Abstract: Isoquinolinesulfonyl compounds are used in ophthalmic compositions to treat glaucoma or other ischemic-borne ocular disorders such as retinopathies or optic neuropathies. These compounds vasodilate ocular blood vessels, lower IOP and prevent or reduce the progression of visual field loss.
Type:
Grant
Filed:
July 31, 2001
Date of Patent:
June 11, 2002
Assignee:
Alcon Laboratories, Inc.
Inventors:
Mark R. Hellberg, Michael A. Kapin, Louis M. Desantis, Jr.
Abstract: The present invention is directed to novel methods of prostanoid synthesis. Specifically, the invention is directed to the addition of alpha chains to prostanoids using cis-alkenylstannane intermediates.
Abstract: A method of lowering intraocular pressure (IOP) employs an upregulating agent that induces increased prostaglandin synthesis in the eye. The method of treatment entails administering to the eye of a mammal in need thereof a prostaglandin upregulating agent to increase endogenous prostaglandin synthesis and thereby effect a reduction in intraocular pressure. In a preferred embodiment the upregulating agent is IL-1.
Abstract: A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:
Type:
Grant
Filed:
June 2, 1999
Date of Patent:
March 5, 2002
Assignee:
Alcon Laboratories, Inc.
Inventors:
Verney L. Sallee, Mark R. Hellberg, Peter G. Klimko, Paul W. Zinke
Abstract: A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:
Type:
Grant
Filed:
June 2, 1999
Date of Patent:
March 5, 2002
Assignee:
Alcon Laboratories, Inc.
Inventors:
Verney L. Sallee, Mark R. Hellberg, Peter G. Klimko
Abstract: Disclosed is the use of cloprostenol and fluprostenol analogues in combination with carbonic anhydrase inhibitors for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor.
Type:
Grant
Filed:
February 6, 2001
Date of Patent:
February 5, 2002
Assignee:
Alcon Manufacturing, Ltd.
Inventors:
Thomas R. Dean, Jesse A. May, Verney L. Sallee, Louis Desantis, Jr.
Abstract: Methods of synthesizing 9-Halo-13,14-dihydroprostaglandins useful in the treatment of glaucoma and ocular hypertension are disclosed. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.
Type:
Grant
Filed:
October 31, 1997
Date of Patent:
February 5, 2002
Assignee:
Alcon Manufacturing, Ltd.
Inventors:
Raymond E. Conrow, Paul W. Zinke, Peter G. Klimko, Robert D. Selliah
Abstract: Disclosed are methods and compositions for the treatment of glaucoma and ocular hypertension, comprising the administration of a prostaglandin analog and a prostaglandin synthesis inhibitor.
Abstract: A teaching aid for use in facilitating the study and understanding of antibodies and antigens is disclosed. The teaching aid comprises models demonstrating how the variable regions of both the light and heavy chains of the antibody protein permit both the diversity and the selectivity of these biomolecules. Teaching methods utilizing the inventive teaching aid are also disclosed.
Abstract: The present invention relates to the field of ophthalmology. In particular the invention relates to the field of ocular disorders including visual field loss and glaucoma using an isoquinolinesulfonyl compound, which lowers intraocular pressure (IOP) and produces dilation of ocular blood vessels.
Type:
Grant
Filed:
January 19, 1999
Date of Patent:
August 7, 2001
Assignee:
Alcon Laboratories, Inc.
Inventors:
Michael A. Kapin, Louis M. Desantis, Jr.
Abstract: Disclosed is the use of cloprostenol and fluprostenol analogues and combinations thereof with other medicaments for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor. Also disclosed are methods of treating optic nerve disorders using the cloprostenol and fluprostenol analogues.
Type:
Grant
Filed:
March 30, 1999
Date of Patent:
February 6, 2001
Assignee:
Alcon Laboratories, Inc.
Inventors:
Peter G. Klimko, John E. Bishop, Verney L. Sallee, Paul W. Zinke, Tom R. Dean, George E. Barnes, Michael L. Chandler
Abstract: 13-thia prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said prostaglandins.
Abstract: Conformationally rigid aryl prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic pharmaceutical compositions comprising said prostaglandins.
Type:
Grant
Filed:
May 12, 1999
Date of Patent:
January 2, 2001
Assignee:
Alcon Laboratories, Inc.
Inventors:
Paul W. Zinke, John E. Bishop, Thomas R. Dean, Mark R. Hellberg
Abstract: 14-Aza analogs of PGF.sub.2.alpha., PGD.sub.2, and PGE.sub.2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.
Abstract: Cyclobutane analogs of PGF.sub.2.alpha., PGD.sub.2, and PGE.sub.2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.