Search Patents
  • Imidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7858649
    Abstract: This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are of the general formula (I) and include any of its stereoisomers, any mixture of its stereoisomers, and pharmaceutically acceptable salts thereof. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: December 28, 2010
    Assignee: Neurosearch A/S
    Inventors: William Dalby Brown, Janus S. Larsen, Lene Teuber, David Tristram Brown, Philip K. Ahring, Naheed Mirza, Elsebet Østergaard Nielsen
  • Recovery from a possible switching error in a computer I/O system
    Patent number: 5206860
    Abstract: A connection recovery apparatus for placing a dynamic connection of a dynamic switch of a computer I/O system in a known state upon the detection of a possible switching error. The I/O system includes transmitting stations each having a link-level facility attached by a link to a dynamic-switch port of a dynamic-switch. The dynamic-switch makes dynamic connections between any two of the stations. Upon the detection of a possible switching error, the detecting link-level facility of a station or its attached dynamic-switch port starts a switch recovery procedure which places any dynamic connection to that station in a known disconnected state.
    Type: Grant
    Filed: August 31, 1990
    Date of Patent: April 27, 1993
    Assignee: International Business Machines Corporation
    Inventors: Paul J. Brown, Matthew J. Kalos, Martin W. Sachs
  • OXAZOLE COMPOUNDS COMPOSITIONS AND METHODS OF USE
    Publication number: 20110060011
    Abstract: The present invention relates generally to compounds represented in Formula (I), pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
    Type: Application
    Filed: March 13, 2009
    Publication date: March 10, 2011
    Applicant: Amgen Inc.
    Inventors: Matthew Brown, Michael Johnson
  • INDIVIDUALIZED OWN VOICE DETECTION IN A HEARING PROSTHESIS
    Publication number: 20230007415
    Abstract: Presented herein are techniques for training a hearing prosthesis to classify/categorize received sound signals as either including a recipient's own voice (i.e., the voice or speech of the recipient of the hearing prosthesis) or external voice (i.e., the voice or speech of one or more persons other than the recipient). The techniques presented herein use the captured voice (speech) of the recipient to train the hearing prosthesis to perform the classification of the sound signals as including the recipient's own voice or external voice.
    Type: Application
    Filed: September 8, 2022
    Publication date: January 5, 2023
    Inventor: Matthew Brown
  • Apparatus and method for preventing unauthorized access to BIOS in a personal computer system
    Patent number: 5022077
    Abstract: An apparatus and method for protecting BIOS stored on a direct access storage device into a personnal computer system. The personal computer system comprises a system processor, a system planar, a random access main memory, a read only memory, a protection means and at least one direct access storage device. The read only memory includes a first portion of BIOS and data representing the type of system processor and system planar I/O configuration. The first portion of BIOS initializes the system and the direct access storage device, and resets the protection means in order to read in a master boot record into the random access memory from a protectable partition on the direct access storage device.
    Type: Grant
    Filed: August 25, 1989
    Date of Patent: June 4, 1991
    Assignee: International Business Machines Corp.
    Inventors: Richard Bealkowski, John W. Blackledge, Jr., Doyle S. Cronk, Richard A. Dayan, Jerry D. Dixon, Scott G. Kinnear, George D. Kovach, Andrew B. McNeill, Matthew S. Palka, Jr., Robert Sachsenmaier, Edward I. Wachtel, Kevin M. Zyvoloski
  • Individualized own voice detection in a hearing prosthesis
    Patent number: 11477587
    Abstract: Presented herein are techniques for training a hearing prosthesis to classify/categorize received sound signals as either including a recipient's own voice (i.e., the voice or speech of the recipient of the hearing prosthesis) or external voice (i.e., the voice or speech of one or more persons other than the recipient). The techniques presented herein use the captured voice (speech) of the recipient to train the hearing prosthesis to perform the classification of the sound signals as including the recipient's own voice or external voice.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: October 18, 2022
    Assignee: Cochlear Limited
    Inventor: Matthew Brown
  • Oxazole compounds compositions and methods of use
    Patent number: 8404722
    Abstract: The present invention relates generally to compounds represented in Formula (I), pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: March 26, 2013
    Assignee: Amgen Inc.
    Inventors: Matthew Brown, Michael G. Johnson
  • Publication layout system
    Patent number: 8245132
    Abstract: Some embodiments disclose a computer-implemented system configured to create an advertisement.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: August 14, 2012
    Assignee: Saepio Technologies, Inc.
    Inventors: Ronald Harold Brown, Matthew Jason Angell
  • INDIVIDUALIZED OWN VOICE DETECTION IN A HEARING PROSTHESIS
    Publication number: 20210058720
    Abstract: Presented herein are techniques for training a hearing prosthesis to classify/categorize received sound signals as either including a recipient's own voice (i.e., the voice or speech of the recipient of the hearing prosthesis) or external voice (i.e., the voice or speech of one or more persons other than the recipient). The techniques presented herein use the captured voice (speech) of the recipient to train the hearing prosthesis to perform the classification of the sound signals as including the recipient's own voice or external voice.
    Type: Application
    Filed: January 9, 2019
    Publication date: February 25, 2021
    Inventor: Matthew Brown
  • TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR
    Publication number: 20190275008
    Abstract: Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.
    Type: Application
    Filed: November 3, 2017
    Publication date: September 12, 2019
    Applicant: AMGEN INC.
    Inventors: Matthew BROWN, Ning CHEN, Xiaoqi CHEN, Yinhong CHEN, Alan C. CHENG, Richard V. CONNORS, Jeffrey DEIGNAN, Paul John DRANSFIELD, Xiaohui DU, Zice FU, James S. HARVEY, Julie Anne HEATH, Lars V. HEUMANN, Jonathan HOUZE, Frank KAYSER, Aarif Yusuf KHAKOO, David j. KOPECKY, Su-Jen LAI, Zhihua MA, Julio C. MEDINA, Jeffrey T. MIHALIC, Steven H. OLSON, Vatee PATTAROPONG, Gayathri SWAMINATH, Xiaodong WANG, Malgorzata WANSKA, Wen-Chen YEH
  • CYCLOALKYLAMINO ACID DERIVATIVES
    Publication number: 20070270438
    Abstract: The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof; wherein B, D, E, R1, R2, R3, R4, R5, R8, m, n, p, q, r, s, t and u are as defined herein. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: May 9, 2007
    Publication date: November 22, 2007
    Inventors: Samit Bhattacharya, Matthew Brown, Peter Dorff, Susan LaGreca, Robert Maguire
  • Pyrrolo[2,3-d]pyrimidine compounds
    Publication number: 20050171128
    Abstract: A compound of the formula wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.
    Type: Application
    Filed: February 23, 2005
    Publication date: August 4, 2005
    Inventors: Todd Blumenkopf, Mark Flanagan, Matthew Brown, Paul Changelian
  • Softstroking of edges for computer graphics
    Patent number: 5977981
    Abstract: A method for rendering or compositing image components, where at least one of the image components has an edge. The edge is rendered or composited a plurality of times, the repetitions being performed with different values of the edge thickness (i.e., the thickness of the line) and with different opacities. This makes it possible to create in this way an opacity gradient or the like, so that the edge may be given a softer and less abrupt appearance, if such is desired.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: November 2, 1999
    Assignees: Canon Information Systems Research Australia Pty Ltd., Canon Kabushiki Kaisha
    Inventor: Craig Matthew Brown
  • Carrier for holding a flexible fluid processing container
    Patent number: 7001321
    Abstract: A fluid processing assembly can be easily inserted into and removed from a rotatable centrifuge channel. The processing assembly comprises a processing container and a carrier. The processing container has flexibility and, in use, occupies the channel to receive fluids for separation in the centrifugal field. The carrier retains the processing container outside the channel in a flexed condition conforming to the channel. The carrier resists deformation of the processing container during its insertion into or removal from the channel.
    Type: Grant
    Filed: March 30, 1998
    Date of Patent: February 21, 2006
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, Ying-Cheng Lo
  • Heteroaryl-hexanoic acid amide derivatives as immonomodulatory agents
    Publication number: 20040097554
    Abstract: The present invention relates to compounds of the formula (I) 1
    Type: Application
    Filed: October 16, 2003
    Publication date: May 20, 2004
    Applicant: Pfizer Inc
    Inventors: Matthew F. Brown, Anderson S. Gaweco, Ronald P. Gladue, John C. Kath, Christopher S. Poss
  • Substituted heterocycles as bromodomain inhibitors
    Patent number: 10292968
    Abstract: The present application relates to substituted heterocycles compound of Formula I and pharmaceutical compositions thereof useful for the inhibition of BET protein function by binding to bromodomains (Formula I).
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: May 21, 2019
    Assignee: Zenith Epigenetics Ltd.
    Inventors: Samuel David Brown, Craig Alan Coburn, Olesya Kharenko
  • Differential Inverse Multiplexing Virtual Channels in 40G Ethernet Applications
    Publication number: 20100092174
    Abstract: A system and method are provided for deinterleaving differential inverse multiplexed (DIM) virtual channels in a 40G Ethernet receiver. The method accepts a 10.3125 gigabits per second (Gbps) (10G) Ethernet virtual channel with 64B/86B blocks, including periodic Lane Alignment Marker (LAM) blocks. The 10G virtual channel is deinterleaved into two 5.15625 Gbps (5G) virtual channels by: 1) deinterleaving consecutive blocks from the 10G virtual channel into the 5G virtual channels in an alternating order, and 2) reversing the order of deinterleaving in response to each detected LAM block. Then, the method supplies the 5G virtual channels (i.e. to a MAC module).
    Type: Application
    Filed: October 13, 2008
    Publication date: April 15, 2010
    Inventors: Matthew Brown, Dimitrios Giannakopoulos, Jim Lew, Michael John Hellmer
  • Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators
    Patent number: 7250442
    Abstract: The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation, particularly congestive heart failure, comprising administering to a patient in need thereof an effective amount of a compound of the formula: I or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 11, 2003
    Date of Patent: July 31, 2007
    Assignee: Eli Lilly and Company
    Inventors: Matthew Lee Brown, Timothy Alan Grese, Prabhakar Kondaji Jadhav, David Andrew Neel, Mitchell Irvin Steinberg, Peter Ambrose Lander
  • Adjustable spacer-gripper
    Patent number: D371332
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: July 2, 1996
    Assignee: Action Manufacturing, Inc.
    Inventors: Matthew J. Chapple, Wesley I. McWethy
  • Combined ball tossing and teeing device
    Patent number: D399286
    Type: Grant
    Filed: August 14, 1997
    Date of Patent: October 6, 1998
    Assignee: The Little Tikes Company
    Inventors: Patrick Brown, Matthew R. Fuligni, John Jeffrey Norton, John Nottingham, John Spirk
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