Abstract: The invention relates to an insect steroid receptor protein which is capable of acting as a gene switch which is responsive to a chemical inducer enabling external control of the gene.

Abstract: An end office support (EOS) routing node implements MTP layers 1-3 on behalf of one or more remote applications that share the true point code of the EOS routing node. Implementing MTP layers 1-3 includes receiving messages addressed to the true point code, determining whether the messages are contain application level information of interest to a remote application, and forwarding the application level information to the remote application. Messages may be routed internally within the EOS routing node using an internal point code used to uniquely identify the remote application within the EOS routing node. The EOS routing node may also perform network management functions on behalf of one or more remote applications.

Abstract: The present invention provides an apparatus for signaling that a predetermined time value has elapsed, having a device for acquiring and storing the amplitude value of a clock signal at an acquisition instant in the temporal profile of the clock signal. A device is provided for continuously comparing the acquired and stored amplitude value of the clock signal with an instantaneous amplitude value of the clock signal and for outputting a comparison signal which has a first logic state if the instantaneous amplitude value of the clock signal is less than the stored amplitude value and has a second logic state if the instantaneous amplitude value of the clock signal is greater than the stored amplitude value.

Abstract: Disclosed is a communications network element that is capable of routing signaling messages and includes a dynamic routing key registration feature which allows Internet protocol (IP) nodes to automatically register/de-register and subsequently direct traffic towards or away from themselves without the need for manual operator intervention. A signaling gateway routing node includes a self-registering data communication module (sDCM) that is adapted to receive and process dynamic routing key registration messages from associated IP nodes. Such dynamic routing key registration messages may include information that is used to register a new routing key association with a TCP/IP connection, de-register an existing routing key association with the TCP/IP connection, or modify routing key information associated with the TCP/IP connection.

Abstract: Methods and systems for automatically bypassing a short message service center for short message service (SMS) messages destined for predetermined SMPP destinations are disclosed. A signal transfer point may receive SMS messages that are global title addressed to a short message service center. The signal transfer point may internally route such messages to a short message gateway. The short message gateway may identify SMS messages destined for predetermined SMPP destinations and forward those messages to the destinations in a manner that bypasses the SMSC. For other SMS messages, the short message gateway may forward these messages to the SMSC for delivery.

Abstract: High speed processor having a data processing unit (13) for processing data, a data memory (20) which is connected to the data processing unit via a data bus (10) and can be addressed by the data processing unit (13) via a data memory address bus (18), at least one input interface buffer (9) which is connected to the data bus (10) and has the purpose of buffering input data, at least one output interface buffer (16) which is connected to the data bus (10) and has the purpose of buffering output data, the input interface buffer (9) and the output interface buffer (26) being directly addressable by the data processing unit (13) via an interface address bus (24).

Abstract: The mutations D188V, V1353L, I1656M in the neuronal gene sodium-channel alpha1-subunit, SCN1A, are disclosed. The methods of using their associated polypeptides for treating sodium channel dysfunction disorders including generalized epilepsy are also disclosed.

Abstract: A method of testing a candidate composition for PAI-1 inhibition activity is disclosed. The method includes the steps of obtaining a transgenic non-human warm blooded vertebrate animal having incorporated into its genome a PAI-1 gene encoding a biologically active PAI-1 polypeptide, the PAI-1 gene being present in the genome in a copy number effective to confer over-expression in the transgenic non-human animal of the PAI-1 polypeptide; administering the composition to the transgenic non-human animal; and observing the transgenic non-human animal for determination of a change in the transgenic non-human animal indicative of inhibition of the activity of PAI-1. A transgenic non-human animal useful in such a method is also disclosed, as is a PAI-1 transgene construct encoding a biologically active PAI-1 polypeptide useful for preparing the transgenic non-human animal.

Abstract: The present invention describes the use of polybenzoxazoles (PBOs) for adhesively bonding articles or materials, especially components used in the semiconductor industry, such as chips and wafers, a process for adhesively bonding materials, especially chips and wafers, chip and/or wafer stacks produced by the process, and adhesive compositions which comprise the polybenzoxazoles of the formula (I).

Abstract: Telecommunication system for bidirectional transmission of data and voice signals with a data network (2), which is connected via a satellite data transmission link (6, 5, 8) for bidirectional data signal transmission to at least one satellite device (7), which is connected to a 10 Base S switching device (14); a telephone network (25), which is connected via a number of subscriber telephone lines (23) for bidirectional voice signal transmission to the 10 Base S switching device (14); and with a number of 10 Base S subscriber modems (18), which are connected for bidirectional voice and data signal transmission to the 10 Base S switching device (14).

Abstract: Isolated and purified platelet voltage dependent calcium channel (VDCC) ?1 subunit polypeptides, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to platelet VDCC ?1 subunit polypeptides, and methods of producing the same, are also disclosed. Platelet VDCC ?1 subunit polypeptides have biological activity in calcium transport. Thus, therapeutic and diagnostic methods involving this activity are also disclosed.

Abstract: A method of eliciting an immune response against an antigen in a vertebrate subject, the method comprising the steps of providing an antigen-adjuvant composition comprising the antigen and a substantially non-toxic adjuvant molecule having biological activity in mucosal tissues, and administering said antigen-adjuvant composition to the vertebrate subject in a manner such that initial contact occurs in mucosal tissue of the vertebrate subject, whereby an immune response is elicited. Cytokines are preferred adjuvants. Preferred cytokines are interleukin-1?(IL-1?) and interleukin-1? (IL-1?).

Abstract: A flexible routing node for re-directing signaling messages in a communications network is disclosed. Re-direction or re-routing of signaling message packets is accomplished through the use of a range or block-based database in conjunction with an exception-based database. The range-based routing instruction databases incorporates a data structure that maps ranges or blocks of mobile identification numbers (MINs) to a single destination network address, while the exceptions database stores any exceptions to these range or block-based rules. The pair of routing databases is implemented such that, when a signaling message is received that requires re-direction, the exception-based database is queried first. If a match is found in the exceptions database, the signaling message is modified using the returned routing instructions and transmitted into an associated communication network. If no match is found in the exception-based database, a default query is performed against the range-based database.

Abstract: A collar to be worn on an object or a large or small animal has been designed incorporating (D)GPS technology. The operation of the device includes programming the three dimensional boundary into the memory of the device and simply installing the collar on the animal. As the animal approaches the preprogrammed boundary, a first alarm sounds when the subject is within an arbitrary user defined distance, and a second more drastic alarm such as a shock correction is applied when the subject approaches a second position closer to the boundary. Means to easily program the device are also included in the system. The device has the capability to call or transmit important information such as location, speed, identity, and medical parameters etc to a station automatically or when polled. All necessary analog and digital circuitry, microprocessor, programming, communications hardware are integrated into the collar.

Abstract: Improved branch metrics for Viterbi decoders in CDMA systems take into account the time dependency of the variance of the multiple access interference in any user's signal after the single-user detector, and the time dependency of the residual multiple access interference in any user's signal after subtractive interference cancellation is applied in two-stage detectors. The (residual) multiple access interference can be modeled as a Gaussian random variable with time dependent variance. Modeling the RMAI in such a way reduces the bit error rate in CDMA systems.

Abstract: Methods and systems for detecting intrusion events, such as war dialing events are disclosed. According to one method, signaling messages associated with calls being made or attempted in a telecommunications network are analyzed. Based on the signaling messages, it is determined whether a war dialing event has occurred or is in progress. In response to determining that a war dialing event has occurred or is in progress, a war dialing event mitigating action is performed.

Abstract: The present invention provides a process for wiring electrical contact sites, in particular on the surface of an electronic or microelectronic component, with the following steps: applying and patterning at least one dielectric on the component surface; currentlessly depositing a conductor starting layer for producing metal wiring interconnects and substitute contact sites with short-circuit contacts for interconnecting the individual metal wiring interconnects and the corresponding electrical contact sites; reinforcing the conductor starting layer by a common electrodepositing process; and separating the short-circuit contacts for separating the electrical contact sites or the contact sites of the wiring from one another.

Abstract: Methods and systems for transmitting user part messages between signaling system seven (SS7) signaling points over an internet protocol (IP) network include receiving, at a signal transfer point, a first SS7 user part message. The first SS7 user part message can be received from a first SS7 signaling point, such as a service switching point (SSP). The first SS7 signaling point is encapsulated in a first IP packet. The first IP packet is transmitted to a second SS7 signaling point over an IP network.

Abstract: The invention relates to a method for the planarization of a semiconductor structure comprising a substrate, in which several sub-structures (STI; AA; AA?; AA?;) are provided. said sub-structures (STI; AA; AA?; AA?,) having a first sub-structure (AA?) with planar regions (PS) and first trench regions (DT). A layer to be planarized is applied over the semiconductor structure, said layer having appropriate recesses above the first trench regions (DT) of the first sub-structure (AA?). The method comprises the following steps: pre-planarization of the layer to be planarized by an etching step, using a pre-planarization mask, then subsequent planarization of the layer to be planarized by a chemical-mechanical polishing step.

Abstract: The present invention relates to recombinant vectors carrying sequences encoding naturally occurring antimicrobial peptides or derivatives thereof for the treatment of mammalian tumours and viral infections such as HIV infections and bacterial and fungal infections. In particular the present invention relates to retroviral vectors. Furthermore, the present invention relates to retroviral vectors which undergo promoter conversion (Procon vectors) carrying such sequences. Since these vectors also carry tumour or virus specific regulatory elements, the therapeutic antimicrobial peptide will be delivered and expressed only in relevant, affected cells and not in innocent bystander cells.