Patents Represented by Attorney Heller Ehrman LLP
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Patent number: 7563232Abstract: These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing having a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. An analyte detecting member is positioned to receive fluid from a wound created by the penetrating member. The detection member is configured to determine a concentration of an analyte in the fluid using a sample of less than 1 mL of the fluid. A user interface is configured to relay at least one of, penetrating member performance or a penetrating member setting.Type: GrantFiled: December 31, 2002Date of Patent: July 21, 2009Assignee: Pelikan Technologies, Inc.Inventors: Dominique M. Freeman, Dirk Boecker, Don Alden
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Patent number: 7454430Abstract: Provided are methods and systems that extract facts of unstructured documents and build an oracle for various domains. The present invention addresses the problem of efficient finding and extraction of facts about a particular subject domain from semi-structured and unstructured documents, makes inferences of new facts from the extracted facts and the ways of verification of the facts, thus becoming a source of knowledge about the domain to be effectively queried. The methods and systems can also extract temporal information from unstructured and semi-structured documents, and can find and extract dynamically generated documents from Deep or Dynamic Web.Type: GrantFiled: June 13, 2005Date of Patent: November 18, 2008Assignee: Glenbrook NetworksInventors: Julia Komissarchik, Edward Komissarchik
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Patent number: 7442192Abstract: An apparatus for dissecting tissue in a substantially uniform plane of dissection includes a housing configured to be advanced under a tissue layer, and control one of a depth of dissection or tissue flap thickness. The housing thermally shields at least a portion of the tissue flap. A roller is coupled to the housing. The roller is configured to smoothly advance housing over tissue. An energy delivery device is coupled to housing. The energy delivery device is configured to be coupled to an energy source. The energy delivery device has a geometry that substantially defines a plane of dissection.Type: GrantFiled: July 14, 2003Date of Patent: October 28, 2008Inventor: Edward W. Knowlton
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Patent number: 7442389Abstract: Microspheres to be implanted into a patient are metered and mixed with fluids, cells, or tissues withdrawn from the patient's own body, and reinserted into the patient's body to achieve augmentation, repair or other treatment of the patient's tissue.Type: GrantFiled: August 22, 2005Date of Patent: October 28, 2008Assignee: Artes Medical, Inc.Inventors: Gerhard Quelle, Russell J. Anderson, Stefan M. Lemperle
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Patent number: 7436579Abstract: Devices and methods are disclosed for realizing a high quality bulk domain grating structure utilizing mobile charges that are generated by means of photo-excitation in a substrate. An effect of light exposure (UV, visible, or a combination of wavelengths) is to generate photo-induced charges. The application of a voltage across the substrate combined with the application of light exposure causes a photo-induced current to flow through the substrate. The photo-induced charges (behaving like virtual electrode inside the material) and the photo-induced current result in both reduction of the coercive field required for domain inversion in the material and improve realization of the domain inversion pattern, which previously has not been possible at room temperature.Type: GrantFiled: September 8, 2006Date of Patent: October 14, 2008Assignee: Arasor CorporationInventors: Lee Lisheng Huang, Simon John Field
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Patent number: 7393809Abstract: This invention provides a new catalyst for purification of diesel engine exhaust gas comprising a carrier of at least one sulfur-resistant refractory oxide and at least one catalytic metal, wherein at least one solid acid and/or sulfuric acid is carried on the carrier by adding at least one precursor of said solid acid and/or sulfuric acid during the preparation of the carrier, and preparation thereof. The catalyst of this invention is thermally and chemically durable and can effectively remove particulate matters, hydrocarbons and nitrogen oxides contained in the diesel engine exhaust gas at low temperatures.Type: GrantFiled: September 7, 2004Date of Patent: July 1, 2008Assignee: KH Chemicals Co., Ltd.Inventor: Young-Nam Kim
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Patent number: 7384632Abstract: The invention concerns agonist anti-trkC monoclonal antoibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.Type: GrantFiled: June 22, 2001Date of Patent: June 10, 2008Assignee: Genentech, Inc.Inventors: Brigitte Devaux, David L. Shelton, Jo-Anne Hongo, Leonard G. Presta
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Patent number: 7371247Abstract: A tissue penetrating system includes a plurality of penetrating members each having a tip. A penetrating member driver is coupled to the plurality of penetrating members. Each tip of a penetrating member is uncovered during launch of the penetrating member by the penetrating member driver. A support is provided with a plurality of openings. Each opening receives a penetrating member.Type: GrantFiled: December 31, 2002Date of Patent: May 13, 2008Assignee: Pelikan Technologies, IncInventors: Dirk Boecker, Don Alden, Dominique M. Freeman
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Patent number: 7368031Abstract: The present invention provides a method for inlaying a design into a laminate sheet and bonding the inlaid laminate sheet to a core structure or core substrate. The method of the present invention includes the steps of die cutting a preselected inlay design out of a laminate sheet, die cutting a congruent insert to be placed in the aperture left by the die cut design, securing the insert into the die cut design aperture, laminating with heat and pressure the laminate sheet to a core material, and conducting a finishing operation such as trimming to clean the excess laminate sheet from around the edges of the core material.Type: GrantFiled: November 17, 2003Date of Patent: May 6, 2008Assignee: Wham-O, Inc.Inventors: Gregory S. Lehr, Alberto Rubio, Salvador Gallegos
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Patent number: 7361096Abstract: A slide is provided with a sliding surface along which a person may slide. The slide includes a bridging structure spanning the sliding surface and a valve mounted to the bridging structure and coupled to a source of water. A spray nozzle is selectively coupled through the valve to the water source. The spray nozzle is mounted to the bridging structure to spray water toward the sliding surface when the valve couples the nozzle to the water source. A trigger hangs from the bridging structure adjacent the sliding surface and controls the valve to direct water to the spray nozzle when the trigger is contacted and displaced by the user. The nozzle sprays water onto the user as the user activates the trigger by sliding under the bridging structure.Type: GrantFiled: March 14, 2006Date of Patent: April 22, 2008Assignee: Wham-O, Inc.Inventor: Terry Sanchez
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Patent number: 7358806Abstract: A power amplifier assembly has a first power amplifier with a first input conditioning circuit. At least first and second amplifiers are in parallel with each other and having inputs and outputs. An input signal is coupled to the inputs of the first and second amplifiers. A first multi-input power combiner is provided. The outputs of the at least first and second parallel amplifiers are combined by the first multi-input power combiner to add signals of the outputs constructively. A second power amplifier has a first input conditioning circuit. At least first and second amplifiers are in parallel with each other and having inputs and outputs. An input signal is coupled to the inputs of the first and second amplifiers. A second multi-input power combiner is provided. The outputs of the at least first and second parallel amplifiers are combined by the second multi-input power combiner to add signals of the outputs constructively.Type: GrantFiled: February 16, 2005Date of Patent: April 15, 2008Assignee: Amalfi Semiconductor, Inc.Inventors: Lawrence Burns, Chong Woo
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Patent number: 7359420Abstract: Arrays of vertical extended cavity surface emitting lasers (VECSELs) are disclosed. The functionality of two or more conventional optical components are combined into an optical unit to reduce the number of components that must be aligned during packaging. A dichroic beamsplitter selectively couples frequency doubled light out of the cavity. In one implementation the dichroic beamsplitter includes at least one prism.Type: GrantFiled: September 25, 2006Date of Patent: April 15, 2008Assignee: Arasor CorporationInventors: Andrei V. Shchegrov, Jason P. Watson, Dicky Lee, Arvydas Umbrasas, Rene Dato, John Green, Michael Jansen, Aram Mooradian
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Patent number: 7358049Abstract: The present invention relates to methods of identifying genes involved in memory formation. This is accomplished by performing a gene chip identification of those genes expressed during transcription-dependent memory formation but not during transcription-independent memory formation. A statistical analysis of the gene chip identification output yields a set of genes that are involved in transcription-dependent memory formation.Type: GrantFiled: August 8, 2005Date of Patent: April 15, 2008Assignees: Cold Spring Harbor Laboratory, Emory University, Hoffmann-La Roche Inc.Inventors: Timothy P. Tully, Joshua I. Dubnau, Michael Davis, Jan Mous, Ulrich Certa
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Patent number: 7354769Abstract: Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising a precipitant to form a mixture; and crystallizing the mixture, optionally also recrystallizing and isolating the crystalline IGF-1. In addition, a method for identifying IGF-1 indirect agonists is provided using a detergent as a standard for the level of inhibition of binding of IGFBP-1 or IGFBP-3 to IGF-1 and/or using the coordinates of the binding pockets of IGF-l to which a candidate indirect agonist binds for structure-based drug design.Type: GrantFiled: June 20, 2006Date of Patent: April 8, 2008Assignee: Genentech, Inc.Inventors: Michelle Schaffer, Mark Ultsch, Felix Vajdos
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Patent number: 7355047Abstract: Substituted quinolone carboxylic acids and their derivatives are described. These compounds modulate the effect of ?-aminobutyric acid (GABA) via a novel site on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.Type: GrantFiled: May 12, 2003Date of Patent: April 8, 2008Assignee: The Regents of the University of CaliforniaInventors: Timothy B. C. Johnstone, Derk J. Hogenkamp, Kelvin W. Gee
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Patent number: 7351545Abstract: IGFBP-3 fusion proteins are provided that are useful, for example, in cell-based assays, as IGF antagonists, and in mapping IGF-I and IGF-II binding sites on other molecules such as wild-type IGFBP-3 and IGF agonist peptides identified by phage display. Methods for making such fusion proteins are also provided.Type: GrantFiled: September 21, 2006Date of Patent: April 1, 2008Assignee: Genentech, Inc.Inventors: Henry Lowman, Samantha Lien
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Patent number: 7348154Abstract: IGFBP-3 fusion proteins are provided that are useful, for example, in cell-based assays, as IGF antagonists, and in mapping IGF-I and IGF-II binding sites on other molecules such as wild-type IGFBP-3 and IGF agonist peptides identified by phage display. Methods for making such fusion proteins are also provided.Type: GrantFiled: September 21, 2006Date of Patent: March 25, 2008Assignee: Genentech, Inc.Inventors: Henry Lowman, Samantha Lien
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Patent number: 7344507Abstract: A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet and a processor coupled to the drive force generator capable of changing the direction and magnitude of force exerted on the lancet during the lancing cycle. The driver further includes a human interface on the housing providing at least one output for communicating with the patient.Type: GrantFiled: September 5, 2002Date of Patent: March 18, 2008Assignee: Pelikan Technologies, Inc.Inventors: Barry Dean Briggs, Dominique M. Freeman, Don Alden, Jon Hewitt Leonard, Dirk Boecker
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Patent number: 7342363Abstract: Methods and apparatus are provided for an amplifier for use with a nonlinear load. In one embodiment, a method is provided for driving a flash lamp. The method comprises providing an amplifier having a resonant reset topology, coupling an output of the amplifier to the flash lamp to provide a pulsed power output to the flash lamp, and driving the amplifier with a controller to provide a pulse width modulation output to the flash lamp. The pulsed output from the amplifier has a period selected to prevent a streamer of said flash lamp from extinguishing during an active use.Type: GrantFiled: February 7, 2005Date of Patent: March 11, 2008Assignee: Continuum Electro•Optics, Inc.Inventors: Timothy D. Logsdon, Richard Thao Ha
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Patent number: D580958Type: GrantFiled: June 2, 2006Date of Patent: November 18, 2008Inventor: Peter Thew