Patents Represented by Attorney, Agent or Law Firm Hamilton, Brook, Smith and Reynolds, P.C.
  • Patent number: 8273715
    Abstract: Subjects having fragile X syndrome are treated with a composition that includes gamma-aminobutyric acid agonists. The gamma-aminobutyric acid agonist (GABA) can be a GABA(B) agonist, such as baclofen, including racemic and R-baclofen.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: September 25, 2012
    Assignee: Seaside Therapeutics, Inc.
    Inventors: Kathryn Roberts, Randall L. Carpenter, Mark F. Bear
  • Patent number: 8268872
    Abstract: This invention provides compounds of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig or salts thereof, pharmaceutical compositions comprising a compound of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig and intermediates useful in the preparation of same.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: September 18, 2012
    Assignee: Radius Health, Inc.
    Inventor: Chris P. Miller
  • Patent number: 8271241
    Abstract: A metamaterial includes a dielectric substrate and an array of discrete resonators at the dielectric substrate, wherein each of the discrete resonators has a shape that is independently selected from: an F-type shape; an E-type shape; or a y-type shape. A parameter of a chiral metamaterial is determined and a chiral metamaterial having such a parameter is prepared by the use of a model of the chiral metamaterial. The metamaterial model includes an array of discrete resonators. In one embodiment, each of the discrete resonators has a shape that is independently selected from the group consisting of: an F-type shape; an E-type shape; and a y-type shape. To the metamaterial model, electromagnetic (EM) radiation, preferably plane-polarized EM radiation in a visible, ultraviolet or near-infrared region, having at least one wavelength that is larger than the largest dimension of at least resonator of the metamaterial model, is applied.
    Type: Grant
    Filed: September 19, 2007
    Date of Patent: September 18, 2012
    Assignee: University of Massachusetts Lowell
    Inventors: Alkim Akyurtlu, Kenneth A. Marx, Nantakan Wongkasem
  • Patent number: 8269844
    Abstract: A method of improving a video image by removing the effects of camera vibration comprising the steps of, obtaining a reference frame, receiving an incoming frame, determining the frame translation vector for the incoming frame, translating the incoming frame to generate a realigned frame, performing low pass filtering in the spatial domain on pixels in the realigned frame, performing low pass filtering in the spatial domain on pixels in the reference frame, determining the absolute difference between the filtered pixels in the reference frame and the filtered pixels in the realigned frame, performing low pass filtering in the temporal domain on the pixels in the realigned frame to generate the output frame if the absolute difference is less than a predetermined threshold, and providing the realigned frame as the output frame if the absolute difference is greater than the predetermined threshold.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: September 18, 2012
    Assignee: Pelco, Inc.
    Inventors: Chien-Min Huang, Farzin Aghdasi
  • Patent number: 8266916
    Abstract: Embodiments of the present invention provide a cover for a Packaged Terminal Air Conditioning (PTAC) unit. Embodiments of the cover include a gasket on an interior portion of the cover sealing against a portion of the PTAC unit to prevent air recirculation. Other embodiments of the cover include a screen configured to capture large debris. Other embodiments of the cover include solid wood panels with stain and lacquer on both sides of the panels.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: September 18, 2012
    Inventor: John Dillon
  • Patent number: 8261562
    Abstract: A helium management control system for controlling the helium refrigerant supply from a common manifold supplies a plurality of cryogenic refrigerators with an appropriate helium supply. The system employs a plurality of sensors to monitor and regulate the overall refrigerant supply to deliver an appropriate refrigerant supply to each of the cryogenic refrigerators depending on the computed aggregate cooling demand of all of the cryogenic refrigerators. An appropriate supply of helium is distributed to each cryopump by sensing excess and sparse helium refrigerant and redistributing refrigerant accordingly. If the total refrigeration supply exceeds the total refrigerant demand, or consumption, excess refrigerant is directed to cryogenic refrigerators which can utilize the excess helium to complete a current cooling function more quickly.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: September 11, 2012
    Assignee: Brooks Automation, Inc.
    Inventors: Paul E. Dresens, Gary S. Ash, Allen J. Bartlett, Bruce Andeen, Y. Roberto Than, Joseph Chopy, Jr.
  • Patent number: 8266010
    Abstract: In typical two-way trading systems, bidders cannot trade directly with other bidders, and sellers cannot trade directly with other sellers, resulting in possible missed trading opportunities. Methods, systems, devices, and networks for enabling two-way trading systems to perform multi-party exchanges are disclosed. Example embodiments allow multiple bidders (buyers), multiple sellers, or a seller and bidder of separate marketplaces to trade among themselves. Embodiments may discover, for bidders and sellers, opportunities to trade with other sellers or bidders, or both, without a time-consuming and limited process of searching and discovering relevant opportunities. Bidders and sellers may not find such opportunities on their own in typical two-way trading systems. The embodiments may be implemented as stand-alone systems or as add-ons that may be used to augment or enhance existing two-way trading systems.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: September 11, 2012
    Inventor: Sri Raghavan
  • Patent number: 8263085
    Abstract: The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
    Type: Grant
    Filed: September 24, 2007
    Date of Patent: September 11, 2012
    Assignees: The Cleveland Clinic Foundation, The Regents of the University of California
    Inventors: Robert H. Silverman, Eric A. Klein, Graham Casey, Joseph DeRisi, Don Ganem
  • Patent number: 8265627
    Abstract: A method and apparatus for handover of a MS of a plurality of MSs to a BS of a plurality of BSs in a wireless communication network. The method includes identifying a target BS from the plurality of BSs for handover of the MS served by a serving BS. A difference between a quality of a signal received by the MS from the target BS and the quality of the signal received by the MS from the serving BS is greater than or equal to a first predefined threshold. The method further includes performing a handover for the MS from the serving BS to the target BS when the quality of the signal received by the MS from the serving BS is greater than or equal to a second predefined threshold.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: September 11, 2012
    Assignee: WiChorus, Inc.
    Inventors: Mustafa Ergen, Rehan Jalil, Tony Mak
  • Patent number: 8266312
    Abstract: Methods (100), systems (200), computer program products, and signal bearing mediums for streaming an eXtensible Markup Language (XML)-type document (210) over a communication network (240) are described. A sequence of commands are received and synchronously converted (112) into XML-type fragments (230) for assembling and streaming a single XML-type document for a mobile device (220) in the communication network (240). The size of the XML-type document (210) exceeds the size limit imposed by the available memory on the device but less than the size limit imposed by the transport layer of a communication network (240). A DTD of the XML-type document (210) can be broken up into logically independent elements. The XML-type fragments (230) are assembled (114) in a buffer that is constrained to be smaller in size than the size constraint of the transport layer of the communication network (240).
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: September 11, 2012
    Assignee: International Business Machines Corporation
    Inventor: Ashok Cherian Mammen
  • Patent number: 8262966
    Abstract: Method for cooling flat plastic products, in which plasticized plastic compound is fed to a calender via a slot nozzle by means of an extruder and is rolled and calibrated to the desired shape in this calender between at least two smoothing rolls, after which the film or sheet produced in this way is fed to a chill section comprising a plurality of adjustable rolls and passes through this section until it is sufficiently cool and dimensionally stable, at least both the gap width between the rolls and the speed of the rolls being controllable by open- and/or closed-loop control. The degree of wrap of the flat plastic product around the respective roll is varied by adjusting the rolls in the chill section into a mutually offset arrangement, hence increasing or minimizing the cooling capacity.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: September 11, 2012
    Assignee: Battenfeld-Cincinnati Germany GmbH
    Inventors: Klaus Becker, Michael Käthler
  • Patent number: 8259841
    Abstract: An equalizer provided in a digital transmitter compensates for attenuation in a signal channel to a digital receiver. The equalizer generates signal levels as a logical function of bit history to emphasize transition signal levels relative to repeated signal levels. The preferred equalizer includes an FIR transition filter using a look-up table. Parallel circuits including FIR filters and digital-to-analog converters provide a high speed equalizer with lower speed circuitry. The equalizer is particularly suited to in-cabinet and local area network transmissions where feedback circuitry facilitates adaptive training of the equalizer.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: September 4, 2012
    Assignee: Massachusetts Institute of Technology
    Inventor: William J. Dally
  • Patent number: 8258777
    Abstract: The present invention relates to an inductive proximity sensor that includes an oscillator having first and second inductor-capacitor circuits arranged such that an inductance of one of the inductor-capacitor circuits has substantially greater sensitivity to an external target than an inductance of the other inductor-capacitor circuit. The sensor also includes an alternating current drive to each of the inductor-capacitor circuits that is in-phase and depends on differences in voltage across the inductor-capacitor circuits. The sensor may be coupled to a calibration device that applies power and triggers a calibration routine within the sensor. In response to the trigger signal, a calibration processor within the sensor executes the calibration routine and adjusts the inductor-capacitor circuits and provides an indication of successful calibration.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: September 4, 2012
    Inventor: Weihua Chen
  • Patent number: 8255380
    Abstract: An expertise locator enables user defined correspondences between experts and respective certain objects. Each object inherits from classes in a hierarchy. Using the correspondences, a locator processor routine finds a candidate expert about a particular subject area. The candidate expert may be in a correspondence with a certain object whose class is a subclass of the particular subject area. Output may display an indication of the candidate expert, relevant expertise per candidate and/or a list of experts per certain object. In the case of the certain objects being topics, the hierarchy is an ontology of the topics.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: August 28, 2012
    Assignee: International Business Machines Corporation
    Inventors: James E. Christensen, Daniel M. Gruen, Susanne Hupfer, Stephen E. Levy, John F. Patterson, Jamie C. Rasmussen, Steven I. Ross
  • Patent number: 8255099
    Abstract: Disclosed is a system and method for diverting from a flight plan without adjusting an autopilot by treating a heading change as the new leg of a flight plan. The present invention allows the pilot of an aircraft to enter a heading to follow into a flight management system, which treats the heading as the current leg of a flight plan otherwise being followed by the flight management system. The present invention graphically displays the heading leg as the predicted track so that the pilot is able to see the airplane's expected path. Such a change allows the autopilot to continue following commands from the flight management system rather than being changed to a mode in which the autopilot follows heading commands directly from the pilot.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: August 28, 2012
    Assignee: Avidyne Corporation
    Inventors: Michael J. Ingram, Steven Lindsley, Michael Keirnan
  • Patent number: 8253290
    Abstract: A retrofit kit for a printing press adjustment hydraulic actuator. The hydraulic actuator is maintained to benefit from its mounting position and alignment, but the hydraulic fluid is removed. A hydraulic actuator shaft is attached to a mechanism that converts the rotary motion of an electric motor to linear motion. The electric motor provides faster and more accurate control of the hydraulic actuator shaft than the hydraulic fluid, providing for faster adjustment of the printing press.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: August 28, 2012
    Assignee: Innovative Motor Controls, Inc.
    Inventor: Dale R. Davis
  • Patent number: 8252884
    Abstract: Disclosed are compositions comprising antioxidants and stabilizers, such as, acid scavengers or organic phosphorus stabilizers, and optionally further comprising co-stabilizers. The disclosed compositions are useful as stabilizers for polyolefins and other polymeric materials. The disclosed compositions and methods generally provide longer shelf lifes and better oxidative resistance to materials than currently available antioxidants.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: August 28, 2012
    Assignee: Polnox Corporation
    Inventors: Vijayendra Kumar, Rajesh Kumar, Ashish Dhawan, Sui-Zhou Yang, Ashok L. Cholli
  • Patent number: 8253438
    Abstract: An integrated circuit includes first circuitry and sleep transistor circuitry. The first circuitry receives input signals and processes the input signals. The first circuitry also retains data in a sleep state that has low leakage. The sleep transistor circuitry is coupled to the first circuitry and receives a sleep signal that has a negative voltage. The sleep circuitry reduces power consumption of the first circuitry in the sleep state to have low leakage based on the sleep signal while retaining the data in the first circuitry.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: August 28, 2012
    Assignee: Mosaid Technologies Incorporated
    Inventors: Barry A. Hoberman, Daniel L. Hillman, William G. Walker, John M. Callahan, Michael A. Zampaglione, Andrew Cole
  • Patent number: D667128
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: September 11, 2012
    Assignee: POD I.P. Pty Ltd.
    Inventor: Brendan Pierce
  • Patent number: RE43639
    Abstract: A technique for correcting charge transfer inefficiencies in a Charge Coupled Device (CCD). The basic approach is to estimate the charge entering at a given stage in a CCD pipeline, and to then determine an estimate of the error introduced by the accumulated leftover charge that will be present at a second point, farther down the pipeline. The error is then corrected by injecting a correcting charge at a third point, farther still down the CCD pipeline. The invention is used, in one embodiment, to correct the output of a charge to digital converter, although principals of the invention may be used for other types of circuits.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: September 11, 2012
    Assignee: Kenet, Inc.
    Inventors: Jeffrey D. Kurtze, Michael P. Anthony