Patents Represented by Attorney, Agent or Law Firm B. Gregory Donner
  • Cell proliferation inhibitors
    Patent number: 6521658
    Abstract: Compounds having formula (I) inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: February 18, 2003
    Assignee: Abbott Laboratories
    Inventors: Qun Li, Hing Sham, Keith W. Woods, Beth A. Steiner, Stephen L. Gwaltney, II, Kenneth J. Barr, Hovis M. Imade, Saul Rosenberg
  • Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
    Patent number: 6518305
    Abstract: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: February 11, 2003
    Assignee: Abbott Laboratories
    Inventors: Clarence J. Maring, Yuanwei Chen, David A. Degoey, Vincent L. Giranda, David J. Grampovnik, Yu Gui Gu, Warren M. Kati, Dale J. Kempf, April Kennedy, Allan C. Krueger, Zhen Lin, Darold L. Madigan, Steven W. Muchmore, Hing L. Sham, Kent D. Stewart, Vincent S. Stoll, Minghua Sun, Gary T. Wang, Sheldon Wang, Ming C. Yeung, Chen Zhao
  • Process for the preparation of Midazolam
    Patent number: 6512114
    Abstract: The present invention provides a process for the synthesis of Midazolam I from a compound of formula II, using thermodynamic, basic workup conditions. Additional steps to isolate the pure bulk product follow.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: January 28, 2003
    Assignee: Abbott Laboratories
    Inventors: Madhup K. Dhaon, Grant L. Esser, Deborah A. Davis, Ashok V. Bhatia
  • Polymeric compositions and a method of making the same
    Patent number: 6503528
    Abstract: The invention relates to a bioerodible polymeric composition, a method of making such a composition, and a controlled delivery device comprising the composition.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: January 7, 2003
    Assignee: Abbott Laboratories
    Inventors: Christopher Bieniarz, Amy Jo Sanders
  • Naphthamidine urokinase inhibitors
    Patent number: 6495562
    Abstract: Compounds having the formula are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions, methods for the preparation of urokinase-inhibitors, and a method of inhibiting urokinase in a mammal.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: December 17, 2002
    Assignee: Abbott Laboratories
    Inventors: Milan Bruncko, Christopher Robin Dalton, Vincent Louis Giranda, Jianchun Gong, Willian J. McClellan, Vicki L. Nienaber, Todd Warren Rockway, Daryl Richard Sauer, Moshe Weitzberg
  • Endothelin antagonists
    Patent number: 6462194
    Abstract: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
    Type: Grant
    Filed: May 15, 2000
    Date of Patent: October 8, 2002
    Assignee: Abbott Laboratories
    Inventors: Martin Winn, Steven A. Boyd, Charles W. Hutchins, Hwan-Soo Jae, Andrew S. Tasker, Thomas W. von Geldern, Jeffrey A. Kester, Bryan K. Sorensen, Bruce G. Szczepankiewicz, Kenneth J. Henry, Gang Liu, Steven J. Wittenberger, Steven A. King
  • Inhibitors of neuraminidases
    Patent number: 6455571
    Abstract: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: September 24, 2002
    Assignee: Abbott Laboratories
    Inventors: Clarence J. Maring, Yu Gui Gu, Hui-Ju Chen, Yuanwei Chen, David A. Degoey, William J. Flosi, Vincent L. Giranda, David J. Grampovnik, Warren M. Kati, Dale J. Kempf, April Kennedy, Larry L. Klein, Allan C. Krueger, Zhen Lin, Darold L. Madigan, Keith F. McDaniel, Steven W. Muchmore, Hing L. Sham, Kent D. Stewart, Vincent S. Stoll, Minghua Sun, Noah P. Tu, Frank L. Wagenaar, Gary T. Wang, Sheldon Wang, Paul E. Wiedeman, Yibo Xu, Ming C. Yeung, Chen Zhao, Stephen Hanessian, Malken Bayrakdarian, Xuehong Luo
  • Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
    Patent number: 6455680
    Abstract: An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: September 24, 2002
    Assignee: Abbott Laboratories
    Inventor: Kirill A. Lukin
  • Process for preparing 6-o-substituted erythromycin derivatives
    Patent number: 6437106
    Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2′-substituted and optionally 4″-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: August 20, 2002
    Assignee: Abbott Laboratories
    Inventors: Eric J. Stoner, Matthew J. Peterson, Yi-Yin Ku, Russell D. Cink, Arthur J. Cooper, Mahendra N. Deshpande, Tim Grieme, Anthony R. Haight, David R. Hill, Margaret Chi-Ping Hsu, Steven A. King, Marvin Robert Leanna, Elaine C. Lee, Maureen A. McLaughlin, Howard E. Morton, James J. Napier, Daniel J. Plata, Prasad S. Raje, Michael Rasmussen, David Riley, Jien-Heh J. Tien, Steven J. Wittenberger
  • 6-O-carbamate ketolide derivatives
    Patent number: 6420535
    Abstract: The invention relates to a novel 6-O-carbamate ketolide compound or a pharmaceutically acceptable salt, ester, solvate or prodrug thereof, to a composition comprising the compound and a suitable carrier, a method of preparing the compound, and a method of treatment and prevention of infections in a mammal.
    Type: Grant
    Filed: May 24, 2000
    Date of Patent: July 16, 2002
    Assignee: Abbott Laboratories
    Inventors: Ly Tam Phan, Yat Sun Or, Zhenkun Ma, Yan Chen
  • Preparation of quinoline-substituted carbonate and carbamate derivatives
    Patent number: 6417366
    Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: July 9, 2002
    Assignee: Abbott Laboratories
    Inventors: Michael S. Allen, Ramiya H. Premchandran, Sou-Jen Chang, Stephen Condon, John A. DeMattei, Steven A. King, Lawrence Kolaczkowski, Sukumar Manna, Paul J. Nichols, Hemant H. Patel, Subhash R. Patel, Daniel J. Plata, Eric J. Stoner, Jien-Heh J. Tien, Steven J. Wittenberger
  • Oxazolidinone chemotherapeutic agents
    Patent number: 6410728
    Abstract: Compounds of the formula or therapeutically acceptable salts or prodrugs thereof, are useful for treating bacterial infections, psoriasis, arthritis, and toxicity due to chemotherapy. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: June 25, 2002
    Assignee: Abbott Laboratories
    Inventors: Richard J. Sciotti, Stevan W. Djuric, Marina Pliushchev
  • Cosolvent formulations
    Patent number: 6361758
    Abstract: Stable pharmaceutical formulations of a therapeutic agent, a low molecular weight alcohol and a glycol derivative are disclosed. Preferred formulations include 19-nor-1&agr;,3&bgr;,25-trihydroxy-9,10-secoergosta-5,7(E),22(E)-triene.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: March 26, 2002
    Assignee: Abbott Laboratories
    Inventors: Lukchiu Li, Edward Anthony Pec, Daniel H. Robinson, Dennis A. Stephens, Kathee Jantzi, Thomas Barton May, John Paul Oberdier
  • Stereoselective process for producing nitro compounds
    Patent number: 6329536
    Abstract: The present invention relates to producing stereoselective nitro compounds by reacting a dicarbonyl compound with a nitrostyrene compound in the presence of a catalyst complex and a base.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: December 11, 2001
    Assignee: Abbott Laboratories
    Inventors: Jianguo Ji, David M. Barnes, Steve King, Frederick A. Plagge, Steven J. Wittenberger, Ji Zhang
  • 3-substituted indole angiogenesis inhibitors
    Patent number: 6323228
    Abstract: 3-Substituted indole carbohydrazides having the formula are useful for inhibiting angiogenesis. Also disclosed are angiogenesis-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: November 27, 2001
    Assignee: Abbott Laboratories
    Inventors: Nwe Y. BaMaung, Richard A. Craig, Megumi Kawai, Jieyi Wang
  • Self-emulsifying systems containing anticancer medicament
    Patent number: 6316497
    Abstract: The present invention relates to a stabilized self-emulsifying system, comprising a therapeutically effective amount of o-(chloroacetylcarbamoyl)fumigillol, a pharmaceutically acceptable carrier and a stabilizing component, wherein the pharmaceutically acceptable carrier comprises an oily constituent and at least one surfactant. The stabilizing component comprises from about 1% to about 15% water relative to the weight of the self-emulsifying system, an acid, an adsorbent, or a complex-forming agent.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: November 13, 2001
    Assignee: Abbott Laboratories
    Inventors: Rong Ron Liu, Zheng Wang
  • Reverse hydroxamate inhibitors of matrix metalloproteinases
    Patent number: 6294573
    Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: September 25, 2001
    Assignee: Abbott Laboratories
    Inventors: Michael L. Curtin, Yujia Dai, Steven K. Davidsen, Joseph F. Dellaria, Jr., Alan S. Florjancic, Jianchun Gong, Yan Guo, Howard R. Heyman, James H. Holms, Michael R. Michaelides, Jamie R. Stacey, Douglas H. Steinman, Carol K. Wada, Lianhong Xu
  • Triazine angiogenesis inhibitors
    Patent number: 6288228
    Abstract: Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: September 11, 2001
    Assignee: Abbott Laboratories
    Inventors: Jack Henkin, Donald J. Davidson, George S. Sheppard, Keith W. Woods, Richard W. McCroskey
  • Inhibitors of matrix metalloproteinases
    Patent number: 6288261
    Abstract: Compounds having the formula and pharmaceutically acceptable salts and prodrugs thereof are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: September 11, 2001
    Assignee: Abbott Laboratories
    Inventors: David J. Augeri, David A. Betebenner, Richard Craig, Steven K. Davidsen, Stephen W. Fesik, Jamie R. Giesler-Stacey, Yan Guo, Philip J. Hajduk, Michael R. Michaelides, David G. Nettesheim
  • Ukokinase inhibitors
    Patent number: 6284796
    Abstract: Compounds having the formula are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: September 4, 2001
    Assignee: Abbott Laboratories
    Inventors: Andrew G. Geyer, William J. McClellan, Todd W. Rockway, Kent D. Stewart, Moshe Weitzberg, Michael D. Wendt