Patents Represented by Attorney, Agent or Law Firm Pillsbury Madison & Sutro
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Patent number: 6284460Abstract: Devices and techniques for hybridization of nucleic acids and for determining the sequence of nucleic acids. Arrays of nucleic acids are formed by techniques, preferably high resolution, light-directed techniques. Positions of hybridization of a target nucleic acid are determined by, e.g., epifluorescence microscopy. Devices and techniques are proposed to determine the sequence of a target nucleic acid more efficiently and more quickly through such synthesis and detection techniques.Type: GrantFiled: June 17, 1997Date of Patent: September 4, 2001Assignee: Affymetrix Inc.Inventors: Stephen P. A. Fodor, Robert J. Lipshutz, Xiaohua Huang
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Patent number: 6274704Abstract: The biologically active peptide of the invention has a number of amino acids of 30 or less, comprises an amino acid sequence described as SEQ ID NO:13 (Tyr Thr Ile Tyr Val Ile Ala Leu) in the sequence listing and has cell adhesion inhibition activity. The peptide of the invention has short length and, therefore, synthesis and handling of the peptide are easy.Type: GrantFiled: September 18, 1997Date of Patent: August 14, 2001Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Fumio Fukai, Takashi Katayama
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Patent number: 6271971Abstract: The invention provides an objective system for use on a single objective type binocular stereomicroscope which, albeit having a parfocal length thereof shorter than a focal length thereof, can reduce various aberrations as much as possible, and a single objective type binocular stereomicroscope system which can be well manipulated while the viewing position is invariable even when objective lenses are interchanged. The objective system for use on a single objective type binocular stereomicroscope comprises an objective lens for converting light from an object into an afocal light flux and two viewing optical units for receiving light emanating from the objective lens to form left and right images, which satisfies condition: 1.0<FL/L<1.6 where FL is a focal length of the objective system, and L is a distance from a first lens surface of the objective system on an image point side to a sample surface.Type: GrantFiled: October 15, 1998Date of Patent: August 7, 2001Assignee: Olympus Optical Co., Ltd.Inventors: Kiyonobu Kurata, Kazuhiko Osa
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Patent number: 6271254Abstract: Pharmaceutical compositions and processes for their preparation containing R-&agr;-lipoic acid or S-&agr;-lipoic acid or pharmaceutically acceptable salts thereof. The pharmaceutical compositions have a cytoprotective activity and are suitable for combatting pain and inflammation.Type: GrantFiled: February 2, 1998Date of Patent: August 7, 2001Assignee: ASTA Pharma AktiengesellschaftInventors: Heinz Ulrich, Carl-Heinrich Weischer, Jürgen Engel, Helmut Hettche
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Patent number: 6268152Abstract: Devices and techniques for hybridization of nucleic acids and for determining the sequence of nucleic acids. Arrays of nucleic acids are formed by techniques, preferably high resolution, light-directed techniques. Positions of hybridization of a target nucleic acid are determined by, e.g., epifluorescence microscopy. Devices and techniques are proposed to determine the sequence of a target nucleic acid more efficiently and more quickly through such synthesis and detection techniques.Type: GrantFiled: April 6, 2000Date of Patent: July 31, 2001Assignee: Affymetrix, Inc.Inventors: Stephen P. A. Fodor, Robert J. Lipshutz, Xiaohua Huang
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Patent number: 6268021Abstract: A binder vehicle composition which is suitable for coating media, containing: A) 20 to 77% by weight of one or more binder vehicles based on oligomeric or polymeric polyol compounds with a hydroxyl number of 80 to 300, an acid number of 0 to 30, a number average molecular weight (Mn) of 500 to 10,000, and a glass transition temperature of −20 to +70° C.; B) 77 to 20% by weight of crosslinking agents based on aliphatic and/or cycloaliphatic polyisocyanates; C) 3 to 20% by weight of oligo- or polyesters, which contain carboxyl groups, as catalyst resins, which have an acid number of 210 to 300 mg KOH/g and a number average molecular weight (Mn) of 420 to 3000; and one or more organic solvents and/or water.Type: GrantFiled: December 11, 1998Date of Patent: July 31, 2001Assignee: Herberts GmbHInventors: Carmen Flosbach, Friedrich Herrmann, Walter Schubert, Dirk Schild
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Patent number: 6269290Abstract: In an engine-motor hybrid vehicle, vehicle drive regions are divided into a plurality of groups specified by a plurality of operation state variables. A learning variable set for each drive region is updated according to an amount of a power state of an engine, when the vehicle is in a steady state running. The learning variable indicates a change in the power state amount with age. When an engine power demand value is determined, it is corrected by using the learning variable of a selected drive region to calculate a corrected engine power demand value compensating a change in the engine with age. In this manner, the engine power is controlled.Type: GrantFiled: June 30, 1999Date of Patent: July 31, 2001Assignee: Denso CorporationInventors: Tsuneyuki Egami, Kazuyoshi Obayashi, Hiroya Tsuji, Yasumasa Kaji, Keiichiro Banzai, Takeshi Sawada
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Patent number: 6268894Abstract: A liquid crystal display apparatus having a plurality of pixel cells is disclosed, each of which comprising a scanning line and a signal line disposed on an insulation substrate in such a manner that the scanning line intersects with the signal line, a switching device disposed at the intersection of the scanning line and the signal line, a display pixel electrode electrically connected to the switching device, an opposite electrode disposed opposite to the display pixel electrode through a liquid crystal layer, and an auxiliary capacitor line disposed in a space between two adjacent display pixel electrodes in parallel with the scanning line and capacitively coupled with the display pixel electrode so as to form an auxiliary capacitor, wherein the scanning line overlaps with the display pixel electrode.Type: GrantFiled: May 31, 1996Date of Patent: July 31, 2001Assignee: Kabushiki Kaisha ToshibaInventors: Yoshiro Aoki, Hajime Sato
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Patent number: 6264809Abstract: One electrode is provided in association with the object to be coated, the other electrode. A pre-stretched ion-exchange membrane in a thin tubular form is sandwiched inbetween two nonconductive water permeable screen tubular housings. The assembly contains a supply line that provides a water way for the electrolyte to flow from the top of the device into a lower cap, then to the lower cap reservoir that allows stabilization and disbursement of electrolyte through the rifled housing Inertia developed through this defined pattern creates a swirling action that scrubs the impurities away from the anode, and to the top of the device to be carried out top. The location of the supply line is just inside the inner screen inserted through both the upper housing and lower cap. The tubular electrode is provided to the inside of membrane housing completing the inner portion of the waterway return chamber.Type: GrantFiled: October 30, 1998Date of Patent: July 24, 2001Assignee: PTI Advanced Filtration, Inc.Inventor: Cheng H. Lee
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Patent number: 6261480Abstract: The thermistor element of the present invention is composed of a mixed sintered body aM1M2O3.bY2O3 of a composition M1M2O3 (wherein M1 is Y, and M2 is at least one element selected from the elements such as Cr, Mn, Ti, etc.) as a perovskite compound and Y2O3, wherein molar fractions a and b satisfy the relations 0.05≦a<1.0, 0<b≦0.95 and a+b=1. Another wide-range type thermistor element of the present invention is composed of a perovskite compound M1(M2M3)O3, wherein M1 is at least one element selected from the elements of the groups II and IIIA excluding La in the Periodic Table, and each of M2 and M3 is at least one element selected from the elements of the groups IIB, IIIB, IVA, VA, VIA, VIIA and VIII. a and b satisfy the relations a+b=1 and 0<b<0.1, where a is a molar fraction of M2 and b is a molar fraction of M3 in M1(M2M3)O3.Type: GrantFiled: August 25, 1999Date of Patent: July 17, 2001Assignees: Denso Corporation, Nippon Soken, Inc.Inventors: Itsuhei Ogata, Takumi Kataoka, Eturo Yasuda, Kaoru Kuzuoka, Masanori Yamada
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Patent number: 6258933Abstract: The present invention relates to a process for the one-stage resalting and purification of oligopeptides. Oligopeptides are often not formed directly as acetates when synthesised. Acetate salts of oligopeptides are however desirable as bulk-active material for medical and formulation reasons. Processes known from the prior art have hitherto involved two separate steps or pyridine-containing solvents. The resalting and purification can be combined in one step and the use of pyridine as solvent can be avoided, if the oligopeptide in the form of its chloride salt is purified with an acetate-containing solvent by liquid chromatography methods.Type: GrantFiled: March 26, 1999Date of Patent: July 10, 2001Assignee: Degussa-Huls AktiengesellschaftInventors: Kurt Günther, Franz-Rudolf Kunz, Karlheinz Drauz, Thomas Müller
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Patent number: 6259919Abstract: A method for identifying a fast speed mobile station (MS) in a radio system, said method comprising measuring the frequency error of radio signals received from a mobile station. In order for a fast speed mobile station to be more reliably identified than before, the method comprises calculating the change (df) in BSC the frequency error from a time interval (t) of predetermined length, and identifying the mobile station as a fast speed mobile station if the change (df) in the calculated frequency error exceeds a predetermined limit value.Type: GrantFiled: February 14, 1997Date of Patent: July 10, 2001Assignee: Nokia Telecommunications OyInventors: Jukka Suonvieri, Kullervo Inkinen
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Patent number: 6258547Abstract: cDNAs encoding mammalian AMP protein kinases, corresponding polypeptides and recombinant proteins together with antibodies thereto. Their uses including the study of gene expression and the characteristics of other proteins.Type: GrantFiled: March 6, 1996Date of Patent: July 10, 2001Assignee: Zeneca LimitedInventors: Rajinder Kumar Beri, David Carling, Robert Anthony Forder
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Patent number: 6249440Abstract: The contact arrangement is a connector block for detachably fastening an electrical component, particularly an integrated circuit having a plurality of terminal contacts disposed in a ball grid array (BGA), in a column grid array (CGA), in a land grid array (LGA) or of the flip-chip type to a printed circuit board. In a support part, a number of contact pins are disposed in a grid in bores. The contact pins project from the bore on the side facing the printed circuit board and are surface-mounted together with contact areas of the printed circuit board. A free end region of each bore is intended for guiding the substantially dome-shaped terminal contacts. Between the end of a contact pin and a terminal contact there is a space bridged for establishing an electrical connection with a contact element, for example an axially compressible coil spring. By means of several holding-down elements disposed peripherally to the integrated circuit, the integrated circuit is pressed down upon the support part.Type: GrantFiled: November 25, 1997Date of Patent: June 19, 2001Assignee: E-TEC AGInventor: Hugo Affolter
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Patent number: 6245825Abstract: Process for preparing a flexible foam by reacting a polyisocyanate having a high 4,4′-MDI content and a polyol having a high EO content in the presence of a foaming agent.Type: GrantFiled: July 2, 1996Date of Patent: June 12, 2001Assignee: Imperial Chemical Industries PLCInventor: Geert Bleys
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Patent number: 6246949Abstract: The present invention aims to facilitate easy correction of the center axis of an obstacle detecting apparatus for a vehicle by calculating deflection of the center axis with respect to the vehicle. Each of most obstacles recognized as moving objects is a preceding vehicle 93, and when the subject vehicle 91 is moving straight, the preceding vehicle 93 is detected in a position straight ahead of the subject vehicle 91. If the optical axis 95 of the transmitting/receiving section 31 is oriented straight ahead of the subject vehicle 91, the preceding vehicle 93 will be detected on the optical axis 95. On the other hand, when the optical axis 95 deviates from the center axis of the vehicle, the preceding vehicle 93 is detected in a position deviated from the optical axis 95 by an angle &thgr; m. In this case, the value &thgr; of deflection of optical axis 95 is equal to −&thgr; m.Type: GrantFiled: December 27, 1996Date of Patent: June 12, 2001Assignee: Denso CorporationInventors: Noriaki Shirai, Katsuhiko Hibino, Takao Nishimura
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Patent number: 6241797Abstract: There is disclosed a process for reducing oxidic slags or combustion residues above a metal bath. The metal bath is formed of an iron alloy containing metals nobler than iron and whose redox potential is adjusted such FeO is reduced to Fe not at all or only partially.Type: GrantFiled: April 16, 1997Date of Patent: June 5, 2001Assignee: “Holderbank” Financiere Glarus AGInventor: Alfred Edlinger
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Patent number: 6242787Abstract: A semiconductor device including a reduced surface field strength type LDMOS transistor which can prevent the breakdown of elements at channel formation portions when a reverse voltage is applied to its drain. A P well and an N well are formed in an N-type substrate to produce a double-well structure, with a source electrode being set to be equal in electric potential to the N-type substrate. The drift region of the N well has a dopant concentration to satisfy the so-called RESURF condition, which can provide a high breakdown voltage a low ON resistance. When a reverse voltage is applied to a drain electrode, a parasitic bipolar transistor comprising the N well, the P well and the N-type substrate develops to form a current-carrying path toward a substrate, so that the element breakdown at the channel formation portions is avoidable at the application of the reverse voltage.Type: GrantFiled: November 15, 1996Date of Patent: June 5, 2001Assignee: Denso CorporationInventors: Yoshiaki Nakayama, Hiroshi Maeda, Makio Iida, Hiroshi Fujimoto, Mitsuhiro Saitou, Hiroshi Imai, Hiroyuki Ban
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Patent number: RE37292Abstract: An image display apparatus which enables observation of a clear image at a wide field angle with substantially no reduction in the brightness of the observation image, and which is extremely small in size and light in weight. The image display apparatus has an image display device (7) and an ocular optical system (8) for projecting the image of the image display device (7) and leading the projected image to an observer's eyeball (1). The ocular optical system (8) has at least three optical surfaces, and a space formed by these surfaces is filled with a medium having a refractive index larger than 1. The three optical surfaces are defined as a first surface (3), a second surface (4), and a third surface (5), respectively, in the order in which light rays pass in backward ray tracing from the observer's eyeball (1) to the image display device (7).Type: GrantFiled: May 21, 1999Date of Patent: July 24, 2001Assignee: Olympus Optical Co., Ltd.Inventors: Takayoshi Togino, Koichi Takahashi
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Patent number: RE37314Abstract: The compounds of the present invention inhibit the HMG-CoA reductase, and subsequently suppress the biosynthesis of cholesterol. And they are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis.Type: GrantFiled: August 27, 1998Date of Patent: August 7, 2001Assignee: Shionogi Seiyaku Kabushiki KaishaInventors: Kentaro Hirai, Teruyuki Ishiba, Haruo Koike, Masamichi Watanabe