Patents Represented by Attorney Edwin P. Ching

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  • Purified mammalian CTLA-8 antigens and related reagents
    Patent number: 6274711
    Abstract: CTLA-8 antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: August 14, 2001
    Assignees: INSERM, Institut National de la Sante et de la Recherche Medicale, Schering Corporation
    Inventors: Pierre Golstein, Eric Rouvier, Francois Fossiez, Serge J. E. Lebecque, Odile Djossou, Jacques Banchereau
  • Mammalian proteinases; related reagents and methods
    Patent number: 6271014
    Abstract: Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: August 7, 2001
    Assignee: Schering-Plough
    Inventors: Blandine Marie de Saint-Vis, François Fossiez, Christophe Caux, Serge J. E. Lebecque
  • Method of inducing calcium flux in cells using mammalian thymokine protein
    Patent number: 6245329
    Abstract: Nucleic acids encoding a thymokine from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 12, 2001
    Assignee: Schering Corporation
    Inventors: Gregory S. Kelner, Jacqueline L. Kennedy, Albert Zlotnik
  • Mammalian cell surface antigens: related reagents
    Patent number: 6242586
    Abstract: Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: June 5, 2001
    Assignee: Schering Corporation
    Inventors: Daniel M. Gorman, Jeanine D. Mattson
  • Mutational variants of mammalian proteins
    Patent number: 6225446
    Abstract: Muteins, which are mutational variants of mammalian proteins. Particular positions of natural proteins are identified as critical in providing various different activities. Specific embodiments demonstrate properties of variations at these positions.
    Type: Grant
    Filed: December 5, 1996
    Date of Patent: May 1, 2001
    Assignee: Schering Corporation
    Inventors: Scott W. Altmann, Fernando L. Rock, J. Fernando Bazan, Robert A. Kastelein
  • Method of eosinophil depletion with antibody to CCR 3 receptor
    Patent number: 6207155
    Abstract: Binding compositions and various methods of use of the binding compositions are provided. In particular, a method is provided which comprises administering an effective amount of the binding composition, alone or in combination with other compounds, to eosinophils, thereby reducing the level of eosinophils in an individual. Preferably, the binding composition is a monoclonal antibody specific for CCR3.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: March 27, 2001
    Assignee: Schering Corporation
    Inventors: J. Christopher Grimaldi, Maureen C. Howard, Robert L. Coffman
  • Ig superfamily `dlair` receptors expressed in monocytes
    Patent number: 6140076
    Abstract: DNA clones encoding a receptor in the Ig superfamily and a related soluble variant have been isolated from a human monocyte library. The invention provides receptor polypeptides, nucleic acids encoding them, expression vectors, and transformed cells for recombinant production of the polypeptides.
    Type: Grant
    Filed: December 5, 1997
    Date of Patent: October 31, 2000
    Assignee: Schering Corporation
    Inventors: Gosse Jan Adema, Linde Meyaard, Daniel M. Gorman, Terrill K. McClanahan, Lewis L. Lanier, Joseph H. Phillips, Jr.
  • Nucleic acids encoding mammalian proteinases; related reagents
    Patent number: 6140098
    Abstract: Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: October 31, 2000
    Assignee: Schering Corporation
    Inventors: Sriram Balasubramanian, John Ford, Daniel M. Gorman, Gerard Zurawski
  • Purified mammalian monocyte antigens and related reagents
    Patent number: 6124436
    Abstract: Cell surface antigens from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: February 13, 1996
    Date of Patent: September 26, 2000
    Assignee: Schering Corporation
    Inventors: Terrill K. McClanahan, Daniel M. Gorman, Laurel M. Bolin
  • Mammalian cell surface antigens; related reagents
    Patent number: 6111090
    Abstract: Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: August 14, 1997
    Date of Patent: August 29, 2000
    Assignee: Schering Corporation
    Inventors: Daniel M. Gorman, Troy D. Randall, Albert Zlotnik
  • Mammalian proteinases; oxidoreductases; related reagents
    Patent number: 6069229
    Abstract: Nucleic acids encoding various proteases, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: May 30, 2000
    Assignee: Schering Corporation
    Inventors: Lynette M. Dowling, Constance F. Huffine, Daniel M. Gorman
  • Uses of mammalian CTLA-8 and related reagents
    Patent number: 6063372
    Abstract: Compositions and methods for using CTLA-8 to treat an abnormal physiological condition in an individual. The methods comprise administering a therapeutically effective amount of CTLA-8 alone, or in combination with other therapeutic reagents; or a CTLA-8 antagonist.
    Type: Grant
    Filed: October 24, 1996
    Date of Patent: May 16, 2000
    Assignees: Inserm, Institut National de la Sante et de la Recherche Medicale, Schering Corporation, Schering-Plough
    Inventors: Jacques Banchereau, Odile Djossou, Leopoldo Flores-Romo, Francois Fossiez, Pierre Golstein, Mala Krishna, Serge J. E. Lebecque, Richard Murray
  • DNA encoding interleukin-B30
    Patent number: 6060284
    Abstract: Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using the reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: May 9, 2000
    Assignee: Schering Corporation
    Inventor: J. Fernando Bazan
  • Lymphotactin uses
    Patent number: 6022534
    Abstract: This invention relates to the use of lymphotactin or lymphotactin antagonists for administration to an animal. The administration of these therapeutic entities will attract certain cell types, or can be blocked to prevent such attraction. It also provides means to protect stem cells.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: February 8, 2000
    Assignee: Schering Corporation
    Inventors: Joseph A. Hedrick, Susan A. Hudak, Albert Zlotnik
  • Nucleic acids encoding cytokine synthesis inhibitory factor (Interleukin-10)
    Patent number: 6018036
    Abstract: Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIFs, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-.gamma..
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 25, 2000
    Assignee: Schering Corporation
    Inventors: Timothy R. Mosmann, Kevin W. Moore, Martha W. Bond, Paulo J. M. Vieira
  • DNA encoding IL-10-like homologue; related reagents
    Patent number: 5989867
    Abstract: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: November 23, 1999
    Inventors: Andrea Knappe, Helmut Fickenscher, Bernhard Fleckenstein
  • Antibodies which specifically bind to the thymokine lymphotactin
    Patent number: 5985580
    Abstract: Nucleic acids encoding a thymokine designated lymphotactin from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 16, 1999
    Assignee: Schering Corporation
    Inventors: Gregory S. Kelner, Jacqueline L. Kennedy, Albert Zlotnik
  • Mammalian cell surface antigens
    Patent number: 5977303
    Abstract: Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of using said reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 2, 1999
    Assignee: Schering Corporation
    Inventors: Gregorio Aversa, Chia-Chun J. Chang, Benjamin G. Cocks, Jan E. de Vries
  • Purified mammalian NK antigens and related reagents
    Patent number: 5965401
    Abstract: NK cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen. Methods of using those reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: October 24, 1996
    Date of Patent: October 12, 1999
    Assignee: Schering Corporation
    Inventors: Chiwen Chang, Lewis L. Lanier, Joseph H. Phillips, Jr.
  • Cytokine-induced proliferation of amniotic t-cells
    Patent number: 5879937
    Abstract: The invention provides improved methods of prenatal diagnosis that can be performed earlier in pregnancy, and/or with greater safety, and/or rapidity, and/or with greater accuracy than conventional methods. A volume of amniotic fluid containing fetal cells is extracted from a pregnant woman, and the fetal T-cells are propagated in a culture medium comprising one or more cytokines. The fetal T-cells are then diagnosed for genetic defects.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: March 9, 1999
    Assignee: Schering Corporation
    Inventor: Maria-Grazia Roncarolo