Particle on membrane assay system
    Publication number: 20050191620
    Abstract: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
    Type: Application
    Filed: December 22, 2004
    Publication date: September 1, 2005
    Inventors: John McDevitt, Nick Christodoulides, Pierre Floriano, Karri Ballard, Bruce Bernard
  • Calibrating single plasmonic nanostructures for quantitative biosening
    Patent number: 10345287
    Abstract: A method for calibrating multiple nanostructures in parallel for quantitative biosensing using a chip for localized surface plasmon resonance (LSPR) biosensing and imaging. The chip is a glass coverslip compatible for use in a standard microscope with at least one array of functionalized plasmonic nanostructures patterned onto it using electron beam nanolithography. The chip is used to collect CCD-based LSPR imagery data of each individual nanostructure and LSPR spectral data of the array. The spectral data is used to determine the fractional occupancy of the array. The imagery data is modeled as a function of fractional occupancy to determine the fractional occupancy of each individual nanostructure.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: July 9, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers
  • DETERMINING EXTRACELLULAR ANALYTE CONCENTRATION WITH NANOPLASMONIC SENSORS
    Publication number: 20160370290
    Abstract: Methods and systems for determining extracellular concentration data of an analyte are disclosed. A method for determining extracellular concentration data of an analyte includes receiving sensor data from one or more arrays of functionalized plasmonic nanostructures on a localized surface plasmon resonance imaging chip in contact with a fluid containing at least one living cell for a plurality of times, determining intensity data for the one or more arrays, determining fractional occupancy based on the intensity data, and determining extracellular concentration data based on the fractional occupancy data. A system for determining extracellular concentration data of an analyte includes a LSPRi chip, a sensor component, an intensity component, a fractional occupancy component, a concentration component, and a processor to implement the components.
    Type: Application
    Filed: June 20, 2016
    Publication date: December 22, 2016
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers, James B. Delehanty
  • DETERMINING EXTRACELLULAR ANALYTE CONCENTRATION WITH NANOPLASMONIC SENSORS
    Publication number: 20200158639
    Abstract: Methods and systems for determining extracellular concentration data of an analyte are disclosed. A method for determining extracellular concentration data of an analyte includes receiving sensor data from one or more arrays of functionalized plasmonic nanostructures on a localized surface plasmon resonance imaging chip in contact with a fluid containing at least one living cell for a plurality of times, determining intensity data for the one or more arrays, determining fractional occupancy based on the intensity data, and determining extracellular concentration data based on the fractional occupancy data. A system for determining extracellular concentration data of an analyte includes a LSPRi chip, a sensor component, an intensity component, a fractional occupancy component, a concentration component, and a processor to implement the components.
    Type: Application
    Filed: January 21, 2020
    Publication date: May 21, 2020
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers, James B. Delehanty
  • Membrane assay system including preloaded particles
    Publication number: 20060257854
    Abstract: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
    Type: Application
    Filed: December 22, 2004
    Publication date: November 16, 2006
    Inventors: John McDevitt, Nick Christodoulides, Pierre Floriano, Karri Ballard, Bruce Bernard
  • SUBSTRATES WITH INDEPENDENTLY TUNABLE TOPOGRAPHIES AND CHEMISTRIES FOR QUANTIFIABLE SURFACE-INDUCED CELL BEHAVIOR
    Publication number: 20190162662
    Abstract: A method for measuring surface-induced cellular behavior that includes one or more lithographically patterned, functionalizable structures on a substrate, for example gold islands or grooved quartz, in contact with a fluid and in registry with at least one living cell for a plurality of times. The structures' shape, height, pitch and ordering are controlled by the lithographic process, such that the physical cues imparted to the cell by topography can be tuned independently of the chemical biofunctionality which is subsequently imparted via surface chemistry. Cellular behavior data, such as adhesion, migration, differentiation, division, secretion, apoptosis and necrosis, is measured using imaging sensors in relation to the surface topography and surface chemistry for a plurality of times.
    Type: Application
    Filed: November 20, 2018
    Publication date: May 30, 2019
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Marc Christophersen, Jeff M. Byers
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