Patents Represented by Attorney, Agent or Law Firm Scott A. Brown
  • Methods of treatment using IL-6
    Patent number: 6284237
    Abstract: IL-6 is produced via recombinant DNA techniques. The peptide is useful in the treatment of disorders characterized by deficiencies in hematopoietic cells and in combination with other hematopoietins in cancer therapies.
    Type: Grant
    Filed: April 6, 1994
    Date of Patent: September 4, 2001
    Inventors: Steven C. Clark, Gordon G. Wong, Paul Schendel, John McCoy
  • Cytosolic phospholipase A.sub.2 -Gamma enzymes and polynucleotides encoding same
    Patent number: 6121031
    Abstract: The invention provides a novel calcium-independent cytosolic phospholipase A.sub.2 -Gamma enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
    Type: Grant
    Filed: July 9, 1997
    Date of Patent: September 19, 2000
    Assignee: Genetics Institute, Inc.
    Inventors: Chuanzheng Song, Ronald Kriz, John Knopf
  • Polynucleotides encoding human CTLA-8 related proteins
    Patent number: 6074849
    Abstract: Polynucleotides encoding human CTLA-8 related proteins are disclosed. Human CTLA-8 proteins and methods for their production are also disclosed. Methods of treatment using human CTLA-8 proteins, rat CTLA-8 proteins and herpesvirus herpes CTLA-8 proteins are also provided.
    Type: Grant
    Filed: July 18, 1996
    Date of Patent: June 13, 2000
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, Kerry Kelleher, McKeough Carlin, Samuel Goldman, Debra Pittman, Sha Mi, Steven Neben, Joanne Giannotti, Margaret M. Golden-Fleet
  • MU-1, member of the cytokine receptor family
    Patent number: 6057128
    Abstract: Polynucleotides encoding the MU-1 hematopoietin receptor superfamily chain and fragments thereof are disclosed. MU-1 proteins and methods for their production are also disclosed.
    Type: Grant
    Filed: March 17, 1998
    Date of Patent: May 2, 2000
    Assignee: Genetics Institute, Inc.
    Inventors: Debra D. Donaldson, Michelle Unger
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5985602
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: November 16, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding, Cheryl Evans
  • Human semaphorin E, secreted proteins and polynucleotides encoding them
    Patent number: 5981222
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: May 19, 1997
    Date of Patent: November 9, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding
  • Interleukin-1 receptor intracellular ligand proteins
    Patent number: 5981482
    Abstract: Novel IL-1-R intracellular ligand proteins are disclosed. Polynucleotides encoding the IL-1-R intracellular ligand protein are also disclosed, along with vectors, host cells, and methods of making the IL-1-R intracellular ligand protein. Pharmaceutical compositions containing the IL-1-R intracellular ligand protein, methods of treating inflammatory conditions, and methods of inhibiting IL-1-R intracellular domain binding are also disclosed. Methods of identifying inhibitors of IL-1-R intracellular domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: October 7, 1996
    Date of Patent: November 9, 1999
    Assignee: Genetics Institute Inc.
    Inventors: Lih-Ling Lin, James Graham
  • Calcium independent cytosolic phospholipase A.sub.2 /B enzymes
    Patent number: 5976854
    Abstract: The invention provides a novel calcium-independent cytosolic phospholipase A.sub.2 /B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
    Type: Grant
    Filed: November 8, 1995
    Date of Patent: November 2, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Simon Jones, Jin Tang
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5976837
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: November 2, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding, Michael J. Agostino
  • Polynucleotides encoding secreted proteins
    Patent number: 5972652
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 26, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, David Merberg
  • Secreted proteins
    Patent number: 5969093
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: October 19, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, Kerry Kelleher, McKeough Carlin, John M. McCoy
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5969125
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: October 19, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5965693
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: May 19, 1997
    Date of Patent: October 12, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Cheryl Evans
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5965388
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: October 12, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Cheryl Evans, Michael Bowman
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5958726
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: September 28, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, David Merberg, Maurice Treacy, Cheryl Evans
  • TNF receptor death domain ligand proteins
    Patent number: 5948638
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: September 7, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella, James Graham
  • Polynucleotides encoding secreted proteins
    Patent number: 5945302
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: January 13, 1997
    Date of Patent: August 31, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg
  • Human GDP-mannose 4,6 dehydratase
    Patent number: 5942228
    Abstract: The invention provides a novel GDP-mannose 4,6-dehydratase.
    Type: Grant
    Filed: September 9, 1998
    Date of Patent: August 24, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Francis Sullivan, Ronald Kriz, Ravindra Kumar
  • Macrophage inflammatory protein variants
    Patent number: 5936067
    Abstract: The present invention provides a Stem Cell Inhibitor (SCT) protein which comprises at least one amino acid alteration from its active form which protein does not significantly aggregate but which retains substantially unaltered stem cell inhibitory activity. The alteration is preferably a conservative substitution of a charged amino acid residue. Such proteins may be used in treating stem cells in a patient undergoing chemotherapy.
    Type: Grant
    Filed: January 29, 1996
    Date of Patent: August 10, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Gerard Graham, Ian Pragnell
  • TNF receptor death domain ligand proteins
    Patent number: 5891675
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: April 6, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella, James Graham