Patents Represented by Attorney, Agent or Law Firm Barry L. Copeland
  • Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia
    Patent number: 6403590
    Abstract: Isoquinolinesulfonyl compounds are used in ophthalmic compositions to treat glaucoma or other ischemic-borne ocular disorders such as retinopathies or optic neuropathies. These compounds vasodilate ocular blood vessels, lower IOP and prevent or reduce the progression of visual field loss.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: June 11, 2002
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark R. Hellberg, Michael A. Kapin, Louis M. Desantis, Jr.
  • Stannane synthesis of prostanoids
    Patent number: 6388128
    Abstract: The present invention is directed to novel methods of prostanoid synthesis. Specifically, the invention is directed to the addition of alpha chains to prostanoids using cis-alkenylstannane intermediates.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: May 14, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Raymond E. Conrow
  • Upregulation of endogenous prostaglandins to lower intraocular pressure
    Patent number: 6376541
    Abstract: A method of lowering intraocular pressure (IOP) employs an upregulating agent that induces increased prostaglandin synthesis in the eye. The method of treatment entails administering to the eye of a mammal in need thereof a prostaglandin upregulating agent to increase endogenous prostaglandin synthesis and thereby effect a reduction in intraocular pressure. In a preferred embodiment the upregulating agent is IL-1.
    Type: Grant
    Filed: December 6, 1999
    Date of Patent: April 23, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Jon C. Nixon, Karen C. David
  • 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension
    Patent number: 6353000
    Abstract: A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:
    Type: Grant
    Filed: June 2, 1999
    Date of Patent: March 5, 2002
    Assignee: Alcon Laboratories, Inc.
    Inventors: Verney L. Sallee, Mark R. Hellberg, Peter G. Klimko, Paul W. Zinke
  • 15-ketal postaglandins for the treatment of glaucoma or ocular hypertension
    Patent number: 6353014
    Abstract: A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:
    Type: Grant
    Filed: June 2, 1999
    Date of Patent: March 5, 2002
    Assignee: Alcon Laboratories, Inc.
    Inventors: Verney L. Sallee, Mark R. Hellberg, Peter G. Klimko
  • Prostaglandin e agonists for treatment of dry eye
    Patent number: 6344477
    Abstract: Compositions and methods for the treatment of dry eye and related diseases utilizing EP4 receptor agonists are disclosed.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: February 5, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Najam A. Sharif
  • Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension
    Patent number: 6344478
    Abstract: Disclosed is the use of cloprostenol and fluprostenol analogues in combination with carbonic anhydrase inhibitors for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor.
    Type: Grant
    Filed: February 6, 2001
    Date of Patent: February 5, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Thomas R. Dean, Jesse A. May, Verney L. Sallee, Louis Desantis, Jr.
  • Method of prostaglandin synthesis
    Patent number: 6344581
    Abstract: Methods of synthesizing 9-Halo-13,14-dihydroprostaglandins useful in the treatment of glaucoma and ocular hypertension are disclosed. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: February 5, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Raymond E. Conrow, Paul W. Zinke, Peter G. Klimko, Robert D. Selliah
  • Use of non-steroidal anti-inflammatory agents in combination with compounds that have FP prostaglandin agonist activity to treat glaucoma and ocular hypertension
    Patent number: 6342524
    Abstract: Disclosed are methods and compositions for the treatment of glaucoma and ocular hypertension, comprising the administration of a prostaglandin analog and a prostaglandin synthesis inhibitor.
    Type: Grant
    Filed: May 22, 2000
    Date of Patent: January 29, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Mark R. Hellberg, Jon C. Nixon
  • Antibody teaching aid
    Patent number: 6280199
    Abstract: A teaching aid for use in facilitating the study and understanding of antibodies and antigens is disclosed. The teaching aid comprises models demonstrating how the variable regions of both the light and heavy chains of the antibody protein permit both the diversity and the selectivity of these biomolecules. Teaching methods utilizing the inventive teaching aid are also disclosed.
    Type: Grant
    Filed: January 29, 2000
    Date of Patent: August 28, 2001
    Inventor: William P. Baker
  • Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia
    Patent number: 6271224
    Abstract: The present invention relates to the field of ophthalmology. In particular the invention relates to the field of ocular disorders including visual field loss and glaucoma using an isoquinolinesulfonyl compound, which lowers intraocular pressure (IOP) and produces dilation of ocular blood vessels.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: August 7, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Michael A. Kapin, Louis M. Desantis, Jr.
  • Use of cis-&Dgr;4 analogs of prostaglandins as ocular hypotensives
    Patent number: 6235779
    Abstract: Cis-&Dgr;4 analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: June 2, 1999
    Date of Patent: May 22, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Peter G. Klimko, Paul W. Zinke
  • 13-Oxa prostaglandins for the treatment of glaucoma and ocular hypertension
    Patent number: 6232344
    Abstract: 13-Oxa analogs of certain prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: May 15, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Zixia Feng, Mark R. Hellberg
  • 11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
    Patent number: 6211226
    Abstract: 11-aza analogs of PGF2&agr; and methods of their use in treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: April 3, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark R. Hellberg, Peter G. Klimko
  • Substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives
    Patent number: 6197812
    Abstract: Substituted tetrahydrofuran analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: March 6, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Robert D. Selliah, Mark R. Hellberg, Peter G. Klimko, Verney L. Sallee, Paul W. Zinke
  • Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension
    Patent number: 6184250
    Abstract: Disclosed is the use of cloprostenol and fluprostenol analogues and combinations thereof with other medicaments for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor. Also disclosed are methods of treating optic nerve disorders using the cloprostenol and fluprostenol analogues.
    Type: Grant
    Filed: March 30, 1999
    Date of Patent: February 6, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Peter G. Klimko, John E. Bishop, Verney L. Sallee, Paul W. Zinke, Tom R. Dean, George E. Barnes, Michael L. Chandler
  • 13-Thia prostaglandins for use in glaucoma therapy
    Patent number: 6172109
    Abstract: 13-thia prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said prostaglandins.
    Type: Grant
    Filed: June 3, 1998
    Date of Patent: January 9, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Paul W. Zinke, Mark R. Hellberg
  • Conformationally rigid aryl prostaglandins for use in glaucoma therapy
    Patent number: 6169111
    Abstract: Conformationally rigid aryl prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic pharmaceutical compositions comprising said prostaglandins.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: January 2, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Paul W. Zinke, John E. Bishop, Thomas R. Dean, Mark R. Hellberg
  • 14-aza prostaglandins for the treatment of glaucoma and ocular hypertension
    Patent number: 6160013
    Abstract: 14-Aza analogs of PGF.sub.2.alpha., PGD.sub.2, and PGE.sub.2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: December 12, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventor: Robert D. Selliah
  • Cyclobutane prostaglandin analogues as ocular hypotensive agents
    Patent number: 6096783
    Abstract: Cyclobutane analogs of PGF.sub.2.alpha., PGD.sub.2, and PGE.sub.2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: August 1, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventor: Mark R. Hellberg