Abstract: An antibody targeted to an antigen is brought into contact with a body component in situ. The resulting antibody/antigen complex is labeled and may be amplified. The label is then detected either in situ or ex situ.
Abstract: Oligonucleotides are provided which are effective in inhibiting the growth, metastasis and/or angiogenesis of tumors, including particularly melanoma and/or lung cancer. Methods are also provided for use of these oligonucleotides in the treatment of diseases.
Type:
Grant
Filed:
February 5, 1997
Date of Patent:
December 15, 1998
Assignee:
ICN Pharmaceuticals, Inc.
Inventors:
Zbigniew Pietrzkowski, Dariusz Cieslak, Gordana Olbina
Abstract: In a petroleum coking drum, a drill stem guide latches internally to a structure adjacent the drum opening, rather than externally to a flange about the drum opening. In preferred embodiments, the latching mechanism is spring loaded, and operated automatically as a function of raising and lowering the guide.
Type:
Grant
Filed:
June 26, 1996
Date of Patent:
December 8, 1998
Assignee:
Fluor Corporation
Inventors:
Samuel A. Martin, Leslie P. Antalffy, Michael B. Knowles, William R. Sines
Abstract: Novel fire-retardant electrolyte compositions are provided. These compositions comprise a lithium salt dissolved in a fire-retardant solvent selected from the group consisting of phosphates, phospholanes, cyclophosphazenes, silanes, fluorinated carbonates, fluorinated polyethers and mixtures thereof. The electrolyte composition optionally contains a CO.sub.2 -generating compound. Also provided are fire-retardant batteries and fire-retardant conductive films formulated with such compositions, as well as methods of manufacturing such films.
Type:
Grant
Filed:
May 24, 1996
Date of Patent:
November 3, 1998
Assignee:
SRI International
Inventors:
Subhash C. Narang, Susanna C. Ventura, Brian J. Dougherty, Ming Zhao, Stuart Smedley, Gary Koolpe
Abstract: A stent system and method for use in the prostate gland. The stent is made of a shape memory alloy such as nitinol, and has a low temperature martensite state, with a martensite transition temperature below body temperature, and a high temperature austenite state, with an austenite transition temperature at or above body temperature, and a memorized shape in the high temperature austenite state which is a helical coil of diameter large enough to hold the prostatic urethra open. The stent is used to heat the prostate and is left in the prostatic urethra while the prostate heals. After the prostate is substantially healed, the stent is cooled to its martensite state and is easily removed from the urethra.
Abstract: A soluble capsule, fairing or adherent material for a stent catheter or other device to inserted into the human body. The capsule, fairing or adherent material is made of a material which dissolves within the body in a convenient time, for example ten or fifteen minutes, allowing a convenient time for placement of the device and protecting the blood vessel from any sharp surfaces of the device.
Abstract: A free spinning annular cylinder-like hollow body, having a leading and trailing end which are open at the ends. The leading end contains a balanced, uniformly and heavily weighted dense rim for generating gyroscopic forces. When the device is propelled forward with a spinning motion about an axis in substantially the direction of flight, the body is gyroscopically stabilized, in reference to direction, attitude and orientation. The weighted rim also shifts the body's center of gravity toward the center of pressure, near the leading edge, which enables creation of lift.
Abstract: Cryocoolers for use in cryosurgery and other applications comprising finned tube helical coil heat exchangers and warming gas flow through a warming gas supply line fitted Joule-Thomson nozzle. The cryocoolers use helium, hydrogen or neon as a warming gas which is expanded from the Joule-Thomson nozzle to heat the probes.
Abstract: An internal combustion engine has a compression stroke which is shorter than the corresponding the expansion (power) stroke. In a preferred class of designs this is accomplished by carrying the crank pin on a planetary gear such that the crank pin traces out a substantially hypocycloid path.
Abstract: Cryocoolers for use in cryosurgery and other applications comprising finned tube helical coil heat exchangers and a flow directing sheath covering portions of the heat exchanger coil and isolating portions of the heat exchanger coil from the outer sheath of the cryocooler. The size and shape of iceballs created by the probes is controlled by the extent and location of the flow directing sheath.
Type:
Grant
Filed:
July 23, 1996
Date of Patent:
September 1, 1998
Assignee:
Endocare, Inc.
Inventors:
Paul W. Mikus, Gregory L. Kelly, Ralph K. Brady
Abstract: Methods and compositions are provided for infecting cells with virus. Specific embodiments involved stressing the cellular membranes with chemical, electrical or mechanical means, such as by incubating the cells in DOTAP or Transfectam.TM.. Other embodiments involve impregnating carriers with virus for use in research a suitable carrier such as a polymer or nanoparticle.
Abstract: A coke drum head is hinged to a coke drum body using a compound joint such as a trammel pivot, and the head is moved between open and closed positions using an actuator. In moving between open and closed positions, the head traces out a non-circular path which reduces the required headroom relative to a head using a standard pivot.
Type:
Grant
Filed:
October 28, 1996
Date of Patent:
July 28, 1998
Assignee:
Fluor Daniel, Inc.
Inventors:
Leslie Peter Antalffy, Robert Benoit, Gerald Bryant, Michael B. Knowles, David W. Malek, Samuel Allen Martin
Abstract: A packaging system for the transportation and storage of materials, including radioactive and other hazardous materials. The system comprises a primary container removably received within a secondary container, and the secondary container being removably received within a tertiary container. The primary container can be centrifuged to minimize unrecoverable material, and in especially radioactive materials, the primary container is the only component that must be considered as radioactive waste.
Abstract: Ribavirin is administered to a patient in a dosage range which is effective to modulate lymphokine expression in activated T cells. In particular, ribavirin is used to suppress Th2-mediated T cell responses and promote Th1-mediated T cell response. Thus, instead of administering ribavirin in its well-recognized role as an anti-viral agent, ribavirin is herein used in the treatment of imbalances in lymphokine expression. Such imbalances may be found to be concomitants of allergic atopic disorders such as allergic asthma and atopic dermatitis, helminth infection and leishmaniasis, and various primary and secondary immunodeficiencies, which may or may not also be associated with viral infection.
Abstract: The invention is related to the synthesis of novel types of maleic-acrylic copolymers containing 60 to 100% of maleate units (by weight), respectively, 40 to 0% of acrylate units (by weight) based on the sum of both monomeric units composing the copolymer. These copolymers show significant techno-economical and ecological advantages over previously synthesized and described acrylic-maleic copolymers. According to the optimal synthetic procedure for this class of copolymers, one uses very concentrated starting alkaline maleate solutions (at best over 60%), hydrogen peroxide and alkaline peroxy salts as initiators--catalysts for the copolymerization process, as well as reaction temperatures between 105.degree. and 115.degree. C. The obtained copolymers have average molecular masses around 20000, while CCDC values are approximately 17-18 ml 0,25M Calcium Acetate per 1 g of copolymer. The obtained copolymers are well suited for their use as incrustation inhibitors, dispersants or ionic exchangers.