Patents Represented by Attorney, Agent or Law Firm Patrick M. Ryan
  • Method of treating dry eye disorders
    Patent number: 7745461
    Abstract: The topical use of EgLN-3 inhibitors is disclosed for the treatment of dry eye.
    Type: Grant
    Filed: February 26, 2007
    Date of Patent: June 29, 2010
    Assignee: Alcon Research, Ltd.
    Inventor: Peter G. Klimko
  • Ophthalmic lens materials containing chromophores that absorb both UV and short wavelength visible light
    Patent number: 7728051
    Abstract: Chromophores that absorb both UV and short wavelength visible light are disclosed. The chromophores are particularly suitable for use in intraocular lens materials.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: June 1, 2010
    Assignee: Alcon, Inc.
    Inventors: Joseph I. Weinschenk, III, Douglas C. Schlueter, David L. Jinkerson
  • Low-tack ophthalmic and otorhinolaryngological device materials
    Patent number: 7714039
    Abstract: Disclosed are soft, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain one or more aryl acrylic hydrophobic monomers as principal device-forming monomers and a tack-reducing macromer additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: May 11, 2010
    Assignee: Alcon, Inc.
    Inventors: Diana M. Cordova, Mutlu Karakelle, Chance Lehman, Douglas C. Schlueter, Joseph I. Weinschenk, III
  • 3,6-substituted imidazol[1,2-b]pyridazine analogs for treating allergic and inflammatory diseases
    Patent number: 7713975
    Abstract: Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically effective amount of a 3,6-substituted imidazol[1,2-b]pyridazine compound.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: May 11, 2010
    Assignee: Alcon, Inc.
    Inventors: Mark R. Hellberg, Steven T. Miller, Andrew Rusinko
  • Dual function UV-absorbers for ophthalmic lens materials
    Patent number: 7709652
    Abstract: Disclosed are UV absorbers that contain a labile functional group capable of initiating free radical polymerization.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: May 4, 2010
    Assignee: Alcon, Inc.
    Inventor: Douglas C. Schlueter
  • Method of treating ocular allergy
    Patent number: 7687539
    Abstract: The topical use of 5,6,7-trihydroxyheptanoic acid and analogs alone or in combination with histamine antagonists and/or mast cell stabilizers is disclosed for the treatment of ocular allergy.
    Type: Grant
    Filed: November 7, 2006
    Date of Patent: March 30, 2010
    Assignee: Alcon Research, Ltd.
    Inventors: Peter G. Klimko, Clay Beauregard
  • Low-tack ophthalmic and otorhinolaryngological device materials
    Patent number: 7585900
    Abstract: Disclosed are soft, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain an aryl acrylic hydrophobic monomer as the single principal device-forming monomer and a tack-reducing macromer additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: September 8, 2009
    Assignee: Alcon, Inc.
    Inventors: Diana M. Cordova, Mutlu Karakelle, Chance Lehman, Douglas C. Schlueter, Joseph I. Weinschenk, III
  • Substituted furo[2,3-g]indazoles for the treatment of glaucoma
    Patent number: 7476687
    Abstract: Substituted furo[2,3-g]indazoles for lowering intraocular pressure and treating glaucoma are disclosed.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: January 13, 2009
    Assignee: Alcon, Inc.
    Inventors: Anura P. Dantanarayana, Jesse Albert May
  • Substituted 1-alkylamino-1-H-indazoles for the treatment of glaucoma
    Patent number: 7439262
    Abstract: Substituted 1-alkylamino-1H-indazoles for lowering intraocular pressure and treating glaucoma are disclosed.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: October 21, 2008
    Assignee: Alcon, Inc.
    Inventors: Anura P. Dantanarayana, Jesse A. May
  • Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
    Patent number: 7425572
    Abstract: Novel dioxinoindazole compounds and dioxoloindazole compounds are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions of one or more of the compounds of the present invention.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: September 16, 2008
    Assignee: Alcon, Inc.
    Inventors: Hwang-Hsing Chen, Jesse A. May
  • Olopatadine formulations for topical administration
    Patent number: 7402609
    Abstract: Topical formulations of olopatadine for treatment of allergic or inflammatory disorders of the eye and nose are disclosed. The aqueous formulations contain approximately 0.17-0.62% (w/v) of olopatadine and an amount of polyvinylpyrrolidone or polystyrene sulfonic acid sufficient to enhance the physical stability of the formulations.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: July 22, 2008
    Assignee: Alcon, Inc.
    Inventors: Ernesto J. Castillo, Wesley Wehsin Han, Huixiang Zhang, Haresh G. Bhagat, Onkar N. Singh, Joseph Paul Bullock, Suresh C. Dixit
  • Dual function UV-absorbers for ophthalmic lens materials
    Patent number: 7396942
    Abstract: Disclosed are UV absorbers that contain a labile functional group capable of initiating free radical polymerization.
    Type: Grant
    Filed: October 9, 2006
    Date of Patent: July 8, 2008
    Assignee: Alcon, Inc.
    Inventor: Douglas C. Schuleter
  • Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
    Patent number: 7338972
    Abstract: Substituted 1-alkylamino-1H-indazoles for lowering intraocular pressure and treating glaucoma are disclosed.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: March 4, 2008
    Assignee: Alcon, Inc.
    Inventors: Anura P. Dantanarayana, Jesse A. May
  • Ophthalmic compositions containing a synergistic combination of three polymers
    Patent number: 7329411
    Abstract: Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of three polymers that have a synergistic effect on viscosity.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: February 12, 2008
    Assignee: Alcon, Inc.
    Inventors: Masood A. Chowhan, Huagang Chen
  • Ophthalmic compositions containing a synergistic combination of three polymers
    Patent number: 7306802
    Abstract: Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of three polymers that have a synergistic effect on viscosity.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: December 11, 2007
    Assignee: Alcon, Inc.
    Inventors: Masood A. Chowhan, Huagang Chen
  • Serotonergic 5HTreceptor compounds for treating ocular and CNS disorders
    Patent number: 7285553
    Abstract: Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
    Type: Grant
    Filed: November 2, 2005
    Date of Patent: October 23, 2007
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Jesse A. May, Thomas R. Dean, Najam A. Sharif, Hwang-Hsing Chen
  • Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
    Patent number: 7268131
    Abstract: Substituted [1,4]oxazino[2,3-g]indazols for lowering intraocular pressure and treating glaucoma are disclosed.
    Type: Grant
    Filed: July 13, 2005
    Date of Patent: September 11, 2007
    Assignee: Alcon, Inc.
    Inventors: Anura P. Dantanarayana, Jesse Albert May
  • Topical brimonidine tartrate formulations that lack chlorine dioxide
    Patent number: 7265117
    Abstract: Topical solution compositions of brimonidine tartrate are disclosed. The solution compositions lack an oxidative preservative.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: September 4, 2007
    Assignee: Alcon, Inc.
    Inventors: Ramon L. Espino, Haresh G. Bhagat
  • Ophthalmic compositions containing a synergistic combination of three polymers
    Patent number: 7244440
    Abstract: Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of three polymers that have a synergistic effect on viscosity.
    Type: Grant
    Filed: June 8, 2004
    Date of Patent: July 17, 2007
    Assignee: Alcon, Inc.
    Inventors: Masood A. Chowhan, Huagang Chen
  • Methods of treating dry eye disorders
    Patent number: 7235556
    Abstract: Fused pyridazine derivatives are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: June 26, 2007
    Assignee: Alcon, Inc.
    Inventors: Najam A. Sharif, Mark R. Hellberg