Patents Represented by Attorney Edwin P. Ching

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  • Antibodies and fragments thereof to MDL-1 protein
    Patent number: 6953843
    Abstract: The purification and isolation of various genes which encode mammalian cell surface polypeptides. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells, e.g., lymphoid and myeloid, are provided, along with methods for their use.
    Type: Grant
    Filed: July 8, 2002
    Date of Patent: October 11, 2005
    Assignee: Schering Corporation
    Inventors: Alexander B. H. Bakker, Joseph H. Phillips, Lewis L. Lanier
  • Nucleic acids encoding a cytokine receptor complex
    Patent number: 6890734
    Abstract: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: May 10, 2005
    Assignee: Schering Corporation
    Inventors: Pedro A. Reche-Gallardo, Vassilli Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, J. Fernando Bazan, Robert A. Kastelein
  • Mammalian cytokines; receptors; related reagents and methods
    Patent number: 6843987
    Abstract: Nucleic acids encoding mammalian, e.g., rodent, IL-1?, IL-1?, purified IL-1? and IL-1? proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: January 18, 2005
    Assignee: Schering Corporation
    Inventors: Johannes Eduard Maria Antonius Debets, Jacqueline C. Timans, J. Fernando Bazan, Robert A. Kastelein
  • Method for detecting IL-B30 polynucleotides
    Patent number: 6835825
    Abstract: The invention provided herein relates generally to purified genes encoding mammalian cytokines as well as reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules. In particular, the novel cytokine, IL-B30, is provided herein as well as methods and kits for the detection of the expression of IL-B30 polynucleotides.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: December 28, 2004
    Assignee: Schering Corporation
    Inventor: J. Fernando Bazan
  • Mammalian cytokine complexes
    Patent number: 6800460
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: March 9, 2000
    Date of Patent: October 5, 2004
    Assignee: Schering Corporation
    Inventors: Birgit Oppmann, Jacqueline C. Timans, Robert A. Kastelein, J. Fernando Bazan
  • AK155 antibodies and binding fragments thereof
    Patent number: 6797813
    Abstract: Purified genes encoding a cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using these reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: September 28, 2004
    Assignee: Schering Corporation
    Inventors: Rene de Waal Malefyt, Helmut Flickensher, Bernhard Fleckenstein, Andrea Knappe
  • IL-23 receptor binding compositions
    Patent number: 6756481
    Abstract: Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: June 29, 2004
    Assignee: Schering Corporation
    Inventors: Madaline Chirica, Robert A. Kastelein, Kevin W. Moore, Christi L. Parham
  • Regulatory T cells; methods
    Patent number: 6746670
    Abstract: Methods for increasing yields of Tr1 cells, useful, e.g., in transplantation contexts. Use of interferon and IL-15 are described.
    Type: Grant
    Filed: August 14, 2001
    Date of Patent: June 8, 2004
    Assignee: Schering Corporation
    Inventors: Megan K. Levings, Rene de Waal Malefyt, Maria Grazia Roncarolo
  • 7 transmembrane receptor family member BLRX
    Patent number: 6737252
    Abstract: Novel chemokines and 7 transmembrane receptors from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding the chemokines and receptors are disclosed. Methods of using the chemokines, receptors, reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: May 18, 2004
    Assignees: Schering Corporation, Canji, Inc.
    Inventors: Joseph A. Hedrick, Bernhard Homey, Alain Vicari, Monica L. Zepeda, Albert Zlotnik
  • Antibodies that bind chemokine teck
    Patent number: 6723520
    Abstract: Novel chemokines from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokines. Chemokine receptors are also provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: April 20, 2004
    Assignee: Schering Corporation
    Inventors: Wei Wang, Kurt C. Gish, Thomas J. Schall, Alain Vicari, Albert Zlotnik
  • Nucleic acids encoding CTLA-8; and related reagents
    Patent number: 6706870
    Abstract: CTLA-8 antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: March 16, 2004
    Assignees: Inserm, Institut National de la Sante et de la Recherche Medicale, Schering Corporation
    Inventors: Pierre Golstein, Eric Rouvier, Francois Fossiez, Serge J. E. Lebecque, Odile Djossou, Jacques Banchereau
  • Nucleic acids encoding mammalian interleukin-1&zgr;, related reagents and methods
    Patent number: 6680380
    Abstract: Nucleic acids encoding mammalian, e.g., primate, IL-1&zgr;, purified IL-1&zgr; polypeptides and fragments thereof. Binding proteins, e.g., antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: January 20, 2004
    Assignee: Schering Corporation
    Inventor: Jacqueline C. Timans
  • Methods of modulating IL-174 response
    Patent number: 6676939
    Abstract: Agonists or antagonists of cytokine designated IL-174, and various methods of their use are provided. In particular, the methods make use of facts that many activities of the IL-174 cytokine are described.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: January 13, 2004
    Assignee: Schering Corporation
    Inventors: Stephen D. Hurst, Sandra M. Zurawski, Donna M. Rennick
  • Regulatory T cells; methods
    Patent number: 6670146
    Abstract: Methods for increasing yields of regulatory T cells, useful, e.g., in transplantation contexts. Use of antigen presenting cells and anti-CD28 are also described.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: December 30, 2003
    Assignee: Schering Corporation
    Inventors: Franck J. Barrat, Pieter Andre Boonstra, Huub Savelkoul, Rene de Waal Malefyt, Anne O'Garra
  • Dendritic cells; methods
    Patent number: 6660523
    Abstract: Dendritic cell subsets, and various methods of making and using same are provided. In particular, methods for making a defined subset of dendritic cells are provided.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: December 9, 2003
    Assignee: Schering Corporation
    Inventors: Bianca Blom, Yong-Jun Liu
  • Method for treating inflammatory conditions using an antibody to MIP-3&agr;
    Patent number: 6645491
    Abstract: Agonists or antagonists of MIP-3&agr;, and various methods of use in dermatological and related applications are provided. In particular, the method makes use of fact that the MIP-3&agr; chemokine is specifically capable of inducing migration of a skin cell subset.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: November 11, 2003
    Assignee: Schering Corporation
    Inventors: Elizabeth R. Oldham, Bernhard Homey, Marie Caroline Dieu-Nosjean, Christophe Caux, Albert Zlotnik
  • Mammalian proteases; related reagents
    Patent number: 6638507
    Abstract: Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: October 28, 2003
    Assignee: Schering Corporation
    Inventors: Sriram Balasubramanian, John Ford, Daniel M. Gorman, Gerard Zurawski
  • Polynucleotides encoding DIRS1
    Patent number: 6586228
    Abstract: Nucleic acids encoding mammalian, e.g., primate or rodent receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: July 1, 2003
    Assignee: Schering Corporation
    Inventors: Christi L. Parham, Kevin W. Moore, Nicholas J. Murgolo
  • Mammalian selenophosphate synthetase
    Patent number: 6586217
    Abstract: Selenophosphate synthetase protein from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this protein. Methods of using these reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: July 1, 2003
    Assignee: Schering Corporation
    Inventors: M. Jorge Guimarães, J. Fernando Bazan, Albert Zlotnik
  • Mammalian CX3C chemokine
    Patent number: 6566503
    Abstract: Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: May 20, 2003
    Assignee: Schering Corporation
    Inventors: Gerard T. Hardiman, Devora L. Rossi, Kevin B Bacon, Bazan Fernando J., Thomas J. Schall, Albert Zlotnik