Patents Represented by Attorney, Agent or Law Firm B. Gregory Donner
-
Patent number: 7030115Abstract: Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.Type: GrantFiled: March 21, 2003Date of Patent: April 18, 2006Assignee: Abbott LaboratoriesInventors: Steven W. Elmore, Cheol-Min Park, Xilu Wang
-
Patent number: 6992069Abstract: Antibacterial compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.Type: GrantFiled: April 24, 2003Date of Patent: January 31, 2006Inventors: Yu-Gui Gu, Zhenkun Ma, Hong Yong
-
Patent number: 6946481Abstract: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.Type: GrantFiled: October 8, 2002Date of Patent: September 20, 2005Assignee: Abbott LaboratoriesInventors: Martin Winn, Steven A. Boyd, Charles W. Hutchins, Hwan-Soo Jae, Andrew S. Tasker, Thomas W. von Geldern, Jeffrey A. Kester, Bryan K. Sorensen, Bruce G. Szczepankiewicz, Kenneth J. Henry, Gang Liu, Steven J. Wittenberger, Steven A. King
-
Patent number: 6933283Abstract: Antibacterial compounds having formula (I) and formula (II) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.Type: GrantFiled: April 23, 2003Date of Patent: August 23, 2005Assignee: Abbott LaboratoriesInventors: Richard Clark, Stevan Djuric, Zhenkun Ma
-
Patent number: 6924304Abstract: Compounds having formula (I) inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.Type: GrantFiled: November 21, 2002Date of Patent: August 2, 2005Assignee: Abbott LaboratoriesInventors: Qun Li, Hing Sham, Keith W. Woods, Beth A. Steiner, Stephen L. Gwaltney, II, Kenneth J. Barr, Hovis M. Imade, Saul Rosenberg
-
Patent number: 6887863Abstract: Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.Type: GrantFiled: February 19, 2004Date of Patent: May 3, 2005Assignee: Abbott LaboratoriesInventors: Richard A. Craig, Megumi Kawai, Linda M. Lynch, Jyoti R. Patel, George S. Sheppard, Jieyi Wang, Fan Yang, Nwe Ba-Maung, Xenia Beebe Searle
-
Patent number: 6831068Abstract: Antibacterial compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.Type: GrantFiled: February 10, 2003Date of Patent: December 14, 2004Assignee: Abbott LaboratoriesInventors: Richard Clark, Stevan Djuric, Zhenkun Ma, Sanyi Wang
-
Patent number: 6831096Abstract: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.Type: GrantFiled: September 24, 2002Date of Patent: December 14, 2004Assignee: Abbott LaboratoriesInventors: Clarence J. Maring, Yu Gui Gu, Hui-Ju Chen, Yuanwei Chen, David A. Degoey, William J. Flosi, Vincent L. Giranda, David J. Grampovnik, Warren M. Kati, Dale J. Kempf, April Kennedy, Larry L. Klein, Allan C. Krueger, Zhen Lin, Darold L. Madigan, Keith F. McDaniel, Steven W. Muchmore, Hing L. Sham, Kent D. Stewart, Vincent S. Stoll, Minghua Sun, Noah P. Tu, Frank L. Wagenaar, Gary T. Wang, Sheldon Wang, Paul E. Wiedeman, Yibo Xu, Ming C. Yeung, Chen Zhao, Stephen Hanessian, Malken Bayrakdarian, Xuehong Luo
-
Patent number: 6764996Abstract: Compounds of formula (I) formula (II) formula (III) and formula (IV) or pharmaceutically acceptable salts or prodrugs thereof, are antibacterial agents. Compositions containing the compounds, processes for making the compounds, synthetic intermediates employed in the processes, and methods for treatment and prevention of bacterial infections are disclosed.Type: GrantFiled: July 25, 2000Date of Patent: July 20, 2004Assignee: Abbott LaboratoriesInventors: Yat Sun Or, Robert F. Keyes, Zhenkun Ma
-
Patent number: 6753408Abstract: Peptides of formula (I) Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11 (I), are useful for inhibiting angiogenesis. Also disclosed are angiogenesis-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.Type: GrantFiled: November 22, 2000Date of Patent: June 22, 2004Inventors: Fortuna Haviv, Jack Henkin, Michael F. Bradley, Douglas M. Kalvin, Andrew J. Schneider
-
Patent number: 6720338Abstract: N-Benzoyl arylsulfonamides having the formula: are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.Type: GrantFiled: September 20, 2001Date of Patent: April 13, 2004Assignee: Abbott LaboratoriesInventors: David J. Augeri, Steven A. Baumeister, Milan Bruncko, Daniel A. Dickman, Hong Ding, Jurgen Dinges, Stephen W. Fesik, Philip J. Hajduk, Aaron R. Kunzer, William McClellan, David G. Nettesheim, Thorsten Oost, Andrew M. Petros, Saul H. Rosenberg, Wang Shen, Sheela A. Thomas, Xilu Wang, Michael D. Wendt
-
Patent number: 6716963Abstract: Peptides having the formula: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10 wherein A0 is selected from hydrogen or an acyl group; A10 is a hydroxyl group or an amino acid amide; and A1, A2, A3, A4, A5, A6, A7, A8, and A9 are amino acyl residues as defined herein.Type: GrantFiled: November 22, 1999Date of Patent: April 6, 2004Assignee: Abbott LaboratoriesInventors: Jack Henkin, Fortuna Haviv, Michael F. Bradley, Douglas M. Kalvin, Andrew J. Schneider
-
Patent number: 6710185Abstract: The instant invention discloses a process for the synthesis of substituted indole cell proliferation inhibitors.Type: GrantFiled: September 20, 2001Date of Patent: March 23, 2004Assignee: Abbott LaboratoriesInventors: Ashok K. Gupta, Steven A. King, Elaine C. Lee, Howard E. Morton, Daniel J. Plata, Yu-Ming Pu, Padam N. Sharma
-
Patent number: 6632961Abstract: Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.Type: GrantFiled: May 21, 1999Date of Patent: October 14, 2003Assignee: Abbott LaboratoriesInventors: Megumi Kawai, Jack Henkin, George S. Sheppard, Richard A. Craig
-
Patent number: 6627743Abstract: The present invention relates to a novel 6-O-methylerythromycin A crystal form, a process for preparing the crystal form, and methods for using the crystal form to prepare a 6-O-methylerythromycin A crystal form II.Type: GrantFiled: December 3, 1999Date of Patent: September 30, 2003Assignee: Abbott LaboratoriesInventors: Jih-Hua Liu, Rodger F. Henry, Stephen G. Spanton, David A. Riley
-
Patent number: 6605707Abstract: Disclosed herein is a process for the preparation of erythromycin derivatives, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.Type: GrantFiled: March 23, 2000Date of Patent: August 12, 2003Assignee: Abbott LaboratoriesInventors: Francis A. J. Kerdesky, Ramiya Premchandran, Gregory S. Wayne, Sou-Jen Chang, Jonathan P. Pease, Lakshmi Bhagavatula, John E. Lallaman, Howard E. Morton, Steven A. King
-
Patent number: 6593335Abstract: Compounds having the formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.Type: GrantFiled: June 23, 1999Date of Patent: July 15, 2003Assignee: Abbott LaboratoriesInventors: William A. Carroll, Yiyuan Chen, Mark W. Holladay, Michael E. Kort, Philip R. Kym, James P. Sullivan, Rui Tang, Lin Yi, Henry Q. Zhang, Irene Drizin
-
Patent number: 6579882Abstract: Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.Type: GrantFiled: March 6, 2001Date of Patent: June 17, 2003Assignee: Abbott LaboratoriesInventors: Andrew O. Stewart, Steven A. Boyd, David L. Arendsen, Pramila Bhatia, Kevin R. Condroski, Jennifer C. Freeman, Indrani W. Gunawardana, Gui-Dong Zhu, Kraig Lartey, Catherine M. McCarty, Nicholas A. Mort, Meena V. Patel, Michael A. Staeger, David M. Stout
-
Patent number: 6579986Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.Type: GrantFiled: April 29, 2002Date of Patent: June 17, 2003Assignee: Abbott LaboratoriesInventors: Michael S. Allen, Ramiya H. Premchandran, Sou-Jen Chang, Stephen Condon, John A. DeMattei, Steven A. King, Lawrence Kolaczkowski, Sukumar Manna, Paul J. Nichols, Hemant H. Patel, Subhash R. Patel, Daniel J. Plata, Eric J. Stoner, Jien-Heh J. Tien, Steven J. Wittenberger
-
Patent number: 6551616Abstract: Disclosed is a pharmaceutical composition for extended release of an erythromycin derivative in the gastrointestinal environment. The composition comprises an erythromycin derivative and a pharmaceutically acceptable polymer so that, when ingested orally, the composition induces statistically significantly lower Cmax in the plasma than an immediate release composition of the erythromycin derivative while maintaining bioavailability and minimum concentration substantially equivalent to that of the immediate release composition of the erythromycin derivative upon multiple dosing. The compositions of the invention have an improved taste profile and reduced gastrointestinal side effects as compared to those for the immediate release composition.Type: GrantFiled: October 13, 1999Date of Patent: April 22, 2003Assignee: Abbott LaboratoriesInventors: Gerard F. Notario, Robert N. Palmer, Richard C. Hom, Jie Zhang, Karen J. Devcich, Susan J. Semla