Patents Represented by Attorney, Agent or Law Firm Rothwell, Figg, Ernst & Manbeck
  • Pharmaceutical composition comprising lipase inhibitor and lipophilic oil absorbent and oral formulation prepared therefrom
    Patent number: 8246985
    Abstract: This invention provides a pharmaceutical composition comprising a lipase inhibitor; a lipophilic oil absorbent selected from the group consisting of hydrogenated castor oil, hydrogenated vegetable oil, glyceryl behenate, glyceryl palmitostearate and a mixture thereof; and a pharmaceutically acceptable additive, an oral formulation of a lipase inhibitor prepared there from and a method for preparing said formulation. The formulation of the present invention can minimize side effects such as oily spotting, fatty/oily stool, abdominal distension and flatus, and thus it can be advantageously used for preventing or treating obesity and hyperlipaemia.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: August 21, 2012
    Assignee: Amorepacific Corporation
    Inventors: Jin Woo Park, Sung Ah Bin, Jeong A Lee, Jung Ju Kim
  • Fish cancer model
    Patent number: 8242326
    Abstract: The present invention is directed to fish whose genome has integrated therein an oncogenic nucleic acid operably linked to a promoter. Methods of making the fish and methods for their use are also provided. The fish may advantageously be utilized in methods of screening for drugs or agents that modulate oncogene-mediated neoplastic or hyperplastic transformation, or that modulate sensitivity to chemotherapy or radiation therapy. Immortal tumor cells lines, methods of making immortal tumor cell lines and methods of their use are also provided.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: August 14, 2012
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Sergey Parinov, Alexander Emelyanov
  • Temperature monitoring for electrical wires and electrical connection apparatus
    Patent number: 8242918
    Abstract: Monitoring apparatus (100, 200, 300) for registration and warning of overtemperature, particularly in connection with harmful heat development in electric installations, as for example outlets, switches and fuse equipment. The apparatus provides for timely warning of heat development, so that overheating and damage is avoided, whereby the operation of electric installation equipment for mounting in electric installations, will have a significantly improved safety. The temperature registration is performed in a unit (100) by means of a sensor (1) which provides an electrical magnitude that is influenced by the temperature, for example a thermistor, which is a temperature-dependent resistor. When a low current is applied to such a component, it will result in a temperature-dependent voltage drop that is measured and gives a direct measure of the temperature.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: August 14, 2012
    Inventors: Stig Werner Brusveen, Anders Sande
  • Pyrone-indole derivatives and process for their preparation
    Patent number: 8242163
    Abstract: The present invention relates to a method for treating insulin resistance, neuronal loss associated with stroke, ischemia, central nervous system trauma, a central nervous system disorder, a neurodegenerative disease, the adverse consequences of the over-stimulation of excitatory amino acids, a psychiatric disease, epilepsy or other convulsive disorder, chronic pain, CMV retinitis, urinary incontinence, or for inducing anesthesia; which comprises administering to an animal or human in need thereof an effective amount of a pharmaceutical formulation comprising an effective amount of a pyrone-indole derivative of formula (I): Ar—B—Ar???(I) wherein Ar represents an indole nucleus ring system: Ar? represents an alpha-, beta- or gamma-pyrone nucleus ring system: and each of B, R1-4, and R1-2? are one of the groups as defined herein.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: August 14, 2012
    Assignee: Neurim Pharmaceuticals (1991) Ltd.
    Inventors: Moshe Laudon, Tal Peleg-Shulman
  • System and method for generating transaction based recommendations
    Patent number: 8239310
    Abstract: A system for generating recommendation data includes an assessment unit and an evaluation unit. The assessment unit is configured to receive transaction data for a plurality of transactions and to assess each transaction and generate assessment data based thereon. The evaluation unit is coupled with the assessment unit and configured to receive an evaluation request including a proposed transaction, and generate recommendation data including a certainty indicator which indicates a level of certainty that the proposed transaction will be successful according to predetermined criteria.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: August 7, 2012
    Inventor: Frank Duane Lortscher, Jr.
  • Treatment of mesothelioma
    Patent number: 8236794
    Abstract: A method of treating mesothelioma in a mammal, whereby a methylol-containing compound is administered to the mammal intrapleurally.
    Type: Grant
    Filed: September 28, 2004
    Date of Patent: August 7, 2012
    Assignee: Ed. Geistlich Soehne AG fuer Chemische Industrie
    Inventor: Rolf W. Pfirrmann
  • Method of accelerating the growth and development of trees and shrubs via enhanced root development
    Patent number: 8236322
    Abstract: A method of developing seedlings includes germinating the seeds and air pruning the seedlings to a depth of about 3 inches.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: August 7, 2012
    Inventors: Wayne Lovelace, Hugh Steavenson, Bob Suddarth
  • Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents
    Patent number: 8236858
    Abstract: This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositions containing these compounds. This invention further is directed to the pharmaceutical use of the compounds for inhibiting GSK3? kinase and/or modulating N-methyl-D-aspartate (NMDA) channel activities for the treatment of neurodegenerative and other disorders.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: August 7, 2012
    Assignee: Neurim Pharmaceuticals (1991) Ltd.
    Inventors: Tal Peleg-Shulman, Moshe Laudon, Dvorah Daily
  • Minimizing security holdings risk during portfolio trading
    Patent number: 8239302
    Abstract: A method and computer program product for minimizing short-term risk to a portfolio of securities holdings during implementation of executing an outstanding trade list of securities to be traded, takes into account covariances between securities in the outstanding trade list and between securities in the outstanding trade list and securities in the portfolio of holdings so as to minimize risk to the portfolio of holdings as well as to a residual trade list of unexecuted orders during said implementation.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: August 7, 2012
    Assignee: ITG Software Solutions, Inc.
    Inventors: John Krowas, Ian Domowitz
  • Multi-mode unstacker device for unstacking mailpieces
    Patent number: 8235377
    Abstract: A mailpiece unstacker device comprises a feed magazine for moving the mailpieces in a stack and on edge in a certain direction towards an unstacker head. It is provided with materials sensors for delivering signals indicating that a current mailpiece has a cover made of a plastics material and/or includes a metal material. A control unit forces the feed magazine and the unstacker head to operate as a function of the signals generated by the sensors so that the mailpieces are presented facing the unstacker head in positions that are inclined backwards to various extents.
    Type: Grant
    Filed: December 2, 2008
    Date of Patent: August 7, 2012
    Assignee: Solystic
    Inventors: Stephane Ambroise, Stephane Samain, Pierre Chorier-Pichon
  • Injectable composite material suitable for use as a bone substitute
    Patent number: 8231909
    Abstract: The invention relates to a new injectable composite material suitable for use as a bone substitute. The composite material according to the invention comprises a reactive ceramic phase based on tricalcium phosphate and an organic phase comprising a polyvinyl alcohol hydrogel. By varying the concentration of the two phases it is possible to modulate the mechanical and injectability properties of the material.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: July 31, 2012
    Assignee: Consiglio Nazionale Delle Ricerche
    Inventors: Luigi Ambrosio, Valeria Sanginario, Maria Pau Ginebra, Josep Anton Planell
  • Substrate processing method and apparatus
    Patent number: 8231285
    Abstract: A resist pattern forming method using a coating and developing apparatus and an aligner being connected thereto which are controlled to form a resist film on a surface of a substrate with a base film and a base pattern formed thereon, followed by inspecting at least one of a plurality of measurement items selected from: reflection ratio and film thickness of the base film and the resist film, line width after a development, an accuracy that the base pattern matches with a resist pattern, a defect on the surface after the development, etc. A parameter subject to amendment is selected based on corresponding data of each measurement item, such as the film thickness of the resist and the line width after the development, and amendment of the parameter is performed. This results in a reduced workload of an operator, and the appropriate amendment can be performed.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: July 31, 2012
    Assignee: Tokyo Electron Limited
    Inventors: Kunie Ogata, Koki Nishimuko, Hiroshi Tomita, Yoshio Kimura, Ryouichi Uemura, Michio Tanaka
  • Optical-based sensing devices
    Patent number: 8233953
    Abstract: An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: July 31, 2012
    Assignee: Sensors for Medicine and Science
    Inventor: Arthur E. Colvin, Jr.
  • Real-time PCR in micro-channels
    Patent number: 8232094
    Abstract: The present invention relates to methods for amplifying nucleic acids in micro-channels. More specifically, the present invention relates to methods for performing a real-time polymerase chain reaction (PCR) in a continuous-flow microfluidic system and to methods for monitoring real-time PCR in such systems.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: July 31, 2012
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Kenton C. Hasson, Gregory A. Dale, Hiroshi Inoue
  • Bifunctional phenyl ISO (THIO) cyanates, processes and intermediates for their preparation
    Patent number: 8232421
    Abstract: A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: July 31, 2012
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerhard Hamprecht, Michael Puhl, Bernd Wolf, Norbert Götz, Michael Keil, Robert Reinhard, Ingo Sagasser, Werner Seitz
  • Method for automatically controling volume level for calculating MOS
    Patent number: 8233590
    Abstract: The present invention relates to a method of automatically controlling the volume level of communication speech for Mean Opinion Score (MOS) measurement, which, before evaluating the quality of communication speech using a MOS measurement method, automatically controls the volume level of actual communication speech to a predetermined optimal level, thus improving the reliability of MOS values.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: July 31, 2012
    Assignee: Innowireless Co., Ltd.
    Inventors: Jong Tae Chung, Jin Soup Joung, Young Su Kwak, Jin Man Kim, Hyun Seok Cho
  • Method for amplification and detection of RNA sequences
    Patent number: 8227191
    Abstract: A process for identifying a viral RNA nucleotide sequence present in a sample of peripheral blood cells which comprises amplifying such RNA simultaneously with at least one other RNA nucleotide sequence present in a virus infected cell in said sample, and thereafter separately and sequentially analyzing the amplification reaction products with probes homologous with authentic RNA and with such other RNA sequence to identify one or both of said RNA nucleotide sequences.
    Type: Grant
    Filed: September 1, 1989
    Date of Patent: July 24, 2012
    Assignee: City of Hope
    Inventors: George J. Murakawa, R. Bruce Wallace, John A. Zaia, John J. Rossi
  • 3D glasses for stereoscopic display device and stereoscopic display device including the same
    Patent number: 8228449
    Abstract: There are provided 3D glasses for use in a stereoscopic display device including a display panel for emitting right-eye image light and left-eye image light and an optical filter including a first area for adjusting a polarized state of the right-eye image light and a second area for adjusting a polarized state of the left-eye image light, comprising a right-eye area allowing right-eye image light to pass therethrough and a left-eye area allowing left-eye image light to pass therethrough; and compensation films disposed at the right-eye area and the left-eye area to compensate for a phase difference deviation between the first and second areas of the optical filter, wherein a phase difference value of the compensation film provided at the right-eye area and that of the compensation film provided at the left-eye area are different.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: July 24, 2012
    Assignee: LG Chem, Ltd.
    Inventors: Dae Hee Lee, Moon-Soo Park, Seung-Hun Chae
  • System, method and program for agency cost estimation
    Patent number: 8229834
    Abstract: A method, system and computer program product for forecasting the transaction cost of a portfolio trade execution that may be applied to any given trading strategy or an optimal trading strategy that minimizes transaction costs. The system accepts user-defined input variables from customers and generates a transaction cost estimation report based on those variables. Two models are utilized: discretionary and non-discretionary. A specific transaction cost estimation and optimization is performed that model the transaction costs of a specific trade execution based on the user's trading profile and market variables.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: July 24, 2012
    Assignee: ITG Software Solutions, Inc.
    Inventors: Milan Borkovec, Ananth Madhavan, Hans Heidle
  • Article handling apparatus
    Patent number: D664166
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: July 24, 2012
    Assignee: Austin Engineering Ltd.
    Inventor: Jamie Vincent Clarke Hall