Abstract: Bicomposite intraocular lenses and methods for their manufacture are disclosed. Bicomposite, hydrogel intraocular lenses with one or more haptic portions having a lower water content than the corresponding optic portions, and methods for their manufacture are disclosed. The bicomposite lenses are manufactured by (i) preparing a bicomposite button of hydrogel material containing one or more polymers or copolymers; (ii) lathing the button to produce a dehydrated intraocular lens with an optic and at least one haptic; and (iii) hydrating the lens.

Abstract: Disclosed is a process for the synthesis of enantiomerically pure R and S isomers of 2,7-difluoro-4-methoxyspiro[9H-fluorene-9,4-imidazolidene]-2',5'-dione from 2,7-difluoro-4-methoxyfluorenone. Intermediate amino acid esters and urea esters and their preparation are also described.

Abstract: A lens for implantation into the cornea of the eye for providing correction for myopia and myopia with accompanying astigmatism wherein a corneal cap section is removed and an implant bed is created to receive the intracorneal lens. The intracorneal lens is formed of a hydrogel type material or other material highly compatible with corneal physiology. In the range of lens powers of approximately -1.0 diopters to -30.0 diopters, the posterior radius of curvature conforms to the receiving surface of the lamellar bed of the cornea and the anterior surface has the radius of curvature necessary to provide the desired lens power for achieving the desired change in the refractive power of the cornea. The lens includes a peripheral transitional zone to join the anterior surface and posterior surface to allow the lens to be implanted onto the corneal bed and to allow for a smooth overlay of the replaced corneal cap section.

Abstract: A pressure control system is disclosed for closely regulating the pressure level of a controlled volume. The system comprises first and second sources, a throttled valve for controlling the flow rate of the fluid between each of the first and second pressure sources and the controlled volume, and a feedback control. The throttled valve comprises a rotationally mounted cam, a housing for receiving the cam and including a chamber, a first port coupled to the first pressure source, a second port coupled to the controlled volume, and a third port coupled to the second pressure source. The cam has first and second cam surface portions for defining corresponding first and second transfer functions of fluid flow through the first and second ports, respectively. First and second metering needles are associated with the first and third ports respectively for throttling the fluid flows therethrough. The first and second metering needles are disposed to engage respectively the first and second cam surface portions.