Patents Represented by Attorney, Agent or Law Firm B. Gregory Donner
  • Inhibitors of protein isoprenyl transferases
    Patent number: 6277871
    Abstract: The present invention relates to novel compounds of Formula I which are useful in inhibiting protein isoprenyl transferases and the farnesylation or geranylgeranylation of the oncogene protein Ras and other related small g-proteins, and compositions containing such compounds and methods of using such compounds.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: August 21, 2001
    Assignee: Abbott Laboratories
    Inventors: Stephen J. O'Connor, Lissa T. J. Nelson
  • Low oxygen content compostions of 1&agr;, 25-dihydroxycholecalciferol
    Patent number: 6274169
    Abstract: The invention relates to stable compositions comprising 1&agr;, 25-dihydroxycholecalciferol, a unit dose system comprising the same in a sealed vessel, and a process for preparing them.
    Type: Grant
    Filed: August 2, 1999
    Date of Patent: August 14, 2001
    Assignee: Abbott Laboratories
    Inventors: Kent Abrahamson, Amy N. Anderson, Haiyan Grady, Kurt J. Hartmann, Randall M. Farmer, John P. Oberdier
  • Process for the preparation of midazolam
    Patent number: 6262260
    Abstract: The present invention provides a process for the synthesis of compounds of formula (II) or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: July 17, 2001
    Assignee: Abbott Laboratories
    Inventor: Madhup K. Dhaon
  • Urokinase inhibitors
    Patent number: 6258822
    Abstract: Compounds having the formula are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: July 10, 2001
    Assignee: Abbott Laboratories
    Inventors: Andrew G. Geyer, William J. McClellan, Todd W. Rockway, Kent D. Stewart, Moshe Weitzberg, Michael D. Wendt
  • Process for the preparation of farnesyltransferase inhibitors
    Patent number: 6248919
    Abstract: A process for the preparation of preparation of farnesyltransferase inhibitors of formula (I) or pharmaceutically acceptable salts or prodrugs thereof, is disclosed.
    Type: Grant
    Filed: October 5, 1999
    Date of Patent: June 19, 2001
    Assignee: Abbott Laboratories
    Inventors: Todd S. McDermott, Anne E. Bailey, Ramiya Premchandran, Lakshima Bhagavatula
  • Substituted &bgr;-amino acid inhibitors of methionine aminopeptidase-2
    Patent number: 6242494
    Abstract: A class of substituted b-amino acids are potent inhibitor of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: June 5, 2001
    Assignee: Abbott Laboratories
    Inventors: Richard A. Craig, Jack Henkin, Megumi Kawai, Linda M. Lynch, Jyoti Patel, George S. Sheppard, Jieyi Wang
  • Reverse hydroxamate inhibitors of matrix metalloproteinases
    Patent number: 6235786
    Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: May 22, 2001
    Assignee: Abbott Laboratories
    Inventors: Yujia Dai, Steven K. Davidsen, Michael R. Michaelides, Jamie R. Stacey, Douglas H. Steinman, Carol K. Wada
  • Cell adhesion-inhibiting antiinflammatory compounds
    Patent number: 6232320
    Abstract: Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: May 15, 2001
    Assignee: Abbott Laboratories
    Inventors: Andrew O. Stewart, Steven A. Boyd, David L. Arendsen, Pramila Bhatia, Kevin R. Condroski, Jennifer C. Freeman, Indrani W. Gunawardana, Gui-Dong Zhu, Kraig Lartey, Catherine M. McCarty, Nicholas A. Mort, Meena V. Patel, Michael A. Staeger, David M. Stout
  • Oxazoline antiproliferative agents
    Patent number: 6228868
    Abstract: Compounds having Formula I are useful for treating cancer. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of treating cancer in a mammal.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: May 8, 2001
    Assignee: Abbott Laboratories
    Inventors: Stephen L. Gwaltney, II, Hwan-Soo Jae, Douglas M. Kalvin, Gang Liu, Hing L. Sham, Qun Li, Akiyo K. Claiborne, Le Wang, Kenneth J. Barr, Keith W. Woods
  • Urokinase inhibitors
    Patent number: 6207701
    Abstract: Compounds having formula I are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: March 27, 2001
    Assignee: Abbott Laboratories
    Inventor: Joseph F. Dellaria, Jr.
  • Imidazole antiproliferative agents
    Patent number: 6201001
    Abstract: Compounds of formula I inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
    Type: Grant
    Filed: August 2, 1999
    Date of Patent: March 13, 2001
    Assignee: Abbott Laboratories
    Inventors: Le Wang, Qun Li, Hing L. Sham, Keith W. Woods