Search Patents
  • High-resolution molecular sensor
    Patent number: 8698481
    Abstract: A solid state molecular sensor having an aperture extending through a thickness of a sensing region is configured with a sensing region thickness that corresponds to the characteristic extent of at least a component of a molecular species to be translocated through the aperture. A change in an electrical characteristic of the sensing region is measured during the molecular species translocation. The sensor can be configured as a field effect transistor molecular sensor. The sensing region can be a region of graphene including an aperture extending through a thickness of the graphene.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: April 15, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Qihua Xiong, Ping Xie, Ying Fang
  • NANOSCOPIC WIRE-BASED DEVICES AND ARRAYS
    Publication number: 20120193602
    Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
    Type: Application
    Filed: April 11, 2012
    Publication date: August 2, 2012
    Applicant: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
  • Stochastic assembly of sublithographic nanoscale interfaces
    Publication number: 20040113138
    Abstract: A method for controlling electric conduction on nanoscale wires is disclosed. The nanoscale wires are provided with controllable regions axially and/or radially distributed. Controlling those regions by means of microscale wires or additional nanoscale wires allows or prevents electric conduction on the controlled nanoscale wires. The controllable regions are of two different types. For example, a first type of controllable region can exhibit a different doping from a second type of controllable region. The method allows one or more of a set of nanoscale wires, packed at sublithographic pitch, to be independently selected.
    Type: Application
    Filed: July 24, 2003
    Publication date: June 17, 2004
    Inventors: Andre DeHon, Charles M. Lieber, Patrick D. Lincoln, John E. Savage
  • Nonoscopic wired-based devices and arrays
    Publication number: 20110174619
    Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
    Type: Application
    Filed: July 13, 2006
    Publication date: July 21, 2011
    Applicant: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
  • Nanoscopic wire-based devices and arrays
    Publication number: 20080116491
    Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
    Type: Application
    Filed: November 21, 2005
    Publication date: May 22, 2008
    Applicant: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
  • Nanometer-scale microscopy probes
    Patent number: 6159742
    Abstract: A carbon-based tip for scanning probe microscopy. The tip used in microscopy to reveal chemical characteristics of a sample includes a structure of the formula:X--(L--M).sub.nin which n is 1 to 100, X is a carbon-based nanotube, L is a linking group bonded at an end of the carbon-based nanotube, and M is a molecular probe bonded to the linking group.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: December 12, 2000
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Stanislaus S. Wong, Adam T. Woolley, Ernesto Joselevich
  • Nanoscopic wire-based devices and arrays
    Patent number: 8471298
    Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: June 25, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
  • Nanoscopic wired-based devices and arrays
    Publication number: 20040188721
    Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
    Type: Application
    Filed: March 29, 2004
    Publication date: September 30, 2004
    Applicant: President and Fellows of Harvard University
    Inventors: Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
  • Nanosensors
    Patent number: 7129554
    Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: October 31, 2006
    Assignee: President & Fellows of Harvard College
    Inventors: Charles M. Lieber, Hongkun Park, Qingqiao Wei, Yi Cui, Wenjie Liang
  • Preparation of carbide nanorods
    Patent number: 5997832
    Abstract: A process utilizing a supported metal catalyst, a volatile species source, and a carbon source has been developed to produce carbide nanorods with diameters of less than about 100 nm and aspect ratios of 10 to 1000. The volatile species source, carbon source, and supported metal catalyst can be used to produce carbide nanorods in single run, batch, and continuous reactors under relatively mild conditions. The method employs a simple catalytic process involving readily available starting materials.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: December 7, 1999
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Eric Wong
  • Nanoscale wire-based sublithographic programmable logic arrays
    Patent number: 7274208
    Abstract: An apparatus and methods for a sublithographic programmable logic array (PLA) are disclosed. The apparatus allows combination of non-restoring, programmable junctions and fixed (non-programmable) restoration logic to implement any logic function or any finite-state machine. The methods disclosed teach how to integrate fixed, restoration logic at sublithographic scales along with programmable junctions. The methods further teach how to integrate addressing from the microscale so that the nanoscale crosspoint junctions can be programmed after fabrication.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: September 25, 2007
    Assignee: California Institute of Technology
    Inventors: André DeHon, Michael J. Wilson, Charles M. Lieber
  • Nanoscopic wire-based electrical crossbar memory-devices and arrays
    Patent number: 8178907
    Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
    Type: Grant
    Filed: March 29, 2004
    Date of Patent: May 15, 2012
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
  • Nanopore sensing by local electrical potential measurement
    Patent number: 10436747
    Abstract: There is provided a method for sensing the translocation of a molecule through a nanopore. In the method, there is directed to an inlet of a nanopore a molecule that is disposed in a first ionic solution of a first ionic concentration. The molecule is caused to translocate through the nanopore from the inlet of the nanopore to an outlet of the nanopore and into a second ionic solution of a second ionic concentration that is different than the first ionic concentration. An electrical potential, local to that ionic solution, of the first and second ionic solutions, which has a lower ionic concentration, is measured while the molecule is caused to translocate through the nanopore.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: October 8, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Ping Xie
  • Nanoscale sensors
    Publication number: 20060269927
    Abstract: Various aspects of the present invention generally relate to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample, and systems and methods of immobilizing entities such as reaction entities relative to nanoscale wires. In one aspect, a nucleic acid, such as DNA, may be immobilized relative to a nanoscale wire, and in some cases, grown from the nanoscale wire. In certain embodiments, the nucleic acid may interact with entities such as other nucleic acids, proteins, etc., and in some cases, such interactions may be reversible. As an example, an enzyme such as telomerase may be allowed to bind to DNA immobilized relative to a nanoscale wire. The telomerase may extend the length of the DNA, for instance, by reaction with free deoxynucleotide triphosphates in solution; additionally, various properties of the nucleic acid may be determined, for example, using electric field interactions between the nucleic acid and the nanoscale wire.
    Type: Application
    Filed: May 25, 2005
    Publication date: November 30, 2006
    Inventors: Charles Lieber, Fernando Patolsky, Gengfeng Zheng
  • Methods of forming nanoscopic wire-based devices and arrays
    Patent number: 7399691
    Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: July 15, 2008
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
  • NANOSCALE WIRE PROBES FOR THE BRAIN AND OTHER APPLICATIONS
    Publication number: 20160302682
    Abstract: The present invention generally relates to nanoscale wires and, in particular, to probes comprising nanoscale wires for use in determining properties such as electrical and/or chemical properties, e.g., for insertion into biological tissue, such as the brain. The probe may be formed from relatively flexible materials such as polymers, and in some cases, the probes may comprises nanoscale wires or other electronic components. The probe may be cooled to a temperature that causes the probe to harden, e.g., to a temperature below a glass transition temperature, prior to insertion, to facilitate the insertion of the probe into the tissue.
    Type: Application
    Filed: December 2, 2014
    Publication date: October 20, 2016
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Charles M. Lieber, Chong Xie, Jia Liu
  • Nanosensors
    Publication number: 20070264623
    Abstract: The present invention generally relates to nanoscale wires for use in determining analytes suspected to be present in a sample, especially in connection with determining information about a sample containing, or suspected of containing, two or more analytes. For example, the invention can involve a competitive, uncompetitive, or non-competitive binding assay including a nanoscale wire to a sample containing a species able to interact with the retain entity to produce a product, where the sample also contains or is suspected of containing a second species able to interact with the reaction entity to prevent production of the product resulting from interaction of the first species and the reaction entity. Based upon determination of production of the product, determination of the second species in the sample can be made.
    Type: Application
    Filed: June 15, 2005
    Publication date: November 15, 2007
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Wayne Wang, Chuo Chen, Keng-Hui Lin, Ying Fang, Charles Lieber
  • Methods of forming nanoscopic wire-based devices and arrays
    Patent number: 7172953
    Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: February 6, 2007
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
  • Nanopore Sensing By Local Electrical Potential Measurement
    Publication number: 20170269029
    Abstract: There is provided a method for sensing the translocation of a molecule through a nanopore. In the method, there is directed to an inlet of a nanopore a molecule that is disposed in a first ionic solution of a first ionic concentration. The molecule is caused to translocate through the nanopore from the inlet of the nanopore to an outlet of the nanopore and into a second ionic solution of a second ionic concentration that is different than the first ionic concentration. An electrical potential, local to that ionic solution, of the first and second ionic solutions, which has a lower ionic concentration, is measured while the molecule is caused to translocate through the nanopore.
    Type: Application
    Filed: June 7, 2017
    Publication date: September 21, 2017
    Applicant: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Ping Xie
  • Nanoscopic wire-based devices and arrays
    Patent number: 6781166
    Abstract: Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes. They can be arranged in crossbar arrays using chemically patterned surfaces for direction, via chemical vapor deposition. Chemical vapor deposition also can be used to form nanotubes in arrays in the presence of directing electric fields, optionally in combination with self-assembled monolayer patterns. Bistable devices are described.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: August 24, 2004
    Assignee: President & Fellows of Harvard College
    Inventors: Charles M. Lieber, Thomas Rueckes, Ernesto Joselevich, Kevin Kim
Narrow Results

Filter by US Classification