Patents Represented by Attorney, Agent or Law Firm Patrick M. Ryan
  • Method of treating dry eye disorders using glycosides
    Patent number: 7223737
    Abstract: The topical use of glycosides for the treatment of dry eye disorders is disclosed.
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: May 29, 2007
    Assignee: Alcon, Inc.
    Inventors: Victor Ke, legal representative, Tai-Lee Ke, deceased
  • Covalently-bound, hydrophilic coating compositions for surgical implants
    Patent number: 7208012
    Abstract: Covalently-bound, hydrophilic copolymer coatings for implants are disclosed. The copolymer coatings comprise a hydrophobic aryl acrylic monomer, a hydrophilic monomer selected from the group consisting of hydroxyalkyl (meth)acrylates, n-vinyl pyrrolidone and acrylamides, and a (meth)acrylamide reactive plasticizer.
    Type: Grant
    Filed: October 19, 2006
    Date of Patent: April 24, 2007
    Assignee: Alcon, Inc.
    Inventors: Thomas A. Callaghan, Albert R. LeBoeuf
  • Benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
    Patent number: 7208512
    Abstract: The present invention provides benzodifuran imidazoline derivatives and benzofuran imidazoline derivatives for lowering intraocular pressure and providing ocular neuroprotection.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: April 24, 2007
    Assignee: Alcon, Inc.
    Inventors: Zixia Feng, Mark R. Hellberg
  • Covalently-bound, hydrophilic coating compositions for surgical implants
    Patent number: 7157538
    Abstract: Covalently-bound, hydrophilic copolymer coatings for implants are disclosed. The copolymer coatings comprise a hydrophobic aryl acrylic monomer, a hydrophilic monomer selected from the group consisting of hydroxyalkyl (meth)acrylates, n-vinyl pyrrolidone and acrylamides, and a (meth)acrylamide reactive plasticizer.
    Type: Grant
    Filed: August 13, 2004
    Date of Patent: January 2, 2007
    Assignee: Alcon, Inc.
    Inventors: Thomas A. Callaghan, Albert R. LeBoeuf
  • Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
    Patent number: 7129257
    Abstract: Pyrazolo[3,4-e]benzoxazoles and analogues thereof for lowering intraocular pressure and treating glaucoma are disclosed.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: October 31, 2006
    Assignee: Alcon, Inc.
    Inventors: Anura P. Dantanarayana, Jesse A. May
  • Dual function UV-absorbers for ophthalmic lens materials
    Patent number: 7119210
    Abstract: Disclosed are UV absorbers that contain a labile functional group capable of initiating free radical polymerization.
    Type: Grant
    Filed: January 8, 2004
    Date of Patent: October 10, 2006
    Assignee: Alcon, Inc.
    Inventor: Douglas C. Schlueter
  • Use of proteasome inhibitors to treat dry eye disorders
    Patent number: 7112588
    Abstract: Proteasome inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Grant
    Filed: March 24, 2004
    Date of Patent: September 26, 2006
    Assignee: Alcon, Inc.
    Inventors: Peter G. Klimko, Mark R. Hellberg
  • Serotonergic 5HTreceptor compounds for treating ocular and CNS disorders
    Patent number: 7060704
    Abstract: Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: June 13, 2006
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Jesse A. May, Thomas R. Dean, Najam A. Sharif, Hwang-Hsing Chen
  • 11,12-oxidoarachidonic acid derivatives and methods of their use in treating dry eye disorders
    Patent number: 7060728
    Abstract: 11,12-Oxidoarachidonic acid derivatives and methods of their use for treating dry eye are disclosed.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: June 13, 2006
    Assignee: Alcon, Inc.
    Inventors: David B. Belanger, Peter G. Klimko
  • Methods of treating dry eye disorders
    Patent number: 7026296
    Abstract: Inhibitors of cytokine synthesis in nonimmune, resident ocular surface cells are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: April 11, 2006
    Assignee: Alcon, Inc.
    Inventor: Daniel A. Gamache
  • Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma
    Patent number: 7005448
    Abstract: The present invention provides novel compounds, compositions containing the compounds of the invention in a pharmaceutically acceptable excipient and methods for using the compositions for lowering intraocular pressure.
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: February 28, 2006
    Assignee: Alcon, Inc.
    Inventor: Jesse A. May
  • 5-Hydroxy indazole derivatives for treating glaucoma
    Patent number: 7005443
    Abstract: 3-(2-aminoethyl)-1H-indazol-5-ols useful for treating elevated intraocular pressure and glaucoma are disclosed.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: February 28, 2006
    Assignee: Alcon, Inc.
    Inventors: Jesse A. May, Zixia Feng
  • Sustained release ophthalmic, otic and nasal suspension
    Patent number: 7001615
    Abstract: Sustained release suspension formulations for ophthalmic, otic and nasal administration are disclosed. The formulations comprise a basic active, a cation exchange resin, and a combination of a polymeric suspending agents to provide superior resuspendability.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: February 21, 2006
    Assignee: Alcon, Inc.
    Inventors: Onkar N. Singh, Ernesto J. Castillo
  • Olopatadine formulations for topical administration
    Patent number: 6995186
    Abstract: Topical formulations of olopatadine for treatment of allergic or inflammatory disorders of the eye and nose are disclosed. The aqueous formulations contain approximately 0.17-0.62% (w/v) of olopatadine and an amount of polyvinylpyrrolidone or polystyrene sulfonic acid sufficient to enhance the physical stability of the formulations.
    Type: Grant
    Filed: June 19, 2002
    Date of Patent: February 7, 2006
    Assignee: Alcon, Inc.
    Inventors: Ernesto J. Castillo, Wesley Wehsin Han, Huixiang Zhang, Haresh G. Bhagat, Onkar N. Singh, Joseph Paul Bullock, Suresh C. Dixit
  • Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
    Patent number: 6989445
    Abstract: Substituted [1,4]oxazino[2,3-g]indazols for lowering intraocular pressure and treating glaucoma are disclosed.
    Type: Grant
    Filed: December 14, 2004
    Date of Patent: January 24, 2006
    Assignee: Alcon, Inc.
    Inventors: Anura P. Dantanarayana, Jesse Albert May
  • Ophthalmic and otorhinolaryngological device materials
    Patent number: 6872793
    Abstract: Disclosed are soft, high refractive index device materials having improved strength. The materials contain microphase-separated aliphatic and aromatic domains.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: March 29, 2005
    Assignee: Alcon, Inc.
    Inventor: Douglas C. Schlueter
  • Use of selective PDE IV inhibitors to treat dry eye disorders
    Patent number: 6872382
    Abstract: Selective PDE-IV inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: March 29, 2005
    Assignee: Alcon, Inc.
    Inventors: Daniel A. Gamache, John M. Yanni
  • Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
    Patent number: 6825232
    Abstract: The topical use of HETE compounds to treat ophthalmic inflammatory disorders involving cytokines is disclosed.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: November 30, 2004
    Assignee: Alcon, Inc.
    Inventor: Daniel A. Gamache
  • Ophthalmic and otorhinolaryngological device materials
    Patent number: 6806337
    Abstract: Disclosed are soft, high refractive index, acrylic device materials having improved strength. The materials contain cross-linked acrylate or methacrylate microspheres.
    Type: Grant
    Filed: July 15, 2003
    Date of Patent: October 19, 2004
    Assignee: Alcon
    Inventors: Douglas C. Schlueter, Albert R. LeBoeuf, Mutlu Karakelle
  • Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
    Patent number: 6803385
    Abstract: Hydroxyeicosatetraenoic acid esters and methods of their use in treating dry eye disorders are disclosed.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: October 12, 2004
    Assignee: Alcon, Inc.
    Inventors: Peter G. Klimko, Mark R. Hellberg, John R. Falck, Raymond E. Conrow